DK1272186T3 - Terapeutiske kombinationer af antihypertensive og antiangiogene midler - Google Patents
Terapeutiske kombinationer af antihypertensive og antiangiogene midlerInfo
- Publication number
- DK1272186T3 DK1272186T3 DK01917305T DK01917305T DK1272186T3 DK 1272186 T3 DK1272186 T3 DK 1272186T3 DK 01917305 T DK01917305 T DK 01917305T DK 01917305 T DK01917305 T DK 01917305T DK 1272186 T3 DK1272186 T3 DK 1272186T3
- Authority
- DK
- Denmark
- Prior art keywords
- antihypertensive
- agent
- therapeutic combinations
- antiangiogenic agents
- angiogenesis
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/556—Angiotensin converting enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0008269.3A GB0008269D0 (en) | 2000-04-05 | 2000-04-05 | Combination chemotherapy |
PCT/GB2001/001522 WO2001074360A1 (en) | 2000-04-05 | 2001-04-02 | Therapeutic combinations of antihypertensive and antiangiogenic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1272186T3 true DK1272186T3 (da) | 2007-05-21 |
Family
ID=9889176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01917305T DK1272186T3 (da) | 2000-04-05 | 2001-04-02 | Terapeutiske kombinationer af antihypertensive og antiangiogene midler |
Country Status (29)
Country | Link |
---|---|
US (1) | US7829573B2 (no) |
EP (3) | EP1272186B1 (no) |
JP (1) | JP2003528917A (no) |
KR (2) | KR100849149B1 (no) |
CN (1) | CN1431902A (no) |
AT (1) | ATE355065T1 (no) |
AU (2) | AU2001244386B2 (no) |
BR (1) | BR0109729A (no) |
CA (1) | CA2401854A1 (no) |
CY (1) | CY1107615T1 (no) |
CZ (1) | CZ299410B6 (no) |
DE (1) | DE60126923T2 (no) |
DK (1) | DK1272186T3 (no) |
EE (1) | EE200200578A (no) |
ES (1) | ES2280349T3 (no) |
GB (1) | GB0008269D0 (no) |
HU (1) | HUP0300426A2 (no) |
IL (1) | IL151503A0 (no) |
IS (2) | IS2455B (no) |
MX (1) | MXPA02009743A (no) |
NO (2) | NO323467B1 (no) |
NZ (2) | NZ520938A (no) |
PL (1) | PL357605A1 (no) |
PT (1) | PT1272186E (no) |
RU (1) | RU2002129353A (no) |
SI (1) | SI1272186T1 (no) |
SK (1) | SK14302002A3 (no) |
WO (1) | WO2001074360A1 (no) |
ZA (1) | ZA200206959B (no) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7381413B1 (en) * | 1998-04-17 | 2008-06-03 | University Of Vermont And State Agricultural College | Methods and products related to metabolic interactions in disease |
HU229414B1 (hu) | 1999-11-05 | 2013-12-30 | Astrazeneca Ab | Kinazolin-származékok mint VEGF-inhibitorok, eljárás az elõállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk |
DE60112268T2 (de) | 2000-03-06 | 2006-05-24 | Astrazeneca Ab | Verwendung von quinazolinderivate als inhibitoren der angiogenese |
MXPA02009891A (es) * | 2000-04-07 | 2003-03-27 | Astrazeneca Ab | Compuestos de quinazolina. |
GB0126879D0 (en) * | 2001-11-08 | 2002-01-02 | Astrazeneca Ab | Combination therapy |
RU2365588C2 (ru) | 2002-02-01 | 2009-08-27 | Астразенека Аб | Хиназолиновые соединения |
US20050215530A1 (en) * | 2002-04-16 | 2005-09-29 | Ryan Anderson J | Combination therapy for the treatment of cancer |
US7358236B1 (en) * | 2002-06-21 | 2008-04-15 | Oxigene, Inc. | Control of acute hypertension and cardiotoxicity in patients treated with vascular targeting agents |
ES2400339T3 (es) * | 2002-07-15 | 2013-04-09 | Symphony Evolution, Inc. | Compuestos, composiciones farmacéuticas de los mismos y su uso en el tratamiento del cáncer |
US7335362B2 (en) * | 2002-07-19 | 2008-02-26 | Beth Israel Deaconess Medical Center | Methods of treating pre-eclampsia or eclampsia |
PT1575416E (pt) * | 2002-07-19 | 2014-01-08 | Beth Israel Hospital | Métodos para o diagnóstico e o tratamento de pré-eclâmpsia ou eclâmpsia |
