DK1408034T4 - Anvendelse af quinolon- og quinolizinon-derivater som kemoterapeutika - Google Patents
Anvendelse af quinolon- og quinolizinon-derivater som kemoterapeutikaInfo
- Publication number
- DK1408034T4 DK1408034T4 DK03028047.3T DK03028047T DK1408034T4 DK 1408034 T4 DK1408034 T4 DK 1408034T4 DK 03028047 T DK03028047 T DK 03028047T DK 1408034 T4 DK1408034 T4 DK 1408034T4
- Authority
- DK
- Denmark
- Prior art keywords
- halo
- alkyl
- optionally substituted
- optionally
- quinolizine
- Prior art date
Links
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 238000011282 treatment Methods 0.000 abstract 3
- FLBAYUMRQUHISI-UHFFFAOYSA-N 1,8-naphthyridine Chemical compound N1=CC=CC2=CC=CN=C21 FLBAYUMRQUHISI-UHFFFAOYSA-N 0.000 abstract 2
- YCAZALSUJDPQPP-UHFFFAOYSA-N 4-oxo-3h-quinoline-3-carboxylic acid Chemical class C1=CC=C2C(=O)C(C(=O)O)C=NC2=C1 YCAZALSUJDPQPP-UHFFFAOYSA-N 0.000 abstract 2
- GDRVFDDBLLKWRI-UHFFFAOYSA-N 4H-quinolizine Chemical compound C1=CC=CN2CC=CC=C21 GDRVFDDBLLKWRI-UHFFFAOYSA-N 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 2
- -1 carboxylate salts Chemical class 0.000 abstract 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 230000000699 topical effect Effects 0.000 abstract 2
- 125000004777 2-fluoroethyl group Chemical group [H]C([H])(F)C([H])([H])* 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002723 alicyclic group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 1
- 229960003405 ciprofloxacin Drugs 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 abstract 1
- 208000032625 disorder of ear Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000030533 eye disease Diseases 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/50—Preparations specially adapted for dental root treatment
- A61K6/54—Filling; Sealing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
- A61K6/69—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19962470A DE19962470A1 (de) | 1999-12-22 | 1999-12-22 | Verwendung von Chemotherapeutika |
PCT/EP2000/013155 WO2001045679A2 (de) | 1999-12-22 | 2000-12-22 | Verwendung von chemotherapeutika zur topischen behandlung |
Publications (2)
Publication Number | Publication Date |
---|---|
DK1408034T3 DK1408034T3 (da) | 2007-12-17 |
DK1408034T4 true DK1408034T4 (da) | 2011-08-15 |
Family
ID=7934136
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00985241T DK1244434T3 (da) | 1999-12-22 | 2000-12-22 | Anvendelse af kemoterapeutiske midler til topisk behandling |
DK03028047.3T DK1408034T4 (da) | 1999-12-22 | 2000-12-22 | Anvendelse af quinolon- og quinolizinon-derivater som kemoterapeutika |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00985241T DK1244434T3 (da) | 1999-12-22 | 2000-12-22 | Anvendelse af kemoterapeutiske midler til topisk behandling |
Country Status (21)
Country | Link |
---|---|
US (5) | US8975275B2 (da) |
EP (2) | EP1408034B2 (da) |
JP (1) | JP5414138B2 (da) |
KR (1) | KR100803442B1 (da) |
CN (2) | CN101513405B (da) |
AT (2) | ATE369344T1 (da) |
AU (1) | AU784496B2 (da) |
BR (1) | BR0017041A (da) |
CA (2) | CA2395459C (da) |
CY (1) | CY1106977T1 (da) |
DE (3) | DE19962470A1 (da) |
DK (2) | DK1244434T3 (da) |
ES (2) | ES2218264T3 (da) |
IL (2) | IL150359A0 (da) |
MX (1) | MXPA02006248A (da) |
NO (2) | NO323727B1 (da) |
PL (2) | PL209943B1 (da) |
PT (2) | PT1244434E (da) |
TR (1) | TR200401396T4 (da) |
WO (1) | WO2001045679A2 (da) |
ZA (1) | ZA200205027B (da) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6509327B1 (en) * | 1998-09-30 | 2003-01-21 | Alcon Manufacturing, Ltd. | Compositions and methods for treating otic, ophthalmic and nasal infections |
