DK1412332T3 - Quinolinderivater og anvendelse deraf som antitumormidler - Google Patents
Quinolinderivater og anvendelse deraf som antitumormidlerInfo
- Publication number
- DK1412332T3 DK1412332T3 DK02752656T DK02752656T DK1412332T3 DK 1412332 T3 DK1412332 T3 DK 1412332T3 DK 02752656 T DK02752656 T DK 02752656T DK 02752656 T DK02752656 T DK 02752656T DK 1412332 T3 DK1412332 T3 DK 1412332T3
- Authority
- DK
- Denmark
- Prior art keywords
- formula
- compound
- antitumor agents
- quinoline derivatives
- salt
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30914401P | 2001-07-31 | 2001-07-31 | |
| PCT/US2002/024442 WO2003011832A1 (en) | 2001-07-31 | 2002-07-31 | Quinoline derivatives and use thereof as antitumor agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1412332T3 true DK1412332T3 (da) | 2005-05-30 |
Family
ID=23196886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02752656T DK1412332T3 (da) | 2001-07-31 | 2002-07-31 | Quinolinderivater og anvendelse deraf som antitumormidler |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US6867219B2 (https=) |
| EP (1) | EP1412332B1 (https=) |
| JP (1) | JP4310185B2 (https=) |
| KR (1) | KR20040055774A (https=) |
| AT (1) | ATE287397T1 (https=) |
| AU (1) | AU2002355747B2 (https=) |
| CA (1) | CA2456173A1 (https=) |
| DE (1) | DE60202682T2 (https=) |
| DK (1) | DK1412332T3 (https=) |
| EA (1) | EA007205B1 (https=) |
| ES (1) | ES2236548T3 (https=) |
| GE (1) | GEP20063754B (https=) |
| HU (1) | HUP0401562A2 (https=) |
| IL (2) | IL160082A0 (https=) |
| MX (1) | MXPA04000968A (https=) |
| NO (1) | NO326463B1 (https=) |
| NZ (1) | NZ530806A (https=) |
| PL (1) | PL367340A1 (https=) |
| PT (1) | PT1412332E (https=) |
| UA (1) | UA75691C2 (https=) |
| WO (1) | WO2003011832A1 (https=) |
| ZA (1) | ZA200401185B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001250783A1 (en) * | 2000-02-29 | 2001-09-12 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
| PT1412332E (pt) * | 2001-07-31 | 2005-06-30 | Jerome P Horwitz | Derivados de quinolina e sua utilizacao como agentes antitumorais |
| UA79293C2 (en) * | 2002-07-03 | 2007-06-11 | Univ Wayne State | 4-(7'-halo-2-quino (xa-) linyloxy)phenoxy propionic acid derivatives as antineoplastic agents |
| EP1536789A1 (de) * | 2002-08-24 | 2005-06-08 | Zentaris GmbH | Arzneimittel enthaltend disorale und ihre derivate und deren anwendung zur behandlung gutartiger und bösartiger tumorerkrankngen |
| US7470788B2 (en) | 2005-09-07 | 2008-12-30 | Wayne State University | Antitumor agents |
| US8183379B2 (en) | 2005-09-07 | 2012-05-22 | Wayne State University | Antitumor agents |
| US20070054938A1 (en) * | 2005-09-07 | 2007-03-08 | Horwitz Jerome P | Antitumor agents |
| EP1897542A1 (en) * | 2006-09-07 | 2008-03-12 | Sanofi-Aventis | Aqueous formulation comprising an antitumor agent |
| JO2685B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان في | Quinoline antibacterial derivatives |
| WO2009002955A1 (en) * | 2007-06-27 | 2008-12-31 | Sanofi-Aventis U.S. Llc | Process for the preparation of (2r)-2-[4-(7-bromo-2-quinolyloxy)phenoxy]propanoic acid |
| JP2014516075A (ja) | 2011-06-06 | 2014-07-07 | シェブロン フィリップス ケミカル カンパニー エルピー | 癌治療のためのメタロセン化合物の使用 |
| EP4583874A1 (en) * | 2022-12-21 | 2025-07-16 | Charles University, Faculty Of Pharmacy In Hradec Kralove | Multitarget nuclear receptor ligands based on 2-(4-(quinolin-2-yloxy)phenoxy)propanoic acid and 2-(4-(quinoxalin-2-yloxy)phenoxy)propanoic acid for the treatment of metabolic and liver diseases |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6033389B2 (ja) | 1979-02-22 | 1985-08-02 | 日産化学工業株式会社 | 複素環エ−テル系フェノシキ脂肪酸誘導体、その製造法および該誘導体を含有する除草剤 |
| US6197728B1 (en) | 1980-08-06 | 2001-03-06 | Nissan Chemical Industries Ltd. | Quinoxaline derivatives and herbicidal composition |
