DK1401841T3 - Substituerede 1-oxa-2,8-diaza-spiro[4,5]dec-2-en-derivater som lægemidler mod smerte - Google Patents
Substituerede 1-oxa-2,8-diaza-spiro[4,5]dec-2-en-derivater som lægemidler mod smerteInfo
- Publication number
- DK1401841T3 DK1401841T3 DK02735422T DK02735422T DK1401841T3 DK 1401841 T3 DK1401841 T3 DK 1401841T3 DK 02735422 T DK02735422 T DK 02735422T DK 02735422 T DK02735422 T DK 02735422T DK 1401841 T3 DK1401841 T3 DK 1401841T3
- Authority
- DK
- Denmark
- Prior art keywords
- diaza
- oxa
- spiro
- medicines
- pain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Otolaryngology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10130020A DE10130020A1 (de) | 2001-06-25 | 2001-06-25 | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
PCT/EP2002/006880 WO2003000699A1 (de) | 2001-06-25 | 2002-06-21 | Substituierte 1-oxa-2,8-diaza-spiro[4,5]dec-2-en-derivate als arzneimittel gegen schmerz |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1401841T3 true DK1401841T3 (da) | 2005-09-19 |
Family
ID=7689008
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02735422T DK1401841T3 (da) | 2001-06-25 | 2002-06-21 | Substituerede 1-oxa-2,8-diaza-spiro[4,5]dec-2-en-derivater som lægemidler mod smerte |
Country Status (30)
Country | Link |
---|---|
US (2) | US8048890B2 (zh) |
EP (1) | EP1401841B1 (zh) |
JP (1) | JP4410554B2 (zh) |
KR (1) | KR100917112B1 (zh) |
CN (1) | CN1315840C (zh) |
AR (1) | AR036098A1 (zh) |
AT (1) | ATE302782T1 (zh) |
AU (1) | AU2002310768B2 (zh) |
BR (1) | BR0211053A (zh) |
CA (1) | CA2451859C (zh) |
CO (1) | CO5540301A2 (zh) |
CZ (1) | CZ20033432A3 (zh) |
DE (2) | DE10130020A1 (zh) |
DK (1) | DK1401841T3 (zh) |
EC (1) | ECSP034924A (zh) |
ES (1) | ES2245402T3 (zh) |
HK (1) | HK1064669A1 (zh) |
HU (1) | HU228774B1 (zh) |
IL (2) | IL159544A0 (zh) |
MX (1) | MXPA03012013A (zh) |
NO (1) | NO332217B1 (zh) |
NZ (1) | NZ530689A (zh) |
PE (1) | PE20030146A1 (zh) |
PL (1) | PL214290B1 (zh) |
PT (1) | PT1401841E (zh) |
RU (1) | RU2296128C2 (zh) |
SI (1) | SI1401841T1 (zh) |
SK (1) | SK287390B6 (zh) |
WO (1) | WO2003000699A1 (zh) |
ZA (1) | ZA200400489B (zh) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10130020A1 (de) | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
US20040092519A1 (en) * | 2002-08-14 | 2004-05-13 | Fred Hassan | New treatment for hot flashes |
DE102004023635A1 (de) * | 2004-05-10 | 2006-04-13 | Grünenthal GmbH | Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate |
DE102005016170A1 (de) * | 2005-04-07 | 2006-10-12 | Grünenthal GmbH | 4,5,6,7- Tetrahydro-isoxazolo(4,5c)pyridin-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
DE102005044814A1 (de) * | 2005-05-19 | 2006-11-23 | Grünenthal GmbH | Substituierte Sprio-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
DE102005044813A1 (de) | 2005-05-19 | 2007-10-04 | Grünenthal GmbH | Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
DE102005023784A1 (de) * | 2005-05-19 | 2006-11-30 | Grünenthal GmbH | Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
US8614324B2 (en) * | 2008-10-31 | 2013-12-24 | Pain Therapeutics, Inc. | Filamin A binding anti-inflammatory and analgesic |
