IS2455B - Meðferðarsamsetningar úr blóðþrýstingslækkandi efnum og efnum sem hamla æðamyndun - Google Patents

Meðferðarsamsetningar úr blóðþrýstingslækkandi efnum og efnum sem hamla æðamyndun

Info

Publication number
IS2455B
IS2455B IS6557A IS6557A IS2455B IS 2455 B IS2455 B IS 2455B IS 6557 A IS6557 A IS 6557A IS 6557 A IS6557 A IS 6557A IS 2455 B IS2455 B IS 2455B
Authority
IS
Iceland
Prior art keywords
agents
angiogenic
agent
therapeutic combinations
antihypertensive
Prior art date
Application number
IS6557A
Other languages
English (en)
Other versions
IS6557A (is
Inventor
Owen Curwen Jon
James Ogilvie Donald
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of IS6557A publication Critical patent/IS6557A/is
Publication of IS2455B publication Critical patent/IS2455B/is

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/556Angiotensin converting enzyme inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
IS6557A 2000-04-05 2002-09-20 Meðferðarsamsetningar úr blóðþrýstingslækkandi efnum og efnum sem hamla æðamyndun IS2455B (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0008269.3A GB0008269D0 (en) 2000-04-05 2000-04-05 Combination chemotherapy
PCT/GB2001/001522 WO2001074360A1 (en) 2000-04-05 2001-04-02 Therapeutic combinations of antihypertensive and antiangiogenic agents

Publications (2)

Publication Number Publication Date
IS6557A IS6557A (is) 2002-09-20
IS2455B true IS2455B (is) 2008-11-15

Family

ID=9889176

Family Applications (2)

Application Number Title Priority Date Filing Date
IS6557A IS2455B (is) 2000-04-05 2002-09-20 Meðferðarsamsetningar úr blóðþrýstingslækkandi efnum og efnum sem hamla æðamyndun
IS8726A IS8726A (is) 2000-04-05 2008-04-16 Meðferðarfræðilegar samsetningar þrýstingslækkandi efna og efna sem hamla gegn æðamyndun

Family Applications After (1)

Application Number Title Priority Date Filing Date
IS8726A IS8726A (is) 2000-04-05 2008-04-16 Meðferðarfræðilegar samsetningar þrýstingslækkandi efna og efna sem hamla gegn æðamyndun

Country Status (29)

