DK1212300T3 - Azacyclololalkanonserinproteaseinhibitorer - Google Patents

Azacyclololalkanonserinproteaseinhibitorer

Info

Publication number
DK1212300T3
DK1212300T3 DK00963388T DK00963388T DK1212300T3 DK 1212300 T3 DK1212300 T3 DK 1212300T3 DK 00963388 T DK00963388 T DK 00963388T DK 00963388 T DK00963388 T DK 00963388T DK 1212300 T3 DK1212300 T3 DK 1212300T3
Authority
DK
Denmark
Prior art keywords
sup
sub
methylene
azacyclolol
alkanone
Prior art date
Application number
DK00963388T
Other languages
Danish (da)
English (en)
Inventor
Scott C Miller
N S Nchez Juan Jose Marug
Kristin D Haslow
Jonathan P Hall
Original Assignee
Dimensional Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dimensional Pharm Inc filed Critical Dimensional Pharm Inc
Application granted granted Critical
Publication of DK1212300T3 publication Critical patent/DK1212300T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DK00963388T 1999-09-13 2000-09-13 Azacyclololalkanonserinproteaseinhibitorer DK1212300T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15323699P 1999-09-13 1999-09-13
PCT/US2000/025006 WO2001019795A1 (en) 1999-09-13 2000-09-13 Azacycloalkanone serine protease inhibitors

Publications (1)

Publication Number Publication Date
DK1212300T3 true DK1212300T3 (da) 2004-03-15

Family

ID=22546339

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00963388T DK1212300T3 (da) 1999-09-13 2000-09-13 Azacyclololalkanonserinproteaseinhibitorer

Country Status (20)

Country Link
US (2) US6469029B1 (es)
EP (1) EP1212300B1 (es)
JP (1) JP2003509409A (es)
KR (1) KR20020027639A (es)
CN (1) CN1373755A (es)
AT (1) ATE253558T1 (es)
AU (1) AU7480800A (es)
BR (1) BR0013926A (es)
CA (1) CA2384247A1 (es)
DE (1) DE60006407T2 (es)
DK (1) DK1212300T3 (es)
ES (1) ES2209987T3 (es)
HK (1) HK1050005A1 (es)
IL (1) IL148358A0 (es)
MX (1) MXPA02002657A (es)
NO (1) NO322753B1 (es)
NZ (1) NZ517603A (es)
PL (1) PL354265A1 (es)
PT (1) PT1212300E (es)
WO (1) WO2001019795A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI288745B (en) 2000-04-05 2007-10-21 Daiichi Seiyaku Co Ethylenediamine derivatives
WO2002060894A2 (en) 2001-01-30 2002-08-08 Bristol-Myers Squibb Company Sulfonamide lactam inhibitors of factor xa
WO2002094787A1 (en) * 2001-05-23 2002-11-28 Ucb, S.A. 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders
WO2003000657A1 (fr) 2001-06-20 2003-01-03 Daiichi Pharmaceutical Co., Ltd. Derives de diamine
GB0127568D0 (en) * 2001-11-16 2002-01-09 Glaxo Group Ltd Chemical compounds
WO2004050637A2 (en) 2002-12-03 2004-06-17 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
US20070191306A1 (en) * 2005-08-17 2007-08-16 Bristol-Myers Squibb Company FACTOR Xa INHIBITOR FORMULATION AND METHOD
JPWO2009096198A1 (ja) * 2008-02-01 2011-05-26 一般社団法人ファルマＩｐ 新規ビアリール誘導体
CN103910688B (zh) * 2013-01-04 2016-05-25 陈春麟 2-丙基-4-氯喹唑啉衍生物及其制备方法和应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727064A (en) 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
GB8506792D0 (en) 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
US5002935A (en) 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
US5385885A (en) 1988-01-15 1995-01-31 Gasic; Gregory P. Inhibition of smooth muscle cell proliferation by antistasin and tick anticoagulant peptide
DE4121947A1 (de) * 1991-07-03 1993-01-07 Basf Ag 2-(3-(4-amidino-phenyl))-propionsaeurederivate, ihre herstellung und verwendung
CA2075154A1 (en) * 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
WO1994020535A1 (en) 1992-12-11 1994-09-15 Corvas International, Inc. ECOTIN AS A FACTOR Xa, XIa, AND XIIa INHIBITOR
WO1995035311A1 (en) 1994-06-17 1995-12-28 Corvas International, Inc. 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors
US5703208A (en) 1994-06-17 1997-12-30 Corvas International, Inc. 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors
WO1997001338A1 (en) 1995-06-27 1997-01-16 Merck & Co., Inc. Pyridinone-thrombin inhibitors
JPH09165370A (ja) * 1995-10-13 1997-06-24 Fuji Yakuhin Kogyo Kk ラクタム誘導体およびその塩
CA2246256A1 (en) 1996-02-13 1997-08-21 Akzo Nobel Nv Serine protease inhibitors
JP2000512616A (ja) 1996-02-22 2000-09-26 メルク エンド カンパニー インコーポレーテッド ピリジノントロンビンインヒビター
ATE341317T1 (de) 1996-03-29 2006-10-15 Ortho Mcneil Pharm Inc Amidinohydrazone als protease-inhibitoren
JP2001504810A (ja) * 1996-10-11 2001-04-10 シーオーアール・セラピューティックス・インコーポレーテッド 選択的第Ｘａ因子阻害剤
WO1999007732A1 (en) 1997-08-11 1999-02-18 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
CA2299610A1 (en) 1997-08-11 1999-02-18 Cor Therapeutics, Inc. Selective factor xa inhibitors
EP1036063B1 (en) 1997-11-26 2006-11-02 Ortho-McNeil Pharmaceuticals, Inc. Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors

Also Published As

Publication number Publication date
PT1212300E (pt) 2004-03-31
HK1050005A1 (zh) 2003-06-06
BR0013926A (pt) 2002-07-23
US6469029B1 (en) 2002-10-22
WO2001019795A1 (en) 2001-03-22
ATE253558T1 (de) 2003-11-15
PL354265A1 (en) 2003-12-29
EP1212300A1 (en) 2002-06-12
US20030109517A1 (en) 2003-06-12
NO20021224L (no) 2002-05-13
NO322753B1 (no) 2006-12-04
IL148358A0 (en) 2002-09-12
MXPA02002657A (es) 2002-10-28
US6962942B2 (en) 2005-11-08
CA2384247A1 (en) 2001-03-22
JP2003509409A (ja) 2003-03-11
KR20020027639A (ko) 2002-04-13
DE60006407D1 (de) 2003-12-11
AU7480800A (en) 2001-04-17
DE60006407T2 (de) 2004-09-09
CN1373755A (zh) 2002-10-09
NO20021224D0 (no) 2002-03-12
NZ517603A (en) 2003-09-26
EP1212300B1 (en) 2003-11-05
ES2209987T3 (es) 2004-07-01

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