US7435419B2 (en) * | 2002-07-19 | 2008-10-14 | Beth Israel Deaconess Medical Center | Methods of diagnosing and treating pre-eclampsia or eclampsia |
GB0218526D0 (en) * | 2002-08-09 | 2002-09-18 | Astrazeneca Ab | Combination therapy |
GB0223380D0 (en) * | 2002-10-09 | 2002-11-13 | Astrazeneca Ab | Combination therapy |
AU2003278383B2 (en) | 2002-11-04 | 2007-06-14 | Astrazeneca Ab | Quinazoline derivatives as Src tyrosine kinase inhibitors |
DK1592423T3 (da) * | 2003-02-13 | 2011-06-27 | Astrazeneca Ab | Kombinationsterapi af ZD6474 med 5-FU og/eller CPT-11 |
GB0307333D0 (en) * | 2003-03-29 | 2003-05-07 | Astrazeneca Ab | Therapeutic agent |
GB0310401D0 (en) * | 2003-05-07 | 2003-06-11 | Astrazeneca Ab | Therapeutic agent |
JP2006527753A (ja) * | 2003-06-18 | 2006-12-07 | アンギオジェン・ファーマシューティカルズ・リミテッド | 結腸直腸癌などの治療のための、血管損傷効果を有する、5−fu、cpt−11または5−fuおよびcpt−11と組み合わせたzd6126を含んでなる組成物 |
GB0316123D0 (en) * | 2003-07-10 | 2003-08-13 | Astrazeneca Ab | Combination therapy |
GB0316127D0 (en) * | 2003-07-10 | 2003-08-13 | Astrazeneca Ab | Combination therapy |
WO2005004870A1 (en) * | 2003-07-10 | 2005-01-20 | Astrazeneca Ab | Use of the quinazoline derivative zd6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability |
GB0318422D0 (en) * | 2003-08-06 | 2003-09-10 | Astrazeneca Ab | Chemical compounds |
DE602004017479D1 (de) | 2003-08-29 | 2008-12-11 | Pfizer | Als neue antiangiogene mittel geeignete thienopyridinphenylacetamide und derivate davon |
OA13349A (en) | 2003-12-23 | 2007-04-13 | Pfizer | Novel quinoline derivatives. |
GB0330002D0 (en) | 2003-12-24 | 2004-01-28 | Astrazeneca Ab | Quinazoline derivatives |
GB0406445D0 (en) * | 2004-03-23 | 2004-04-28 | Astrazeneca Ab | Combination therapy |
NZ549552A (en) * | 2004-03-23 | 2009-12-24 | Astrazeneca Ab | Combination therapy involving 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline (AZD2171) and a platinum anti-tumour agent |
CN1938025A (zh) | 2004-04-06 | 2007-03-28 | 血管遗传瑞典股份公司 | 影响血管生成的化合物及其使用方法 |
US20070142308A1 (en) * | 2005-04-06 | 2007-06-21 | Helmut Augustin | Angiogenesis-affecting compounds and methods for use thereof |
US20070142433A1 (en) * | 2004-04-06 | 2007-06-21 | Helmut Augustin | Angiogenesis-affecting compounds and methods of use thereof |
JP2007536251A (ja) * | 2004-05-04 | 2007-12-13 | チルドレンズ メディカル センター コーポレーション | 子癇前症の処置のための方法および組成物 |
JP4880591B2 (ja) | 2004-06-04 | 2012-02-22 | テバ ファーマシューティカル インダストリーズ リミティド | イルベサルタンを含む医薬組成物 |
EP2347765B1 (en) | 2004-09-24 | 2014-01-22 | Beth Israel Deaconess Medical Center | Methods of diagnosing and treating complications of pregnancy |
US7740849B2 (en) * | 2004-09-24 | 2010-06-22 | Beth Israel Deaconess Medical Center | Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders |
JP2008514577A (ja) * | 2004-09-27 | 2008-05-08 | アストラゼネカ アクチボラグ | Zd6474及びイマチニブを含んでなる組合せ |
GB0424339D0 (en) * | 2004-11-03 | 2004-12-08 | Astrazeneca Ab | Combination therapy |
JP4954085B2 (ja) * | 2004-12-06 | 2012-06-13 | メディシノバ, インコーポレイテッド | 神経障害性疼痛及びその関連する症状を治療するためのイブジラスト |
JP2008523816A (ja) * | 2004-12-15 | 2008-07-10 | ベス イスラエル ディーコネス メディカル センター | 妊娠合併症の診断および処置に有用な核酸およびポリペプチド |
EP1853298A2 (en) * | 2005-02-11 | 2007-11-14 | Regeneron Pharmaceuticals, Inc. | Therapeutic combination of a vegf antagonist (vegf trap) and an anti-hypertensive agent |
BRPI0608343A2 (pt) * | 2005-03-09 | 2016-10-04 | Merck & Co Inc | composto, composição farmacêutica, e, métodos para tratamento ou controle de uma doença ou condição, para intensificação da qualidade do sono, para aumento de sono rem e do sono de onda lenta, para diminuição da fragmentação de padrões do sono, para intensificação de cognição, para aumento da retenção de memória, e, para tratamento, controle, melhora ou redução do risco de esquizofrenia em um paciente mamífero em necessidade destes |
WO2007003933A2 (en) * | 2005-07-06 | 2007-01-11 | Astrazeneca Ab | Combination therapy of cancer with azd2171 and gemcitabine |
KR20080027923A (ko) | 2005-08-08 | 2008-03-28 | 화이자 인코포레이티드 | Vegf-r 억제제의 염 및 다형체 |
AU2006279658A1 (en) * | 2005-08-12 | 2007-02-22 | Regeneron Pharmaceuticals, Inc. | Treatment of diseases by subcutaneous administration of a VEGF antagonist |
SI1971338T1 (sl) * | 2005-12-22 | 2011-06-30 | Astrazeneca Ab | Kombinacija ZD6474 in pemetrekseda |
KR20080077678A (ko) * | 2005-12-22 | 2008-08-25 | 아스트라제네카 아베 | Azd2171 및 페메트렉시드의 조합물 |
US20090286271A1 (en) * | 2006-05-31 | 2009-11-19 | Karumanchi Ananth S | Methods of Diagnosing and Treating Complications of Pregnancy |
WO2008037996A1 (en) * | 2006-09-29 | 2008-04-03 | Astrazeneca Ab | Combination of zd6474 and bevacizumab for cancer therapy |
US20080153819A1 (en) * | 2006-12-21 | 2008-06-26 | Bingaman David P | Methods for treating macular edema and pathologic ocular angiogenesis using a neuroprotective agent and a receptor tyrosine kinase inhibitor |
DK2131841T3 (da) * | 2007-01-30 | 2012-10-15 | Avigen Inc | Fremgangsmåder til behandling af akut smerte |
US20080190689A1 (en) * | 2007-02-12 | 2008-08-14 | Ballard Ebbin C | Inserts for engine exhaust systems |
JP2010526073A (ja) * | 2007-05-02 | 2010-07-29 | ティーエーユー・セラピューティクス・エルエルシー | 癌または前癌性症状およびその他の症状の治療のためのジヒドロピリジン誘導体 |
US20080287402A1 (en) * | 2007-05-03 | 2008-11-20 | Johnson Kirk W | Use of a glial attenuator to prevent amplified pain responses caused by glial priming |
EP2175725A1 (en) * | 2007-07-10 | 2010-04-21 | Merck Sharp & Dohme Corp. | Quinazolinone t-type calcium channel antagonists |
AU2009271579A1 (en) | 2008-07-14 | 2010-01-21 | The Regents Of The University Of Colorado | Methods and products for treating proliferative diseases |
ES2557407T3 (es) | 2010-03-01 | 2016-01-25 | Tau Therapeutics Llc | Procedimiento de imaginología de una enfermedad |
JO3283B1 (ar) | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
CN103110614B (zh) * | 2013-01-18 | 2015-02-18 | 杭州雷索药业有限公司 | 舒洛地尔在制备抗血管生成类药物中的应用 |
CN105189462B (zh) | 2013-02-20 | 2017-11-10 | 卡拉制药公司 | 治疗性化合物和其用途 |
WO2015157471A1 (en) | 2014-04-08 | 2015-10-15 | The Methodist Hospital | Inos-inhibitory compositions and their use as breast cancer therapeutics |
HUE043951T2 (hu) | 2014-07-18 | 2019-09-30 | Sanofi Sa | Eljárás rákgyanús beteg aflibercepttel történõ kezelése kimenetének elõrejelzésére |
US10265111B2 (en) | 2016-04-26 | 2019-04-23 | Medtronic Holding Company Sárl | Inflatable bone tamp with flow control and methods of use |
US10799138B2 (en) | 2018-04-05 | 2020-10-13 | University Of Maryland, Baltimore | Method of administering sotalol IV/switch |
WO2020028007A1 (en) * | 2018-07-31 | 2020-02-06 | Colorado State University Research Foundation | Compositions, methods and uses for modulating the tumor microenvironment to enhance antitumor immunity |
US11610660B1 (en) | 2021-08-20 | 2023-03-21 | AltaThera Pharmaceuticals LLC | Antiarrhythmic drug dosing methods, medical devices, and systems |
US11344518B2 (en) | 2018-08-14 | 2022-05-31 | AltaThera Pharmaceuticals LLC | Method of converting atrial fibrillation to normal sinus rhythm and loading oral sotalol in a shortened time frame |
US10512620B1 (en) | 2018-08-14 | 2019-12-24 | AltaThera Pharmaceuticals, LLC | Method of initiating and escalating sotalol hydrochloride dosing |
