DK1370552T3 - Rho-kinase-inhibitorer - Google Patents
Rho-kinase-inhibitorerInfo
- Publication number
- DK1370552T3 DK1370552T3 DK02713884T DK02713884T DK1370552T3 DK 1370552 T3 DK1370552 T3 DK 1370552T3 DK 02713884 T DK02713884 T DK 02713884T DK 02713884 T DK02713884 T DK 02713884T DK 1370552 T3 DK1370552 T3 DK 1370552T3
- Authority
- DK
- Denmark
- Prior art keywords
- kinase inhibitors
- rho kinase
- rho
- inhibitors
- kinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27797401P | 2001-03-23 | 2001-03-23 | |
US31533801P | 2001-08-29 | 2001-08-29 | |
PCT/US2002/008660 WO2002076977A2 (fr) | 2001-03-23 | 2002-03-22 | Inhibiteurs de rho-kinase |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1370552T3 true DK1370552T3 (da) | 2007-05-07 |
Family
ID=26958818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02713884T DK1370552T3 (da) | 2001-03-23 | 2002-03-22 | Rho-kinase-inhibitorer |
Country Status (19)
Country | Link |
---|---|
US (3) | US20030087919A1 (fr) |
EP (1) | EP1370552B1 (fr) |
JP (1) | JP4320705B2 (fr) |
AR (1) | AR035792A1 (fr) |
AT (1) | ATE353889T1 (fr) |
AU (1) | AU2002245709A1 (fr) |
CA (1) | CA2441501C (fr) |
CY (1) | CY1108041T1 (fr) |
DE (1) | DE60218138T2 (fr) |
DK (1) | DK1370552T3 (fr) |
ES (1) | ES2280517T3 (fr) |
HK (1) | HK1061029A1 (fr) |
MX (1) | MXPA03008659A (fr) |
MY (1) | MY142915A (fr) |
PE (1) | PE20020958A1 (fr) |
PT (1) | PT1370552E (fr) |
TW (1) | TWI336328B (fr) |
UY (1) | UY27225A1 (fr) |
WO (1) | WO2002076977A2 (fr) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
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US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
IL144144A0 (en) | 1999-01-13 | 2002-05-23 | Bayer Ag | Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
EP2324825A1 (fr) | 2002-02-11 | 2011-05-25 | Bayer Healthcare LLC | Arylurées dotées d'une activité d'inhibition de l'angiogenèse |
US7645878B2 (en) * | 2002-03-22 | 2010-01-12 | Bayer Healthcare Llc | Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof |
ES2382733T3 (es) | 2002-08-29 | 2012-06-13 | Santen Pharmaceutical Co., Ltd. | Remedio para el glaucoma que comprende un inhibidor de la Rho quinasa y prostaglandinas |
GB0307333D0 (en) * | 2003-03-29 | 2003-05-07 | Astrazeneca Ab | Therapeutic agent |
JP4566130B2 (ja) * | 2003-04-18 | 2010-10-20 | 千寿製薬株式会社 | 角膜知覚回復剤 |
ATE384264T1 (de) | 2003-05-20 | 2008-02-15 | Bayer Pharmaceuticals Corp | Diaryl-harnstoffe mit kinasehemmender wirkung |
NZ580384A (en) | 2003-07-23 | 2011-03-31 | Bayer Pharmaceuticals Corp | 4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide and metabolites for the treatment and prevention of diseases and conditions |
JP4110324B2 (ja) | 2003-10-15 | 2008-07-02 | 宇部興産株式会社 | 新規インダゾール誘導体 |
KR101335932B1 (ko) | 2005-03-07 | 2013-12-04 | 바이엘 헬스케어 엘엘씨 | 암의 치료를 위한 오메가-카르복시아릴 치환된 디페닐우레아를 포함하는 제약 조성물 |
CR9465A (es) | 2005-03-25 | 2008-06-19 | Surface Logix Inc | Compuestos mejorados farmacocineticamente |
KR101149954B1 (ko) | 2005-08-30 | 2012-06-01 | 아사히 가세이 파마 가부시키가이샤 | 술폰아미드 화합물 |
TW200815398A (en) * | 2006-06-08 | 2008-04-01 | Ube Industries | A novel indazole derivative having spirocyclic structure in the side chain |
CA2700988A1 (fr) * | 2006-09-27 | 2008-05-08 | Surface Logix, Inc. | Inhibiteurs de la rho kinase |
ES2524009T3 (es) | 2006-12-08 | 2014-12-03 | Irm Llc | Compuestos y composiciones como inhibidores de la proteína quinasa |
PL2091918T3 (pl) * | 2006-12-08 | 2015-02-27 | Novartis Ag | Związki i kompozycje jako inhibitory kinazy białkowej |
US8415372B2 (en) | 2007-02-27 | 2013-04-09 | Asahi Kasei Pharma Corporation | Sulfonamide compound |
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US20150044178A1 (en) | 2011-12-28 | 2015-02-12 | Kyoto Prefectural Public University Corporation | Normalization of culture of corneal endothelial cells |
