DK1207904T3 - Nye kliniske parametre til bestemmelse af hæmatologisk toksicitet forud for radioimmunterapi - Google Patents
Nye kliniske parametre til bestemmelse af hæmatologisk toksicitet forud for radioimmunterapiInfo
- Publication number
- DK1207904T3 DK1207904T3 DK00959150T DK00959150T DK1207904T3 DK 1207904 T3 DK1207904 T3 DK 1207904T3 DK 00959150 T DK00959150 T DK 00959150T DK 00959150 T DK00959150 T DK 00959150T DK 1207904 T3 DK1207904 T3 DK 1207904T3
- Authority
- DK
- Denmark
- Prior art keywords
- clinical parameters
- radioimmunotherapy
- new clinical
- haematological toxicity
- toxicity prior
- Prior art date
Links
- 231100000226 haematotoxicity Toxicity 0.000 title abstract 2
- 238000011363 radioimmunotherapy Methods 0.000 title 1
- 206010025323 Lymphomas Diseases 0.000 abstract 1
- 210000001185 bone marrow Anatomy 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Ecology (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14828899P | 1999-08-11 | 1999-08-11 | |
US09/625,856 US6451284B1 (en) | 1999-08-11 | 2000-07-26 | Clinical parameters for determining hematologic toxicity prior to radioimmunotheraphy |
PCT/US2000/020733 WO2001010461A1 (en) | 1999-08-11 | 2000-07-31 | New clinical parameters for determining hematologic toxicity prior to radioimmunotherapy |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1207904T3 true DK1207904T3 (da) | 2008-07-07 |
Family
ID=26845721
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00959150T DK1207904T3 (da) | 1999-08-11 | 2000-07-31 | Nye kliniske parametre til bestemmelse af hæmatologisk toksicitet forud for radioimmunterapi |
Country Status (17)
Country | Link |
---|---|
US (3) | US6451284B1 (es) |
EP (1) | EP1207904B1 (es) |
JP (1) | JP4662672B2 (es) |
CN (2) | CN1596985A (es) |
AT (1) | ATE387915T1 (es) |
AU (2) | AU780222B2 (es) |
CA (1) | CA2378584C (es) |
CY (1) | CY1108118T1 (es) |
DE (1) | DE60038239T2 (es) |
DK (1) | DK1207904T3 (es) |
ES (1) | ES2302698T3 (es) |
MX (1) | MXPA02001403A (es) |
MY (1) | MY135734A (es) |
NO (1) | NO329592B1 (es) |
PT (1) | PT1207904E (es) |
TW (1) | TWI317284B (es) |
WO (1) | WO2001010461A1 (es) |
Families Citing this family (36)
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EP1176981B1 (en) | 1999-05-07 | 2005-11-30 | Genentech, Inc. | Treatment of autoimmune diseases with antagonists which bind to b cell surface markers |
US6451284B1 (en) * | 1999-08-11 | 2002-09-17 | Idec Pharmaceuticals Corporation | Clinical parameters for determining hematologic toxicity prior to radioimmunotheraphy |
JP2003513012A (ja) * | 1999-08-11 | 2003-04-08 | アイデック ファーマスーティカルズ コーポレイション | 抗cd20抗体による骨髄病変を伴う非ホジキンリンパ腫を有する患者の治療 |
JP2004512262A (ja) * | 2000-06-20 | 2004-04-22 | アイデック ファーマスーティカルズ コーポレイション | 非放射性抗cd20抗体/放射標識抗cd22抗体の組合せ |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
AU2002250352C1 (en) * | 2001-04-02 | 2009-04-30 | Genentech, Inc. | Combination therapy |
DE60332957D1 (de) | 2002-12-16 | 2010-07-22 | Genentech Inc | Immunoglobulinvarianten und deren verwendungen |
ME00426B (me) | 2003-04-09 | 2011-10-10 | Genentech Inc | Liječenje autoimunih bolesti kod pacijenata sa neadekvatnim odgovorom na tnf-alfa inhibitor |
JP5416338B2 (ja) * | 2003-05-09 | 2014-02-12 | デューク ユニバーシティ | Cd20特異的抗体およびその使用方法 |
AU2004251679C1 (en) | 2003-06-05 | 2009-05-28 | Genentech, Inc. | Combination therapy for B cell disorders |
CN102373214B (zh) | 2003-11-05 | 2014-07-09 | 罗氏格黎卡特股份公司 | 具有增加的Fc受体结合亲和性和效应子功能的CD20抗体 |
EP1755646A2 (en) * | 2004-06-02 | 2007-02-28 | Sidney Kimmel Cancer Center | Vascular targets for detecting, imaging and treating neoplasia or neovasculature |
MXPA06014069A (es) | 2004-06-04 | 2007-04-25 | Genentech Inc | Metodo para tratar esclerosis multiple. |
AU2006272597A1 (en) | 2005-07-25 | 2007-02-01 | Emergent Product Development Seattle Llc | Single dose use of CD20-specific binding molecules |
UA97469C2 (uk) | 2005-07-25 | 2012-02-27 | Емерджент Продакт Дівелопмент Сіетл, Елелсі | Гуманізована специфічна до cd37 зв'язувальна молекула імуноглобуліну |
MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