US9340558B2 (en) | 2007-11-02 | 2016-05-17 | Pain Therapeutics Inc. | Filamin a binding anti-inflammatory and analgesic |
US8653068B2 (en) | 2009-10-30 | 2014-02-18 | Pain Therapeutics, Inc. | Filamin A binding anti-inflammatory and analgesic |
CA2779252C (en) * | 2008-10-31 | 2015-05-05 | Pain Therapeutics, Inc. | Filamin a-binding anti-inflammatory analgesic |
US8580808B2 (en) * | 2009-10-30 | 2013-11-12 | Pain Therapeutic, Inc. | Filamin A-binding anti-inflammatory analgesic |
US20100279996A1 (en) * | 2009-05-04 | 2010-11-04 | Lindsay Burns Barbier | Novel analgesic that binds filamin a |
KR20150116466A (ko) * | 2009-01-26 | 2015-10-15 | 이스라엘 인스티튜트 포 바이올로지컬 리서치 | 이환형 헤테로사이클릭 스피로 화합물 |
US8580809B2 (en) * | 2009-10-30 | 2013-11-12 | Pain Therapeutics, Inc. | Filamin A-binding anti-inflammatory analgesic |
US8822464B2 (en) | 2011-11-28 | 2014-09-02 | Boehringer Ingelheim International Gmbh | N-aryl-piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors |
US8741892B2 (en) | 2011-12-05 | 2014-06-03 | Boehringer Ingelheim International Gmbh | Compounds |
US8642774B2 (en) * | 2011-12-08 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Compounds |
US8846948B2 (en) | 2011-12-13 | 2014-09-30 | Boehringer Ingelheim International Gmbh | Compounds |
US8796467B2 (en) | 2011-12-13 | 2014-08-05 | Boehringer Ingelheim International Gmbh | Compounds |
US8716277B2 (en) | 2011-12-14 | 2014-05-06 | Boehringer Ingelheim International Gmbh | Substituted imidazole compounds useful as positive allosteric modulators of mGlu5 receptor activity |
US8883789B2 (en) | 2011-12-14 | 2014-11-11 | Boehringer Ingelheim International Gmbh | Piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors |
US8937176B2 (en) | 2011-12-14 | 2015-01-20 | Boehringer Ingelheim International Gmbh | Compounds |
US8889677B2 (en) | 2012-01-17 | 2014-11-18 | Boehringer Ingellheim International GmbH | Substituted triazoles useful as mGlu5 receptor modulators |
EP2872899B1 (en) | 2012-07-13 | 2018-07-11 | Pain Therapeutics, Inc. | Alzheimer's disease assay in a living patient |
WO2014011917A2 (en) | 2012-07-13 | 2014-01-16 | Pain Therapeutics, Inc. | A method of inhibiting tau phosphorylation |
US9433604B2 (en) | 2013-10-08 | 2016-09-06 | Pain Therapeutics Inc. | Method for inhibiting growth of cancer cells |
MX2018008640A (es) | 2016-01-13 | 2018-11-19 | Gruenenthal Gmbh | Derivados de 3-(carboxietil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]- decano. |
AR107434A1 (es) | 2016-01-13 | 2018-05-02 | Gruenenthal Gmbh | Derivados de 3-((hetero)aril)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano |
BR112018014303B1 (pt) | 2016-01-13 | 2023-10-03 | Grünenthal GmbH | Derivados de 3-((hetero-)aril)-alquil-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano |
HUE051642T2 (hu) | 2016-01-13 | 2021-03-01 | Gruenenthal Gmbh | 8-amino-2-oxo-1,3-diaza-spiro-[4,5]-dekán származékok |
WO2017121649A1 (en) | 2016-01-13 | 2017-07-20 | Grünenthal GmbH | 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
HRP20220026T1 (hr) * | 2017-04-12 | 2022-04-01 | Il Dong Pharmaceutical Co., Ltd. | Derivati izoksazola kao agonisti nuklearnog receptora i njihove uporabe |
