DK1278889T3 - Hydridiseringsbeacon og fremgangsmåde til hurtig sekvensdetektion og distinktion - Google Patents
Hydridiseringsbeacon og fremgangsmåde til hurtig sekvensdetektion og distinktionInfo
- Publication number
- DK1278889T3 DK1278889T3 DK01915549T DK01915549T DK1278889T3 DK 1278889 T3 DK1278889 T3 DK 1278889T3 DK 01915549 T DK01915549 T DK 01915549T DK 01915549 T DK01915549 T DK 01915549T DK 1278889 T3 DK1278889 T3 DK 1278889T3
- Authority
- DK
- Denmark
- Prior art keywords
- targets
- probes
- oligonucleotide probes
- oligonucleotide
- stranded
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Monitoring And Testing Of Transmission In General (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0007622A GB0007622D0 (en) | 2000-03-29 | 2000-03-29 | Hybridisation beacon and method of sequence detection |
GB0026749A GB0026749D0 (en) | 2000-11-02 | 2000-11-02 | Hybridisation beacon and rapid method of sequence detection and discrimination |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1278889T3 true DK1278889T3 (da) | 2006-11-27 |
Family
ID=26243981
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK06117641.8T DK1715063T3 (da) | 2000-03-29 | 2001-03-28 | Hydridiseringsbeacon og fremgangsmåde til hurtig sekvensdetektion og distinktion |
DK01915549T DK1278889T3 (da) | 2000-03-29 | 2001-03-28 | Hydridiseringsbeacon og fremgangsmåde til hurtig sekvensdetektion og distinktion |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK06117641.8T DK1715063T3 (da) | 2000-03-29 | 2001-03-28 | Hydridiseringsbeacon og fremgangsmåde til hurtig sekvensdetektion og distinktion |
Country Status (12)
Country | Link |
---|---|
US (1) | US7348141B2 (pt) |
EP (2) | EP1278889B1 (pt) |
JP (1) | JP5112592B2 (pt) |
AT (2) | ATE334228T1 (pt) |
AU (2) | AU4263401A (pt) |
CA (1) | CA2404174C (pt) |
DE (2) | DE60143974D1 (pt) |
DK (2) | DK1715063T3 (pt) |
ES (1) | ES2269365T3 (pt) |
NZ (1) | NZ521593A (pt) |
PT (2) | PT1715063E (pt) |
WO (1) | WO2001073118A2 (pt) |
Families Citing this family (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7998673B2 (en) * | 2000-03-29 | 2011-08-16 | Lgc Limited | Hybridisation beacon and method of rapid sequence detection and discrimination |
CA2417986C (en) | 2000-08-11 | 2013-11-26 | University Of Utah Research Foundation | Single-labeled oligonucleotide probes |
WO2003018837A2 (de) * | 2001-08-24 | 2003-03-06 | Adnagen Ag | Verfahren und diagnosekit zur molekularen diagnostik pharmakologisch relevanter gene |
BR0303224A (pt) * | 2002-02-11 | 2004-07-06 | Applied Research Systems | Detecção de nucleotìdeos por transferência de energia de ressonância fluorescente e métodos para a mesma |
US8030000B2 (en) | 2002-02-21 | 2011-10-04 | Alere San Diego, Inc. | Recombinase polymerase amplification |
US7399590B2 (en) | 2002-02-21 | 2008-07-15 | Asm Scientific, Inc. | Recombinase polymerase amplification |
WO2003072805A2 (en) | 2002-02-21 | 2003-09-04 | Asm Scientific, Inc. | Recombinase polymerase amplification |