Country Link
US (1) US7829573B2 (is)
EP (3) EP1790340A3 (is)
JP (1) JP2003528917A (is)
KR (2) KR100849149B1 (is)
CN (1) CN1431902A (is)
AT (1) ATE355065T1 (is)
AU (2) AU2001244386B2 (is)
BR (1) BR0109729A (is)
CA (1) CA2401854A1 (is)
CY (1) CY1107615T1 (is)
CZ (1) CZ299410B6 (is)
DE (1) DE60126923T2 (is)
DK (1) DK1272186T3 (is)
EE (1) EE200200578A (is)
ES (1) ES2280349T3 (is)
GB (1) GB0008269D0 (is)
HU (1) HUP0300426A2 (is)
IL (1) IL151503A0 (is)
IS (2) IS2455B (is)
MX (1) MXPA02009743A (is)
NO (2) NO323467B1 (is)
NZ (2) NZ534455A (is)
PL (1) PL357605A1 (is)
PT (1) PT1272186E (is)
RU (1) RU2002129353A (is)
SI (1) SI1272186T1 (is)
SK (1) SK14302002A3 (is)
WO (1) WO2001074360A1 (is)
ZA (1) ZA200206959B (is)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7381413B1 (en) * 1998-04-17 2008-06-03 University Of Vermont And State Agricultural College Methods and products related to metabolic interactions in disease
KR100881105B1 (ko) 1999-11-05 2009-02-02 아스트라제네카 아베 Vegf 억제제로서의 퀴나졸린 유도체
AU2001235804A1 (en) 2000-03-06 2001-09-17 Astrazeneca Ab Therapy
DE60121931T2 (de) * 2000-04-07 2007-03-01 Astrazeneca Ab Chinazolinverbindungen
GB0126879D0 (en) * 2001-11-08 2002-01-02 Astrazeneca Ab Combination therapy
BR0307151A (pt) * 2002-02-01 2004-12-07 Astrazeneca Ab Composto ou um sal do mesmo, processo para a preparação do mesmo, composição farmacêutica, uso do composto ou de um seu sal, método para produzir um efeito antiangiogênico e/ou redutor da permeabilidade vascular em um animal de sangue quente, como um ser humano, que necessita de um tratamento do tipo referido, e, processos para a preparação de 5-bromo-7- azaindol, e para a produção de 5-metóxi-7-azaindol
ES2280735T3 (es) * 2002-04-16 2007-09-16 Astrazeneca Ab Terapia de combinacion para el tratamiento de cancer.
US7358236B1 (en) * 2002-06-21 2008-04-15 Oxigene, Inc. Control of acute hypertension and cardiotoxicity in patients treated with vascular targeting agents
EP2280003B1 (en) * 2002-07-15 2014-04-02 Symphony Evolution, Inc. Process for preparing receptor-type kinase modulators
JP5650876B2 (ja) * 2002-07-19 2015-01-07 ベス・イスラエル・ディーコニス・メディカル・センター 子癇前症または子癇の診断方法および治療方法
US7335362B2 (en) 2002-07-19 2008-02-26 Beth Israel Deaconess Medical Center Methods of treating pre-eclampsia or eclampsia
US7435419B2 (en) * 2002-07-19 2008-10-14 Beth Israel Deaconess Medical Center Methods of diagnosing and treating pre-eclampsia or eclampsia
GB0218526D0 (en) * 2002-08-09 2002-09-18 Astrazeneca Ab Combination therapy
GB0223380D0 (en) * 2002-10-09 2002-11-13 Astrazeneca Ab Combination therapy
SI1562955T1 (sl) 2002-11-04 2008-06-30 Astrazeneca Ab Derivati kinazolina kot inhibitorji Src-triozin kinaze
US20060142316A1 (en) * 2003-02-13 2006-06-29 Wedge Stephen R Combination therapy
GB0307333D0 (en) * 2003-03-29 2003-05-07 Astrazeneca Ab Therapeutic agent
GB0310401D0 (en) * 2003-05-07 2003-06-11 Astrazeneca Ab Therapeutic agent
BRPI0411567A (pt) * 2003-06-18 2006-08-01 Angiogene Pharm Ltd uso de zd6126 ou um seu sal farmaceuticamente aceitável e um dentre 5-fu, cpt-11, e 5-fu e cpt-11, composição farmacêutica, kit, e, métodos para a produção de um efeito de dano vascular em um animal de sangue quente e para o tratamento de um cáncer envolvendo um tumor sólido em um animal de sangue quente