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TWI592417B (zh) | 2012-09-13 | 2017-07-21 | 葛蘭素史克智慧財產發展有限公司 | 胺基喹唑啉激酶抑制劑之前藥 |
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WO2020047229A1 (fr) | 2018-08-29 | 2020-03-05 | University Of Massachusetts | Inhibition de protéines kinases pour traiter la maladie de friedreich |
US20210207088A1 (en) | 2018-08-31 | 2021-07-08 | The Doshisha | Composition and method for preserving or culturing ocular cells |
EP3862424A4 (fr) | 2018-10-02 | 2022-06-29 | The Doshisha | Procédé et récipient pour la conservation de cellules endothéliales cornéennes |
EP3900787A4 (fr) | 2018-12-21 | 2022-02-23 | Kyoto University | Tissu de type cartilage à lubricine localisée, procédé pour sa production et composition le comprenant pour le traitement de lésions du cartilage articulaire |
WO2020193802A1 (fr) | 2019-03-28 | 2020-10-01 | Fundación De La Comunidad Valenciana Centro De Investigación Príncipe Felipe | Conjugués polymères et leurs utilisations |
JP7489377B2 (ja) | 2019-03-29 | 2024-05-23 | 株式会社カネカ | 多能性幹細胞を含む細胞集団及びその製造方法 |
WO2020230832A1 (fr) | 2019-05-15 | 2020-11-19 | 味の素株式会社 | Procédé de purification de cellules de crête neurale ou de cellules épithéliales cornéennes |
CN115427551A (zh) | 2020-02-27 | 2022-12-02 | 京都府公立大学法人 | 人功能性角膜内皮细胞及其应用 |
CN116802276A (zh) | 2021-01-08 | 2023-09-22 | 国立大学法人京都大学 | 用于扩增培养肾元祖细胞的培养基、扩增培养肾元祖细胞的方法以及肾脏类器官的制造方法 |
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-
2002
- 2002-03-22 DK DK02713884T patent/DK1370552T3/da active
- 2002-03-22 MY MYPI20021019A patent/MY142915A/en unknown
- 2002-03-22 US US10/103,565 patent/US20030087919A1/en not_active Abandoned
- 2002-03-22 PE PE2002000225A patent/PE20020958A1/es not_active Application Discontinuation
- 2002-03-22 TW TW091105577A patent/TWI336328B/zh not_active IP Right Cessation
- 2002-03-22 JP JP2002576235A patent/JP4320705B2/ja not_active Expired - Fee Related
- 2002-03-22 DE DE60218138T patent/DE60218138T2/de not_active Expired - Lifetime
- 2002-03-22 EP EP02713884A patent/EP1370552B1/fr not_active Expired - Lifetime
- 2002-03-22 PT PT02713884T patent/PT1370552E/pt unknown
- 2002-03-22 UY UY27225A patent/UY27225A1/es unknown
- 2002-03-22 AT AT02713884T patent/ATE353889T1/de active
- 2002-03-22 AR ARP020101070A patent/AR035792A1/es active IP Right Grant
- 2002-03-22 CA CA2441501A patent/CA2441501C/fr not_active Expired - Fee Related
- 2002-03-22 MX MXPA03008659A patent/MXPA03008659A/es active IP Right Grant
- 2002-03-22 WO PCT/US2002/008660 patent/WO2002076977A2/fr active IP Right Grant
- 2002-03-22 AU AU2002245709A patent/AU2002245709A1/en not_active Abandoned
- 2002-03-22 ES ES02713884T patent/ES2280517T3/es not_active Expired - Lifetime
-
2004
- 2004-06-09 HK HK04104114A patent/HK1061029A1/xx not_active IP Right Cessation
-
2006
- 2006-02-16 US US11/354,978 patent/US20060142314A1/en not_active Abandoned
-
2007
- 2007-04-19 CY CY20071100536T patent/CY1108041T1/el unknown
-
2010
- 2010-03-18 US US12/726,660 patent/US20100249159A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
PE20020958A1 (es) | 2002-11-14 |
US20060142314A1 (en) | 2006-06-29 |
EP1370552B1 (fr) | 2007-02-14 |
US20030087919A1 (en) | 2003-05-08 |
CA2441501C (fr) | 2010-09-14 |
CA2441501A1 (fr) | 2002-10-03 |
WO2002076977A3 (fr) | 2002-12-12 |
EP1370552A2 (fr) | 2003-12-17 |
WO2002076977A2 (fr) | 2002-10-03 |
DE60218138D1 (de) | 2007-03-29 |
AR035792A1 (es) | 2004-07-14 |
PT1370552E (pt) | 2007-04-30 |
DE60218138T2 (de) | 2007-09-20 |
ATE353889T1 (de) | 2007-03-15 |
JP4320705B2 (ja) | 2009-08-26 |
UY27225A1 (es) | 2002-10-31 |
MY142915A (en) | 2011-01-31 |
ES2280517T3 (es) | 2007-09-16 |
TWI336328B (en) | 2011-01-21 |
MXPA03008659A (es) | 2005-04-08 |
CY1108041T1 (el) | 2013-09-04 |
HK1061029A1 (en) | 2004-09-03 |
JP2004528314A (ja) | 2004-09-16 |
US20100249159A1 (en) | 2010-09-30 |
AU2002245709A1 (en) | 2002-10-08 |
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