ATE394373T1 - Synthese von indolthiazolverbindungen als liganden des ah-rezeptors - Google Patents

Synthese von indolthiazolverbindungen als liganden des ah-rezeptors

Info

Publication number
ATE394373T1
ATE394373T1 AT03707863T AT03707863T ATE394373T1 AT E394373 T1 ATE394373 T1 AT E394373T1 AT 03707863 T AT03707863 T AT 03707863T AT 03707863 T AT03707863 T AT 03707863T AT E394373 T1 ATE394373 T1 AT E394373T1
Authority
AT
Austria
Prior art keywords
synthesis
indolthiazole
ligands
receptor
compounds
Prior art date
Application number
AT03707863T
Other languages
English (en)
Inventor
Hector Deluca
Pawel Grzywacz
Rafal Sicinski
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/074,102 external-priority patent/US6916834B2/en
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Application granted granted Critical
Publication of ATE394373T1 publication Critical patent/ATE394373T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT03707863T 2002-02-12 2003-02-11 Synthese von indolthiazolverbindungen als liganden des ah-rezeptors ATE394373T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35658502P 2002-02-12 2002-02-12
US10/074,102 US6916834B2 (en) 2001-02-14 2002-02-12 Preparations and use of an Ah receptor ligand, 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester

Publications (1)

Publication Number Publication Date
ATE394373T1 true ATE394373T1 (de) 2008-05-15

Family

ID=27736819

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03707863T ATE394373T1 (de) 2002-02-12 2003-02-11 Synthese von indolthiazolverbindungen als liganden des ah-rezeptors

Country Status (10)

Country Link
US (2) US7002019B2 (de)
EP (1) EP1480951B1 (de)
JP (1) JP4445266B2 (de)
CN (2) CN1642910A (de)
AT (1) ATE394373T1 (de)
AU (1) AU2003209130B2 (de)
CA (1) CA2475331C (de)
DE (1) DE60320766D1 (de)
MX (1) MXPA04007767A (de)
WO (1) WO2003068742A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE431823T1 (de) * 2001-02-14 2009-06-15 Wisconsin Alumni Res Found Zubereitungen und verwendung eines ah-rezeptor- liganden, 2-(1'h-indol-3'-carbonyl)-thiazol-4- carbonsäure-methylester
DK1397130T3 (da) 2001-06-20 2007-11-12 Wyeth Corp Substituerede indolsyrederivater som inhibitorer af plasminogenaktivatorinhibitor-1 (PAI-1)
TWI224101B (en) 2001-06-20 2004-11-21 Wyeth Corp Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
CA2475331C (en) * 2002-02-12 2012-06-12 Wisconsin Alumni Research Foundation Synthesis of indole thiazole compounds as ligands for the ah receptor
DE60306548T2 (de) 2002-12-10 2007-06-21 Wyeth Substituierte 3-carbonyl-1-yl-essigsäure-derivate als plasminogen aktivator inhibitor(pai-1) inhibitoren
UA80453C2 (en) 2002-12-10 2007-09-25 Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
JP2006510673A (ja) 2002-12-10 2006-03-30 ワイス プラスミノゲンアクティベータインヒビター１（ｐａｉ−１）のインヒビターとしての、アリール、アリールオキシ、および、アルキルオキシ置換１ｈ−インドール−３−イルグリオキシル酸誘導体
BR0316584A (pt) * 2002-12-10 2005-10-04 Wyeth Corp Derivados de ácido acético indol oxo-acetil amino substituìdo como inibidores do inibidor-1 do ativador do plasminogênio (pai-1)
US7230133B2 (en) 2003-05-01 2007-06-12 Bristol-Myers Squibb Company Malonamides and malonamide derivatives as modulators of chemokine receptor activity
US7411083B2 (en) 2003-09-25 2008-08-12 Wyeth Substituted acetic acid derivatives
WO2006023865A1 (en) 2004-08-23 2006-03-02 Wyeth Oxazolo-naphthyl acids as plaminogen activator inhibtor type-1 (pai-1) modulators useful in the treatment of thrombosis and cardiovascular diseases
AU2006279496A1 (en) 2005-08-17 2007-02-22 Wyeth Substituted indoles and use thereof
EP2082736A1 (de) * 2008-01-23 2009-07-29 Jean Hilaire Saurat Pharmazeutische Zusammensetzung zur lokalen Anwendung
US8236849B2 (en) 2008-10-15 2012-08-07 Ohio Northern University Model for glutamate racemase inhibitors and glutamate racemase antibacterial agents
EP2496081B1 (de) 2009-11-02 2020-03-25 Ariagen, Inc. Ite zur krebsbehandlung und -eliminierung
US10632106B2 (en) 2009-11-02 2020-04-28 Ariagen, Inc. Methods of cancer treatment with 2-(1′H-Indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester
CN102775399A (zh) * 2011-12-27 2012-11-14 盛世泰科生物医药技术(苏州)有限公司 arylhydrocarbon受体(AHR)的内源性配体,2-(1’H3’-吲哚羰基)噻唑-4-羧酸甲酯的合成新方法
WO2015013510A1 (en) * 2013-07-25 2015-01-29 Ecole Polytechnique Federale De Lausanne Epfl High aspect ratio nanofibril materials
CA2959178C (en) * 2014-09-12 2021-08-03 Ahr Pharmaceuticals, Inc. Efficient and scalable systhesis of 2-(1'h-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester and its structural analogs
CN108239083B (zh) * 2016-12-26 2021-08-17 阿里根公司 芳香烃受体调节剂
TW201925194A (zh) 2017-11-20 2019-07-01 美商雅里俊公司 吲哚化合物及其用途
EP3956327A1 (de) 2019-04-15 2022-02-23 Ariagen, Inc. Chirale indolverbindungen und deren verwendung
US11136318B2 (en) 2019-06-21 2021-10-05 Noramco, Llc Processes for the preparation of aryl hydrocarbon receptor ligands