GB0316127D0 (en) * 2003-07-10 2003-08-13 Astrazeneca Ab Combination therapy
GB0316123D0 (en) * 2003-07-10 2003-08-13 Astrazeneca Ab Combination therapy
DE602004028834D1 (de) * 2003-07-10 2010-10-07 Astrazeneca Ab Verwendung des chinazolin-derivats zd6474 in kombination mit platinverbindungen und optional ionisierender strahlung bei der behandlung von erkrankungen im zusammenhang mit angiogenese und/oder erhöhter gefässpermeabilität
GB0318422D0 (en) * 2003-08-06 2003-09-10 Astrazeneca Ab Chemical compounds
WO2005021554A1 (en) 2003-08-29 2005-03-10 Pfizer Inc. Thienopyridine-phenylacet amides and their derivatives useful as new anti-angiogenic agents
JP4503022B2 (ja) 2003-12-23 2010-07-14 ファイザー・インク 新規キノリン誘導体
GB0330002D0 (en) 2003-12-24 2004-01-28 Astrazeneca Ab Quinazoline derivatives
GB0406445D0 (en) * 2004-03-23 2004-04-28 Astrazeneca Ab Combination therapy
EP1740170A2 (en) * 2004-03-23 2007-01-10 AstraZeneca AB Combination therapy with azd2171 and platinum anti-tumour agent
CN1938025A (zh) 2004-04-06 2007-03-28 血管遗传瑞典股份公司 影响血管生成的化合物及其使用方法
US20070142433A1 (en) * 2004-04-06 2007-06-21 Helmut Augustin Angiogenesis-affecting compounds and methods of use thereof
US20070142308A1 (en) * 2005-04-06 2007-06-21 Helmut Augustin Angiogenesis-affecting compounds and methods for use thereof
AU2005244167A1 (en) * 2004-05-04 2005-11-24 Beth Israel Deaconess Medical Center Methods and compositions for treatment of preeclampsia
DE602005025755D1 (de) 2004-06-04 2011-02-17 Teva Pharma Irbesartan enthaltende pharmazeutische zusammensetzung
US7740849B2 (en) * 2004-09-24 2010-06-22 Beth Israel Deaconess Medical Center Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders
EP1804836B1 (en) 2004-09-24 2010-11-17 Beth Israel Deaconess Medical Center Methods of diagnosing and treating complications of pregnancy
JP2008514577A (ja) * 2004-09-27 2008-05-08 アストラゼネカ アクチボラグ Zd6474及びイマチニブを含んでなる組合せ
GB0424339D0 (en) * 2004-11-03 2004-12-08 Astrazeneca Ab Combination therapy
AU2005314133B2 (en) 2004-12-06 2012-03-08 Medicinova, Inc. Ibudilast for treating neuropathic pain and associated syndromes
DE602005023216D1 (de) * 2004-12-15 2010-10-07 Beth Israel Hospital Nukleinsäuren und polypeptide zur diagnose und behandlung von schwangerschaftskomplikationen
CA2597247A1 (en) 2005-02-11 2006-08-17 Regeneron Pharmaceuticals, Inc. Therapeutic combination of a vegf antagonist (vegf trap) and an anti-hypertensive agent
RU2007137266A (ru) * 2005-03-09 2009-04-20 Мерк энд Ко., Инк. (US) Хиназолиноновые антагонисты кальциевых каналов т-типа
US20090176731A1 (en) * 2005-07-06 2009-07-09 Stephen Robert Wedge Combination therapy of cancer with azd2171 and gemcitabine
US7928226B2 (en) 2005-08-08 2011-04-19 Agouron Pharmaceuticals Inc. Salts and polymorphs of a VEGF-R inhibitor
CA2615636A1 (en) 2005-08-12 2007-02-22 Regeneron Pharmaceuticals, Inc. Treatment of diseases by subcutaneous administration of a vegf antagonist
ATE502641T1 (de) * 2005-12-22 2011-04-15 Astrazeneca Ab Kombination aus azd2171 und pemetrexed
