DK1313721T3 - Ikke-imidazol-aryloxyalkylaminer som H3-receptorligander - Google Patents

Ikke-imidazol-aryloxyalkylaminer som H3-receptorligander

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Publication number
DK1313721T3
DK1313721T3 DK01963813T DK01963813T DK1313721T3 DK 1313721 T3 DK1313721 T3 DK 1313721T3 DK 01963813 T DK01963813 T DK 01963813T DK 01963813 T DK01963813 T DK 01963813T DK 1313721 T3 DK1313721 T3 DK 1313721T3
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DK
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Prior art keywords
receptor ligands
aryloxyalkylamines
imidazole
imidazole aryloxyalkylamines
formula
Prior art date
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DK01963813T
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Danish (da)
English (en)
Inventor
Richard Apodaca
Nicholas I Carruthers
Curt A Dvorak
Chandravadan R Shah
Wei Xiao
Dale A Rudolph
Original Assignee
Ortho Mcneil Pharm Inc
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Publication of DK1313721T3 publication Critical patent/DK1313721T3/da

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
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EP1313721A2 (en) 2003-05-28
US7186732B2 (en) 2007-03-06
KR100819381B1 (ko) 2008-04-04
BR0113162A (pt) 2004-04-06
AU8473301A (en) 2002-02-18
JP5279161B2 (ja) 2013-09-04
HU230055B1 (hu) 2015-06-29
US20020065278A1 (en) 2002-05-30
US20100004241A1 (en) 2010-01-07
DE60117814T2 (de) 2006-11-02
HUP0302959A3 (en) 2006-04-28
HK1053110A1 (zh) 2003-10-10
AU2001284733B2 (en) 2006-11-02
DE60117814D1 (de) 2006-05-04
BRPI0113162B1 (pt) 2016-06-28
BRPI0113162B8 (pt) 2021-05-25
EP1313721B1 (en) 2006-03-08
PL360886A1 (en) 2004-09-20
CZ2003685A3 (cs) 2003-08-13
HUP0302959A2 (hu) 2003-12-29
US20080306085A1 (en) 2008-12-11
WO2002012214A3 (en) 2002-06-20
ES2260276T3 (es) 2006-11-01
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