DK1185666T3 - Hyaluronidase fra Hirudinaria manillensis, isolering, oprensning og rekombinant fremgangsmåde til fremstilling - Google Patents

Hyaluronidase fra Hirudinaria manillensis, isolering, oprensning og rekombinant fremgangsmåde til fremstilling

Info

Publication number
DK1185666T3
DK1185666T3 DK00947835T DK00947835T DK1185666T3 DK 1185666 T3 DK1185666 T3 DK 1185666T3 DK 00947835 T DK00947835 T DK 00947835T DK 00947835 T DK00947835 T DK 00947835T DK 1185666 T3 DK1185666 T3 DK 1185666T3
Authority
DK
Denmark
Prior art keywords
hyaluronidase
isolation
purification
preparation
recombinant method
Prior art date
Application number
DK00947835T
Other languages
Danish (da)
English (en)
Inventor
Maria Kordowicz
Detlef Guessow
Uwe Hofmann
Tadeusz Pacuszka
Andrzej Gardas
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK1185666T3 publication Critical patent/DK1185666T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK00947835T 1999-06-12 2000-06-06 Hyaluronidase fra Hirudinaria manillensis, isolering, oprensning og rekombinant fremgangsmåde til fremstilling DK1185666T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99111468 1999-06-12

Publications (1)

Publication Number Publication Date
DK1185666T3 true DK1185666T3 (da) 2006-07-03

Family

ID=8238352

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00947835T DK1185666T3 (da) 1999-06-12 2000-06-06 Hyaluronidase fra Hirudinaria manillensis, isolering, oprensning og rekombinant fremgangsmåde til fremstilling

Country Status (23)

Country Link
US (1) US7049124B1 (no)
EP (1) EP1185666B1 (no)
JP (1) JP2003502045A (no)
KR (1) KR20020011138A (no)
CN (1) CN1355850A (no)
AR (1) AR024335A1 (no)
AT (1) ATE324452T1 (no)
AU (1) AU6149300A (no)
BR (1) BR0011500A (no)
CA (1) CA2376467A1 (no)
CZ (1) CZ20014383A3 (no)
DE (1) DE60027562T2 (no)
DK (1) DK1185666T3 (no)
ES (1) ES2258976T3 (no)
HK (1) HK1046297A1 (no)
HU (1) HUP0201452A2 (no)
MX (1) MXPA01012806A (no)
NO (1) NO20016047L (no)
PL (1) PL352060A1 (no)
PT (1) PT1185666E (no)
SK (1) SK17612001A3 (no)
WO (1) WO2000077221A1 (no)
ZA (1) ZA200200233B (no)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866120A (en) 1995-11-22 1999-02-02 Advanced Corneal Systems, Inc. Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase
US6610292B2 (en) 1995-11-22 2003-08-26 Ista Pharmaceuticals, Inc. Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
KR20010041806A (ko) 1998-03-09 2001-05-25 에드워드 에이취. 댄스 효소 각막교정술에 사용되는 각막 경화제의 용도
CA2522544A1 (en) * 2003-04-15 2004-10-28 Ista Pharmaceuticals, Inc. Process for isolating and purifing ovine hyaluronidase
WO2004110479A1 (de) * 2003-05-27 2004-12-23 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Hyaluronatlyase enthaltendes mittel zur behandlung des akuten myokardinfarktes bzw. symptomen darauf sowie zur behandlung von postinfarktioneller myokarditis und myokardischämie
US20070009989A1 (en) * 2003-09-26 2007-01-11 Christian Steinkuhler Synthetic heparanase molecules and uses thereof
US8288142B2 (en) * 2007-06-19 2012-10-16 Uvarkina Tamara P Hyaluronidase and method of use thereof
GB0717166D0 (en) * 2007-09-04 2007-10-17 Univ Brighton Method for stabilisation of purified P-Glycoprotein
FI4269578T3 (fi) * 2008-03-06 2024-06-07 Halozyme Inc Liukoisen hyaluronidaasin suurimittainen tuotanto
ES2413492T3 (es) * 2008-10-14 2013-07-16 Burgard, Gunther, Dr. Uso de hialuronidasa para la prevención o el tratamiento de la hipertensión arterial
JP6029674B2 (ja) * 2011-10-18 2016-11-24 ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー 第ｖｉｉｉ因子のバイオアベイラビリティを改善するための、硫酸化グリコサミノグリカン及びヒアルロニダーゼの組み合わせ使用
EP2698636A1 (en) * 2012-08-13 2014-02-19 Fundació Institut d'Investigació Biomèdica de Bellvitge Methods and reagents for prevention and/or treatment of transplant rejection
US8784896B2 (en) * 2012-09-17 2014-07-22 Biopep Solutions, Inc Antioxidant therapy with a whole, leech saliva extract
KR101454646B1 (ko) 2012-11-05 2014-10-27 (주)한국비엠아이 히알루로니다아제의 안정화 제제 및 이를 포함하는 액상제제
CN103060291B (zh) * 2012-12-28 2014-10-08 青岛九龙生物医药有限公司 一种玻璃酸酶的提取方法
US9279111B2 (en) * 2013-07-29 2016-03-08 Jiangnan University Leech hyaluronidase and its application
CN103695448B (zh) * 2013-07-29 2016-08-17 江南大学 一种透明质酸酶编码基因及其发酵生产和纯化方法
CN104263666B (zh) * 2014-09-12 2017-07-14 江南大学 一种产小分子透明质酸的重组毕赤酵母及其构建方法
CN106148302A (zh) * 2016-07-08 2016-11-23 中国人民解放军军事医学科学院生物工程研究所 一种重组蛋白质的纯化方法
CN106520728B (zh) * 2016-11-08 2019-06-21 江南大学 一种提高水蛭透明质酸酶酶活的方法
CN109298113B (zh) * 2018-12-11 2021-06-18 华熙生物科技股份有限公司 一种测定包含有柠檬酸的溶液中的透明质酸含量的方法
WO2021213623A1 (en) * 2020-04-20 2021-10-28 Pharmact Holding Ag A modified bacterial hyaluronidase polypeptide, production process, pharmaceutical compositions and their uses
CN112915106A (zh) * 2021-02-05 2021-06-08 张虎山 一种肿瘤免疫微环境调控剂的制备及其应用
EP4419663A1 (en) * 2021-10-19 2024-08-28 Pharmact Holding AG A production of a purified modified bacterial hyaluronidase polypeptide, pharmaceutical compositions and their uses
CN116640745B (zh) * 2023-06-29 2023-12-08 江南大学 透明质酸酶突变体及其在水解硫酸软骨素中的应用
CN117165558B (zh) * 2023-09-27 2024-07-09 四川德博尔制药有限公司 一种透明质酸酶的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8504025D0 (en) 1985-02-16 1985-03-20 Biopharm Ltd Hyaluronidase
DE4440892A1 (de) * 1994-11-17 1996-05-23 Gruenenthal Gmbh Proteine mit fibrinolytischen und gerinnungshemmenden Eigenschaften
US5747027A (en) * 1995-04-07 1998-05-05 The Regents Of The University Of California BH55 hyaluronidase

