DE60026877D1 - Polymorphe, amorphe und hydratisierte formen von 5-chlor-3-(methansulfonylphenyl)-6'-methyl-2,3'übipyridinyl - Google Patents
Polymorphe, amorphe und hydratisierte formen von 5-chlor-3-(methansulfonylphenyl)-6'-methyl-2,3'übipyridinylInfo
- Publication number
- DE60026877D1 DE60026877D1 DE60026877T DE60026877T DE60026877D1 DE 60026877 D1 DE60026877 D1 DE 60026877D1 DE 60026877 T DE60026877 T DE 60026877T DE 60026877 T DE60026877 T DE 60026877T DE 60026877 D1 DE60026877 D1 DE 60026877D1
- Authority
- DE
- Germany
- Prior art keywords
- polymorphic
- amorphous
- methansulfonylphenyl
- bipyridinyl
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- SIWGXOWLPMUMEU-UHFFFAOYSA-N 5-chloro-2-(6-methylpyridin-3-yl)-3-(2-methylsulfonylphenyl)pyridine Chemical compound ClC=1C=C(C(=NC=1)C=1C=NC(=CC=1)C)C1=C(C=CC=C1)S(=O)(=O)C SIWGXOWLPMUMEU-UHFFFAOYSA-N 0.000 title 1
- 102000010907 Cyclooxygenase 2 Human genes 0.000 abstract 2
- 108010037462 Cyclooxygenase 2 Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16792299P | 1999-11-29 | 1999-11-29 | |
US167922P | 1999-11-29 | ||
PCT/US2000/032353 WO2001037833A1 (en) | 1999-11-29 | 2000-11-27 | Polymorphic, amorphous and hydrated forms of 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3']bipyridinyl |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60026877D1 true DE60026877D1 (de) | 2006-05-11 |
DE60026877T2 DE60026877T2 (de) | 2006-11-23 |
Family
ID=22609368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60026877T Expired - Lifetime DE60026877T2 (de) | 1999-11-29 | 2000-11-27 | Polymorphe, amorphe und hydratisierte formen von 5-chlor-3-(methansulfonylphenyl)-6'-methyl-[2,3']bipyridinyl |
Country Status (11)
Country | Link |
---|---|
US (3) | US6441002B1 (de) |
EP (1) | EP1248618B1 (de) |
JP (1) | JP4425514B2 (de) |
AT (1) | ATE320809T1 (de) |
AU (1) | AU776544B2 (de) |
CA (1) | CA2391650C (de) |
DE (1) | DE60026877T2 (de) |
DK (1) | DK1248618T3 (de) |
ES (1) | ES2259295T3 (de) |
PT (1) | PT1248618E (de) |
WO (1) | WO2001037833A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH12001001175B1 (en) * | 2000-05-26 | 2006-08-10 | Merck Sharp & Dohme | 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl- (2,3')bipyridinyl in pure crystalline form and process for synthesis |
US6521642B2 (en) | 2000-05-26 | 2003-02-18 | Merck & Co., Inc. | 5-chloro-3-(4-methanesulfonylphenyl)-6′-methyl-[2,3′]bipyridinyl in pure crystalline form and process for synthesis |
WO2005085199A1 (en) * | 2004-01-14 | 2005-09-15 | Cadila Healthcare Limited | Novel polymorphs of etoricoxib |
BRPI1006374A2 (pt) | 2009-02-27 | 2019-09-24 | Cadila Healthcare Ltda | "processo para a preparação de etoricoxib, composto, processo para a purificação de etoricoxib, forma polimórfica, etoricoxib" |
EP2714676B1 (de) * | 2011-05-27 | 2019-04-24 | Farma GRS, d.o.o. | Verfahren zur herstellung einer polymorphen form i von etoricoxib |
WO2013105106A1 (en) | 2011-11-03 | 2013-07-18 | Cadila Healthcare Limited | An improved process for the preparation of etoricoxib and polymorphs thereof |
WO2013075732A1 (en) | 2011-11-21 | 2013-05-30 | Synthon Bv | Process for making crystalline form i of etoricoxib |
EP2601952A1 (de) | 2011-12-07 | 2013-06-12 | Zentiva, k.s. | Neue pharmazeutisch annehmbare Salze und Kokristalle von 5-Chlor-3-(4-methansulfonylphenyl)-6'-methyl-[2,3']bipyridinyl und ihre therapeutische Anwendungen |
WO2013144977A2 (en) * | 2012-03-30 | 2013-10-03 | Mylan Laboratories Ltd. | An improved process for the preparation of etoricoxib |
WO2014041558A2 (en) | 2012-08-27 | 2014-03-20 | Glenmark Pharmaceuticals Limited; Glenmark Generics Limited | Process for preparation of crystalline etoricoxib |
CN104418799A (zh) * | 2013-09-03 | 2015-03-18 | 天津药物研究院 | 一种依托考昔的晶型及其制备方法和应用 |
WO2015036550A1 (en) | 2013-09-13 | 2015-03-19 | Synthon B.V. | Process for making etoricoxib |
CN107056691B (zh) * | 2017-06-21 | 2020-03-10 | 四川尚锐生物医药有限公司 | 一种制备依托考昔晶型v的方法 |
MX2018013070A (es) | 2017-12-29 | 2019-10-15 | Gruenenthal Gmbh | Combinación farmacéutica que comprende clorhidrato de tramadol de liberación extendida y etoricoxib de liberación inmediata, y su uso para el tratamiento del dolor. |
