DE60221870D1 - Substituierte isoxazole und deren verwendung als antibiotika - Google Patents

Substituierte isoxazole und deren verwendung als antibiotika

Info

Publication number
DE60221870D1
DE60221870D1 DE60221870T DE60221870T DE60221870D1 DE 60221870 D1 DE60221870 D1 DE 60221870D1 DE 60221870 T DE60221870 T DE 60221870T DE 60221870 T DE60221870 T DE 60221870T DE 60221870 D1 DE60221870 D1 DE 60221870D1
Authority
DE
Germany
Prior art keywords
alkyl
alkoxy
substituted
het
triazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60221870T
Other languages
English (en)
Other versions
DE60221870T2 (de
Inventor
Gallemi Carles Farrerons
Arnal Carmen Lagunas
Serrat Anna Fernandez
Ruiz Juan Lorenzo Catena
Bono Ignacio Jose Miquel
Lopez Dolors Balsa
Roca Carolina Salcedo
Mesa Natividad Toledo
Garcia Andres Fernandez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
L V A T LAB SA
Laboratorios Salvat SA
Original Assignee
L V A T LAB SA
Laboratorios Salvat SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by L V A T LAB SA, Laboratorios Salvat SA filed Critical L V A T LAB SA
Publication of DE60221870D1 publication Critical patent/DE60221870D1/de
Application granted granted Critical
Publication of DE60221870T2 publication Critical patent/DE60221870T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60221870T 2001-07-20 2002-07-17 Substituierte isoxazole und deren verwendung als antibiotika Expired - Fee Related DE60221870T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES200101793A ES2180456B1 (es) 2001-07-20 2001-07-20 Isoxazoles sustituidos y su utilizacion como antibioticos.
ES200101793 2001-07-20
PCT/ES2002/000358 WO2003008395A1 (es) 2001-07-20 2002-07-17 Isoxazoles sustituidos y su utilizacion como antibioticos

Publications (2)

Publication Number Publication Date
DE60221870D1 true DE60221870D1 (de) 2007-09-27
DE60221870T2 DE60221870T2 (de) 2008-05-08

Family

ID=8498579

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60221870T Expired - Fee Related DE60221870T2 (de) 2001-07-20 2002-07-17 Substituierte isoxazole und deren verwendung als antibiotika

Country Status (14)

