DK1248618T3 - Polymorfe, amorfe og hydratiserede former af 5-chlor-3-(4-methansulfonylphenyl)-6'-methyl-[2,3']bipyridinyl - Google Patents
Polymorfe, amorfe og hydratiserede former af 5-chlor-3-(4-methansulfonylphenyl)-6'-methyl-[2,3']bipyridinylInfo
- Publication number
- DK1248618T3 DK1248618T3 DK00980817T DK00980817T DK1248618T3 DK 1248618 T3 DK1248618 T3 DK 1248618T3 DK 00980817 T DK00980817 T DK 00980817T DK 00980817 T DK00980817 T DK 00980817T DK 1248618 T3 DK1248618 T3 DK 1248618T3
- Authority
- DK
- Denmark
- Prior art keywords
- polymorphic
- amorphous
- methanesulfonylphenyl
- bipyridinyl
- chloro
- Prior art date
Links
- MNJVRJDLRVPLFE-UHFFFAOYSA-N etoricoxib Chemical group C1=NC(C)=CC=C1C1=NC=C(Cl)C=C1C1=CC=C(S(C)(=O)=O)C=C1 MNJVRJDLRVPLFE-UHFFFAOYSA-N 0.000 title 1
- 102000010907 Cyclooxygenase 2 Human genes 0.000 abstract 2
- 108010037462 Cyclooxygenase 2 Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16792299P | 1999-11-29 | 1999-11-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1248618T3 true DK1248618T3 (da) | 2006-07-10 |
Family
ID=22609368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00980817T DK1248618T3 (da) | 1999-11-29 | 2000-11-27 | Polymorfe, amorfe og hydratiserede former af 5-chlor-3-(4-methansulfonylphenyl)-6'-methyl-[2,3']bipyridinyl |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US6441002B1 (https=) |
| EP (1) | EP1248618B1 (https=) |
| JP (1) | JP4425514B2 (https=) |
| AT (1) | ATE320809T1 (https=) |
| AU (1) | AU776544B2 (https=) |
| CA (1) | CA2391650C (https=) |
| DE (1) | DE60026877T2 (https=) |
| DK (1) | DK1248618T3 (https=) |
| ES (1) | ES2259295T3 (https=) |
| PT (1) | PT1248618E (https=) |
| WO (1) | WO2001037833A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12001001175B1 (en) * | 2000-05-26 | 2006-08-10 | Merck Sharp & Dohme | 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl- (2,3')bipyridinyl in pure crystalline form and process for synthesis |
| US6521642B2 (en) | 2000-05-26 | 2003-02-18 | Merck & Co., Inc. | 5-chloro-3-(4-methanesulfonylphenyl)-6′-methyl-[2,3′]bipyridinyl in pure crystalline form and process for synthesis |
| WO2005085199A1 (en) * | 2004-01-14 | 2005-09-15 | Cadila Healthcare Limited | Novel polymorphs of etoricoxib |
| PL2479166T3 (pl) | 2009-02-27 | 2014-11-28 | Cadila Healthcare Ltd | Sposób otrzymywania etorykoksybu |
| WO2012163839A1 (en) | 2011-05-27 | 2012-12-06 | Farma Grs, D.O.O. | A process for the preparation of polymorphic form i of etoricoxib |
| EP2773618A1 (en) | 2011-11-03 | 2014-09-10 | Cadila Healthcare Limited | An improved process for the preparation of etoricoxib and polymorphs thereof |
| WO2013075732A1 (en) | 2011-11-21 | 2013-05-30 | Synthon Bv | Process for making crystalline form i of etoricoxib |
| EP2601952A1 (en) | 2011-12-07 | 2013-06-12 | Zentiva, k.s. | Novel pharmaceutically acceptable salts and cocrystals of 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3']bipyridinyl and their therapeutic uses |
| EP2831045A2 (en) * | 2012-03-30 | 2015-02-04 | Mylan Laboratories, Limited | An improved process for the preparation of etoricoxib |
