DK1307427T5 - Fremgangsmåde til cyanering af aldehyder - Google Patents

Fremgangsmåde til cyanering af aldehyder

Info

Publication number
DK1307427T5
DK1307427T5 DK01953252T DK01953252T DK1307427T5 DK 1307427 T5 DK1307427 T5 DK 1307427T5 DK 01953252 T DK01953252 T DK 01953252T DK 01953252 T DK01953252 T DK 01953252T DK 1307427 T5 DK1307427 T5 DK 1307427T5
Authority
DK
Denmark
Prior art keywords
chiral
aldehyde
leaving group
catalyst
nucleophilic attack
Prior art date
Application number
DK01953252T
Other languages
Danish (da)
English (en)
Other versions
DK1307427T3 (da
Inventor
Michael North
Yuri Belokon
Original Assignee
King S College London
Nesmeyanov Inst Of Organoeleme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by King S College London, Nesmeyanov Inst Of Organoeleme filed Critical King S College London
Application granted granted Critical
Publication of DK1307427T3 publication Critical patent/DK1307427T3/da
Publication of DK1307427T5 publication Critical patent/DK1307427T5/da

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B01J31/2204—Organic complexes the ligands containing oxygen or sulfur as complexing atoms
    • B01J31/2208—Oxygen, e.g. acetylacetonates
    • B01J31/2226—Anionic ligands, i.e. the overall ligand carries at least one formal negative charge
    • B01J31/2243—At least one oxygen and one nitrogen atom present as complexing atoms in an at least bidentate or bridging ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/08—Formation or introduction of functional groups containing nitrogen of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/30—Addition reactions at carbon centres, i.e. to either C-C or C-X multiple bonds
    • B01J2231/34—Other additions, e.g. Monsanto-type carbonylations, addition to 1,2-C=X or 1,2-C-X triplebonds, additions to 1,4-C=C-C=X or 1,4-C=-C-X triple bonds with X, e.g. O, S, NH/N
    • B01J2231/341—1,2-additions, e.g. aldol or Knoevenagel condensations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/02—Compositional aspects of complexes used, e.g. polynuclearity
    • B01J2531/0202—Polynuclearity
    • B01J2531/0205—Bi- or polynuclear complexes, i.e. comprising two or more metal coordination centres, without metal-metal bonds, e.g. Cp(Lx)Zr-imidazole-Zr(Lx)Cp
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/02—Compositional aspects of complexes used, e.g. polynuclearity
    • B01J2531/0238—Complexes comprising multidentate ligands, i.e. more than 2 ionic or coordinative bonds from the central metal to the ligand, the latter having at least two donor atoms, e.g. N, O, S, P
    • B01J2531/0241—Rigid ligands, e.g. extended sp2-carbon frameworks or geminal di- or trisubstitution
    • B01J2531/0252—Salen ligands or analogues, e.g. derived from ethylenediamine and salicylaldehyde
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/40—Complexes comprising metals of Group IV (IVA or IVB) as the central metal
    • B01J2531/46—Titanium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/50—Complexes comprising metals of Group V (VA or VB) as the central metal
    • B01J2531/56—Vanadium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Manufacture And Refinement Of Metals (AREA)
DK01953252T 2000-08-02 2001-08-01 Fremgangsmåde til cyanering af aldehyder DK1307427T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0018973.8A GB0018973D0 (en) 2000-08-02 2000-08-02 Synthesis of chiral cyanohydrins
PCT/GB2001/003456 WO2002010095A2 (en) 2000-08-02 2001-08-01 Process for the cyanation of aldehydes

Publications (2)

Publication Number Publication Date
DK1307427T3 DK1307427T3 (da) 2006-07-31
DK1307427T5 true DK1307427T5 (da) 2009-06-15

Family

ID=9896847

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01953252T DK1307427T5 (da) 2000-08-02 2001-08-01 Fremgangsmåde til cyanering af aldehyder

Country Status (17)

