HUP0400810A2 - Helyettesített 1-oxa-2,8-diaza-spiro[4.5]dec-2-én-származékok, eljárás előállításukra, alkalmazásuk, és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
Helyettesített 1-oxa-2,8-diaza-spiro[4.5]dec-2-én-származékok, eljárás előállításukra, alkalmazásuk, és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0400810A2 HUP0400810A2 HU0400810A HUP0400810A HUP0400810A2 HU P0400810 A2 HUP0400810 A2 HU P0400810A2 HU 0400810 A HU0400810 A HU 0400810A HU P0400810 A HUP0400810 A HU P0400810A HU P0400810 A2 HUP0400810 A2 HU P0400810A2
- Authority
- HU
- Hungary
- Prior art keywords
- aryl
- alkylheterocyclic
- alkylcycloalkyl
- alkylaryl
- heterocyclic
- Prior art date
Links
- ZTUPVEXGISXGGN-UHFFFAOYSA-N 1-oxa-2,8-diazaspiro[4.5]dec-2-ene Chemical class C1C=NOC11CCNCC1 ZTUPVEXGISXGGN-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 13
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 12
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 11
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 abstract 11
- 125000000217 alkyl group Chemical group 0.000 abstract 11
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 11
- 125000000623 heterocyclic group Chemical group 0.000 abstract 11
- 229910052739 hydrogen Inorganic materials 0.000 abstract 10
- 239000001257 hydrogen Substances 0.000 abstract 10
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 101100173726 Arabidopsis thaliana OR23 gene Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
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- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
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- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
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- Urology & Nephrology (AREA)
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Abstract
A találmány (I) általános képletű helyettesített 1-oxa-2,8-diaza-spiro[4.5]dec-2-en-származékokra, sóikra, e vegyületek előállítására,gyógyszerek készítésére történő felhasználására és a fentivegyületeket tartalmazó gyógyszerekre vonatkozik. A képletben Rl és R2jelentése egymástól függetlenül hidrogénatom, alkil-, cikloalkil-,alkil- cikloalkil-, aril-, alkil-aril-, heterociklikus-, alkil-heterociklikus- vagy NH-C(=O)-aril-csoport; mimellett Rl és R2 közüllegalább az egyik hidrogénatomtól eltérő jelentésű; vagy Rl és R2együtt -(CR4R5)m,-(CR6R7)nY-(CR8R9)p-(CRI0RI1)q- csoportot képez, aholm, n, p és q jelentése 0, 1, 2; 3, 4 vagy 5; azzal a feltétellel, hogym+n < 1 és p+q< 1,vagy -CH2-CH-C(aril)=CH-CH2; R3 jelentésehidrogénatom, SO2R12 vagy COR13; R4, R5, R6, R7, R8, R9, R10 és R11jelentése egymástól függetlenül hidrogénatom, alkil-, cikloalkil-,alkil-cikloalkil-, aril-, alkil-aril-, heterociklikus-, alkil-heterociklikus vagy C(=O)R14 csoport; Y jelentése CR15R16; NR17 vagyO; R12 és R13 jelentése egymástól függetlenül alkil-, cikloalkil-,alkil-cikloalkil-, aril-, alkil-aril-, heterociklikus-, alkil-heterociklikus- vagy NR18R19 csoport; R14 jelentése hidrogénatom,alkil-, cikloalkil-, alkil-cikloalkil-, aril-, alkil-aril-,heterociklikus-, alkil-heterociklikus- vagy OR20csoport; R15 és RI6jelentése egymástól függetlenül hidrogénatom, alkil-, cikloalkil-,alkil-cikloalkil, aril-, alkil-aril-, heterociklikus-, alkil-heterociklikus- vagy C(=O)R21; R17 jelentése hidrogénatom, alkil-,cikloalkil-, alkil-cikloalkil-, aril-, alkil-aril-, heterociklikus-,aIkil-heterociklikus- vagy C(=O)R22 csoport; R18 és R19 jelentéseegymástól függetlenül hidrogénatom, alkil-, cikloalkil-, alkil-cikloalkil-, aril-, alkil-aril-, heterociklikus- vagy alkil-heterociklikus-csoport; R20 jelentése hidrogénatom, alkil-,cikloalkil-, alkil-cikloalkil-, aril-, alkil-aril-, heterociklikus-vagy alkil-heterociklikus-csoport; R21 jelentése hidrogénatom, alkil-,cikloalkil-, alkil-cikloalkil-, aril-, alkil-aril-, heterociklikus-,alkil-heterociklikus- vagy OR23 csoport; R22 jelentése hidrogénatom,alkil-, cikloalkil-, alkil-cikloalkil-, aril-, alkil-aril-,heterociklikus-, alkil-heterociklikus- vagy OR24 csoport; és R23 ésR24 jelentése egymástól függetlenül hidrogénatom, alkil-, cikloalkil-,alkil-cikloalkil-, aril-, alkil-aril-, heterociklikus- vagy alkil-heterociklikus-csoport. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10130020A DE10130020A1 (de) | 2001-06-25 | 2001-06-25 | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
