DE60221391D1 - Substituierte indolsäurederivate als inhibitoren von plasminogen-aktivator-inhibitor-1 (pai-1) - Google Patents

Substituierte indolsäurederivate als inhibitoren von plasminogen-aktivator-inhibitor-1 (pai-1)

Info

Publication number
DE60221391D1
DE60221391D1 DE60221391T DE60221391T DE60221391D1 DE 60221391 D1 DE60221391 D1 DE 60221391D1 DE 60221391 T DE60221391 T DE 60221391T DE 60221391 T DE60221391 T DE 60221391T DE 60221391 D1 DE60221391 D1 DE 60221391D1
Authority
DE
Germany
Prior art keywords
sub
cycloalkyl
pyridinyl
pai
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60221391T
Other languages
English (en)
Other versions
DE60221391T2 (de
Inventor
Hassan Mahmoud Elokdah
Geraldine Ruth Mcfarlane
David Zenan Li
Lee Dalton Jennings
David Leroy Crandall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Application granted granted Critical
Publication of DE60221391D1 publication Critical patent/DE60221391D1/de
Publication of DE60221391T2 publication Critical patent/DE60221391T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60221391T 2001-06-20 2002-06-18 Substituierte indolsäurederivate als inhibitoren von plasminogen-aktivator-inhibitor-1 (pai-1) Expired - Lifetime DE60221391T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29965701P 2001-06-20 2001-06-20
US299657P 2001-06-20
PCT/US2002/019344 WO2003000253A1 (en) 2001-06-20 2002-06-18 Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)

Publications (2)

Publication Number Publication Date
DE60221391D1 true DE60221391D1 (de) 2007-09-06
DE60221391T2 DE60221391T2 (de) 2008-04-17

Family

ID=23155702

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60221391T Expired - Lifetime DE60221391T2 (de) 2001-06-20 2002-06-18 Substituierte indolsäurederivate als inhibitoren von plasminogen-aktivator-inhibitor-1 (pai-1)

Country Status (10)

Country Link
US (3) US7074817B2 (de)
EP (1) EP1397130B1 (de)
JP (1) JP4399253B2 (de)
AT (1) ATE367812T1 (de)
CY (1) CY1106901T1 (de)
DE (1) DE60221391T2 (de)
DK (1) DK1397130T3 (de)
ES (1) ES2290318T3 (de)
PT (1) PT1397130E (de)
WO (1) WO2003000253A1 (de)

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DE60221391T2 (de) 2008-04-17
US20060167059A1 (en) 2006-07-27
CY1106901T1 (el) 2012-09-26
WO2003000253A1 (en) 2003-01-03
ES2290318T3 (es) 2008-02-16
US7368471B2 (en) 2008-05-06
JP4399253B2 (ja) 2010-01-13
US7074817B2 (en) 2006-07-11
US20030125371A1 (en) 2003-07-03
EP1397130A1 (de) 2004-03-17
DK1397130T3 (da) 2007-11-12
ATE367812T1 (de) 2007-08-15
PT1397130E (pt) 2007-11-13
US20080214647A1 (en) 2008-09-04
EP1397130B1 (de) 2007-07-25

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