CN109793713B (zh) * | 2019-03-26 | 2021-05-28 | 李世系 | 一种用于麻醉的短效催眠镇静的药物组合物及其注射剂制备方法及应用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL127065C (zh) * | 1964-04-22 | |||
GB1227365A (zh) * | 1968-07-29 | 1971-04-07 | ||
JPH02164882A (ja) * | 1988-12-20 | 1990-06-25 | Yamanouchi Pharmaceut Co Ltd | スピロ化合物及びその中間体 |
US5534520A (en) | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
US5073560A (en) * | 1990-07-20 | 1991-12-17 | Fisons Corporation | Spiro-isoxazolidine derivatives as cholinergic agents |
US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
US5739336A (en) | 1995-06-23 | 1998-04-14 | Syntex (U.S.A.) Inc. | 1,3,8-triaza- and 3,8-diaza-1-oxaspiro 4,5! decane derivatives |
DE19528472A1 (de) | 1995-08-03 | 1997-02-06 | Boehringer Ingelheim Kg | Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan |
EP0854869B1 (en) * | 1995-09-29 | 2004-08-25 | Eli Lilly And Company | Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation |
JP2001527513A (ja) * | 1996-03-15 | 2001-12-25 | デュポン ファーマシューティカルズ カンパニー | スピロ環インテグリン阻害剤 |
ZA972195B (en) * | 1996-03-15 | 1998-09-14 | Du Pont Merck Pharma | Spirocycle integrin inhibitors |
WO1998043962A1 (en) * | 1997-03-28 | 1998-10-08 | Du Pont Pharmaceuticals Company | Heterocyclic integrin inhibitor prodrugs |
US6548677B1 (en) | 1998-11-18 | 2003-04-15 | Basf Aktiengesellschaft | Method of producing 2-alkyl-3-(4,5-dihydroisoxazole-3-yl)-halobenzenes |
KR20030000243A (ko) | 2001-06-22 | 2003-01-06 | 이 석 민 | 동물사료 제조방법 및 그에 적합한 기밀 플라스틱백발효용기 |
DE10130020A1 (de) | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
-
2001
- 2001-06-25 DE DE10130020A patent/DE10130020A1/de not_active Withdrawn
-
2002
- 2002-06-19 AR ARP020102303A patent/AR036098A1/es unknown
- 2002-06-21 SK SK1570-2003A patent/SK287390B6/sk not_active IP Right Cessation
- 2002-06-21 AU AU2002310768A patent/AU2002310768B2/en not_active Ceased
- 2002-06-21 RU RU2004100823/04A patent/RU2296128C2/ru not_active IP Right Cessation
- 2002-06-21 AT AT02735422T patent/ATE302782T1/de active
- 2002-06-21 CN CNB028166825A patent/CN1315840C/zh not_active Expired - Fee Related
- 2002-06-21 SI SI200230221T patent/SI1401841T1/sl unknown
- 2002-06-21 HU HU0400810A patent/HU228774B1/hu not_active IP Right Cessation
- 2002-06-21 CA CA2451859A patent/CA2451859C/en not_active Expired - Fee Related
- 2002-06-21 CZ CZ20033432A patent/CZ20033432A3/cs unknown
- 2002-06-21 NZ NZ530689A patent/NZ530689A/en not_active IP Right Cessation
- 2002-06-21 MX MXPA03012013A patent/MXPA03012013A/es active IP Right Grant
- 2002-06-21 JP JP2003507102A patent/JP4410554B2/ja not_active Expired - Fee Related
- 2002-06-21 DE DE50204037T patent/DE50204037D1/de not_active Expired - Lifetime
- 2002-06-21 BR BR0211053-9A patent/BR0211053A/pt not_active IP Right Cessation
- 2002-06-21 ES ES02735422T patent/ES2245402T3/es not_active Expired - Lifetime
- 2002-06-21 EP EP02735422A patent/EP1401841B1/de not_active Expired - Lifetime
- 2002-06-21 PT PT02735422T patent/PT1401841E/pt unknown
- 2002-06-21 KR KR1020037016835A patent/KR100917112B1/ko not_active IP Right Cessation