CN111410629A (zh) * | 2020-03-31 | 2020-07-14 | 天津大学 | 依托考昔溶剂化物及其制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5321033A (en) | 1991-11-15 | 1994-06-14 | Merck Frosst Canada, Inc. | Amorphous (quinolin-2-ylmethoxy)indole compounds useful for treating inflammatory diseases |
RS49881B (sr) | 1996-07-18 | 2008-08-07 | Merck Frosst Canada Ltd., | Supstituisani piridini kao selektivni inhibitori ciklooksigenaze-2 |
US5861419A (en) * | 1996-07-18 | 1999-01-19 | Merck Frosst Canad, Inc. | Substituted pyridines as selective cyclooxygenase-2 inhibitors |
US6127545A (en) | 1997-04-18 | 2000-10-03 | Merck & Co., Inc. | Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors |
US6130334A (en) | 1998-04-15 | 2000-10-10 | Merck & Co., Inc. | Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors |
US6040450A (en) | 1997-09-25 | 2000-03-21 | Merck & Co., Inc. | Process for making diaryl pyridines useful as cox-2-inhibitors |
RS49945B (sr) | 1998-04-24 | 2008-09-29 | Merck & Co.Inc., | Postupak za sintetizovanje inhibitora cox-2 |
PH12001001175B1 (en) * | 2000-05-26 | 2006-08-10 | Merck Sharp & Dohme | 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl- (2,3')bipyridinyl in pure crystalline form and process for synthesis |
US6521642B2 (en) * | 2000-05-26 | 2003-02-18 | Merck & Co., Inc. | 5-chloro-3-(4-methanesulfonylphenyl)-6′-methyl-[2,3′]bipyridinyl in pure crystalline form and process for synthesis |
-
2000
- 2000-11-27 AU AU18031/01A patent/AU776544B2/en not_active Expired
- 2000-11-27 JP JP2001539448A patent/JP4425514B2/ja not_active Expired - Lifetime
- 2000-11-27 WO PCT/US2000/032353 patent/WO2001037833A1/en active IP Right Grant
- 2000-11-27 ES ES00980817T patent/ES2259295T3/es not_active Expired - Lifetime
- 2000-11-27 CA CA2391650A patent/CA2391650C/en not_active Expired - Lifetime
- 2000-11-27 PT PT00980817T patent/PT1248618E/pt unknown
- 2000-11-27 DE DE60026877T patent/DE60026877T2/de not_active Expired - Lifetime
- 2000-11-27 DK DK00980817T patent/DK1248618T3/da active
- 2000-11-27 EP EP00980817A patent/EP1248618B1/de not_active Expired - Lifetime
- 2000-11-27 AT AT00980817T patent/ATE320809T1/de active
- 2000-11-28 US US09/724,522 patent/US6441002B1/en not_active Expired - Lifetime
-
2002
- 2002-06-26 US US10/180,399 patent/US20020198238A1/en not_active Abandoned
-
2003
- 2003-01-14 US US10/342,379 patent/US20030144327A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1248618A4 (de) | 2003-05-14 |
ATE320809T1 (de) | 2006-04-15 |
US20030144327A1 (en) | 2003-07-31 |
US6441002B1 (en) | 2002-08-27 |
DK1248618T3 (da) | 2006-07-10 |
EP1248618B1 (de) | 2006-03-22 |
DE60026877T2 (de) | 2006-11-23 |
AU1803101A (en) | 2001-06-04 |
EP1248618A1 (de) | 2002-10-16 |
JP4425514B2 (ja) | 2010-03-03 |
CA2391650A1 (en) | 2001-05-31 |
ES2259295T3 (es) | 2006-10-01 |
CA2391650C (en) | 2011-01-25 |
WO2001037833A1 (en) | 2001-05-31 |
US20020198238A1 (en) | 2002-12-26 |
PT1248618E (pt) | 2006-07-31 |
JP2003514859A (ja) | 2003-04-22 |
AU776544B2 (en) | 2004-09-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: MERCK & CO., INC., WHITEHOUSE STATION, N.J., US Owner name: MERCK FROSST CANADA LTD., KIRKLAND, QUEBEC, CA |
|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: MERCK FROSST CANADA LTD., KIRKLAND, QUEBEC, CA Owner name: MERCK SHARP & DOHME CORP., NEW JERSEY, N.J., US |
|
R081 | Change of applicant/patentee |
Ref document number: 1248618 Country of ref document: EP Owner name: SCHERING CORPORATION, US Free format text: FORMER OWNER: MERCK FROSST CANADA LTD., MERCK SHARP & DOHME CORP., , US Effective date: 20121213 Ref document number: 1248618 Country of ref document: EP Owner name: MERCK FROSST CANADA LTD., CA Free format text: FORMER OWNER: MERCK FROSST CANADA LTD., MERCK SHARP & DOHME CORP., , US Effective date: 20121213 |
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R082 | Change of representative |
Ref document number: 1248618 Country of ref document: EP Representative=s name: ABITZ & PARTNER, DE Effective date: 20121213 |