US6740664B2 (en) | 1998-09-30 | 2004-05-25 | Alcon, Inc. | Methods for treating otic and ophthalmic infections |
US6716830B2 (en) | 1998-09-30 | 2004-04-06 | Alcon, Inc. | Ophthalmic antibiotic compositions containing moxifloxacin |
DE19962470A1 (de) | 1999-12-22 | 2001-07-12 | Schulz Hans Herrmann | Verwendung von Chemotherapeutika |
US20040176337A1 (en) * | 2002-12-31 | 2004-09-09 | Wockhardt Limited | Benzoquinolizine-2-carboxylic acid-containing compositions |
JP2006513188A (ja) * | 2002-12-31 | 2006-04-20 | ウックハート リミテッド | ベンゾキノリンジカルボン酸抗菌薬の組成物 |
BRPI0407368A (pt) | 2003-02-10 | 2006-02-14 | Bayer Healthcare Ag | tratamento de doenças bacterianas dos órgãos respiratórios mediante aplicação local e fluor-quinolonas. |
DE10337191A1 (de) * | 2003-08-13 | 2005-03-17 | Bayer Healthcare Ag | Neue Verwendung von Chinolon-Antibiotika |
AU2004272414B2 (en) * | 2003-09-10 | 2009-05-28 | Kyorin Pharmaceutical Co., Ltd. | 7-(4-substituted 3- cyclopropylaminomethyl-1- pyrrolidinyl) quinolonecarboxylic acid derivative |
US20090169585A1 (en) * | 2003-10-23 | 2009-07-02 | Resveratrol Partners, Llc | Resveratrol-Containing Compositions And Their Use In Modulating Gene Product Concentration Or Activity |
US20050158376A1 (en) * | 2003-10-23 | 2005-07-21 | Sardi William F. | Dietary supplement and method of processing same |
US7759362B2 (en) | 2004-04-21 | 2010-07-20 | Institut Of Medicinal Biotechnology Chinese Academy Of Medical Sciences | Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof |
CN1244582C (zh) * | 2004-04-21 | 2006-03-08 | 中国医学科学院医药生物技术研究所 | 喹诺酮羧酸类化合物及其制备方法和医药用途 |
WO2006134431A1 (en) * | 2005-05-03 | 2006-12-21 | Ranbaxy Laboratories Limited | Formate salt of gemifloxacin |
WO2007025187A2 (en) * | 2005-08-26 | 2007-03-01 | Emory University | Compounds and methods for modulating the silencing of a polynucleotide of interest |
DE102005045145A1 (de) * | 2005-09-15 | 2007-03-29 | Schülke & Mayr GmbH | Verwendung von Octenidindihydrochlorid in halbfesten Zubereitungen |
EP1954307A4 (en) | 2005-11-14 | 2009-12-02 | Univ Maryland Biotech Inst | ORAL VACCINES AGAINST MILZBRAND ON SALMONELLA BASE |
DE102006029500A1 (de) * | 2006-06-27 | 2008-01-03 | Schulz, Hans H. | Verwendung einer antimikrobiellen härtenden Alginatmasse zur topischen Behandlung von Wunden und Entzündungen in der Human-, Zahn- und Veterinärmedizin |
DE102007040569A1 (de) | 2007-08-28 | 2009-03-05 | Schulz, Hans H. | Verfahren zur Prophylaxe von Karies und Parodontopathien |
DE102008022086A1 (de) | 2008-05-05 | 2009-11-12 | Schulz, Hans H. | Zweikomponenten-Alginat |
EP2409702A1 (en) * | 2010-07-21 | 2012-01-25 | Bayer Innovation GmbH | Combination of siloxane and active ingredient for treating dental disorder of hard tissues |
US8916528B2 (en) | 2011-11-16 | 2014-12-23 | Resveratrol Partners, Llc | Compositions containing resveratrol and nucleotides |
CN103087042B (zh) * | 2012-03-09 | 2015-02-18 | 南京优科生物医药有限公司 | 西他沙星的盐及制药用途 |
US9446131B2 (en) | 2013-01-31 | 2016-09-20 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US8778365B1 (en) | 2013-01-31 | 2014-07-15 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US9452173B2 (en) | 2013-01-31 | 2016-09-27 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US9433680B2 (en) * | 2013-01-31 | 2016-09-06 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
EP3099301B1 (en) * | 2014-01-29 | 2019-12-18 | Vyome Therapeutics Limited | Besifloxacin for the treatment of resistant acne |
EP3137011A4 (en) * | 2014-04-29 | 2018-01-03 | Dentsply International Inc. | Endodontic treatment with long term drug delivery system |
CN110997020A (zh) * | 2017-02-08 | 2020-04-10 | Hkl医疗有限责任公司 | 位点内施用和剂量方法以及其中使用的药物 |