- 2002-06-21 IL IL15954402A patent/IL159544A0/xx unknown
- 2002-06-21 WO PCT/EP2002/006880 patent/WO2003000699A1/de active IP Right Grant
- 2002-06-21 PE PE2002000537A patent/PE20030146A1/es not_active Application Discontinuation
- 2002-06-21 DK DK02735422T patent/DK1401841T3/da active
- 2002-06-21 PL PL367748A patent/PL214290B1/pl not_active IP Right Cessation
-
2003
- 2003-12-19 NO NO20035730A patent/NO332217B1/no not_active IP Right Cessation
- 2003-12-22 EC EC2003004924A patent/ECSP034924A/es unknown
- 2003-12-22 CO CO03111723A patent/CO5540301A2/es active IP Right Grant
- 2003-12-24 IL IL159544A patent/IL159544A/en not_active IP Right Cessation
- 2003-12-24 US US10/744,082 patent/US8048890B2/en not_active Expired - Fee Related
-
2004
- 2004-01-22 ZA ZA200400489A patent/ZA200400489B/en unknown
- 2004-09-30 HK HK04107516A patent/HK1064669A1/xx unknown
-
2011
- 2011-05-26 US US13/116,578 patent/US8557796B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1401841T3 (da) | Substituerede 1-oxa-2,8-diaza-spiro[4,5]dec-2-en-derivater som lægemidler mod smerte | |
AU2002310768A1 (en) | Substituted 1-oxa-2,8-diaza-spiro[4,5]dec-2-ene derivatives as medicaments for the treatment of pain | |
NO20034149D0 (no) | Legemidler inneholdende triazaspiro[5.5]undekanderivater som den aktive bestanddel | |
NO20041567L (no) | 1,8-nafthyridinderivater som antidiabetiske midler | |
DK1381363T3 (da) | Imidazo[1,2-a]pyridinderivater som mGluR5-antagonister | |
NO20042372L (no) | Nye 1,2,4-tiadiazolderivater som melanokortinreseptormodulatorer | |
DE60214428D1 (de) | 1, 4-dihydro-1, 4-diphenylpyridin-derivate | |
NO20015477D0 (no) | 4,5,6,7-tetrahydroindazol-derivater som anti-tumor midler | |
DK1444215T3 (da) | 1,2,4-Thiadiazoliumderivater som melanocortinreceptormodulatorer | |
DK1291384T3 (da) | Benzofuran-2-oner som stabilisatorer for syntetiske polymerer | |
DE602004021572D1 (de) | SUBSTITUIERTE 8-PERFLUORO-6,7,8,9-TETRAHYDROPYRIMIDOi1,2-A PYRIMIDIN-4-ON-DERIVATE | |
DK1453810T3 (da) | Substituerede 4-phenyltetrahydroisoquinoliner, fremgangsmåde til deres fremstilling, deres anvendelse som medikament indeholdende samme | |
IS8042A (is) | Benz[1,2,5]thíadíazól efnasambönd | |
DK1389213T3 (da) | 3,7-Diazabicyclo[3.3.1]formuleringer som antiarytmiske forbindelser | |
AU2002258054A1 (en) | Oxazolidinone derivatives as antimicrobials | |
AU2003247706A1 (en) | 6, 11-4-carbon bridged erythromycin derivatives | |
DK1427732T3 (da) | Spirocyclisk-6,7-dihydro-5H-pyrazolo[1,2-a] pyrazol-1-oner som kontrollerer inflammatoriske cytokiner | |
MXPA03007432A (es) | Derivados de isoxazolinas y su uso como antidepresivos. | |
NO20034529L (no) | 3,7-diazabicyklo(3,3,1) - formuleringer som anti-arytmi- forbindelser | |
NO20030474D0 (no) | Demens-legemiddel som inneholder 2-aryl-8- oksodihydropurinderivater som denaktive bestanddel | |
IS7042A (is) | (Pýridó/þíenó)-[f]-oxasepín-5-on afleiður | |
NO20040913L (no) | Nye 2,4-diaminotiazolderivater | |
ES1051471Y (es) | Sandalia multiforme perfeccionada | |
AU2002333299A1 (en) | Isoxazoline derivatives as p, n ligands | |
AU2002334220A1 (en) | Isoxazoline derivatives useful as antimicrobials |