| PCT/EP2002/006880 WO2003000699A1 (de) | 2001-06-25 | 2002-06-21 | Substituierte 1-oxa-2,8-diaza-spiro[4,5]dec-2-en-derivate als arzneimittel gegen schmerz |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0400810A2 true HUP0400810A2 (hu) | 2004-07-28 |
| HUP0400810A3 HUP0400810A3 (en) | 2007-11-28 |
| HU228774B1 HU228774B1 (en) | 2013-05-28 |
Family
ID=7689008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0400810A HU228774B1 (en) | 2001-06-25 | 2002-06-21 | Substituted 1-oxa-2,8-diaza-spiro[4.5]dec-2-ene derivatives, process for their preparation, their use and pharmaceutical compositions containing them |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US8048890B2 (hu) |
| EP (1) | EP1401841B1 (hu) |
| JP (1) | JP4410554B2 (hu) |
| KR (1) | KR100917112B1 (hu) |
| CN (1) | CN1315840C (hu) |
| AR (1) | AR036098A1 (hu) |
| AT (1) | ATE302782T1 (hu) |
| AU (1) | AU2002310768B2 (hu) |
| BR (1) | BR0211053A (hu) |
| CA (1) | CA2451859C (hu) |
| CO (1) | CO5540301A2 (hu) |
| CZ (1) | CZ20033432A3 (hu) |
| DE (2) | DE10130020A1 (hu) |
| DK (1) | DK1401841T3 (hu) |
| EC (1) | ECSP034924A (hu) |
| ES (1) | ES2245402T3 (hu) |
| HK (1) | HK1064669A1 (hu) |
| HU (1) | HU228774B1 (hu) |
| IL (2) | IL159544A0 (hu) |
| MX (1) | MXPA03012013A (hu) |
| NO (1) | NO332217B1 (hu) |
| NZ (1) | NZ530689A (hu) |
| PE (1) | PE20030146A1 (hu) |
| PL (1) | PL214290B1 (hu) |
| PT (1) | PT1401841E (hu) |
| RU (1) | RU2296128C2 (hu) |
| SI (1) | SI1401841T1 (hu) |
| SK (1) | SK287390B6 (hu) |
| WO (1) | WO2003000699A1 (hu) |
| ZA (1) | ZA200400489B (hu) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10130020A1 (de) | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
| PL373956A1 (en) * | 2002-08-14 | 2005-09-19 | Pharmacia & Upjohn Company Llc | Use of reboxetine for the treatment of hot flashes |
| DE102004023635A1 (de) * | 2004-05-10 | 2006-04-13 | Grünenthal GmbH | Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102005016170A1 (de) * | 2005-04-07 | 2006-10-12 | Grünenthal GmbH | 4,5,6,7- Tetrahydro-isoxazolo(4,5c)pyridin-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| DE102005044814A1 (de) * | 2005-05-19 | 2006-11-23 | Grünenthal GmbH | Substituierte Sprio-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| DE102005044813A1 (de) | 2005-05-19 | 2007-10-04 | Grünenthal GmbH | Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| DE102005023784A1 (de) * | 2005-05-19 | 2006-11-30 | Grünenthal GmbH | Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| US9340558B2 (en) | 2007-11-02 | 2016-05-17 | Pain Therapeutics Inc. | Filamin a binding anti-inflammatory and analgesic |
| US8653068B2 (en) | 2009-10-30 | 2014-02-18 | Pain Therapeutics, Inc. | Filamin A binding anti-inflammatory and analgesic |
| US8614324B2 (en) * | 2008-10-31 | 2013-12-24 | Pain Therapeutics, Inc. | Filamin A binding anti-inflammatory and analgesic |
| US8580808B2 (en) * | 2009-10-30 | 2013-11-12 | Pain Therapeutic, Inc. | Filamin A-binding anti-inflammatory analgesic |
| WO2010051476A1 (en) * | 2008-10-31 | 2010-05-06 | Pain Therapeutics, Inc. | Filamin a-binding anti-inflammatory analgesic |
| US20100279996A1 (en) * | 2009-05-04 | 2010-11-04 | Lindsay Burns Barbier | Novel analgesic that binds filamin a |
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