WO2005075682A1 (en) * | 2004-02-04 | 2005-08-18 | Hee-Kyung Park | Microarray comprising qc probes and method for fabricating the same |
WO2006128192A2 (en) * | 2005-05-27 | 2006-11-30 | John Wayne Cancer Institute | Use of free circulating dna for diagnosis, prognosis, and treatment of cancer |
GB0514889D0 (en) | 2005-07-20 | 2005-08-24 | Lgc Ltd | Oligonucleotides |
US8062850B2 (en) | 2005-07-25 | 2011-11-22 | Alere San Diego, Inc. | Methods for multiplexing recombinase polymerase amplification |
JP5537034B2 (ja) | 2005-12-23 | 2014-07-02 | ナノストリング テクノロジーズ,インコーポレーテッド | ナノレポーターならびにその作製方法および使用方法 |
US8133984B2 (en) | 2006-03-16 | 2012-03-13 | Pentabase Aps | Oligonucleotides comprising signalling pairs and hydrophobic nucleotides, stemless beacons, for detection of nucleic acids, methylation status and mutants of nucleic acids |
EP3088533B1 (en) | 2006-05-04 | 2018-01-17 | Alere San Diego, Inc. | Recombinase polymerase amplification |
US11001881B2 (en) | 2006-08-24 | 2021-05-11 | California Institute Of Technology | Methods for detecting analytes |
WO2008014485A2 (en) | 2006-07-28 | 2008-01-31 | California Institute Of Technology | Multiplex q-pcr arrays |
US11525156B2 (en) | 2006-07-28 | 2022-12-13 | California Institute Of Technology | Multiplex Q-PCR arrays |
JPWO2008018305A1 (ja) * | 2006-08-08 | 2009-12-24 | アークレイ株式会社 | 変異の検出方法およびそれに用いるキット |
CN101443457B (zh) * | 2006-08-09 | 2015-05-27 | 爱科来株式会社 | 利用pcr的扩增产物的制造方法及其用途 |
US11560588B2 (en) | 2006-08-24 | 2023-01-24 | California Institute Of Technology | Multiplex Q-PCR arrays |
CN102154274A (zh) * | 2006-11-30 | 2011-08-17 | 爱科来株式会社 | Nat2基因扩增用引物对、含有其的nat2基因扩增用试剂及其用途 |
US20090269756A1 (en) * | 2006-11-30 | 2009-10-29 | Arkray, Inc. | Primer set for amplifying cyp2c19 gene, reagent for amplifying cyp2c19 gene containing the same, and the uses thereof |
EP2450444B1 (en) * | 2006-11-30 | 2013-06-05 | ARKRAY, Inc. | Probe for analyzing a polymorphism in the beta2AR gene, reagent, and obesity gene analysis method |
US9938641B2 (en) * | 2006-12-18 | 2018-04-10 | Fluidigm Corporation | Selection of aptamers based on geometry |
JP4942508B2 (ja) * | 2007-02-20 | 2012-05-30 | アークレイ株式会社 | abl遺伝子変異の検出用プローブおよびその用途 |
JP4410269B2 (ja) | 2007-03-28 | 2010-02-03 | 株式会社東芝 | N−アセチルトランスフェラーゼ2(nat2)の遺伝子型を検出するための核酸プライマーセット、キット、及び該プライマーセットを用いた検出方法 |
JP2009148245A (ja) * | 2007-06-12 | 2009-07-09 | Toyobo Co Ltd | 核酸の迅速な検出方法 |
WO2008156591A1 (en) * | 2007-06-15 | 2008-12-24 | The Feinstein Institute Medical Research | Prediction of schizophrenia risk using homozygous genetic markers |
NZ584739A (en) | 2007-10-22 | 2012-06-29 | Lgc Ltd | Simultaneous detection of tandem repeats in target polynucleotides at a given polymorphic locus |
JPWO2009081967A1 (ja) * | 2007-12-26 | 2011-05-06 | アークレイ株式会社 | 標的核酸配列の増幅方法およびそれに用いるプローブ |
WO2010018245A1 (es) * | 2008-08-12 | 2010-02-18 | Biotools Biotechnological & Medical Laboratories, S.A. | Método para la detección y/o cuantificación de un ácido nucleico substrato |
NZ594443A (en) | 2009-02-03 | 2014-06-27 | Netbio Inc | Nucleic acid purification |
WO2010135310A1 (en) | 2009-05-20 | 2010-11-25 | Biosite Incorporated | Dna glycosylase/lyase and ap endonuclease substrates |
AU2010286368B2 (en) | 2009-08-31 | 2015-09-03 | Gen-Probe Incorporated | Dengue virus assay |
WO2011027966A2 (en) | 2009-09-03 | 2011-03-10 | Seegene, Inc. | Td probe and its uses |
PL389135A1 (pl) * | 2009-09-28 | 2011-04-11 | Michał Lower | Sposób i sonda DNA do otrzymywania endonukleaz restrukcyjnych, zwłaszcza o pożądanej specyficzności sekwencyjnej |
WO2011069160A1 (en) * | 2009-12-05 | 2011-06-09 | Evogen, Inc. | Methods of quantifying nucleic acids |
US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
GB201010237D0 (en) | 2010-06-18 | 2010-07-21 | Lgc Ltd | Methods and apparatuses |
MX340258B (es) | 2011-01-11 | 2016-07-01 | Seegene Inc | Detección de secuencias de ácido nucleico objetivo mediante ensayo de escisión y extensión del pto. |
CN108866169A (zh) * | 2011-07-06 | 2018-11-23 | 探索诊断投资公司 | 病毒和细菌病原体的直接扩增和检测 |
US20140155275A1 (en) * | 2011-07-06 | 2014-06-05 | The Johns Hopkins University | Semi-digital ligation assay |
ES2788139T3 (es) * | 2011-10-14 | 2020-10-20 | Accugenomics Inc | Amplificación cuantitativa de ácidos nucleicos |
US8981318B1 (en) | 2011-12-30 | 2015-03-17 | Gene Capture, Inc. | Multi-dimensional scanner for nano-second time scale signal detection |
EP4361607A2 (en) | 2012-02-03 | 2024-05-01 | California Institute of Technology | Signal encoding and decoding in multiplexed biochemical assays |
CN104364392B (zh) | 2012-02-27 | 2018-05-25 | 赛卢拉研究公司 | 用于分子计数的组合物和试剂盒 |
CA2864523C (en) | 2012-03-05 | 2019-02-05 | Seegene, Inc. | Detection of nucleotide variation on target nucleic acid sequence by pto cleavage and extension assay |
AU2013202808B2 (en) | 2012-07-31 | 2014-11-13 | Gen-Probe Incorporated | System and method for performing multiplex thermal melt analysis |
WO2014022827A1 (en) | 2012-08-03 | 2014-02-06 | California Institute Of Technology | Multiplexing and quantification in pcr with reduced hardware and requirements |
ES2662825T3 (es) | 2013-02-25 | 2018-04-09 | Seegene, Inc. | Detección de variación de nucleótido en una secuencia de ácidos nucleicos diana |
EP2971115B1 (en) | 2013-03-13 | 2022-07-27 | Seegene, Inc. | Quantification of target nucleic acid using melting peak analysis |
GB201310823D0 (en) * | 2013-06-18 | 2013-07-31 | Lgc Ltd | Fluorophore-based oligonucleotide probes with a universal element |
KR20230074639A (ko) | 2013-08-28 | 2023-05-30 | 벡톤 디킨슨 앤드 컴퍼니 | 대량의 동시 단일 세포 분석 |
KR101757473B1 (ko) | 2013-10-18 | 2017-07-13 | 주식회사 씨젠 | hCTO를 이용하는 PTO 절단 및 연장 분석에 의한 고상에서의 타겟 핵산 서열 검출 |
WO2015147370A1 (en) | 2014-03-28 | 2015-10-01 | Seegene, Inc. | Detection of target nucleic acid sequences using different detection temperatures |
EP4098753A1 (en) * | 2014-10-23 | 2022-12-07 | Ricardo Mancebo | Reagents and methods for isothermal chain reaction |
US9708647B2 (en) | 2015-03-23 | 2017-07-18 | Insilixa, Inc. | Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays |
EP4180535A1 (en) | 2015-03-30 | 2023-05-17 | Becton, Dickinson and Company | Methods and compositions for combinatorial barcoding |
US9499861B1 (en) | 2015-09-10 | 2016-11-22 | Insilixa, Inc. | Methods and systems for multiplex quantitative nucleic acid amplification |
ES2745694T3 (es) * | 2015-09-11 | 2020-03-03 | Cellular Res Inc | Métodos y composiciones para normalización de biblioteca de ácido nucleico |
JP6685396B2 (ja) | 2015-11-20 | 2020-04-22 | シージーン アイエヌシー | 標的分析物質に対するデータセットの補正方法 |
US10978173B2 (en) | 2016-02-05 | 2021-04-13 | Seegene, Inc. | Method for reducing noise level of data set for a target analyte |
WO2017155858A1 (en) | 2016-03-07 | 2017-09-14 | Insilixa, Inc. | Nucleic acid sequence identification using solid-phase cyclic single base extension |
EP4219519A3 (en) | 2016-04-01 | 2023-09-13 | Chromacode, Inc. | Competitive probes for engineering signal generation |
US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
EP3472354A4 (en) | 2016-06-17 | 2020-01-01 | California Institute of Technology | NUCLEIC ACID ACTIONS AND RELATED PROCEDURES AND COMPOSITIONS |
KR102301305B1 (ko) | 2016-06-30 | 2021-09-13 | 주식회사 씨젠 | 핵산 증폭용 튜브 및 핵산 증폭용 반응 용기 |
JP7091348B2 (ja) | 2016-09-26 | 2022-06-27 | ベクトン・ディキンソン・アンド・カンパニー | バーコード付きオリゴヌクレオチド配列を有する試薬を用いたタンパク質発現の測定 |
JP6938641B2 (ja) | 2016-12-29 | 2021-09-22 | シージーン アイエヌシー | プライマーダイマー形成を減少させ、増幅効率を増加させる方法 |
WO2018144240A1 (en) | 2017-02-01 | 2018-08-09 | Cellular Research, Inc. | Selective amplification using blocking oligonucleotides |
US11591645B2 (en) | 2017-08-31 | 2023-02-28 | Seegene, Inc. | Evaluation of performance of components using a pair of dimer-forming primers |
KR102345601B1 (ko) | 2017-09-29 | 2021-12-30 | 주식회사 씨젠 | Pto 절단 및 연장-의존적 연장 분석에 의한 타겟 핵산 서열의 검출 |
CA3095292A1 (en) | 2018-04-02 | 2019-10-10 | Progenity, Inc. | Methods, systems, and compositions for counting nucleic acid molecules |
CA3095112A1 (en) | 2018-04-20 | 2019-10-24 | Seegene, Inc. | Method and apparatus for detecting a plurality of target nucleic acid sequences in sample |
KR101919896B1 (ko) * | 2018-05-03 | 2018-11-19 | 주식회사 유디피아 | 단일 형광 채널 유전자증폭기기를 이용한 다중 핵산 검출 방법 |
WO2019213294A1 (en) | 2018-05-03 | 2019-11-07 | Becton, Dickinson And Company | High throughput multiomics sample analysis |
US11365409B2 (en) | 2018-05-03 | 2022-06-21 | Becton, Dickinson And Company | Molecular barcoding on opposite transcript ends |
WO2020072380A1 (en) | 2018-10-01 | 2020-04-09 | Cellular Research, Inc. | Determining 5' transcript sequences |
WO2020097315A1 (en) | 2018-11-08 | 2020-05-14 | Cellular Research, Inc. | Whole transcriptome analysis of single cells using random priming |
JP7035972B2 (ja) * | 2018-11-09 | 2022-03-15 | 横河電機株式会社 | 核酸配列計測用デバイス |
CN113195717A (zh) | 2018-12-13 | 2021-07-30 | 贝克顿迪金森公司 | 单细胞全转录组分析中的选择性延伸 |
WO2020154247A1 (en) | 2019-01-23 | 2020-07-30 | Cellular Research, Inc. | Oligonucleotides associated with antibodies |
JP2022525322A (ja) | 2019-03-14 | 2022-05-12 | インシリクサ, インコーポレイテッド | 時間ゲート蛍光ベースの検出のための方法およびシステム |
EP3947718A4 (en) | 2019-04-02 | 2022-12-21 | Enumera Molecular, Inc. | METHODS, SYSTEMS AND COMPOSITIONS FOR COUNTING NUCLEIC ACID MOLECULES |
EP4004231A1 (en) | 2019-07-22 | 2022-06-01 | Becton, Dickinson and Company | Single cell chromatin immunoprecipitation sequencing assay |
WO2021092386A1 (en) | 2019-11-08 | 2021-05-14 | Becton Dickinson And Company | Using random priming to obtain full-length v(d)j information for immune repertoire sequencing |
EP4090763A1 (en) | 2020-01-13 | 2022-11-23 | Becton Dickinson and Company | Methods and compositions for quantitation of proteins and rna |
US11149320B1 (en) | 2020-03-31 | 2021-10-19 | Diasorin S.P.A. | Assays for the detection of SARS-CoV-2 |
US11661625B2 (en) | 2020-05-14 | 2023-05-30 | Becton, Dickinson And Company | Primers for immune repertoire profiling |
US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
US11739443B2 (en) | 2020-11-20 | 2023-08-29 | Becton, Dickinson And Company | Profiling of highly expressed and lowly expressed proteins |
WO2023043280A1 (ko) | 2021-09-17 | 2023-03-23 | 주식회사 씨젠 | 합성 비자연 염기를 포함하는 태그 올리고뉴클레오타이드를 이용한 타겟 핵산 서열의 검출 |
KR20240056605A (ko) | 2021-09-30 | 2024-04-30 | 주식회사 씨젠 | 분자진단 시스템의 샘플 처리 및 분석 방법 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5656493A (en) * | 1985-03-28 | 1997-08-12 | The Perkin-Elmer Corporation | System for automated performance of the polymerase chain reaction |
US4889818A (en) * | 1986-08-22 | 1989-12-26 | Cetus Corporation | Purified thermostable enzyme |
US5512439A (en) * | 1988-11-21 | 1996-04-30 | Dynal As | Oligonucleotide-linked magnetic particles and uses thereof |
JPH05508323A (ja) * | 1991-04-11 | 1993-11-25 | デイド、ベーリング、インコーポレイテッド | 蛍光分極によるdna/rnaの検出 |
US5849544A (en) * | 1992-07-24 | 1998-12-15 | University Of Australia | Amplification and detection process |
US5501238A (en) * | 1993-01-11 | 1996-03-26 | Von Borstel; Reid W. | Cigarette filter containing a humectant |
US5746231A (en) * | 1993-01-11 | 1998-05-05 | Craig Lesser | Tobacco smoke filter for removing toxic compounds |
US5538848A (en) * | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
US5597696A (en) | 1994-07-18 | 1997-01-28 | Becton Dickinson And Company | Covalent cyanine dye oligonucleotide conjugates |
US5817461A (en) * | 1996-01-03 | 1998-10-06 | Hamilton Civic Hospitals Research Development Inc. | Methods and compositions for diagnosis of hyperhomocysteinemia |
SE506700C2 (sv) * | 1996-05-31 | 1998-02-02 | Mikael Kubista | Sond och förfaranden för analys av nukleinsyra |
CA2274587A1 (en) * | 1996-12-10 | 1998-06-18 | Genetrace Systems Inc. | Releasable nonvolatile mass-label molecules |
AU7847798A (en) | 1996-12-13 | 1998-07-03 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Fluorescent nucleotide analog hairpin formation for detection of nuclei c acid hybridization |
