DK142326B - Analogifremgangsmåde til fremstilling af 2,9alfa-dichlor-6alfa-fluor-16alfa-methyl-11beta, 17alfa,21-trihydroxy-pregna-1,4-dien-3,20-dionforbindelser eller salte af estere af polybasiske syrer. - Google Patents

Analogifremgangsmåde til fremstilling af 2,9alfa-dichlor-6alfa-fluor-16alfa-methyl-11beta, 17alfa,21-trihydroxy-pregna-1,4-dien-3,20-dionforbindelser eller salte af estere af polybasiske syrer. Download PDF

Info

Publication number
DK142326B
DK142326B DK557576AA DK557576A DK142326B DK 142326 B DK142326 B DK 142326B DK 557576A A DK557576A A DK 557576AA DK 557576 A DK557576 A DK 557576A DK 142326 B DK142326 B DK 142326B
Authority
DK
Denmark
Prior art keywords
acid
dichloro
fluoro
methyl
esters
Prior art date
Application number
DK557576AA
Other languages
Danish (da)
English (en)
Other versions
DK557576A (de
DK142326C (de
Inventor
Georg Anner
Charles Meystre
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK557576A publication Critical patent/DK557576A/da
Publication of DK142326B publication Critical patent/DK142326B/da
Application granted granted Critical
Publication of DK142326C publication Critical patent/DK142326C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J21/00Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
DK557576AA 1975-12-12 1976-12-10 Analogifremgangsmåde til fremstilling af 2,9alfa-dichlor-6alfa-fluor-16alfa-methyl-11beta, 17alfa,21-trihydroxy-pregna-1,4-dien-3,20-dionforbindelser eller salte af estere af polybasiske syrer. DK142326B (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1615075A CH626632A5 (en) 1975-12-12 1975-12-12 Process for the preparation of halopregnadienes
CH1615075 1975-12-12

Publications (3)

Publication Number Publication Date
DK557576A DK557576A (de) 1977-06-13
DK142326B true DK142326B (da) 1980-10-13
DK142326C DK142326C (de) 1981-03-09

Family

ID=4414834

Family Applications (1)

Application Number Title Priority Date Filing Date
DK557576AA DK142326B (da) 1975-12-12 1976-12-10 Analogifremgangsmåde til fremstilling af 2,9alfa-dichlor-6alfa-fluor-16alfa-methyl-11beta, 17alfa,21-trihydroxy-pregna-1,4-dien-3,20-dionforbindelser eller salte af estere af polybasiske syrer.

Country Status (19)

Country Link
JP (1) JPS5273852A (de)
AT (1) AT353432B (de)
AU (1) AU510864B2 (de)
BE (1) BE849267A (de)
CA (1) CA1078824A (de)
CH (2) CH626632A5 (de)
DD (1) DD128682A5 (de)
DE (1) DE2655802A1 (de)
DK (1) DK142326B (de)
ES (2) ES454119A1 (de)
FR (1) FR2358152A1 (de)
GB (1) GB1563595A (de)
HU (1) HU176936B (de)
IE (1) IE44512B1 (de)
IL (1) IL51085A (de)
NL (1) NL7613711A (de)
NZ (1) NZ182865A (de)
SE (1) SE7613919L (de)
ZA (1) ZA767381B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT78973A (en) * 1984-07-25 1984-08-01 Joao Emerico Villax New preparation process of the 9alpha-fluoro 17,21-acylates or hidroxilades in 17 and 21 chloro-corticosteroid

Also Published As

Publication number Publication date
DK557576A (de) 1977-06-13
GB1563595A (en) 1980-03-26
SE7613919L (sv) 1977-06-13
ZA767381B (en) 1977-11-30
FR2358152B1 (de) 1982-10-22
AU510864B2 (en) 1980-07-17
AT353432B (de) 1979-11-12
NL7613711A (nl) 1977-06-14
JPS5273852A (en) 1977-06-21
IL51085A0 (en) 1977-02-28
DK142326C (de) 1981-03-09
AU2047176A (en) 1978-06-15
CA1078824A (en) 1980-06-03
CH626632A5 (en) 1981-11-30
HU176936B (hu) 1981-06-28
IE44512L (en) 1977-06-12
ES465551A1 (es) 1978-09-16
CH626094A5 (en) 1981-10-30
NZ182865A (en) 1979-06-08
FR2358152A1 (fr) 1978-02-10
IL51085A (en) 1980-09-16
BE849267A (fr) 1977-06-10
ES454119A1 (es) 1978-03-01
IE44512B1 (en) 1981-12-30
ATA914176A (de) 1979-04-15
DD128682A5 (de) 1977-12-07
DE2655802A1 (de) 1977-06-16

Similar Documents

Publication Publication Date Title
DE2707336C2 (de)
CA1234564A (en) Carboxylic acid esters
IE44473B1 (en) 6,9,21-trihalo-steroids of the pregnane series
US3981894A (en) Chemical compounds
NO156515B (no) Hudpleiepreparat.
DE2715863A1 (de) Verfahren zur herstellung von steroidcarbonsaeuren und ihren estern
DK142326B (da) Analogifremgangsmåde til fremstilling af 2,9alfa-dichlor-6alfa-fluor-16alfa-methyl-11beta, 17alfa,21-trihydroxy-pregna-1,4-dien-3,20-dionforbindelser eller salte af estere af polybasiske syrer.
CA1101410A (en) Polyhalogenated steroids
NO157864B (no) Analogifremgangsaate for fremstilling av nye, terapeutisk virksomme diklorerte 16alfa-methylpregnanderivater.
US2985650A (en) 6alpha-ammonio-derivatives of 11-keto cortical hormones
DK145666B (da) Fremgangsmaade til fremstilling af 17alfa-(3-jodbenzoyloxy)-9alfa-chlor-4-pregnen-3,20-dioner eller deres d-homoanaloge
DK168631B1 (da) Corticoidderivater, fremgangsmåde til fremstilling af corticoidderivaterne, farmaceutisk præparat indeholdende corticoidderivaterne samt mellemprodukter
SE453194B (sv) Rifamycinderivat, forfarande for framstellning derav samt farmaceutiska kompositioner innehallande dessa
US2864839A (en) delta4, 7, 9(11)-pregnatriene-17alpha, 21-diol-3, 20-dione and process therefor
US3018295A (en) 21-methylene steroid compounds
US4221786A (en) Novel halogenopregnadienes and process for the manufacture thereof
US3462423A (en) Cyano-derivatives of steroids
Batres et al. Steroids. CLVII. 1 6-Aminoandrostanes
SE440656B (sv) Sett att framstella 16-metyl-9alfa-halogen-prednisolonestrar och -etrar
US3261831A (en) 11-keto-12beta-hydroxy progesterone and derivatives thereof
US3234215A (en) 4-alkyl-delta1, 3, 5(10)-19-norpregnatriene-1, 16, 17-triol-20-ones and acetals and ketals thereof
US3393230A (en) Alpha-norsteroids
JPS617293A (ja) 新規なコルチコイド誘導体およびその製法
CS208495B2 (en) Method of making the alcyesters of the 4-halogen-3-oxo-androsta-1,4-dien beta-carboxyle acid
JPH0533235B2 (de)