Country Link
US (1) US20050014806A1 (de)
EP (1) EP1437349B9 (de)
JP (1) JP2005502634A (de)
KR (1) KR100882377B1 (de)
CN (1) CN1556797A (de)
AT (1) ATE370129T1 (de)
AU (1) AU2002319320B2 (de)
BR (1) BR0211588A (de)
CA (1) CA2453846A1 (de)
DE (1) DE60221870T2 (de)
DK (1) DK1437349T3 (de)
ES (2) ES2180456B1 (de)
PT (1) PT1437349E (de)
WO (1) WO2003008395A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1443930A1 (de) 2001-10-25 2004-08-11 AstraZeneca AB Isoxazolinderivative verwendbar als antimikrobielle agenzien
US20050256130A1 (en) * 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
WO2003105853A1 (en) 2002-06-12 2003-12-24 Chemocentryx, Inc. 1-aryl-4-substituted piperazines derivatives for use as ccr1 antagonists for the treatment of inflammation and immune disorders
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
US7842693B2 (en) 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
EP1517898A1 (de) * 2002-06-29 2005-03-30 Zentaris GmbH Aryl- und heteroarylcarbonylpiperazine und deren verwendung zur behandlung gutartiger und b sartiger tumorerkrankungen
WO2005082892A2 (en) * 2004-02-17 2005-09-09 Dr. Reddy's Laboratories Ltd. Triazole compounds as antibacterial agents and pharmaceutical compositions containing them
AU2005219438B2 (en) 2004-03-03 2011-02-17 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US7435831B2 (en) 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US7696352B2 (en) 2004-06-18 2010-04-13 Millennium Pharmaceuticals, Inc. Factor Xa inhibitors
CA2565437A1 (en) 2004-06-18 2006-01-05 Millennium Pharmaceuticals, Inc. Factor xa inhibitors
BRPI0706938A2 (pt) * 2006-01-19 2011-04-12 Salvat Lab Sa compostos dicarbonìlicos com atividade antibacterial
MX2008014193A (es) 2006-05-05 2009-03-31 Millennium Pharm Inc Inhibidores del factor xa.
US20100004287A1 (en) * 2006-05-22 2010-01-07 Merck Frosst Canada Ltd. Cyclic Derivatives as Inhibitors of Stearoyl-Coenzyme a Delta-9 Desaturase
CN101220000B (zh) * 2007-12-28 2010-12-22 天津药物研究院 酰氯和磺酰氯类衍生物及其用途
JP5524215B2 (ja) 2008-09-19 2014-06-18 ファイザー・インク 抗菌剤として有用なヒドロキサム酸誘導体
WO2011073845A1 (en) 2009-12-16 2011-06-23 Pfizer Inc. N-linked hydroxamic acid derivatives useful as antibacterial agents
JP5796872B2 (ja) 2009-12-17 2015-10-21 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 第Ｘａ因子阻害剤の結晶性塩
US8742120B2 (en) 2009-12-17 2014-06-03 Millennium Pharmaceuticals, Inc. Methods of preparing factor xa inhibitors and salts thereof
CN101798303B (zh) * 2010-03-10 2011-09-07 天津药物研究院 一类氮唑的衍生物、其制备方法和用途
CN101781294B (zh) * 2010-03-10 2012-02-01 天津药物研究院 一类咪唑的衍生物、其制备方法和用途
BR112013022536B1 (pt) 2011-03-07 2020-05-26 Pfizer, Inc. Derivados flúor-piridinona, suas composições farmacêuticas e usos como agentes antibacterianos
EP2694481B1 (de) 2011-04-08 2015-12-30 Pfizer Inc Imidazol-, pyrazol- und triazolderivate als antibakterika
SG193367A1 (en) * 2011-04-08 2013-10-30 Pfizer Isoxazole derivatives useful as antibacterial agents
KR101369584B1 (ko) * 2011-04-19 2014-03-06 일양약품주식회사 페닐-이속사졸 유도체 및 그의 제조방법
US9708276B2 (en) 2011-10-12 2017-07-18 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer
CN103172584A (zh) * 2013-03-15 2013-06-26 吉林大学 双异噁唑甲醚衍生物及制备方法
ES2753244T3 (es) 2013-03-15 2020-04-07 Univ Degli Studi Di Milano Bicocca Compuestos novedosos 1,2,4 oxadiazol activos contra patógenos gram positivos
CA2924527C (en) 2013-09-20 2022-07-12 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Compounds for treating prostate cancer
US20160257657A1 (en) 2013-09-20 2016-09-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
US10518196B2 (en) * 2014-01-29 2019-12-31 General Electric Company Devices for separation of particulates, associated methods and systems
US10980806B2 (en) 2016-03-24 2021-04-20 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
CN109369553B (zh) * 2018-10-22 2023-04-11 上海凌凯医药科技有限公司 一种合成n-3-异恶唑氨基甲酸叔丁酯的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1054874E (pt) * 1998-02-13 2003-01-31 Upjohn Co Derivados de aminofenil-isoxazolina substituidos uteis como anti-microbianos
TW572757B (en) * 1998-08-24 2004-01-21 Bristol Myers Squibb Co Novel isoxazolinone antibacterial agents
GB9928568D0 (en) * 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
ATE370129T1 (de) 2007-09-15
JP2005502634A (ja) 2005-01-27
EP1437349B1 (de) 2007-08-15
DK1437349T3 (da) 2007-12-03
WO2003008395A1 (es) 2003-01-30
EP1437349A1 (de) 2004-07-14
US20050014806A1 (en) 2005-01-20
ES2180456A1 (es) 2003-02-01
ES2291481T3 (es) 2008-03-01
BR0211588A (pt) 2004-07-13
CA2453846A1 (en) 2003-01-30
ES2180456B1 (es) 2004-05-01
AU2002319320B2 (en) 2008-03-06
KR20040043164A (ko) 2004-05-22
PT1437349E (pt) 2007-11-19
DE60221870T2 (de) 2008-05-08
CN1556797A (zh) 2004-12-22
EP1437349B9 (de) 2008-09-10
KR100882377B1 (ko) 2009-02-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee