DK1425035T3 - Anvendelse af biologisk aktiv HIV-1 Tat, fragmenter eller derivater deraf til targeting og/eller aktivering af antigen-præsenterende celler og/eller til afgivelse af cargo molekyler til forebyggende eller terapeutisk vaccination og/eller til behandling.. - Google Patents

Anvendelse af biologisk aktiv HIV-1 Tat, fragmenter eller derivater deraf til targeting og/eller aktivering af antigen-præsenterende celler og/eller til afgivelse af cargo molekyler til forebyggende eller terapeutisk vaccination og/eller til behandling..

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Publication number
DK1425035T3
DK1425035T3 DK02767265.8T DK02767265T DK1425035T3 DK 1425035 T3 DK1425035 T3 DK 1425035T3 DK 02767265 T DK02767265 T DK 02767265T DK 1425035 T3 DK1425035 T3 DK 1425035T3
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DK
Denmark
Prior art keywords
preventative
tat
targeting
fragments
derivatives
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Application number
DK02767265.8T
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English (en)
Inventor
Barbara Ensoli
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Ist Superiore Sanita
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    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5154Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16311Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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DK02767265.8T 2001-07-26 2002-07-26 Anvendelse af biologisk aktiv HIV-1 Tat, fragmenter eller derivater deraf til targeting og/eller aktivering af antigen-præsenterende celler og/eller til afgivelse af cargo molekyler til forebyggende eller terapeutisk vaccination og/eller til behandling.. DK1425035T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01118114A EP1279404A1 (en) 2001-07-26 2001-07-26 Use of HIV-1 tat, fragments or derivatives thereof, to target or to activate antigen-presenting cells, to deliver cargo molecules for vaccination or to treat other diseases
PCT/EP2002/008377 WO2003009867A1 (en) 2001-07-26 2002-07-26 Use of biologically active hiv-1 tat, fragments or derivates thereof, to target and/or to activate antigen-presenting cells, and/or to deliver cargo molecules for preventive or therapeutic vaccination and/or to treat other diseases

Publications (1)

Publication Number Publication Date
DK1425035T3 true DK1425035T3 (da) 2011-08-29

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Application Number Title Priority Date Filing Date
DK02767265.8T DK1425035T3 (da) 2001-07-26 2002-07-26 Anvendelse af biologisk aktiv HIV-1 Tat, fragmenter eller derivater deraf til targeting og/eller aktivering af antigen-præsenterende celler og/eller til afgivelse af cargo molekyler til forebyggende eller terapeutisk vaccination og/eller til behandling..

Country Status (19)

Country Link
US (1) US7811573B2 (da)
EP (2) EP1279404A1 (da)
JP (1) JP5134183B2 (da)
CN (1) CN1318091C (da)
AP (1) AP2004002986A0 (da)
AT (1) ATE510558T1 (da)
AU (1) AU2002331350B2 (da)
BR (1) BR0211474A (da)
CA (1) CA2455227C (da)
DK (1) DK1425035T3 (da)
EA (1) EA006850B1 (da)
ES (1) ES2367255T3 (da)
HU (1) HUP0400660A2 (da)
IL (1) IL160015A0 (da)
MX (1) MXPA04000287A (da)
NZ (1) NZ531364A (da)
OA (1) OA12701A (da)
PL (1) PL368243A1 (da)
WO (1) WO2003009867A1 (da)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0323840D0 (en) * 2003-10-10 2003-11-12 Ist Superiore Sanita Vaccines
GB0405480D0 (en) 2004-03-11 2004-04-21 Istituto Superiore Di Sanito Novel tat complexes,and vaccines comprising them
WO2005090968A1 (en) 2004-03-16 2005-09-29 Inist Inc. Tat-based immunomodulatory compositions and methods of their discovery and use
US9492400B2 (en) 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
CN100429228C (zh) * 2005-06-17 2008-10-29 中国人民解放军第三军医大学第三附属医院 重组人a20蛋白及其用途
WO2007070682A2 (en) 2005-12-15 2007-06-21 Massachusetts Institute Of Technology System for screening particles
ES2776100T3 (es) 2006-03-31 2020-07-29 Massachusetts Inst Technology Sistema para el suministro dirigido de agentes terapéuticos
CA2652280C (en) 2006-05-15 2014-01-28 Massachusetts Institute Of Technology Polymers for functional particles
WO2007150030A2 (en) 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
CA2660830A1 (en) * 2006-08-14 2008-02-21 Gideon Goldstein Compositions and methods for the treatment and prophylaxis of multiple strains and subtypes of hiv-1
WO2008098165A2 (en) 2007-02-09 2008-08-14 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
JP2010523595A (ja) 2007-04-04 2010-07-15 マサチューセッツ インスティテュート オブ テクノロジー ポリ(アミノ酸)ターゲッティング部分
EP2394657A1 (en) 2007-10-12 2011-12-14 Massachusetts Institute Of Technology Vaccine nanotechnology
GB0802224D0 (en) * 2008-02-06 2008-03-12 Inst Superiore Di Sanito Process for the production of vaccine components
JP2011511674A (ja) 2008-02-07 2011-04-14 ユニヴァーシティ オブ ワシントン 周方向エアロゾルデバイス
EP2106803A1 (en) * 2008-04-04 2009-10-07 Fondazione Centro San Raffaele del Monte Tabor Method to design and uses of overlapping peptides for monitoring T-cell responses in HIV patients
US9439922B2 (en) 2008-05-14 2016-09-13 Jawaharlal Nehru Centre For Advanced Scientific Research Tat DNA sequences, gene constructs, vaccine and processes thereof
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
CA2755897C (en) 2009-03-23 2020-01-28 Nanirx, Inc. Treatment of cancers with immunostimulatory hiv tat derivative polypeptides
EP2536838A4 (en) * 2010-02-18 2013-08-21 Univ Emory VECTOR FOR THE EXPRESSION OF HIV ANTIGENES AND GM-CSF AND CORRESPONDING METHODS FOR GENERATING IMMUNE RESPONSE
US20110287045A1 (en) * 2010-05-20 2011-11-24 Zongdong Li Enhanced immune response against infections
CA2828884C (en) 2011-03-03 2021-04-27 Impel Neuropharma, Inc. Nasal drug delivery device
AU2012253569B2 (en) 2011-05-09 2018-02-15 Impel Pharmaceuticals Inc. Nozzles for nasal drug delivery
WO2014041505A1 (en) * 2012-09-13 2014-03-20 Universite De Geneve Cell penetrating peptides
CN103880961A (zh) * 2012-12-19 2014-06-25 邱书奇 一种诱导免疫耐受融合肽构建
HK1222358A1 (zh) 2013-04-28 2017-06-30 Impel Neuropharma Inc. 医用单位剂量容器
CA2926221A1 (en) 2013-10-04 2015-04-09 Pin Pharma, Inc. Immunostimulatory hiv tat derivative polypeptides for use in cancer treatment
US20170044218A1 (en) * 2014-04-24 2017-02-16 Janssen Sciences Ireland Uc Use of a HIV derived accessory protein for the reactivation of latent HIV
JP6753927B2 (ja) 2015-09-10 2020-09-09 インペル ニューロファーマ インコーポレイテッド 直列形経鼻送達デバイス
PL3402802T3 (pl) 2016-01-08 2023-06-05 Geovax, Inc. Kompozycje i sposoby generowania odpowiedzi immunologicznej względem antygenu powiązanego z guzem nowotworowym