| EP2888231B1 (en) | 2012-08-27 | 2019-01-09 | Glenmark Pharmaceuticals Limited | Process for preparation of crystalline etoricoxib |
| CN104418799A (zh) * | 2013-09-03 | 2015-03-18 | 天津药物研究院 | 一种依托考昔的晶型及其制备方法和应用 |
| WO2015036550A1 (en) | 2013-09-13 | 2015-03-19 | Synthon B.V. | Process for making etoricoxib |
| CN107056691B (zh) * | 2017-06-21 | 2020-03-10 | 四川尚锐生物医药有限公司 | 一种制备依托考昔晶型v的方法 |
| MX2018013070A (es) | 2017-12-29 | 2019-10-15 | Gruenenthal Gmbh | Combinación farmacéutica que comprende clorhidrato de tramadol de liberación extendida y etoricoxib de liberación inmediata, y su uso para el tratamiento del dolor. |
| CN111410629A (zh) * | 2020-03-31 | 2020-07-14 | 天津大学 | 依托考昔溶剂化物及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5321033A (en) | 1991-11-15 | 1994-06-14 | Merck Frosst Canada, Inc. | Amorphous (quinolin-2-ylmethoxy)indole compounds useful for treating inflammatory diseases |
| IL127441A (en) | 1996-07-18 | 2003-02-12 | Merck Frosst Canada Inc | Substituted pyridines, pharmaceutical compositions comprising them and their use in the preparation of anti-inflammatory medicaments or as selective cyclooxygenase-2 inhibitors |
| US5861419A (en) * | 1996-07-18 | 1999-01-19 | Merck Frosst Canad, Inc. | Substituted pyridines as selective cyclooxygenase-2 inhibitors |
| US6127545A (en) | 1997-04-18 | 2000-10-03 | Merck & Co., Inc. | Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors |
| US6130334A (en) | 1998-04-15 | 2000-10-10 | Merck & Co., Inc. | Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors |
| US6040450A (en) | 1997-09-25 | 2000-03-21 | Merck & Co., Inc. | Process for making diaryl pyridines useful as cox-2-inhibitors |
| HU227627B1 (en) * | 1998-04-24 | 2011-10-28 | Merck Sharp & Dohme | Process for synthesizing pyridine derivatives as cox-2 inhibitors and the intermediates |
| US6521642B2 (en) * | 2000-05-26 | 2003-02-18 | Merck & Co., Inc. | 5-chloro-3-(4-methanesulfonylphenyl)-6′-methyl-[2,3′]bipyridinyl in pure crystalline form and process for synthesis |
| PH12001001175B1 (en) * | 2000-05-26 | 2006-08-10 | Merck Sharp & Dohme | 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl- (2,3')bipyridinyl in pure crystalline form and process for synthesis |
-
2000
- 2000-11-27 CA CA2391650A patent/CA2391650C/en not_active Expired - Lifetime
- 2000-11-27 AT AT00980817T patent/ATE320809T1/de active
- 2000-11-27 EP EP00980817A patent/EP1248618B1/en not_active Expired - Lifetime
- 2000-11-27 PT PT00980817T patent/PT1248618E/pt unknown
- 2000-11-27 DK DK00980817T patent/DK1248618T3/da active
- 2000-11-27 WO PCT/US2000/032353 patent/WO2001037833A1/en not_active Ceased
- 2000-11-27 DE DE60026877T patent/DE60026877T2/de not_active Expired - Lifetime
- 2000-11-27 JP JP2001539448A patent/JP4425514B2/ja not_active Expired - Lifetime
- 2000-11-27 AU AU18031/01A patent/AU776544B2/en not_active Expired
- 2000-11-27 ES ES00980817T patent/ES2259295T3/es not_active Expired - Lifetime
- 2000-11-28 US US09/724,522 patent/US6441002B1/en not_active Expired - Lifetime
-
2002