US5846603A (en) * | 1997-07-28 | 1998-12-08 | Superior Fibers, Inc. | Uniformly tacky filter media |
EP1009852A2 (en) * | 1997-09-04 | 2000-06-21 | Bayer Corporation | Oligonucleotide probes bearing quenchable fluorescent labels, and methods of use thereof |
EP1025120B1 (en) * | 1997-10-27 | 2010-08-18 | Boston Probes, Inc. | Methods, kits and compositions pertaining to pna molecular beacons |
US5952202A (en) * | 1998-03-26 | 1999-09-14 | The Perkin Elmer Corporation | Methods using exogenous, internal controls and analogue blocks during nucleic acid amplification |
EP1190097A2 (en) | 1999-06-22 | 2002-03-27 | Invitrogen Corporation | Improved primers and methods for the detection and discrimination of nucleic acids |
SE9902565D0 (sv) * | 1999-07-05 | 1999-07-05 | Jonas Karlsson | Probe for analysis of nucleic acids |
FR2805348B1 (fr) * | 2000-02-23 | 2002-07-12 | Commissariat Energie Atomique | Analyse de cibles biologiques utilisant une biopuce comportant un marqueur fluorescent |
CA2417986C (en) * | 2000-08-11 | 2013-11-26 | University Of Utah Research Foundation | Single-labeled oligonucleotide probes |
-
2001
- 2001-03-28 AT AT01915549T patent/ATE334228T1/de active
- 2001-03-28 US US10/239,913 patent/US7348141B2/en not_active Expired - Lifetime
- 2001-03-28 AU AU4263401A patent/AU4263401A/xx active Pending
- 2001-03-28 PT PT06117641T patent/PT1715063E/pt unknown
- 2001-03-28 CA CA2404174A patent/CA2404174C/en not_active Expired - Lifetime
- 2001-03-28 NZ NZ521593A patent/NZ521593A/en not_active IP Right Cessation
- 2001-03-28 JP JP2001570832A patent/JP5112592B2/ja not_active Expired - Fee Related
- 2001-03-28 EP EP01915549A patent/EP1278889B1/en not_active Expired - Lifetime
- 2001-03-28 ES ES01915549T patent/ES2269365T3/es not_active Expired - Lifetime
- 2001-03-28 PT PT01915549T patent/PT1278889E/pt unknown
- 2001-03-28 AT AT06117641T patent/ATE497019T1/de active
- 2001-03-28 EP EP06117641A patent/EP1715063B1/en not_active Expired - Lifetime
- 2001-03-28 DE DE60143974T patent/DE60143974D1/de not_active Expired - Lifetime
- 2001-03-28 DK DK06117641.8T patent/DK1715063T3/da active
- 2001-03-28 DE DE60121750T patent/DE60121750T2/de not_active Expired - Lifetime
- 2001-03-28 DK DK01915549T patent/DK1278889T3/da active
- 2001-03-28 WO PCT/GB2001/001430 patent/WO2001073118A2/en active IP Right Grant
- 2001-03-28 AU AU2001242634A patent/AU2001242634B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
CA2404174A1 (en) | 2001-10-04 |
PT1278889E (pt) | 2006-12-29 |
DE60143974D1 (de) | 2011-03-10 |
DE60121750D1 (de) | 2006-09-07 |
AU2001242634B2 (en) | 2006-06-01 |
EP1715063A3 (en) | 2007-05-02 |
DK1715063T3 (da) | 2011-05-16 |
PT1715063E (pt) | 2011-04-28 |
NZ521593A (en) | 2004-11-26 |
WO2001073118A2 (en) | 2001-10-04 |
EP1715063B1 (en) | 2011-01-26 |
US20040091864A1 (en) | 2004-05-13 |
JP2003528626A (ja) | 2003-09-30 |
DE60121750T2 (de) | 2007-08-16 |