AU2006328189B2 (en) * 2005-12-22 2010-01-21 Astrazeneca Ab Combination of ZD6474 and pemetrexed
US20090286271A1 (en) * 2006-05-31 2009-11-19 Karumanchi Ananth S Methods of Diagnosing and Treating Complications of Pregnancy
CN101553253A (zh) * 2006-09-29 2009-10-07 阿斯利康(瑞典)有限公司 用于癌症治疗的zd6474和贝伐单抗的组合
US20080153819A1 (en) * 2006-12-21 2008-06-26 Bingaman David P Methods for treating macular edema and pathologic ocular angiogenesis using a neuroprotective agent and a receptor tyrosine kinase inhibitor
ES2392116T3 (es) * 2007-01-30 2012-12-04 Avigen, Inc. Procedimientos para el tratamiento del dolor agudo y subcrónico
US20080190689A1 (en) * 2007-02-12 2008-08-14 Ballard Ebbin C Inserts for engine exhaust systems
AU2008248188A1 (en) * 2007-05-02 2008-11-13 Tau Therapeutics Llc Dihydropyridine derivative for treating cancer or a pre-cancerous condition and other conditions
WO2008137012A1 (en) * 2007-05-03 2008-11-13 Avigen, Inc. Use of a glial attenuator to prevent amplified pain responses caused by glial priming
EP2175725A1 (en) * 2007-07-10 2010-04-21 Merck Sharp & Dohme Corp. Quinazolinone t-type calcium channel antagonists
AU2009271579A1 (en) 2008-07-14 2010-01-21 The Regents Of The University Of Colorado Methods and products for treating proliferative diseases
CN102781316B (zh) 2010-03-01 2016-07-06 陶制药有限责任公司 癌症诊断和成像
JO3283B1 (ar) 2011-04-26 2018-09-16 Sanofi Sa تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI)
CN103110614B (zh) * 2013-01-18 2015-02-18 杭州雷索药业有限公司 舒洛地尔在制备抗血管生成类药物中的应用
EP2958895B1 (en) 2013-02-20 2020-08-19 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
AU2015243537B2 (en) 2014-04-08 2020-10-22 The Methodist Hospital INOS-inhibitory compositions and their use as breast cancer therapeutics
DK3170005T3 (da) 2014-07-18 2019-07-08 Sanofi Sa Fremgangsmåde til forudsigelse af resultatet af en behandling med aflibercept hos en patient, der mistænkes for at lide af cancer
US10265111B2 (en) 2016-04-26 2019-04-23 Medtronic Holding Company Sárl Inflatable bone tamp with flow control and methods of use
US10799138B2 (en) 2018-04-05 2020-10-13 University Of Maryland, Baltimore Method of administering sotalol IV/switch
WO2020028007A1 (en) * 2018-07-31 2020-02-06 Colorado State University Research Foundation Compositions, methods and uses for modulating the tumor microenvironment to enhance antitumor immunity
US10512620B1 (en) 2018-08-14 2019-12-24 AltaThera Pharmaceuticals, LLC Method of initiating and escalating sotalol hydrochloride dosing
US11344518B2 (en) 2018-08-14 2022-05-31 AltaThera Pharmaceuticals LLC Method of converting atrial fibrillation to normal sinus rhythm and loading oral sotalol in a shortened time frame
US11696902B2 (en) 2018-08-14 2023-07-11 AltaThera Pharmaceuticals, LLC Method of initiating and escalating sotalol hydrochloride dosing
US11610660B1 (en) 2021-08-20 2023-03-21 AltaThera Pharmaceuticals LLC Antiarrhythmic drug dosing methods, medical devices, and systems
US11484355B2 (en) 2020-03-02 2022-11-01 Medtronic Holding Company Sàrl Inflatable bone tamp and method for use of inflatable bone tamp