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3265931A (en) * 1964-09-21 1966-08-09 Martin E Gerry Magnetic ignition distributor
US3285931A (en) 1964-12-21 1966-11-15 Union Carbide Corp Preparation of substituted pyrrole derivatives
US5366685A (en) * 1989-07-18 1994-11-22 Idemitsu Petrochemical Co., Ltd. Process of molding thermoplastic sheet by plug assist vacuum forming
US6323228B1 (en) 2000-09-15 2001-11-27 Abbott Laboratories 3-substituted indole angiogenesis inhibitors
US6523228B1 (en) * 2000-10-26 2003-02-25 Avery Dennison Corporation Tamper-proof tie
ATE431823T1 (de) * 2001-02-14 2009-06-15 Wisconsin Alumni Res Found Zubereitungen und verwendung eines ah-rezeptor- liganden, 2-(1'h-indol-3'-carbonyl)-thiazol-4- carbonsäure-methylester
EP1427413A2 (de) * 2001-09-13 2004-06-16 Synta Pharmaceuticals Corporation 2-aroylimidazol-verbindungen zur behandlung von krebs
CA2475331C (en) * 2002-02-12 2012-06-12 Wisconsin Alumni Research Foundation Synthesis of indole thiazole compounds as ligands for the ah receptor

Also Published As

Publication number Publication date
EP1480951A1 (de) 2004-12-01
CN1642910A (zh) 2005-07-20
CA2475331A1 (en) 2003-08-21
EP1480951B1 (de) 2008-05-07
JP4445266B2 (ja) 2010-04-07
CN1915991B (zh) 2010-05-26
JP2005525340A (ja) 2005-08-25
US20040204588A1 (en) 2004-10-14
US7241900B2 (en) 2007-07-10
AU2003209130A1 (en) 2003-09-04
US20060079692A1 (en) 2006-04-13
WO2003068742A1 (en) 2003-08-21
EP1480951A4 (de) 2006-03-22
US7002019B2 (en) 2006-02-21
DE60320766D1 (de) 2008-06-19
AU2003209130B2 (en) 2008-06-05
CN1915991A (zh) 2007-02-21
CA2475331C (en) 2012-06-12
MXPA04007767A (es) 2004-10-15

Similar Documents

Publication Publication Date Title
ATE394373T1 (de) Synthese von indolthiazolverbindungen als liganden des ah-rezeptors
DE60041584D1 (de) Substituierte oxoazaheterozyclische verbindungen
EA200600925A1 (ru) Производные триазола в качестве антагонистов вазопрессина
NO20093402L (no) Framgangsmate for syntetisering av camptothesin relaterte forbindelser
RS20050380A (en) 3-amino piperidine derivatives and methods of manufacture
ATE452882T1 (de) Herstellung von quetiapin
MX2007004637A (es) Sintesis asimetrica de derivados de dihidrobenzofurano.
NO20060219L (no) Forbindelser
DE50306845D1 (de) Disubstituierte thiazolylcarboxanilide und ihre verwendung als mikrobizide
NO982850L (no) Ny syntese
GB0129476D0 (en) Organic compounds
GB0031103D0 (en) Chemical compounds
HUP0102723A2 (hu) Új difenilkarbamid-származékok, eljárás előállításukra és ezeket tartalmazó gyógyászati készítmények
ME00428B (me) 5-hlor0-3-(4-metansulfonilfenil)-6'-metil-(2,3')bipiridinil u čistom kristalnom obliku i postupak sinteza
ATE301117T1 (de) Neue cyclopropane als cgrp-antagonisten, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
ATE429429T1 (de) Pharmazeutisches verfahren und damit hergestellte verbindungen
ATE453389T1 (de) Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen
BR0209901A (pt) Processos para a sìntese de derivados de 2,3-dihidro-1,4-dioxino-[2,3-f] quinolina
TR200302288T2 (tr) Terapi için yeni bileşikler ve metotlar.
EP1555261A4 (de) Valerolactonverbindungen und parf mzusammensetzung
WO2005000804A3 (en) Substituted indoles and a process for preparing substituted indoles
ATE257831T1 (de) Synthese von wasserlöslischem 9-dihydroplacitaxel derivate aus 9-dihydro-13-acetylbacchatin iii
IS2486B (is) Aralkýl-tetrahýdró-pýridín, framleiðsla þeirra oglyfjasamsetningar sem innihalda þau
WO2004039776A3 (en) A process for the preparation of benzyl 2-oxo-4- (heteroaryl) dithio-alpha-isoprenyl-1- azetidineazetate derivatives
DK1105392T3 (da) Fremgangsmåde til fremstilling af mellemprodukter for imidazodiazepin

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties