DK139359B - Analogifremgangsmåde til fremstilling af pyrrolo(3,4-b)-pyrazin-derivater, eller syreadditionssalte deraf. - Google Patents

Analogifremgangsmåde til fremstilling af pyrrolo(3,4-b)-pyrazin-derivater, eller syreadditionssalte deraf.

Info

Publication number
DK139359B
DK139359B DK6973AA DK6973A DK139359B DK 139359 B DK139359 B DK 139359B DK 6973A A DK6973A A DK 6973AA DK 6973 A DK6973 A DK 6973A DK 139359 B DK139359 B DK 139359B
Authority
DK
Denmark
Prior art keywords
pyrrolo
preparation
acid addition
addition salts
pyrazine derivatives
Prior art date
Application number
DK6973AA
Other languages
Danish (da)
English (en)
Other versions
DK139359C (cs
Inventor
Claude Cotrel
Claude Jeanmart
Mayer Naoum Messer
Original Assignee
Rhone Poulenc Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7200505A external-priority patent/FR2166314A1/fr
Priority claimed from FR7239731A external-priority patent/FR2205318A2/fr
Application filed by Rhone Poulenc Sa filed Critical Rhone Poulenc Sa
Publication of DK139359B publication Critical patent/DK139359B/da
Application granted granted Critical
Publication of DK139359C publication Critical patent/DK139359C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK6973AA 1972-01-07 1973-01-05 Analogifremgangsmåde til fremstilling af pyrrolo(3,4-b)-pyrazin-derivater, eller syreadditionssalte deraf. DK139359B (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7200505A FR2166314A1 (en) 1972-01-07 1972-01-07 6-substd 5-(4-methyl 1-piperazinyl)carbonyloxy 7-oxo - 5,6-dihydro-pyrrolo (3,4-b)pyrazines - tranquillizers and anticonvuls
FR7239731A FR2205318A2 (en) 1972-11-09 1972-11-09 6-substd 5-(4-methyl 1-piperazinyl)carbonyloxy 7-oxo - 5,6-dihydro-pyrrolo (3,4-b)pyrazines - tranquillizers and anticonvuls

Publications (2)

Publication Number Publication Date
DK139359B true DK139359B (da) 1979-02-05
DK139359C DK139359C (cs) 1979-07-09

Family

ID=26216824

Family Applications (1)

Application Number Title Priority Date Filing Date
DK6973AA DK139359B (da) 1972-01-07 1973-01-05 Analogifremgangsmåde til fremstilling af pyrrolo(3,4-b)-pyrazin-derivater, eller syreadditionssalte deraf.

Country Status (22)

Country Link
US (1) US3862149A (cs)
JP (3) JPS523952B2 (cs)
AR (1) AR195097A1 (cs)
AT (1) AT323181B (cs)
AU (1) AU466586B2 (cs)
BE (1) BE793730A (cs)
CA (1) CA991183A (cs)
CY (1) CY915A (cs)
DD (1) DD102698A5 (cs)
DE (1) DE2300491C3 (cs)
DK (1) DK139359B (cs)
FI (1) FI54124C (cs)
GB (1) GB1358680A (cs)
HK (1) HK60077A (cs)
HU (1) HU164821B (cs)
IE (1) IE37056B1 (cs)
IL (1) IL41232A (cs)
LU (1) LU66800A1 (cs)
NL (1) NL7217852A (cs)
NO (1) NO136843C (cs)
OA (1) OA04285A (cs)
SE (1) SE398503B (cs)

