BR0211053A - Derivados 1-oxa-2,8-diaza-spiro [4,5] dec-2-en substituìdos como medicamentos para o tratamento de dor - Google Patents

Derivados 1-oxa-2,8-diaza-spiro [4,5] dec-2-en substituìdos como medicamentos para o tratamento de dor

Info

Publication number
BR0211053A
BR0211053A BR0211053-9A BR0211053A BR0211053A BR 0211053 A BR0211053 A BR 0211053A BR 0211053 A BR0211053 A BR 0211053A BR 0211053 A BR0211053 A BR 0211053A
Authority
BR
Brazil
Prior art keywords
diaza
oxa
spiro
dec
substituted
Prior art date
Application number
BR0211053-9A
Other languages
English (en)
Inventor
Helmut Heirinch Buschmann
Werner Gunter Englberger
Tieno Germann
Hagen Heinrich Hennies
Bernd Sundermann
Jorg Holenz
Corinna Maul
Original Assignee
Gr Nenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gr Nenthal Gmbh filed Critical Gr Nenthal Gmbh
Publication of BR0211053A publication Critical patent/BR0211053A/pt

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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  • Health & Medical Sciences (AREA)
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Abstract

"DERIVADOS 1 -OXA-2,8-DIAZA-SPIRO[4,5]DEC-2-EN SUBSTITUìDOS COMO MEDICAMENTOS PARA O TRATAMENTO DE DOR". A presente invenção refere-se a derivados 1-oxa-2,8-diaza-spiro[4,5]dec-2-en substituídos da fórmula geral (I), bem como a processos para a sua obtenção, seu emprego para a produção de medicamentos e medicamentos contendo estes compostos.
BR0211053-9A 2001-06-25 2002-06-21 Derivados 1-oxa-2,8-diaza-spiro [4,5] dec-2-en substituìdos como medicamentos para o tratamento de dor BR0211053A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10130020A DE10130020A1 (de) 2001-06-25 2001-06-25 Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate
PCT/EP2002/006880 WO2003000699A1 (de) 2001-06-25 2002-06-21 Substituierte 1-oxa-2,8-diaza-spiro[4,5]dec-2-en-derivate als arzneimittel gegen schmerz

Publications (1)

Publication Number Publication Date
BR0211053A true BR0211053A (pt) 2004-07-20

Family

ID=7689008

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0211053-9A BR0211053A (pt) 2001-06-25 2002-06-21 Derivados 1-oxa-2,8-diaza-spiro [4,5] dec-2-en substituìdos como medicamentos para o tratamento de dor

Country Status (30)

Country Link
US (2) US8048890B2 (pt)
EP (1) EP1401841B1 (pt)
JP (1) JP4410554B2 (pt)
KR (1) KR100917112B1 (pt)
CN (1) CN1315840C (pt)
AR (1) AR036098A1 (pt)
AT (1) ATE302782T1 (pt)
AU (1) AU2002310768B2 (pt)
BR (1) BR0211053A (pt)
CA (1) CA2451859C (pt)
CO (1) CO5540301A2 (pt)
CZ (1) CZ20033432A3 (pt)
DE (2) DE10130020A1 (pt)
DK (1) DK1401841T3 (pt)
EC (1) ECSP034924A (pt)
ES (1) ES2245402T3 (pt)
HK (1) HK1064669A1 (pt)
HU (1) HU228774B1 (pt)
IL (2) IL159544A0 (pt)
MX (1) MXPA03012013A (pt)
NO (1) NO332217B1 (pt)
NZ (1) NZ530689A (pt)
PE (1) PE20030146A1 (pt)
PL (1) PL214290B1 (pt)
PT (1) PT1401841E (pt)
RU (1) RU2296128C2 (pt)
SI (1) SI1401841T1 (pt)
SK (1) SK287390B6 (pt)
WO (1) WO2003000699A1 (pt)
ZA (1) ZA200400489B (pt)

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EP1530476A1 (en) * 2002-08-14 2005-05-18 Pharmacia & Upjohn Company LLC Use of reboxetine for the treatment of hot flashes
DE102004023635A1 (de) * 2004-05-10 2006-04-13 Grünenthal GmbH Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate
DE102005016170A1 (de) * 2005-04-07 2006-10-12 Grünenthal GmbH 4,5,6,7- Tetrahydro-isoxazolo(4,5c)pyridin-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
DE102005023784A1 (de) * 2005-05-19 2006-11-30 Grünenthal GmbH Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
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DE102005044814A1 (de) * 2005-05-19 2006-11-23 Grünenthal GmbH Substituierte Sprio-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
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US8796467B2 (en) 2011-12-13 2014-08-05 Boehringer Ingelheim International Gmbh Compounds
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US8716277B2 (en) 2011-12-14 2014-05-06 Boehringer Ingelheim International Gmbh Substituted imidazole compounds useful as positive allosteric modulators of mGlu5 receptor activity
US8937176B2 (en) 2011-12-14 2015-01-20 Boehringer Ingelheim International Gmbh Compounds
US8883789B2 (en) 2011-12-14 2014-11-11 Boehringer Ingelheim International Gmbh Piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors
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JP6566867B2 (ja) 2012-07-13 2019-08-28 ペイン セラピューティクス インコーポレイテッド 生きている患者でのアルツハイマー病アッセイ
DK2882428T3 (en) 2012-07-13 2019-04-15 Pain Therapeutics Inc PROCEDURE TO INHIBIT TAU PHOSPHORIZATION
US9433604B2 (en) 2013-10-08 2016-09-06 Pain Therapeutics Inc. Method for inhibiting growth of cancer cells
HUE049134T2 (hu) 2016-01-13 2020-08-28 Gruenenthal Gmbh 3-(karboximetil)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-dekán származékok
AU2017207467B2 (en) 2016-01-13 2020-07-16 Grünenthal GmbH 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
TWI635082B (zh) 2016-01-13 2018-09-11 歌林達有限公司 ３－（（雜－）芳基）－８－胺基－２－側氧－１,３－二氮雜－螺－［４.５］－癸烷衍生物
TWI654181B (zh) 2016-01-13 2019-03-21 歌林達有限公司 ８－胺基－２－側氧基－１，３－二氮－螺－［４．５］－癸烷衍生物
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SI1401841T1 (sl) 2006-02-28
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CA2451859C (en) 2011-06-14
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CN1315840C (zh) 2007-05-16
IL159544A (en) 2009-05-04
PE20030146A1 (es) 2003-03-15
SK15702003A3 (sk) 2004-07-07
HUP0400810A3 (en) 2007-11-28
PT1401841E (pt) 2005-11-30
EP1401841A1 (de) 2004-03-31
DE50204037D1 (de) 2005-09-29
KR20040008226A (ko) 2004-01-28
AR036098A1 (es) 2004-08-11
DK1401841T3 (da) 2005-09-19
US8048890B2 (en) 2011-11-01
RU2004100823A (ru) 2005-06-20
US20040192916A1 (en) 2004-09-30
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PL367748A1 (en) 2005-03-07
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HUP0400810A2 (hu) 2004-07-28
CO5540301A2 (es) 2005-07-29
SK287390B6 (sk) 2010-08-09
IL159544A0 (en) 2004-06-01
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US8557796B2 (en) 2013-10-15
RU2296128C2 (ru) 2007-03-27
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ATE302782T1 (de) 2005-09-15
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HU228774B1 (en) 2013-05-28
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PL214290B1 (pl) 2013-07-31
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DE10130020A1 (de) 2003-12-04

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