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4010797A1 (de) 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
US5646136A (en) * 1994-01-04 1997-07-08 Duke University Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids
GB9624482D0 (en) * 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
ES2194181T3 (es) * 1996-02-13 2003-11-16 Astrazeneca Ab Derivados de quinazolina como inhibidores de vegf.
DK0885198T3 (da) * 1996-03-05 2002-03-25 Astrazeneca Ab 4-Anilinoquinazolinderivater
DE69734149T2 (de) * 1996-03-15 2006-07-06 Astrazeneca Ab Cinoline derivate und verwendung als heilmittel
GB9707800D0 (en) * 1996-05-06 1997-06-04 Zeneca Ltd Chemical compounds
AU733551B2 (en) * 1996-09-25 2001-05-17 Astrazeneca Ab Qinoline derivatives inhibiting the effect of growth factors such as VEGF
GB9718972D0 (en) * 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
CA2275708A1 (en) 1996-12-23 1998-07-02 Cambridge University Technical Services Limited Diagnosis and treatment of pathological pregnancies
US6294532B1 (en) * 1997-08-22 2001-09-25 Zeneca Limited Oxindolylquinazoline derivatives as angiogenesis inhibitors
AU758353B2 (en) * 1998-03-17 2003-03-20 Genentech Inc. Polypeptides homologous to VEGF and BMP1
US6191144B1 (en) * 1998-08-17 2001-02-20 Warner-Lambert Company Method of using angiotensin converting enzyme inhibitor to stimulate angiogenesis
JP2002524421A (ja) 1998-09-09 2002-08-06 サイオス インコーポレイテッド 微小血管障害の処置
JP2002534475A (ja) * 1999-01-15 2002-10-15 カーディオヴァスキュラー リサーチ ファンデイション 血管壁内における微細血管の発生の抑制
CN1167422C (zh) * 1999-02-10 2004-09-22 阿斯特拉曾尼卡有限公司 用作血管生成抑制剂的喹唑啉衍生物
KR100881105B1 (ko) * 1999-11-05 2009-02-02 아스트라제네카 아베 Vegf 억제제로서의 퀴나졸린 유도체
MXPA03000386A (es) * 2000-07-13 2004-02-26 Alteon Inc Imidazolios y tiazolios substituidos con cianometilo y tratamientos de desordenes asociados con la maduracion de la proteina.
GB0126879D0 (en) 2001-11-08 2002-01-02 Astrazeneca Ab Combination therapy
AU2003249000B2 (en) 2002-08-09 2007-04-05 Astrazeneca Ab Combination of ZD6474, an inhibitor of the vasuclar endothelial growth factor receptor, with radiotherapy in the treatment of cancer
GB0218526D0 (en) 2002-08-09 2002-09-18 Astrazeneca Ab Combination therapy
GB0223380D0 (en) 2002-10-09 2002-11-13 Astrazeneca Ab Combination therapy
US20060142316A1 (en) 2003-02-13 2006-06-29 Wedge Stephen R Combination therapy
GB0310401D0 (en) 2003-05-07 2003-06-11 Astrazeneca Ab Therapeutic agent
GB0316127D0 (en) 2003-07-10 2003-08-13 Astrazeneca Ab Combination therapy
GB0316123D0 (en) 2003-07-10 2003-08-13 Astrazeneca Ab Combination therapy
DE602004028834D1 (de) 2003-07-10 2010-10-07 Astrazeneca Ab Verwendung des chinazolin-derivats zd6474 in kombination mit platinverbindungen und optional ionisierender strahlung bei der behandlung von erkrankungen im zusammenhang mit angiogenese und/oder erhöhter gefässpermeabilität
EP1740170A2 (en) 2004-03-23 2007-01-10 AstraZeneca AB Combination therapy with azd2171 and platinum anti-tumour agent
GB0406445D0 (en) 2004-03-23 2004-04-28 Astrazeneca Ab Combination therapy
GB0406446D0 (en) 2004-03-23 2004-04-28 Astrazeneca Ab Combination therapy
EP1796672A1 (en) 2004-09-27 2007-06-20 AstraZeneca AB Cancer combination therapy comprising azd2171 and imatinib
JP2008514577A (ja) 2004-09-27 2008-05-08 アストラゼネカ アクチボラグ Zd6474及びイマチニブを含んでなる組合せ
GB0424339D0 (en) 2004-11-03 2004-12-08 Astrazeneca Ab Combination therapy
US20090176731A1 (en) 2005-07-06 2009-07-09 Stephen Robert Wedge Combination therapy of cancer with azd2171 and gemcitabine
CN103341168B (zh) 2005-12-15 2016-11-02 阿斯利康(瑞典)有限公司 治疗癌症的促血管生成素-2拮抗剂和VEGF-A、KDR和/或Flt1拮抗剂的组合
ATE502641T1 (de) 2005-12-22 2011-04-15 Astrazeneca Ab Kombination aus azd2171 und pemetrexed
AU2006328189B2 (en) 2005-12-22 2010-01-21 Astrazeneca Ab Combination of ZD6474 and pemetrexed
CN101553253A (zh) 2006-09-29 2009-10-07 阿斯利康(瑞典)有限公司 用于癌症治疗的zd6474和贝伐单抗的组合
EP2134340A1 (en) 2007-04-13 2009-12-23 AstraZeneca AB Combination therapy comprising azd2171 and azd6244 or mek-inhibitor ii

