DK1296671T3 - Gabapentinanaloger til sövnforstyrrelser - Google Patents

Gabapentinanaloger til sövnforstyrrelser

Info

Publication number
DK1296671T3
DK1296671T3 DK01939192T DK01939192T DK1296671T3 DK 1296671 T3 DK1296671 T3 DK 1296671T3 DK 01939192 T DK01939192 T DK 01939192T DK 01939192 T DK01939192 T DK 01939192T DK 1296671 T3 DK1296671 T3 DK 1296671T3
Authority
DK
Denmark
Prior art keywords
sleep disorders
gabapentin analogues
gabapentin
analogues
compounds
Prior art date
Application number
DK01939192T
Other languages
Danish (da)
English (en)
Inventor
Leonard Theodore Meltzer
Justin Stephen Bryans
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of DK1296671T3 publication Critical patent/DK1296671T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK01939192T 2000-06-26 2001-05-18 Gabapentinanaloger til sövnforstyrrelser DK1296671T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21417100P 2000-06-26 2000-06-26
PCT/US2001/016343 WO2002000209A2 (en) 2000-06-26 2001-05-18 Gabapentin analogues for sleep disorders

Publications (1)

Publication Number Publication Date
DK1296671T3 true DK1296671T3 (da) 2008-06-16

Family

ID=22798045

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01939192T DK1296671T3 (da) 2000-06-26 2001-05-18 Gabapentinanaloger til sövnforstyrrelser

Country Status (24)

Country Link
US (1) US7141606B2 (cs)
EP (1) EP1296671B1 (cs)
JP (1) JP3909842B2 (cs)
KR (1) KR100785182B1 (cs)
CN (1) CN1279900C (cs)
AT (1) ATE390133T1 (cs)
AU (2) AU2001264736B2 (cs)
BR (1) BR0111913A (cs)
CA (1) CA2414008C (cs)
CZ (1) CZ20024110A3 (cs)
DE (1) DE60133389T2 (cs)
DK (1) DK1296671T3 (cs)
ES (1) ES2300332T3 (cs)
HK (1) HK1056681A1 (cs)
HU (1) HUP0300833A3 (cs)
IL (2) IL152770A0 (cs)
MX (1) MXPA02010668A (cs)
NZ (1) NZ522480A (cs)
PL (1) PL359872A1 (cs)
PT (1) PT1296671E (cs)
SK (1) SK17922002A3 (cs)
TW (1) TWI298020B (cs)
WO (1) WO2002000209A2 (cs)
ZA (1) ZA200209418B (cs)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL366406A1 (en) 2001-04-19 2005-01-24 Warner-Lambert Company Llc Fused bicyclic or tricyclic amino acids
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
ES2296956T5 (es) * 2001-06-11 2011-07-12 Xenoport, Inc. Profármacos de análogos de gaba, composiciones y sus usos.
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
EP1412324A4 (en) 2001-06-11 2004-09-29 Xenoport Inc AMINO ACID CONJUGATES THAT RESULT IN GABA ANALOGA LASTING SYSTEMIC CONCENTRATIONS
AU2002316231A1 (en) 2002-02-19 2003-09-29 Xenoport, Inc. Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
WO2003080588A1 (en) 2002-03-20 2003-10-02 Xenoport Cyclic 1-(acyloxy)-alkyl prodrugs of gaba analogs, compositions and uses thereof
WO2003099338A2 (en) 2002-05-17 2003-12-04 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
US7060727B2 (en) 2002-12-11 2006-06-13 Xenoport, Inc. Prodrugs of fused GABA analogs, pharmaceutical compositions and uses thereof
CA2451267A1 (en) * 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
JP2006511605A (ja) * 2002-12-13 2006-04-06 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 線維筋痛及び他の関連障害のためのガバペンチン類縁体
EP1622603A4 (en) * 2003-03-25 2010-03-24 Kiel Lab Inc GABAPENTINIC PHENOLIC ACID SALTS IN SOLID DOSAGE FORMS AND METHODS OF USE
KR20060119971A (ko) 2003-09-11 2006-11-24 제노포트 인코포레이티드 Ｇａｂａ 유사체의 전구약물을 이용한 요실금의 치료및/또는 예방
CN1871021B (zh) 2003-09-17 2010-07-28 什诺波特有限公司 用gaba类似物的前药治疗或预防多动腿综合征
SI1677767T1 (sl) 2003-10-14 2011-11-30 Xenoport Inc Kristalinična oblika analoga gama-aminomaslene kisline
JP4613031B2 (ja) * 2004-05-06 2011-01-12 エスエス製薬株式会社 催眠剤組成物
JP2005325070A (ja) * 2004-05-14 2005-11-24 Ss Pharmaceut Co Ltd 睡眠改善剤
BRPI0517227B8 (pt) 2004-11-04 2021-05-25 Xenoport Inc comprimido oral de liberação prolongada do ácido 1-{[alfa-isobutanoiloxietoxi)carbonil]amino metil}-1-cicloexano acético, e, uso do comprimido
US7837982B2 (en) 2005-06-23 2010-11-23 Emory University Imaging agents
KR20070070307A (ko) * 2005-08-24 2007-07-04 에스에스 세야쿠 가부시키 가이샤 수면 개선 의약 조성물
EP1993529A1 (en) * 2006-03-06 2008-11-26 Pfizer Products Inc. Alpha-2-delta ligands for non-restorative sleep
TWI369202B (en) 2008-01-25 2012-08-01 Xenoport Inc Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs
US7868043B2 (en) 2008-01-25 2011-01-11 Xenoport, Inc. Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
US7872046B2 (en) 2008-01-25 2011-01-18 Xenoport, Inc. Crystalline form of a (3S)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use
CN102216257B (zh) 2008-10-08 2015-11-25 凯飞药业公司 Gaba偶联物及其使用方法
JP5815552B2 (ja) 2009-12-08 2015-11-17 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ 眼疾患を治療する化合物および方法
US9066853B2 (en) 2013-01-15 2015-06-30 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable fiber
HUE047629T2 (hu) 2013-01-28 2020-05-28 Lopez Hector L Eljárások ß-alanin tolerancia, farmakodinamika és hatékonyság javítására és azok alkalmazása
SG11201811368SA (en) * 2016-05-26 2019-01-30 Amino Up Chemical Co Ltd Sleep improving agent
EP4227293A3 (en) 2018-05-14 2023-10-04 Xgene Pharmaceutical Inc Crystalline forms of 1-(acyloxy)-alkyl carbamate drug conjugates of naproxen and pregabalin