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FR2607504B1 (fr) * 1986-12-02 1989-01-27 Rhone Poulenc Sante Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2671800B1 (fr) 1991-01-17 1993-03-12 Rhone Poulenc Rorer Sa Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
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US6339086B1 (en) * 1999-05-14 2002-01-15 Swpracor, Inc. Methods of making and using N-desmethylzopiclone
ES2203319B1 (es) * 2002-04-03 2005-03-01 Universidad De Oviedo Nuevos carbonatos opticamente activos como intermedios en la sintesis de (+)-zopiclona.
JP5646126B2 (ja) 2003-12-11 2014-12-24 サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． 鎮静剤と神経伝達物質調節剤の併用、および睡眠の質の向上方法および鬱の治療方法
EP1904066B1 (en) 2005-07-06 2018-05-23 Sunovion Pharmaceuticals Inc. COMBINATIONS OF ESZOPICLONE AND TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE OR TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPTHALENAMINE, for treating MENOPAUSE, perimenopause AND COGNITIVE DISORDERS
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US20100216734A1 (en) * 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
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WO2007109799A2 (en) * 2006-03-23 2007-09-27 Teva Pharmaceutical Industries Ltd. Polymorphs of eszopiclone malate
JP2008543953A (ja) * 2006-04-20 2008-12-04 テバ ファーマシューティカル インダストリーズ リミティド エスゾピクロン結晶形態ａ、実質的に純粋なエスゾピクロン及び光学的に豊富なエスゾピクロンを調製するための方法
CN101058581B (zh) * 2006-04-21 2011-06-08 天津天士力集团有限公司 右佐匹克隆中间体6-(5-氯-2-吡啶基)-5,7-二氧代-6,7-二氢-5H-吡咯并[3,4-b]吡嗪的制备方法
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KR20100101051A (ko) * 2007-12-11 2010-09-16 씨아이피엘에이 엘티디. 조피클론 결정성 다형체, 이들의 제조 공정 및 이들의 약제 조성물
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US8268832B2 (en) * 2007-12-19 2012-09-18 Sunovion Pharmaceuticals Inc. Maleate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8198277B2 (en) 2007-12-19 2012-06-12 Sunovion Pharmaceuticals Inc. L-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
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CN100467471C (zh) * 2007-12-19 2009-03-11 齐鲁天和惠世制药有限公司 佐匹克隆的制备方法
US20110053945A1 (en) * 2007-12-19 2011-03-03 Sepracor Inc. Salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihy-dro-5h-pyrrolo[3,4-b]pyrazine
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CN105399745A (zh) * 2015-12-17 2016-03-16 天津华津制药有限公司 一种吡嗪并羟基吡咯烷酮类化合物的制备方法
EP3468545A4 (en) 2016-06-08 2020-07-22 President and Fellows of Harvard College METHODS AND COMPOSITIONS FOR REDUCING TACTILE DYSFUNCTION AND ANXIETY ASSOCIATED WITH AUTISM SPECTRUM DISORDER, RETT SYNDROME AND FRAGILE X SYNDROME
CN106220630B (zh) * 2016-07-23 2019-12-10 迪嘉药业集团有限公司 一种n-取代吡咯并[3,4-b]吡嗪-5,7(6h)-二酮的制备方法
AU2019272778B2 (en) 2018-05-22 2024-10-03 President And Fellows Of Harvard College Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment
EP3801512A4 (en) * 2018-05-29 2022-01-19 President and Fellows of Harvard College COMPOSITIONS AND METHODS FOR REDUCING TOUCH DYSFUNCTION, ANXIETY AND SOCIAL DISABILITY
US12077512B2 (en) 2019-03-25 2024-09-03 President And Fellows Of Harvard College Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment
CN114437027A (zh) * 2021-12-22 2022-05-06 深圳市祥根生物医药有限公司 一种佐匹克隆n-氧化杂质的制备方法

Also Published As

Publication number Publication date
FI54124C (fi) 1978-10-10
JPS535315B2 (cs) 1978-02-25
NO136843C (no) 1977-11-16
CY915A (en) 1977-12-23
DE2300491B2 (de) 1977-09-08
LU66800A1 (cs) 1973-07-18
OA04285A (fr) 1979-12-31
AU5075473A (en) 1974-07-04
DE2300491A1 (de) 1973-07-19
IL41232A (en) 1975-12-31
JPS4876892A (cs) 1973-10-16
IE37056B1 (en) 1977-04-27
JPS5248687A (en) 1977-04-18
JPS5248688A (en) 1977-04-18
BE793730A (fr) 1973-07-05
DD102698A5 (cs) 1973-12-20
JPS523952B2 (cs) 1977-01-31
AT323181B (de) 1975-06-25
NL7217852A (cs) 1973-07-10
GB1358680A (en) 1974-07-03
FI54124B (fi) 1978-06-30
HK60077A (en) 1977-12-09
DE2300491C3 (de) 1978-05-18
NO136843B (no) 1977-08-08
AR195097A1 (es) 1973-09-10
HU164821B (cs) 1974-04-11
CA991183A (fr) 1976-06-15
SE398503B (sv) 1977-12-27
IE37056L (en) 1973-07-07
AU466586B2 (en) 1975-10-30
JPS5231358B2 (cs) 1977-08-13
DK139359C (cs) 1979-07-09
IL41232A0 (en) 1973-03-30
US3862149A (en) 1975-01-21

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