Also Published As

Publication number Publication date
CA2401854A1 (en) 2001-10-11
NO326277B1 (no) 2008-10-27
DE60126923T2 (de) 2007-10-31
US20030144298A1 (en) 2003-07-31
SI1272186T1 (sl) 2007-06-30
KR100849149B1 (ko) 2008-07-31
EP1658849A2 (en) 2006-05-24
AU2001244386B2 (en) 2005-01-27
SK14302002A3 (sk) 2003-05-02
GB0008269D0 (en) 2000-05-24
NO20024814L (no) 2002-11-12
ES2280349T3 (es) 2007-09-16
WO2001074360A1 (en) 2001-10-11
NZ534455A (en) 2007-01-26
EP1658849A3 (en) 2009-02-18
NZ520938A (en) 2005-08-26
EP1790340A3 (en) 2009-03-18
NO323467B1 (no) 2007-05-21
EP1272186B1 (en) 2007-02-28
ATE355065T1 (de) 2006-03-15
EP1790340A2 (en) 2007-05-30
CY1107615T1 (el) 2013-03-13
IS6557A (is) 2002-09-20
CZ299410B6 (cs) 2008-07-16
PL357605A1 (en) 2004-07-26
EP1272186A1 (en) 2003-01-08
CN1431902A (zh) 2003-07-23
AU4438601A (en) 2001-10-15
NO20024814D0 (no) 2002-10-04
NO20062050L (no) 2001-10-08
JP2003528917A (ja) 2003-09-30
ZA200206959B (en) 2003-12-01
PT1272186E (pt) 2007-04-30
KR20080034523A (ko) 2008-04-21
DE60126923D1 (de) 2007-04-12
DK1272186T3 (da) 2007-05-21
BR0109729A (pt) 2003-02-04
MXPA02009743A (es) 2003-03-27
KR20030007491A (ko) 2003-01-23
IS8726A (is) 2008-04-16
US7829573B2 (en) 2010-11-09
EE200200578A (et) 2004-06-15
IL151503A0 (en) 2003-04-10
HUP0300426A2 (hu) 2003-06-28
RU2002129353A (ru) 2004-03-20

Similar Documents

Publication Publication Date Title
IS8726A (is) Meðferðarfræðilegar samsetningar þrýstingslækkandi efna og efna sem hamla gegn æðamyndun
DK1346041T3 (da) Terapeutiske midler og fremgangsmåder til anvendelse deraf til behandling af en amyloidogen sygdom
MXPA03010085A (es) Composiciones y su uso en la hiperplasia.
EP1558220A4 (en) ORAL COMPOSITIONS FOR THE TREATMENT OF DISEASES
NO20031019L (no) Vedvarende frigivelsesformuleringer av oksymorfon
MY143795A (en) Tetrahydropyridoindole derivatives
AU2459402A (en) Composition
YU71901A (sh) NOVE VRSTE LEKOVITIH KOMPOZICIJA NA BAZI JEDINJENJA KOJA DELUJU ANTIHOLINERGIJSKI I beta-MIMETIKA
MXPA03009772A (es) Metodos y composiciones para tratar lesiones orales y del esofago.
BG66093B1 (bg) Състави с контролирано освобождаване, съдържащи нимесулид
AR034900A1 (es) Uso de una cantidad eficaz de un inhibidor de pde4 y un agente anticolinergico, bien en forma combinada sola o por separado, composiciones farmaceuticas que los comprenden, metodo para prepararlas, y uso de una composicion que comprende una cantidad eficaz de un inhibidor de pde4, una cantidad efica
ATE357928T1 (de) Pharmazeutische zusammensetzung für thrombinpeptidderivaten
GB2368525A (en) Hyaluronan as a cytotoxic agent, drug pre-sensitizer and chemo-sensitizer in the treatment of disease
ATE413187T1 (de) Pharmazeutische zusammensetzungen mit interferon- tau
SE0000303D0 (sv) Novel compounds
WO2002053099A3 (en) Methods and compositions for treating periodontal disease
SE0103210D0 (sv) New formulations and use thereof
SE0203817D0 (sv) New composition
JP2003526659A5 (is)
DE602006016168D1 (de) 1,3,5-triazepin-dionen zur Behandlung von Malaria
TW200500073A (en) Pharmaceutical composition comprising an indolopyrrolocarbazole derivative and use thereof