Country Link
EP (1) EP1307427B3 (zh)
JP (1) JP2004505097A (zh)
KR (1) KR100820273B1 (zh)
CN (1) CN100406433C (zh)
AT (1) ATE323069T1 (zh)
AU (1) AU2001275740A1 (zh)
CA (1) CA2418116A1 (zh)
CZ (1) CZ2003276A3 (zh)
DE (2) DE60118752D1 (zh)
DK (1) DK1307427T5 (zh)
ES (1) ES2262665T7 (zh)
GB (1) GB0018973D0 (zh)
HK (1) HK1062008A1 (zh)
HU (1) HUP0301824A3 (zh)
MX (1) MXPA03000903A (zh)
PT (1) PT1307427E (zh)
WO (1) WO2002010095A2 (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0212017D0 (en) * 2002-05-24 2002-07-03 King S College London Catalyst and process
GB0103857D0 (en) * 2001-02-16 2001-04-04 Avecia Ltd Preparation of chloromandelic acid
DE10131810A1 (de) * 2001-06-30 2003-02-27 Clariant Gmbh Verfahren zur Herstellung von optisch aktiven Cyanhydrinen und deren korrespondierenden Säuren
DE10131811A1 (de) * 2001-06-30 2003-04-03 Clariant Gmbh Optisch aktive Katalysatoren
BR0211073A (pt) 2001-07-12 2004-12-14 Avecia Ltd Sistema de catalisador, e, processos para a preparação de um catalisador microencapsulado, de bifenilas opcionalmente substituìdas, de alcenos opcionalmente substituìdos, de um produto hidrogenado e de dióis
DE10259162A1 (de) * 2002-12-18 2004-07-08 Clariant Gmbh Optisch aktive Komplexe enthaltende Mischungen
DE602005016955D1 (de) 2004-10-15 2009-11-12 Mitsui Chemicals Inc Titanverbindung und verfahren zur herstellung optisch aktiver cyanhydrine
UA94449C2 (ru) * 2006-03-10 2011-05-10 Ниссан Кэмикал Индастриз, Лтд. Способ получения оптически активного соединения оксида хромена
AU2007225765B2 (en) * 2006-03-10 2012-05-24 Nissan Chemical Industries, Ltd. Process for producing optically active chromene oxide compound
WO2008121074A1 (en) * 2007-03-29 2008-10-09 Agency For Science, Technology And Research Method of producing an optically active cyanohydrin derivative
CN102234291B (zh) * 2010-04-23 2014-10-15 中国科学院上海有机化学研究所 桥连双希夫碱钛络合物、合成方法及其应用
CN106552671A (zh) * 2015-09-25 2017-04-05 沈阳中化农药化工研发有限公司 一种多相催化剂及其制备和应用
CN116987004B (zh) * 2023-09-27 2023-12-12 新华制药（寿光）有限公司 一种3-(3,4-二甲氧基苯基)-2-氨基-2-甲基丙腈的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2919974A1 (de) * 1979-05-17 1980-11-27 Hoechst Ag Verfahren zur herstellung von cyanhydrinacylaten von aldehyden
JPH0429965A (ja) * 1990-05-28 1992-01-31 Katakura Chitsukarin Kk α―Ｎ―アルキルアミノニトリル誘導体鏡像異性体の製造方法
JP3303327B2 (ja) * 1992-03-18 2002-07-22 住友化学工業株式会社 不斉誘起触媒
US5349079A (en) * 1992-12-14 1994-09-20 Akzo Nobel Nv Process for forming α-aminonitriles from carbonyl compound and fatty amine hydrohalide
JPH06271522A (ja) * 1993-01-21 1994-09-27 Sumitomo Chem Co Ltd 光学活性シアノヒドリンエステルの製造方法
JPH0770040A (ja) * 1993-06-22 1995-03-14 Sumitomo Chem Co Ltd 光学活性シアノヒドリンエステルの製造法

Also Published As

Publication number Publication date
GB0018973D0 (en) 2000-09-20
HK1062008A1 (en) 2004-10-15
ATE323069T1 (de) 2006-04-15
EP1307427B1 (en) 2006-04-12
AU2001275740A1 (en) 2002-02-13
DE60118752T2 (de) 2007-03-15
DE60118752D1 (de) 2006-05-24
EP1307427A2 (en) 2003-05-07
DK1307427T3 (da) 2006-07-31
MXPA03000903A (es) 2004-08-02
KR20030022339A (ko) 2003-03-15
CA2418116A1 (en) 2002-02-07
ES2262665T3 (es) 2006-12-01
HUP0301824A3 (en) 2005-11-28
CN100406433C (zh) 2008-07-30
HUP0301824A2 (hu) 2003-09-29
DE60118752T4 (de) 2009-10-22
CN1468212A (zh) 2004-01-14
CZ2003276A3 (cs) 2003-05-14
WO2002010095A3 (en) 2002-04-18
PT1307427E (pt) 2006-07-31
ES2262665T7 (es) 2009-11-05
EP1307427B3 (en) 2009-04-29
KR100820273B1 (ko) 2008-04-07
WO2002010095A2 (en) 2002-02-07
JP2004505097A (ja) 2004-02-19

Similar Documents

Publication Publication Date Title
DK1307427T3 (da) Fremgangsmåde til cyanering af aldehyder
EA200500198A1 (ru) Композиция водного связующего для минеральных волокон, не содержащая формальдегида
WO2001092579A3 (en) Methods for detecting target nucleic acids using coupled ligation and amplification
ATE444956T1 (de) Dihydroxypyrimidin-carbonsäuren als virale polymerase inhibitoren
DE69923313D1 (de) Nachweis von liganden mit signalverstärkung
JP2008531255A5 (zh)
BR0004144A (pt) Catalisador, processo para a preparação de um catalisador, e processo para a preparação de um composto selecionado do grupo que consiste de um aldeìdo não saturado e um ácido carboxìlico
DE50001509D1 (de) Carboxylfunktionelles additiv zur aufkondensierung von polyamiden
NO20042039L (no) Fremgangsmate for a lime trebaserte materialer og limsystem av melaminaminoharpiks og fenolharpiks
DE60207490D1 (de) Verfahren zur Herstellung von (Meth)Acrylsäureanhydrid
WO2003099435A3 (en) Catalyst and process for the cyanation of aldehydes
JP2004505097A5 (zh)
BR0104320A (pt) Processo para preparar um catalisador, catalisador, processos para preparar um ácido carboxìlico ou aldeìdo insaturado, e, para preparar uma nitrila insaturada
YU49182B (sh) Postupak za proizvodnju vinil acetetata korišćenjem katalizatora tipa paladijum-zlato-bakar
NO20014885L (no) Fremgangsmåte til fremstilling av en amidforbindelse
ATE256103T1 (de) Verfahren zur umsetzung von aldehyden zu nitrilen durch reaktion mit ammoniak and wasserstoff- peroxid
DK1099676T3 (da) Fremgangsmåde til fremstilling af 1,1,4,4-tetramethoxybuten-2
EP1584613A3 (en) Improved catalytic oxidation process
EA199700391A1 (ru) Способ получения производных карбоновых кислот
WO2003005010A3 (de) Verfahren zur herstellung von optisch aktiven cyanhydrinen
DE50107453D1 (de) Verfahren zur herstellung von zimtsäureester
DE50200355D1 (de) Wasserdampfdurchlässiges, wasserresistentes Verbundmaterial
DK0677506T3 (da) Fremgangsmåde til fremstilling af sekundært butylacrylat
IL137027A0 (en) A process for the preparation of cyclopropane carboxylic acids
WO2003104167A3 (en) CYANHYDRIN ETHERS AND ESTERS FOR USE AS HIGH-SENSITIVITY ENZYMATIC SUBSTRATES