| US5364831A (en) | 1980-08-06 | 1994-11-15 | Nissan Chemical Industries Ltd. | Quinoxaline derivatives and herbicidal composition |
| US5250690A (en) * | 1985-05-02 | 1993-10-05 | Dowelanco | Haloalkoxy anilide derivatives of 2-4(-heterocyclic oxyphenoxy)alkanoic or alkenoic acids and their use as herbicides |
| PT1412332E (pt) | 2001-07-31 | 2005-06-30 | Jerome P Horwitz | Derivados de quinolina e sua utilizacao como agentes antitumorais |
| UA79293C2 (en) * | 2002-07-03 | 2007-06-11 | Univ Wayne State | 4-(7'-halo-2-quino (xa-) linyloxy)phenoxy propionic acid derivatives as antineoplastic agents |
| US7470788B2 (en) * | 2005-09-07 | 2008-12-30 | Wayne State University | Antitumor agents |
-
2002
- 2002-07-31 PT PT02752656T patent/PT1412332E/pt unknown
- 2002-07-31 PL PL02367340A patent/PL367340A1/xx not_active Application Discontinuation
- 2002-07-31 DE DE60202682T patent/DE60202682T2/de not_active Expired - Lifetime
- 2002-07-31 MX MXPA04000968A patent/MXPA04000968A/es active IP Right Grant
- 2002-07-31 ES ES02752656T patent/ES2236548T3/es not_active Expired - Lifetime
- 2002-07-31 AU AU2002355747A patent/AU2002355747B2/en not_active Ceased
- 2002-07-31 IL IL16008202A patent/IL160082A0/xx unknown
- 2002-07-31 NZ NZ530806A patent/NZ530806A/en unknown
- 2002-07-31 EP EP02752656A patent/EP1412332B1/en not_active Expired - Lifetime
- 2002-07-31 HU HU0401562A patent/HUP0401562A2/hu unknown
- 2002-07-31 UA UA2004021374A patent/UA75691C2/uk unknown
- 2002-07-31 WO PCT/US2002/024442 patent/WO2003011832A1/en not_active Ceased
- 2002-07-31 AT AT02752656T patent/ATE287397T1/de not_active IP Right Cessation
- 2002-07-31 JP JP2003517024A patent/JP4310185B2/ja not_active Expired - Fee Related
- 2002-07-31 DK DK02752656T patent/DK1412332T3/da active
- 2002-07-31 CA CA002456173A patent/CA2456173A1/en not_active Abandoned
- 2002-07-31 KR KR10-2004-7001559A patent/KR20040055774A/ko not_active Abandoned
- 2002-07-31 GE GE5486A patent/GEP20063754B/en unknown
- 2002-07-31 US US10/210,781 patent/US6867219B2/en not_active Expired - Lifetime
- 2002-07-31 EA EA200400219A patent/EA007205B1/ru not_active IP Right Cessation
-
2004
- 2004-01-27 IL IL160082A patent/IL160082A/en not_active IP Right Cessation
- 2004-01-28 NO NO20040382A patent/NO326463B1/no not_active IP Right Cessation
- 2004-02-13 ZA ZA200401185A patent/ZA200401185B/en unknown
- 2004-12-10 US US11/009,457 patent/US7241894B2/en not_active Expired - Fee Related
-
2007
- 2007-05-24 US US11/753,197 patent/US7507749B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL160082A (en) | 2009-06-15 |
| JP4310185B2 (ja) | 2009-08-05 |
| MXPA04000968A (es) | 2005-02-17 |
| DE60202682D1 (de) | 2005-02-24 |
| US20070232643A1 (en) | 2007-10-04 |
| HUP0401562A2 (hu) | 2004-12-28 |
| GEP20063754B (en) | 2006-02-27 |
| IL160082A0 (en) | 2004-06-20 |
| EP1412332B1 (en) | 2005-01-19 |
| EP1412332A1 (en) | 2004-04-28 |
| PL367340A1 (en) | 2005-02-21 |
| NZ530806A (en) | 2006-05-26 |
| EA007205B1 (ru) | 2006-08-25 |
| ZA200401185B (en) | 2004-10-21 |
| KR20040055774A (ko) | 2004-06-26 |
| ES2236548T3 (es) | 2005-07-16 |
| PT1412332E (pt) | 2005-06-30 |
| US20050159447A1 (en) | 2005-07-21 |
| UA75691C2 (en) | 2006-05-15 |
| EA200400219A1 (ru) | 2004-12-30 |
| ATE287397T1 (de) | 2005-02-15 |
| US7241894B2 (en) | 2007-07-10 |
| AU2002355747B2 (en) | 2007-12-20 |
| NO326463B1 (no) | 2008-12-08 |
| JP2004538314A (ja) | 2004-12-24 |
| DE60202682T2 (de) | 2005-12-29 |
| WO2003011832A1 (en) | 2003-02-13 |
| US20030144321A1 (en) | 2003-07-31 |
| US6867219B2 (en) | 2005-03-15 |
| CA2456173A1 (en) | 2003-02-13 |
| US7507749B2 (en) | 2009-03-24 |
| NO20040382L (no) | 2004-03-26 |
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