MX2019014931A (es) * | 2017-06-16 | 2020-02-13 | Kyorin Seiyaku Kk | Agente terapeutico para neumonia por aspiracion, supuracion pulmonar, o absceso pulmonar. |
US11376216B2 (en) | 2018-01-02 | 2022-07-05 | New York University | Periodontal disease therapy |
WO2021081267A1 (en) * | 2019-10-23 | 2021-04-29 | Taigen Biotechnology Co., Ltd | Quinolone carboxylic derivatives |
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FR2387647A1 (fr) * | 1977-04-20 | 1978-11-17 | Spad Lab | Pate de traitement endodontique pour l'obturation canalaire de dents |
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-
1999
- 1999-12-22 DE DE19962470A patent/DE19962470A1/de not_active Withdrawn
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2000
- 2000-12-22 CN CN2009101183278A patent/CN101513405B/zh not_active Expired - Fee Related
- 2000-12-22 DE DE50014553T patent/DE50014553D1/de not_active Expired - Lifetime
- 2000-12-22 BR BR0017041-0A patent/BR0017041A/pt not_active Application Discontinuation
- 2000-12-22 CA CA2395459A patent/CA2395459C/en not_active Expired - Lifetime
- 2000-12-22 KR KR1020027008087A patent/KR100803442B1/ko not_active IP Right Cessation
- 2000-12-22 EP EP03028047A patent/EP1408034B2/de not_active Expired - Lifetime
- 2000-12-22 IL IL15035900A patent/IL150359A0/xx active IP Right Grant
- 2000-12-22 CN CNB008190674A patent/CN100488950C/zh not_active Expired - Lifetime
- 2000-12-22 US US10/168,441 patent/US8975275B2/en not_active Expired - Fee Related
- 2000-12-22 AU AU21716/01A patent/AU784496B2/en not_active Ceased
- 2000-12-22 DK DK00985241T patent/DK1244434T3/da active
- 2000-12-22 PT PT00985241T patent/PT1244434E/pt unknown
- 2000-12-22 JP JP2001546418A patent/JP5414138B2/ja not_active Expired - Fee Related
- 2000-12-22 PL PL387061A patent/PL209943B1/pl unknown
- 2000-12-22 AT AT03028047T patent/ATE369344T1/de active
- 2000-12-22 EP EP00985241A patent/EP1244434B1/de not_active Expired - Lifetime
- 2000-12-22 TR TR2004/01396T patent/TR200401396T4/xx unknown
- 2000-12-22 AT AT00985241T patent/ATE261722T1/de active
- 2000-12-22 ES ES00985241T patent/ES2218264T3/es not_active Expired - Lifetime
- 2000-12-22 WO PCT/EP2000/013155 patent/WO2001045679A2/de active IP Right Grant
- 2000-12-22 CA CA2717246A patent/CA2717246C/en not_active Expired - Fee Related
- 2000-12-22 PL PL357379A patent/PL205148B1/pl unknown
- 2000-12-22 PT PT03028047T patent/PT1408034E/pt unknown
- 2000-12-22 DK DK03028047.3T patent/DK1408034T4/da active
- 2000-12-22 MX MXPA02006248A patent/MXPA02006248A/es active IP Right Grant
- 2000-12-22 ES ES03028047T patent/ES2291583T5/es not_active Expired - Lifetime
- 2000-12-22 DE DE50005742T patent/DE50005742D1/de not_active Expired - Lifetime
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2002
- 2002-06-20 IL IL150359A patent/IL150359A/en unknown
- 2002-06-21 NO NO20023026A patent/NO323727B1/no not_active IP Right Cessation
- 2002-06-21 ZA ZA200205027A patent/ZA200205027B/en unknown
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2007
- 2007-01-04 US US11/619,823 patent/US20070197501A1/en not_active Abandoned
- 2007-04-17 NO NO20071958A patent/NO331317B1/no not_active IP Right Cessation
- 2007-11-06 CY CY20071101421T patent/CY1106977T1/el unknown
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2010
- 2010-08-18 US US12/858,527 patent/US20100330165A1/en not_active Abandoned
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2014
- 2014-06-03 US US14/294,874 patent/US20140287028A1/en not_active Abandoned
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- 2015-10-05 US US14/875,053 patent/US20160045490A1/en not_active Abandoned
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