DK1401841T3 - Substituerede 1-oxa-2,8-diaza-spiro[4,5]dec-2-en-derivater som lægemidler mod smerte - Google Patents

Substituerede 1-oxa-2,8-diaza-spiro[4,5]dec-2-en-derivater som lægemidler mod smerte

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Publication number
DK1401841T3
DK1401841T3 DK02735422T DK02735422T DK1401841T3 DK 1401841 T3 DK1401841 T3 DK 1401841T3 DK 02735422 T DK02735422 T DK 02735422T DK 02735422 T DK02735422 T DK 02735422T DK 1401841 T3 DK1401841 T3 DK 1401841T3
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DK
Denmark
Prior art keywords
diaza
oxa
spiro
medicines
pain
Prior art date
Application number
DK02735422T
Other languages
English (en)
Inventor
Joerg Holenz
Helmut Heinrich Buschmann
Werner Guenter Englberger
Tieno Germann
Hagen-Heinrich Hennies
Corinna Maul
Bernd Sundermann
Michael Haurand
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Application granted granted Critical
Publication of DK1401841T3 publication Critical patent/DK1401841T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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    • A61P27/02—Ophthalmic agents
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Otolaryngology (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
DK02735422T 2001-06-25 2002-06-21 Substituerede 1-oxa-2,8-diaza-spiro[4,5]dec-2-en-derivater som lægemidler mod smerte DK1401841T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10130020A DE10130020A1 (de) 2001-06-25 2001-06-25 Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate
PCT/EP2002/006880 WO2003000699A1 (de) 2001-06-25 2002-06-21 Substituierte 1-oxa-2,8-diaza-spiro[4,5]dec-2-en-derivate als arzneimittel gegen schmerz

Publications (1)

Publication Number Publication Date
DK1401841T3 true DK1401841T3 (da) 2005-09-19

Family

ID=7689008

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02735422T DK1401841T3 (da) 2001-06-25 2002-06-21 Substituerede 1-oxa-2,8-diaza-spiro[4,5]dec-2-en-derivater som lægemidler mod smerte

Country Status (30)

Country Link
US (2) US8048890B2 (da)
EP (1) EP1401841B1 (da)
JP (1) JP4410554B2 (da)
KR (1) KR100917112B1 (da)
CN (1) CN1315840C (da)
AR (1) AR036098A1 (da)
AT (1) ATE302782T1 (da)
AU (1) AU2002310768B2 (da)
BR (1) BR0211053A (da)
CA (1) CA2451859C (da)
CO (1) CO5540301A2 (da)
CZ (1) CZ20033432A3 (da)
DE (2) DE10130020A1 (da)
DK (1) DK1401841T3 (da)
EC (1) ECSP034924A (da)
ES (1) ES2245402T3 (da)
HK (1) HK1064669A1 (da)
HU (1) HU228774B1 (da)
IL (2) IL159544A0 (da)
MX (1) MXPA03012013A (da)
NO (1) NO332217B1 (da)
NZ (1) NZ530689A (da)
PE (1) PE20030146A1 (da)
PL (1) PL214290B1 (da)
PT (1) PT1401841E (da)
RU (1) RU2296128C2 (da)
SI (1) SI1401841T1 (da)
SK (1) SK287390B6 (da)
WO (1) WO2003000699A1 (da)
ZA (1) ZA200400489B (da)

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US8614324B2 (en) * 2008-10-31 2013-12-24 Pain Therapeutics, Inc. Filamin A binding anti-inflammatory and analgesic
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US20100279996A1 (en) * 2009-05-04 2010-11-04 Lindsay Burns Barbier Novel analgesic that binds filamin a
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US8580809B2 (en) * 2009-10-30 2013-11-12 Pain Therapeutics, Inc. Filamin A-binding anti-inflammatory analgesic
US8822464B2 (en) 2011-11-28 2014-09-02 Boehringer Ingelheim International Gmbh N-aryl-piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors
US8741892B2 (en) 2011-12-05 2014-06-03 Boehringer Ingelheim International Gmbh Compounds
US8642774B2 (en) * 2011-12-08 2014-02-04 Boehringer Ingelheim International Gmbh Compounds
US8796467B2 (en) 2011-12-13 2014-08-05 Boehringer Ingelheim International Gmbh Compounds
US8846948B2 (en) 2011-12-13 2014-09-30 Boehringer Ingelheim International Gmbh Compounds
US8883789B2 (en) 2011-12-14 2014-11-11 Boehringer Ingelheim International Gmbh Piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors
US8716277B2 (en) 2011-12-14 2014-05-06 Boehringer Ingelheim International Gmbh Substituted imidazole compounds useful as positive allosteric modulators of mGlu5 receptor activity
US8937176B2 (en) 2011-12-14 2015-01-20 Boehringer Ingelheim International Gmbh Compounds
US8889677B2 (en) 2012-01-17 2014-11-18 Boehringer Ingellheim International GmbH Substituted triazoles useful as mGlu5 receptor modulators
EP2872899B1 (en) 2012-07-13 2018-07-11 Pain Therapeutics, Inc. Alzheimer's disease assay in a living patient
JP6417324B2 (ja) 2012-07-13 2018-11-07 ペイン セラピューティクス インコーポレイテッド τリン酸化を阻害する方法
US9433604B2 (en) 2013-10-08 2016-09-06 Pain Therapeutics Inc. Method for inhibiting growth of cancer cells
LT3402783T (lt) 2016-01-13 2020-05-11 Grünenthal GmbH 3-(karboksietil)-8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekano dariniai
SI3402785T1 (sl) 2016-01-13 2020-07-31 Gruenenthal Gmbh Derivati 3-(karboksimetil)-8-amino-2-okso-1,3-diaza-spiro-(4.5)-dekana
JP6917379B2 (ja) 2016-01-13 2021-08-11 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ８−アミノ−２−オキソ−１，３−ジアザ−スピロ−［４．５］−デカン誘導体
RS60315B1 (sr) 2016-01-13 2020-07-31 Gruenenthal Gmbh Derivati 3-((hetero-)aril)-alkil-8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekana
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CA2451859C (en) 2011-06-14
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AU2002310768B2 (en) 2007-01-11
CO5540301A2 (es) 2005-07-29
RU2296128C2 (ru) 2007-03-27
NO20035730L (no) 2004-02-19
EP1401841B1 (de) 2005-08-24
NO20035730D0 (no) 2003-12-19
HUP0400810A2 (hu) 2004-07-28
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PE20030146A1 (es) 2003-03-15
WO2003000699A8 (de) 2003-11-20
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CN1547584A (zh) 2004-11-17
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US20040192916A1 (en) 2004-09-30
EP1401841A1 (de) 2004-03-31
PL214290B1 (pl) 2013-07-31
HUP0400810A3 (en) 2007-11-28
PT1401841E (pt) 2005-11-30
US8557796B2 (en) 2013-10-15
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