ES2269365T3 (es) | 2007-04-01 |
CA2404174C (en) | 2010-05-18 |
JP5112592B2 (ja) | 2013-01-09 |
WO2001073118A3 (en) | 2002-09-12 |
EP1278889A2 (en) | 2003-01-29 |
ATE334228T1 (de) | 2006-08-15 |
EP1715063A2 (en) | 2006-10-25 |
AU4263401A (en) | 2001-10-08 |
US7348141B2 (en) | 2008-03-25 |
EP1278889B1 (en) | 2006-07-26 |
ATE497019T1 (de) | 2011-02-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1278889T3 (da) | Hydridiseringsbeacon og fremgangsmåde til hurtig sekvensdetektion og distinktion | |
US6287781B1 (en) | Method for detection of target nucleic acids using PCR | |
US6972174B2 (en) | Method for detecting single nucleotide polymorphisms (SNP's) and point mutations | |
Whitcombe et al. | Advances in approaches to DNA-based diagnostics | |
US20070059690A1 (en) | "Met/fret based method of target nucleic acid detection whereby the donor/acceptor moieties are on complementary strands" | |
WO2008102057A9 (en) | Method and test kit for determining the amounts of target sequences and nucleotide variations therein | |
ATE427999T1 (de) | Erkennung von nukleinsaurepolymorphismen | |
EP1436426A2 (en) | Methods for detecting genetic haplotypes by interaction with probes | |
US6821734B2 (en) | Method for testing nucleic acid sequence | |
CN101705292B (zh) | 基于核酸外切酶ⅲ/ⅰ保护分析检测单核苷酸多态性的荧光生物传感方法 | |
CN111996244B (zh) | 一种单核苷酸多态性检测用组合物及其应用 | |
WO2003074739A3 (en) | Automated allele determination using fluorometric genotyping | |
ATE286144T1 (de) | VERWENDUNG VON FLUORESZIERENDEN ßMOLECULAR BEACONSß ZUM NACHWEIS VON METHYLIERTEN NUKLEINSÄUREN | |
EP1426448A1 (en) | Method for lowering the effects of sequence variations in a diagnostic hybridization assay, probe for use in the assay and assay | |
Rickert et al. | Refinement of single-nucleotide polymorphism genotyping methods on human genomic DNA: amplifluor allele-specific polymerase chain reaction versus ligation detection reaction-TaqMan | |
Akhmetova et al. | Barley haplotyping using biplex deoxyribozyme nanomachine | |
Murphy et al. | Evaluation of temperature gradient capillary electrophoresis for detection of the factor v leiden mutation: coincident identification of a novel polymorphism in factor v | |
Hori et al. | High fidelity SNP genotyping using sequence-specific primer elongation and fluorescence correlation spectroscopy | |
Kiviniemi et al. | Locked nucleic acid (LNA) probes in high-throughput genetic analysis: application to an assay for type 1 diabetes-related HLA-DQB1 alleles | |
US8530165B2 (en) | Nucleic acid detection method for determining if one or more analyte nucleotides are present in a nucleic acid | |
JP3974557B2 (ja) | 変異解析方法及びそのためのシステム | |
Lehmusvuori et al. | Closed-tube human leukocyte antigen DQA1∗ 05 genotyping assay based on switchable lanthanide luminescence probes | |
JP4310675B2 (ja) | 塩基多型の同定方法 | |
KR20160047302A (ko) | 리포터 및 소광자가 포함된 내부 정량 컨트롤 프로브를 이용한 새로운 정량 분석 방법 | |
WO2002016637A1 (en) | Analysis methods for hemochromatosis mutation |