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087544A (en) 1974-12-21 1978-05-02 Warner-Lambert Company Treatment of cranial dysfunctions using novel cyclic amino acids
DE2460891C2 (de) 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US5084479A (en) 1990-01-02 1992-01-28 Warner-Lambert Company Novel methods for treating neurodegenerative diseases
US6197819B1 (en) 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
US5510381A (en) 1995-05-15 1996-04-23 Warner-Lambert Company Method of treatment of mania and bipolar disorder
DE19525598C2 (de) * 1995-07-13 1997-09-25 Max Planck Gesellschaft Schlafmittel
NZ331142A (en) * 1996-03-14 2001-04-27 Warner Lambert Co Bridged cyclic amino acids as pharmaceutical agents
US6372792B1 (en) * 1996-04-26 2002-04-16 Guy Chouinard Method for treating anxiety, anxiety disorders and insomnia
DE69834204T2 (de) * 1997-10-27 2007-03-29 Warner-Lambert Co. Llc Zyklische aminosäuren und deren derivate als arzneimittel
PL345338A1 (en) * 1998-07-09 2001-12-17 Warner Lambert Co Method for the treatment of insomnia
WO2000073300A1 (en) * 1999-06-02 2000-12-07 Warner-Lambert Company Amino heterocycles useful as pharmaceutical agents
HN2000000224A (es) * 1999-10-20 2001-04-11 Warner Lambert Co Aminoacidos biciclicos como agentes farmaceuticos
EP1237847B1 (en) * 1999-12-08 2006-05-17 Warner-Lambert Company Llc Method for the stereoselective synthesis of cyclic amino acids
GB9930083D0 (en) * 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments

Also Published As

Publication number Publication date
HK1056681A1 (en) 2004-02-27
IL152770A (en) 2009-12-24
MXPA02010668A (es) 2003-03-10
CA2414008A1 (en) 2002-01-03
AU2001264736B2 (en) 2006-04-27
EP1296671B1 (en) 2008-03-26
WO2002000209A3 (en) 2003-01-16
KR100785182B1 (ko) 2007-12-11
EP1296671A2 (en) 2003-04-02
US7141606B2 (en) 2006-11-28
JP3909842B2 (ja) 2007-04-25
DE60133389D1 (de) 2008-05-08
SK17922002A3 (sk) 2003-11-04
NZ522480A (en) 2005-06-24
CZ20024110A3 (cs) 2003-10-15
KR20030019455A (ko) 2003-03-06
PL359872A1 (en) 2004-09-06
WO2002000209A2 (en) 2002-01-03
CN1436075A (zh) 2003-08-13
ES2300332T3 (es) 2008-06-16
DE60133389T2 (de) 2008-06-26
ZA200209418B (en) 2005-03-10
JP2004501189A (ja) 2004-01-15
TWI298020B (en) 2008-06-21
IL152770A0 (en) 2003-06-24
BR0111913A (pt) 2004-01-06
ATE390133T1 (de) 2008-04-15
CN1279900C (zh) 2006-10-18
PT1296671E (pt) 2008-05-09
CA2414008C (en) 2011-04-26
AU6473601A (en) 2002-01-08
HUP0300833A2 (hu) 2003-08-28
US20030212133A1 (en) 2003-11-13
HUP0300833A3 (en) 2009-08-28

Similar Documents

Publication Publication Date Title
DK1296671T3 (da) Gabapentinanaloger til sövnforstyrrelser
GB0223040D0 (en) Therapeutic compounds
BG106586A (en) Pyrazolopyramidines as therapeutic agents
BG108269A (en) Pyrazolopyrimidines as therapeutic agents
DE60124684D1 (de) Sulfonamido-substituierte verbrückte bicycloalkylderivative
GB0005251D0 (en) Therapeutic compounds
ATE512163T1 (de) Verabreichung von mitteln zur behandlung von entzündungen
GB0108592D0 (en) Therapeutic agents
GB0108591D0 (en) Therapeutic agents
DE60223694D1 (de) Pflaster zur behandlung von funktionsstörungen und störungen des nagelwachstums
IS6069A (is) N-cýanómetýlamíð sem próteasalatar
SI1509232T1 (sl) Kombinacija antagonista nmda in zaviralcev acetilholinesteraze za zdravljenje alzheimerjeve bolezni
CY2009002I2 (el) Χρηση αμινοξικων αντισπασμωδικων για τη θεραπευτικη αγωγη του πονου
TR200101120T2 (tr) Serin proteaz inhibitörü
SE9603669D0 (sv) New combination
DE60312736D1 (de) 1,2,4-triaminobenzolderivate zur behandlung von erkrankungen des zentralnervensystems
DE60205899D1 (en) 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
BR0314844A (pt) Novo composto
BR0314843A (pt) Novo composto
ATE432068T1 (de) Cetirizin und pseudoephedrin enthaltende tablette
PL376894A1 (pl) Pochodne 4-(fenylopiperazynylometylo) benzamidu i ich zastosowanie do leczenia bólu lub zaburzeń żołądkowo-jelitowych
PL376895A1 (pl) Pochodne 4-(fenylopiperazynylometylo) benzamidu i ich zastosowanie do leczenia bólu lub zaburzeń żołądkowo-jelitowych
IS6087A (is) N-(2-fenýl-4-amínó-bútýl)-1-naftamíð sem virka á móti taugakínín-1 viðtaka
AU2003303141A8 (en) Hydroxypropyl amides for the treatment of alzheimer's disease
AU2003278664A1 (en) 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders