DK1437349T3 - Substituerede isoxazoler og anvendelse deraf som antibiotika - Google Patents

Substituerede isoxazoler og anvendelse deraf som antibiotika

Info

Publication number
DK1437349T3
DK1437349T3 DK02748888T DK02748888T DK1437349T3 DK 1437349 T3 DK1437349 T3 DK 1437349T3 DK 02748888 T DK02748888 T DK 02748888T DK 02748888 T DK02748888 T DK 02748888T DK 1437349 T3 DK1437349 T3 DK 1437349T3
Authority
DK
Denmark
Prior art keywords
alkyl
alkoxy
substituted
het
triazol
Prior art date
Application number
DK02748888T
Other languages
Danish (da)
English (en)
Inventor
Gallemi Carles Farrerons
Arnal Carmen Lagunas
Serrat Anna Fernandez
Ruiz Juan Lorenzo Catena
Bono Ignacio Jose Miquel
Lopez Dolors Balsa
Roca Carolina Salcedo
Mesa Natividad Toledo
Garcia Andres Fernandez
Original Assignee
S A L V A T Lab Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S A L V A T Lab Sa filed Critical S A L V A T Lab Sa
Application granted granted Critical
Publication of DK1437349T3 publication Critical patent/DK1437349T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK02748888T 2001-07-20 2002-07-17 Substituerede isoxazoler og anvendelse deraf som antibiotika DK1437349T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200101793A ES2180456B1 (es) 2001-07-20 2001-07-20 Isoxazoles sustituidos y su utilizacion como antibioticos.
PCT/ES2002/000358 WO2003008395A1 (es) 2001-07-20 2002-07-17 Isoxazoles sustituidos y su utilizacion como antibioticos

Publications (1)

Publication Number Publication Date
DK1437349T3 true DK1437349T3 (da) 2007-12-03

Family

ID=8498579

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02748888T DK1437349T3 (da) 2001-07-20 2002-07-17 Substituerede isoxazoler og anvendelse deraf som antibiotika

Country Status (14)

Country Link
US (1) US20050014806A1 (ja)
EP (1) EP1437349B9 (ja)
JP (1) JP2005502634A (ja)
KR (1) KR100882377B1 (ja)
CN (1) CN1556797A (ja)
AT (1) ATE370129T1 (ja)
AU (1) AU2002319320B2 (ja)
BR (1) BR0211588A (ja)
CA (1) CA2453846A1 (ja)
DE (1) DE60221870T2 (ja)
DK (1) DK1437349T3 (ja)
ES (2) ES2180456B1 (ja)
PT (1) PT1437349E (ja)
WO (1) WO2003008395A1 (ja)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005512975A (ja) 2001-10-25 2005-05-12 アストラゼネカ アクチボラグ 抗菌薬として有用なイソキサゾリン誘導体
US7842693B2 (en) 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
KR101255356B1 (ko) 2002-06-12 2013-04-17 케모센트릭스, 인크. 염증 및 면역 질병의 치료를 위한 ｃｃｒ１ 길항물질로서사용하기 위한 1-아릴-4-치환된 피페라진 유도체
US20050256130A1 (en) * 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
MXPA04012959A (es) * 2002-06-29 2005-05-16 Zentaris Gmbh Arilcarbonilpiperacinas y heteroarilcarbonilpiperacinas y su uso para tratamiento de enfermedades de tumor benigno y maligno.
WO2005082892A2 (en) * 2004-02-17 2005-09-09 Dr. Reddy's Laboratories Ltd. Triazole compounds as antibacterial agents and pharmaceutical compositions containing them
JP4845873B2 (ja) 2004-03-03 2011-12-28 ケモセントリックス インコーポレーティッド 二環式および架橋した窒素複素環
US7435831B2 (en) 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
NZ552187A (en) 2004-06-18 2010-08-27 Millennium Pharm Inc Thiophene-2-carboxamide derivatives
US7696352B2 (en) 2004-06-18 2010-04-13 Millennium Pharmaceuticals, Inc. Factor Xa inhibitors
EP1976837A1 (en) * 2006-01-19 2008-10-08 Laboratorios SALVAT, S.A. Dicarbonylic compounds with antibacterial activity
CA2651303A1 (en) 2006-05-05 2007-11-15 Millennium Pharmaceuticals, Inc. Factor xa inhibitors
CA2651700A1 (en) * 2006-05-22 2007-11-29 Merck Frosst Canada Ltd. Cyclic amine derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
CN101220000B (zh) * 2007-12-28 2010-12-22 天津药物研究院 酰氯和磺酰氯类衍生物及其用途
EP2334636A2 (en) 2008-09-19 2011-06-22 Pfizer Inc. Hydroxamic acid derivatives useful as antibacterial agents
WO2011073845A1 (en) 2009-12-16 2011-06-23 Pfizer Inc. N-linked hydroxamic acid derivatives useful as antibacterial agents
CA2784921A1 (en) 2009-12-17 2011-07-14 Millennium Pharmaceuticals, Inc. Salts and crystalline forms of a factor xa inhibitor
WO2011075602A1 (en) 2009-12-17 2011-06-23 Millennium Pharmaceuticals, Inc. Methods of preparing factor xa inhibitors and salts thereof
CN101798303B (zh) * 2010-03-10 2011-09-07 天津药物研究院 一类氮唑的衍生物、其制备方法和用途
CN101781294B (zh) * 2010-03-10 2012-02-01 天津药物研究院 一类咪唑的衍生物、其制备方法和用途
CN104529883A (zh) 2011-03-07 2015-04-22 辉瑞大药厂 可用作抗菌剂的氟吡啶酮衍生物
AU2012238374B2 (en) * 2011-04-08 2015-04-02 Pfizer Inc. Isoxazole derivatives useful as antibacterial agents
CN103492368A (zh) 2011-04-08 2014-01-01 辉瑞大药厂 用作抗菌剂的咪唑、吡唑和噻唑衍生物
KR101369584B1 (ko) * 2011-04-19 2014-03-06 일양약품주식회사 페닐-이속사졸 유도체 및 그의 제조방법
WO2013055793A1 (en) 2011-10-12 2013-04-18 University Of Pittsburg-Of The Commonwealth System Of Higher Education Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer
ES2753244T3 (es) 2013-03-15 2020-04-07 Univ Degli Studi Di Milano Bicocca Compuestos novedosos 1,2,4 oxadiazol activos contra patógenos gram positivos
CN103172584A (zh) * 2013-03-15 2013-06-26 吉林大学 双异噁唑甲醚衍生物及制备方法
JP6564380B2 (ja) * 2013-09-20 2019-08-21 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 前立腺癌を治療するための化合物
US20160257657A1 (en) 2013-09-20 2016-09-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
US10518196B2 (en) * 2014-01-29 2019-12-31 General Electric Company Devices for separation of particulates, associated methods and systems
US10980806B2 (en) 2016-03-24 2021-04-20 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
CN109369553B (zh) * 2018-10-22 2023-04-11 上海凌凯医药科技有限公司 一种合成n-3-异恶唑氨基甲酸叔丁酯的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999041244A1 (en) * 1998-02-13 1999-08-19 Pharmacia & Upjohn Company Substituted aminophenyl isoxazoline derivatives useful as antimicrobials
TW572757B (en) * 1998-08-24 2004-01-21 Bristol Myers Squibb Co Novel isoxazolinone antibacterial agents
GB9928568D0 (en) * 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
WO2003008395A1 (es) 2003-01-30
ES2180456A1 (es) 2003-02-01
KR20040043164A (ko) 2004-05-22
DE60221870T2 (de) 2008-05-08
EP1437349A1 (en) 2004-07-14
BR0211588A (pt) 2004-07-13
CN1556797A (zh) 2004-12-22
AU2002319320B2 (en) 2008-03-06
EP1437349B1 (en) 2007-08-15
KR100882377B1 (ko) 2009-02-05
DE60221870D1 (de) 2007-09-27
CA2453846A1 (en) 2003-01-30
US20050014806A1 (en) 2005-01-20
ES2180456B1 (es) 2004-05-01
EP1437349B9 (en) 2008-09-10
JP2005502634A (ja) 2005-01-27
ATE370129T1 (de) 2007-09-15
PT1437349E (pt) 2007-11-19
ES2291481T3 (es) 2008-03-01