CA2629306A1 (en) | 2005-11-23 | 2007-05-31 | Genentech, Inc. | Methods and compositions related to b cell assays |
NZ573646A (en) | 2006-06-12 | 2012-04-27 | Wyeth Llc | Single-chain multivalent binding proteins with effector function |
KR101456728B1 (ko) | 2006-09-08 | 2014-10-31 | 메디뮨 엘엘씨 | 인간화 항-cd19 항체, 및 이것의 종양학, 이식 및 자가면역 질환의 치료에서의 용도 |
EP4335863A2 (en) | 2007-07-09 | 2024-03-13 | Genentech, Inc. | Prevention of disulfide bond reduction during recombinant production of polypeptides |
AU2008312406B2 (en) | 2007-10-16 | 2014-03-06 | Ares Trading S.A. | Combination of BLyS inhibition and anti-CD 20 agents for treatment of autoimmune disease |
EP2077281A1 (en) | 2008-01-02 | 2009-07-08 | Bergen Teknologioverforing AS | Anti-CD20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome |
US7914785B2 (en) | 2008-01-02 | 2011-03-29 | Bergen Teknologieverforing As | B-cell depleting agents, like anti-CD20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome |
JP6013733B2 (ja) | 2008-04-11 | 2016-10-25 | エマージェント プロダクト デベロップメント シアトル, エルエルシー | Cd37免疫治療薬および二機能性化学療法薬とのその組合せ |
TW201438738A (zh) | 2008-09-16 | 2014-10-16 | Genentech Inc | 治療進展型多發性硬化症之方法 |
WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
MY186219A (en) | 2009-08-11 | 2021-06-30 | Genentech Inc | Production of proteins in glutamine-free cell culture media |
JP5841072B2 (ja) | 2010-02-10 | 2016-01-06 | イミュノジェン・インコーポレーテッド | Cd20抗体およびその使用 |
CA2970734C (en) * | 2013-12-17 | 2019-09-24 | Alentic Microscience Inc. | Dosimeters including lensless imaging systems |
WO2016196344A1 (en) | 2015-05-30 | 2016-12-08 | Molecular Templates, Inc. | De-immunized, shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same |
IL302486A (en) | 2015-06-24 | 2023-06-01 | Hoffmann La Roche | Antibodies against the transnephrine receptor with adapted affinity |
EP3352760A4 (en) | 2015-09-21 | 2019-03-06 | Aptevo Research and Development LLC | CD3 BINDING POLYPEPTIDES |
AR106230A1 (es) | 2015-10-02 | 2017-12-27 | Hoffmann La Roche | Anticuerpos biespecíficos contra el cd20 humano y el receptor de transferrina humano y métodos de uso |
AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
EP3714937A1 (en) * | 2019-03-28 | 2020-09-30 | Koninklijke Philips N.V. | Determining hematologic toxicity risk following radiotherapy |
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US5242679A (en) * | 1985-01-14 | 1993-09-07 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
US5099069A (en) | 1986-09-05 | 1992-03-24 | Gansow Otto A | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
US5246692A (en) | 1986-09-05 | 1993-09-21 | The United States Of America As Represented By The Secretary Of Health And Human Services | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
US5591632A (en) * | 1987-03-02 | 1997-01-07 | Beth Israel Hospital | Recombinant BCG |
US5124471A (en) | 1990-03-26 | 1992-06-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Bifunctional dtpa-type ligand |
EP0556285A4 (en) | 1990-11-05 | 1993-10-27 | Bristol-Myers Squibb Company | Synergistic therapy with combinations of anti-tumor antibodies and biologically active agents |
US7744877B2 (en) * | 1992-11-13 | 2010-06-29 | Biogen Idec Inc. | Expression and use of anti-CD20 Antibodies |
US5736137A (en) * | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
DK0669836T3 (da) | 1992-11-13 | 1996-10-14 | Idec Pharma Corp | Terapeutisk anvendelse af kimære og radioaktivt mærkede antistoffer og humant B-lymfocytbegrænset differentieringsantigen til behandling af B-cellelymfom |
US5595721A (en) * | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
IL114909A (en) * | 1994-08-12 | 1999-10-28 | Immunomedics Inc | Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells |
US6113898A (en) * | 1995-06-07 | 2000-09-05 | Idec Pharmaceuticals Corporation | Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies |
US5843436A (en) * | 1996-04-22 | 1998-12-01 | The Trustees Of Columbia University, In The City Of New York | Method of preventing and treating bacterial infection of sutures and prosthetic devices, and promoting ingress of leukocytes into tumor foci |
US6306393B1 (en) * | 1997-03-24 | 2001-10-23 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
