DK1397130T3 - Substituerede indolsyrederivater som inhibitorer af plasminogenaktivatorinhibitor-1 (PAI-1) - Google Patents

Substituerede indolsyrederivater som inhibitorer af plasminogenaktivatorinhibitor-1 (PAI-1)

Info

Publication number
DK1397130T3
DK1397130T3 DK02744425T DK02744425T DK1397130T3 DK 1397130 T3 DK1397130 T3 DK 1397130T3 DK 02744425 T DK02744425 T DK 02744425T DK 02744425 T DK02744425 T DK 02744425T DK 1397130 T3 DK1397130 T3 DK 1397130T3
Authority
DK
Denmark
Prior art keywords
sub
cycloalkyl
pyridinyl
pai
inhibitors
Prior art date
Application number
DK02744425T
Other languages
Danish (da)
English (en)
Inventor
David Leroy Crandall
Hassan Mahmoud Elokdah
Geraldine Ruth Mcfarlane
David Zenan Li
Lee Dalton Jennings
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of DK1397130T3 publication Critical patent/DK1397130T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK02744425T 2001-06-20 2002-06-18 Substituerede indolsyrederivater som inhibitorer af plasminogenaktivatorinhibitor-1 (PAI-1) DK1397130T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29965701P 2001-06-20 2001-06-20
PCT/US2002/019344 WO2003000253A1 (en) 2001-06-20 2002-06-18 Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)

Publications (1)

Publication Number Publication Date
DK1397130T3 true DK1397130T3 (da) 2007-11-12

Family

ID=23155702

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02744425T DK1397130T3 (da) 2001-06-20 2002-06-18 Substituerede indolsyrederivater som inhibitorer af plasminogenaktivatorinhibitor-1 (PAI-1)

Country Status (10)

Country Link
US (3) US7074817B2 (pt)
EP (1) EP1397130B1 (pt)
JP (1) JP4399253B2 (pt)
AT (1) ATE367812T1 (pt)
CY (1) CY1106901T1 (pt)
DE (1) DE60221391T2 (pt)
DK (1) DK1397130T3 (pt)
ES (1) ES2290318T3 (pt)
PT (1) PT1397130E (pt)
WO (1) WO2003000253A1 (pt)

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UA80453C2 (en) 2002-12-10 2007-09-25 Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
WO2004052856A1 (en) 2002-12-10 2004-06-24 Wyeth Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
CA2509170A1 (en) 2002-12-10 2004-06-24 Wyeth Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
EP1569900B1 (en) 2002-12-10 2006-06-28 Wyeth Substituted 3-carbonyl-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
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US7342039B2 (en) 2003-09-25 2008-03-11 Wyeth Substituted indole oximes
US7141592B2 (en) 2003-09-25 2006-11-28 Wyeth Substituted oxadiazolidinediones
US7582773B2 (en) 2003-09-25 2009-09-01 Wyeth Substituted phenyl indoles
US7442805B2 (en) 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7163954B2 (en) 2003-09-25 2007-01-16 Wyeth Substituted naphthyl benzothiophene acids
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US20050215626A1 (en) 2003-09-25 2005-09-29 Wyeth Substituted benzofuran oximes
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US7265148B2 (en) 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
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JP4399253B2 (ja) 2010-01-13
CY1106901T1 (el) 2012-09-26
PT1397130E (pt) 2007-11-13
US20060167059A1 (en) 2006-07-27
ES2290318T3 (es) 2008-02-16
US7368471B2 (en) 2008-05-06
EP1397130B1 (en) 2007-07-25
EP1397130A1 (en) 2004-03-17
US7074817B2 (en) 2006-07-11
ATE367812T1 (de) 2007-08-15
US20030125371A1 (en) 2003-07-03
DE60221391D1 (de) 2007-09-06
WO2003000253A1 (en) 2003-01-03
US20080214647A1 (en) 2008-09-04
JP2004534817A (ja) 2004-11-18

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