Similar Documents

Publication Publication Date Title
DK1437349T3 (da) Substituerede isoxazoler og anvendelse deraf som antibiotika
TR200000243T2 (tr) 1,2,4- triazol [4,3-B] pridol [3,2-D] piridazin türevleri ve bunları ihtiva eden farmasötik bileşimler.
KR100441334B1 (ko) 헤테로-방향족고리치환된페닐옥사졸리딘온항균제
HUP9901820A2 (hu) 4-Amino-pirimidin-származékok, ezeket tartalmazó gyógyszerkészítmények, alkalmazásuk és eljárás előállításukra
YU48714B (sh) Derivati benzofurana, benzotiofena, indola i indolizina i postupak za njihovo dobijanje
CA2285891A1 (en) Triazole antifungal agents
HUP0400266A2 (hu) Imidazo[1,2-a]piridin-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk herpeszvírus-fertőzések megelőzésére vagy kezelésére
WO2001009103A3 (en) Imidazole antiproliferative agents
WO2002051819A3 (en) Heterocyclic compounds having antibacterial activity, process for their preparation and pharmaceutical compositions containing them
CA2494832A1 (en) Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
GB9121456D0 (en) Triazole antifungal agents
WO2005116023A8 (en) 3- {4- (pyridin-3-yl) phenyl} -5- (1h-1, 2, 3-triazol-1-ylmethyl) -1, 3-oxazolidin-2-ones as antibacterial agents
ATE298570T1 (de) Antibakterielle verbindungen
CN103497173A (zh) 具有杂环的新化合物
NO20065889L (no) 3-`4-{6-substituert alkanoyl)pyridin-3-yf}-3-fenyl!-5-(1 H-1,2,3-triazol-1-ylmetyl)-1,3-oksazolidin-2-oner som antibakterielle midler.
ES8207525A1 (es) Un procedimiento para la preparacion de nuevos derivados de la quinoleina.
NO20022123L (no) Osoksazolderivater for anvendelse som inhibitorer for fosfodiesterase VII
CA2345069A1 (en) 2-phenylpyran-4-one derivatives
AU3014592A (en) Systemic control of parasites
TW349950B (en) Substituted tetracyclic azepine derivatives
NZ501982A (en) N-oxide forms of 2,4,4-trisubstituted-1,3-dioxolane as anti-fungal agents
IL101032A0 (en) 1,2,4-triazolo(1,5-a)pyrimidine derivatives,their preparation and pharmaceutical compositions containing them
UA35545C2 (uk) Спосіб одержання похідних 4-оксохіноліну або хромону