US6183744B1 (en) | 1997-03-24 | 2001-02-06 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
PL195870B1 (pl) * | 1998-08-11 | 2007-11-30 | Biogen Idec Inc | Zastosowanie przeciwciała anty-CD20, zastosowanieznakowanego radioaktywnie przeciwciała anty-CD20,zastosowanie przeciwciała anty-CD20 do przygotowania leku zwierającego przeciwciało i chemioterapięoraz zastosowanie przeciwciała anty-CD20 do przygotowania leku zawierającego przeciwciało i szpik kostny |
US6224866B1 (en) | 1998-10-07 | 2001-05-01 | Biocrystal Ltd. | Immunotherapy of B cell involvement in progression of solid, nonlymphoid tumors |
EP1176981B1 (en) | 1999-05-07 | 2005-11-30 | Genentech, Inc. | Treatment of autoimmune diseases with antagonists which bind to b cell surface markers |
CA2375912C (en) | 1999-06-09 | 2014-03-11 | Immunomedics, Inc. | Immunotherapy of autoimmune disorders using antibodies which target b-cells |
US6451284B1 (en) * | 1999-08-11 | 2002-09-17 | Idec Pharmaceuticals Corporation | Clinical parameters for determining hematologic toxicity prior to radioimmunotheraphy |
US20020006404A1 (en) * | 1999-11-08 | 2002-01-17 | Idec Pharmaceuticals Corporation | Treatment of cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications |
US20020058029A1 (en) * | 2000-09-18 | 2002-05-16 | Nabil Hanna | Combination therapy for treatment of autoimmune diseases using B cell depleting/immunoregulatory antibody combination |
-
2000
- 2000-07-26 US US09/625,856 patent/US6451284B1/en not_active Expired - Lifetime
- 2000-07-31 MX MXPA02001403A patent/MXPA02001403A/es active IP Right Grant
- 2000-07-31 DK DK00959150T patent/DK1207904T3/da active
- 2000-07-31 CA CA2378584A patent/CA2378584C/en not_active Expired - Lifetime
- 2000-07-31 CN CNA2004100590274A patent/CN1596985A/zh active Pending
- 2000-07-31 DE DE60038239T patent/DE60038239T2/de not_active Expired - Lifetime
- 2000-07-31 AT AT00959150T patent/ATE387915T1/de active
- 2000-07-31 WO PCT/US2000/020733 patent/WO2001010461A1/en active IP Right Grant
- 2000-07-31 ES ES00959150T patent/ES2302698T3/es not_active Expired - Lifetime
- 2000-07-31 AU AU70521/00A patent/AU780222B2/en not_active Expired
- 2000-07-31 EP EP00959150A patent/EP1207904B1/en not_active Expired - Lifetime
- 2000-07-31 CN CNB008124426A patent/CN100540053C/zh not_active Expired - Lifetime
- 2000-07-31 JP JP2001514977A patent/JP4662672B2/ja not_active Expired - Lifetime
- 2000-07-31 PT PT00959150T patent/PT1207904E/pt unknown
- 2000-08-04 MY MYPI20003577A patent/MY135734A/en unknown
- 2000-08-11 TW TW089116242A patent/TWI317284B/zh not_active IP Right Cessation
-
2002
- 2002-02-08 NO NO20020637A patent/NO329592B1/no not_active IP Right Cessation
- 2002-07-16 US US10/195,426 patent/US7195750B2/en not_active Expired - Lifetime
-
2005
- 2005-06-10 AU AU2005202560A patent/AU2005202560B2/en not_active Expired
-
2007
- 2007-02-27 US US11/679,687 patent/US20070148714A1/en not_active Abandoned
-
2008
- 2008-06-03 CY CY20081100584T patent/CY1108118T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US7195750B2 (en) | 2007-03-27 |
EP1207904A1 (en) | 2002-05-29 |
NO329592B1 (no) | 2010-11-22 |
JP4662672B2 (ja) | 2011-03-30 |
ES2302698T3 (es) | 2008-08-01 |
CA2378584C (en) | 2011-10-11 |
NO20020637D0 (no) | 2002-02-08 |
AU780222B2 (en) | 2005-03-10 |
PT1207904E (pt) | 2008-06-17 |
US6451284B1 (en) | 2002-09-17 |
DE60038239T2 (de) | 2009-04-30 |
US20070148714A1 (en) | 2007-06-28 |
WO2001010461A1 (en) | 2001-02-15 |
ATE387915T1 (de) | 2008-03-15 |
US20030211038A1 (en) | 2003-11-13 |
DE60038239D1 (de) | 2008-04-17 |
AU2005202560A1 (en) | 2005-07-07 |
CN1450911A (zh) | 2003-10-22 |
CA2378584A1 (en) | 2001-02-15 |
CN1596985A (zh) | 2005-03-23 |
CN100540053C (zh) | 2009-09-16 |
AU7052100A (en) | 2001-03-05 |
JP2003506414A (ja) | 2003-02-18 |
NO20020637L (no) | 2002-04-11 |
TWI317284B (en) | 2009-11-21 |
EP1207904A4 (en) | 2002-10-25 |
MXPA02001403A (es) | 2002-08-12 |
AU2005202560B2 (en) | 2008-01-31 |
MY135734A (en) | 2008-06-30 |
CY1108118T1 (el) | 2014-02-12 |
EP1207904B1 (en) | 2008-03-05 |
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