Also Published As

Publication number Publication date
EP1185666B1 (en) 2006-04-26
HUP0201452A2 (en) 2002-08-28
PL352060A1 (en) 2003-07-28
EP1185666A1 (en) 2002-03-13
CZ20014383A3 (cs) 2002-03-13
WO2000077221A1 (en) 2000-12-21
MXPA01012806A (es) 2002-09-02
SK17612001A3 (sk) 2002-04-04
US7049124B1 (en) 2006-05-23
DE60027562D1 (de) 2006-06-01
ATE324452T1 (de) 2006-05-15
NO20016047D0 (no) 2001-12-11
ZA200200233B (en) 2003-06-25
NO20016047L (no) 2001-12-11
AR024335A1 (es) 2002-10-02
CA2376467A1 (en) 2000-12-21
AU6149300A (en) 2001-01-02
JP2003502045A (ja) 2003-01-21
CN1355850A (zh) 2002-06-26
HK1046297A1 (zh) 2003-01-03
PT1185666E (pt) 2006-09-29
KR20020011138A (ko) 2002-02-07
DE60027562T2 (de) 2006-11-02
ES2258976T3 (es) 2006-09-16
BR0011500A (pt) 2002-03-12

Similar Documents

Publication Publication Date Title
DK1185666T3 (da) Hyaluronidase fra Hirudinaria manillensis, isolering, oprensning og rekombinant fremgangsmåde til fremstilling
DK1185536T3 (da) Hemisyntesefremgangsmåde og mellemprodukter deraf
NO995660L (no) FremgangsmÕte ved kommunikasjon og anordning for samme
IS6197A (is) Aðferð og búnaður til að koma lyfjablöndum á úðaform
NO20000011D0 (no) Skumdempersammensetninger og fremgangsmåter
NO994392D0 (no) Oksiranderivat og fremgangsmÕte for dets fremstilling
DK1206495T3 (da) Kimære polypeptider, fremgangsmåde til frembringelse og anvendelser deraf
DK1372686T3 (da) Fremgangsmåder og sammensætninger til peptidsyntese
IS6521A (is) Aðferð til að hreinsa gerjunarseyði
DK1261697T3 (da) Kuldeaktiv beta-galactosidase, fremgangsmåde til fremstilling heraf og anvendelsen deraf
NO20032819L (no) Komposittsystem og fremgangsmåte for termisk beskyttelse
NO20032332L (no) Benzodiazepinderivatforbindelser, fremgangsmåte til fremstilling og anvendelse derav
EP1154452A4 (en) RELAY AND METHOD FOR THE PRODUCTION THEREOF
DK1228193T3 (da) Felint calicivirirus-gener og rekombinante vacciner der indeholder dem
DK1311731T3 (da) Fremgangsmåde og arrangement til stolpesystem
NO20052188D0 (no) System og fremgangsmate for fremstilling av polysulfid
NO20040368L (no) Fremgangsmate til fremstilling og rensing av natriumhydrid
DE60005783D1 (de) Gas enthaltende schokolade und herstellungsverfahren
NO20013735L (no) Fremgangsmåte til fremstilling av di-iso-butaner, di-iso- butener og di-n-butener fra feltbutaner
DK1131052T3 (da) Vaginalt indgivelige progesteron-holdige tabletter og fremgangsmåde til fremstilling deraf
NO20033743D0 (no) Fremgangsmåte og fremstilling citalopram
GB2389182B (en) Method of purifying b-secretase
DK1046719T3 (da) D-galactosesammensætning og fremgangsmåde til fremstilling deraf
PT1230212E (pt) Metodo de embalar elementos de construcao de brinquedo
GB9924752D0 (en) Method of construction