- 2002-06-26 US US10/180,399 patent/US20020198238A1/en not_active Abandoned
-
2003
- 2003-01-14 US US10/342,379 patent/US20030144327A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6441002B1 (en) | 2002-08-27 |
| EP1248618A4 (en) | 2003-05-14 |
| JP4425514B2 (ja) | 2010-03-03 |
| AU776544B2 (en) | 2004-09-16 |
| US20030144327A1 (en) | 2003-07-31 |
| ATE320809T1 (de) | 2006-04-15 |
| US20020198238A1 (en) | 2002-12-26 |
| EP1248618A1 (en) | 2002-10-16 |
| CA2391650A1 (en) | 2001-05-31 |
| DE60026877T2 (de) | 2006-11-23 |
| AU1803101A (en) | 2001-06-04 |
| WO2001037833A1 (en) | 2001-05-31 |
| CA2391650C (en) | 2011-01-25 |
| JP2003514859A (ja) | 2003-04-22 |
| DE60026877D1 (de) | 2006-05-11 |
| EP1248618B1 (en) | 2006-03-22 |
| PT1248618E (pt) | 2006-07-31 |
| ES2259295T3 (es) | 2006-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1248618T3 (da) | Polymorfe, amorfe og hydratiserede former af 5-chlor-3-(4-methansulfonylphenyl)-6'-methyl-[2,3']bipyridinyl | |
| DK0912518T3 (da) | Substituerede pyridiner som selektive cyclooxygenase-2 inhibitorer | |
| AU2002219322A1 (en) | Closed loop fluid-handing system for well drilling | |
| DE69906311D1 (de) | Diarylbenzopyranderivate als cyclooxygenase-2-inhibitoren | |
| AU2002352359A1 (en) | Method for joining tubulars by expansion | |
| YU5503A (sh) | Nesteroidni supresori zapaljenja | |
| IS6846A (is) | Nikotínamíð bíarýlafleiður, nytsamlegar sem hindrar PDE4 samsætuensíma | |
| NO20072142L (no) | Mellomprodukter for fremstilling av heterocyklylalkylpiperidinderivater og forbindelser for fremstilling av disse | |
| WO2003029600A3 (en) | Cementing system for wellbores | |
| WO2001030781A3 (en) | INHIBITORS OF αLβ2 MEDIATED CELL ADHESION | |
| AU2001284242A1 (en) | Substituted pyrimidines as selective cyclooxygenase-2 inhibitors | |
| IS2806B (is) | 5-klór-3-(4-metansúlfónýlfenýl)-6'-metýl-[2,3']bípýridínýl á hreinu kristallaformi og aðferð til efnasmíði | |
| AU2002356533A1 (en) | Methods using 1, 2-dithiol-3-thiones and their derivatives and metabolites for inhibiting angiogenesis | |
| WO2000005214A3 (en) | Isoquinolines as urokinase inhibitors | |
| AU2002216314A1 (en) | Heterocyclic angiogenesis inhibitors | |
| AU2001288092A1 (en) | Method of crystallization | |
| NO990914L (no) | Amorfe benzotiofener, fremgangsmÕter for fremstilling og fremgangsmÕter for anvendelse | |
| DZ3356A1 (en) | Novel polymorph v of torasemide. | |
| AU2001294408A1 (en) | Method for erecting a building, block and dowel therefore | |
| AU2001285388A1 (en) | Open loop timing control for synchronous cdma systems | |
| PT1073438E (pt) | Composicoes orais de 8-cloro-6,11-dihidro-11-(4-piperidilidina)-5h-benzo¬5,6|ciclohepta¬1,2-b|piridina | |
| NO20000290D0 (no) | Isolasjonssystem, fremgangsmåte for isolering og anvendelse av isolasjonssystem | |
| DK1091938T3 (da) | Antihistamin piperidinderivativer og mellemprodukter til fremstilling af disse | |
| DE60118941D1 (de) | Pyrrolidin-2-carbonsäure-hydrazid-derivate als metalloprotease-inhibitoren | |
| AU7766900A (en) | Nicotinyl aspartyl ketones as inhibitors of caspase-3 |