CN105535937B (zh) * 2016-03-11 2018-03-13 刘红 一种用于治疗类风湿性关节炎的皮下注射用原位凝胶
US20190209615A1 (en) * 2016-09-15 2019-07-11 Virex Ab T-cell immunotherapy
US11311612B2 (en) 2017-09-19 2022-04-26 Geovax, Inc. Compositions and methods for generating an immune response to treat or prevent malaria
KR102131898B1 (ko) * 2017-10-31 2020-07-08 주식회사 노벨티노빌리티 Scf 및 갈렉틴-1을 표적으로 하는 이중표적항체 및 그 용도
JP7191099B2 (ja) 2017-11-21 2022-12-16 インペル ファーマシューティカルズ インコーポレイテッド 浸漬管を備えた鼻腔内装置
WO2019104192A1 (en) 2017-11-21 2019-05-31 Impel Neuropharma, Inc. Intranasal device with inlet interface
WO2019136308A1 (en) 2018-01-05 2019-07-11 Impel Neuropharma, Inc. Intranasal delivery of olanzapine by precision olfactory device
CN111936140A (zh) 2018-01-05 2020-11-13 英倍尔药业股份有限公司 通过精密鼻装置的双氢麦角胺的鼻内递送
US11517548B2 (en) 2018-07-19 2022-12-06 Impel Pharmaceuticals Inc. Respiratory tract delivery of levodopa and DOPA decarboxylase inhibitor for treatment of Parkinson's Disease
JP7213991B2 (ja) 2019-01-03 2023-01-27 インペル ファーマシューティカルズ インコーポレイテッド 経鼻薬送達器具
EP3907504A4 (en) * 2019-01-04 2022-11-30 Kyoto University TEST PROCEDURE FOR ULCERATIVE COLITIS AND PRIMARY SCLEROTIC CHOLANGITIS
WO2020236658A1 (en) 2019-05-17 2020-11-26 Impel Neuropharma, Inc. Single-use nasal delivery device
US12016920B2 (en) 2019-06-06 2024-06-25 Denka Company Limited Adjuvant based on peptide nucleic acid
JP7640976B2 (ja) * 2019-12-31 2025-03-06 シァメン・ユニヴァーシティ 分子の細胞内送達用の多量体化送達システム
CN111450082A (zh) * 2020-04-26 2020-07-28 天津大学 一种系统性红斑狼疮治疗纳米颗粒的合成方法
CN115869416A (zh) * 2021-09-28 2023-03-31 上海交通大学医学院附属第九人民医院 用于眼部靶向递药的细胞膜、药物载体、组合物及其制备方法和用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9720585D0 (en) * 1997-09-26 1997-11-26 Smithkline Beecham Biolog Vaccine
IT1297090B1 (it) * 1997-12-01 1999-08-03 Barbara Ensoli Tat di hiv-1 o suoi derivati, da soli od in combinazione, a scopo vaccinale, profilattico e terapeutico, contro l'aids i tumori e le
FI105105B (fi) * 1998-02-27 2000-06-15 Finnish Immunotechnology Ltd O Itsereplikoiva DNA-vektori immunisoimiseksi HIV:ta vastaan
AU4082300A (en) * 1999-06-21 2001-01-09 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Hiv tat peptides and multiple peptide conjugate system
EP1198249B1 (en) 1999-06-29 2005-10-19 GlaxoSmithKline Biologicals S.A. Use of cpg as an adjuvant for hiv vaccine
ATE465754T1 (de) 1999-08-12 2010-05-15 Inist Inc Nicht-immunsuppresives hiv tat-protein
WO2001019393A1 (en) * 1999-09-13 2001-03-22 Cornell Research Foundation, Inc. Delivering to eucaryotic cells bacterial proteins that are secreted via type iii secretion systems
CA2398611A1 (en) 2000-01-31 2001-08-02 Smithkline Beecham Biologicals S.A. Vaccine for the prophylactic or therapeutic immunization against hiv
WO2001054717A1 (en) 2000-01-31 2001-08-02 Vic Jira Vaccine composition, process and methods
US6544780B1 (en) 2000-06-02 2003-04-08 Genphar, Inc. Adenovirus vector with multiple expression cassettes
AT410635B (de) * 2000-10-18 2003-06-25 Cistem Biotechnologies Gmbh Vakzin-zusammensetzung

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MXPA04000287A (es) 2005-03-07
IL160015A0 (en) 2004-06-20
US20050036985A1 (en) 2005-02-17
CA2455227A1 (en) 2003-02-06
WO2003009867A1 (en) 2003-02-06
ATE510558T1 (de) 2011-06-15
AP2004002986A0 (en) 2004-03-31
EP1279404A1 (en) 2003-01-29
NZ531364A (en) 2005-12-23
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US7811573B2 (en) 2010-10-12
CN1318091C (zh) 2007-05-30
AU2002331350B2 (en) 2008-06-12
OA12701A (en) 2006-06-23
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EP1425035A1 (en) 2004-06-09
HUP0400660A2 (hu) 2005-01-28
ES2367255T3 (es) 2011-10-31
CA2455227C (en) 2012-01-24
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BR0211474A (pt) 2004-07-13
EA200400227A1 (ru) 2004-06-24
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