US11696902B2 (en) | 2018-08-14 | 2023-07-11 | AltaThera Pharmaceuticals, LLC | Method of initiating and escalating sotalol hydrochloride dosing |
US11484355B2 (en) | 2020-03-02 | 2022-11-01 | Medtronic Holding Company Sàrl | Inflatable bone tamp and method for use of inflatable bone tamp |
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DE4010797A1 (de) | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
US5646136A (en) * | 1994-01-04 | 1997-07-08 | Duke University | Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids |
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CZ291386B6 (cs) * | 1996-02-13 | 2003-02-12 | Zeneca Limited | Chinazolinové deriváty jako inhibitory VEGF, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje |
KR100489174B1 (ko) * | 1996-03-05 | 2005-09-30 | 제네카-파마 소시에떼아노님 | 4-아닐리노퀴나졸린유도체 |
AU2103097A (en) * | 1996-03-15 | 1997-10-10 | Zeneca Limited | Cinnoline derivatives and use as medicine |
GB9707800D0 (en) * | 1996-05-06 | 1997-06-04 | Zeneca Ltd | Chemical compounds |
GB9718972D0 (en) * | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
DE69733825T2 (de) * | 1996-09-25 | 2006-06-08 | Astrazeneca Ab | Chinolin-derivate die den effekt von wachstumsfaktoren wie vegf vezögern |
CA2275708A1 (en) | 1996-12-23 | 1998-07-02 | Cambridge University Technical Services Limited | Diagnosis and treatment of pathological pregnancies |
WO1999047677A2 (en) * | 1998-03-17 | 1999-09-23 | Genentech, Inc. | Polypeptides homologous to vegf and bmp1 |
JP4959049B2 (ja) * | 1997-08-22 | 2012-06-20 | アストラゼネカ・ユーケイ・リミテッド | 血管新生阻害剤としてのオキシインドリルキナゾリン誘導体 |
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NZ537753A (en) | 2002-08-09 | 2008-04-30 | Astrazeneca Ab | Combination of ZD6474, an inhibitor of the vascular endothelial growth factor receptor, with radiotherapy in the treatment of cancer |
GB0218526D0 (en) | 2002-08-09 | 2002-09-18 | Astrazeneca Ab | Combination therapy |
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GB0310401D0 (en) | 2003-05-07 | 2003-06-11 | Astrazeneca Ab | Therapeutic agent |
GB0316123D0 (en) | 2003-07-10 | 2003-08-13 | Astrazeneca Ab | Combination therapy |
GB0316127D0 (en) | 2003-07-10 | 2003-08-13 | Astrazeneca Ab | Combination therapy |
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GB0406446D0 (en) | 2004-03-23 | 2004-04-28 | Astrazeneca Ab | Combination therapy |
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JP2008514577A (ja) | 2004-09-27 | 2008-05-08 | アストラゼネカ アクチボラグ | Zd6474及びイマチニブを含んでなる組合せ |
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2000
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2001
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- 2001-04-02 BR BR0109729-6A patent/BR0109729A/pt not_active Application Discontinuation
- 2001-04-02 RU RU2002129353/14A patent/RU2002129353A/ru unknown
- 2001-04-02 MX MXPA02009743A patent/MXPA02009743A/es active IP Right Grant
- 2001-04-02 DE DE60126923T patent/DE60126923T2/de not_active Expired - Lifetime
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- 2001-04-02 AT AT01917305T patent/ATE355065T1/de active
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- 2001-04-02 US US10/240,413 patent/US7829573B2/en not_active Expired - Fee Related
- 2001-04-02 PT PT01917305T patent/PT1272186E/pt unknown
- 2001-04-02 EP EP06003576A patent/EP1658849A3/en not_active Withdrawn
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- 2001-04-02 KR KR1020087007835A patent/KR20080034523A/ko not_active Application Discontinuation
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