DK1168934T3 - Hydrogeldannende system med hydrofobe og hydrofile komponenter - Google Patents

Hydrogeldannende system med hydrofobe og hydrofile komponenter

Info

Publication number
DK1168934T3
DK1168934T3 DK00917865T DK00917865T DK1168934T3 DK 1168934 T3 DK1168934 T3 DK 1168934T3 DK 00917865 T DK00917865 T DK 00917865T DK 00917865 T DK00917865 T DK 00917865T DK 1168934 T3 DK1168934 T3 DK 1168934T3
Authority
DK
Denmark
Prior art keywords
hydrophobic
forming system
hydrophilic components
hydrogel forming
unsaturated group
Prior art date
Application number
DK00917865T
Other languages
Danish (da)
English (en)
Inventor
Chee-Youb Won
Yeli Zhang
Chih-Chang Chu
Original Assignee
Cornell Res Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Res Foundation Inc filed Critical Cornell Res Foundation Inc
Application granted granted Critical
Publication of DK1168934T3 publication Critical patent/DK1168934T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/02Dextran; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00Polymeric products of isocyanates or isothiocyanates
    • C08G18/06Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40High-molecular-weight compounds
    • C08G18/64Macromolecular compounds not provided for by groups C08G18/42 - C08G18/63
    • C08G18/6484Polysaccharides and derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00Polymeric products of isocyanates or isothiocyanates
    • C08G18/06Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/81Unsaturated isocyanates or isothiocyanates
    • C08G18/8108Unsaturated isocyanates or isothiocyanates having only one isocyanate or isothiocyanate group
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/06Unsaturated polyesters
    • C08L67/07Unsaturated polyesters having terminal carbon-to-carbon unsaturated bonds
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2210/00Compositions for preparing hydrogels
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S525/00Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S525/937Utility as body contact e.g. implant, contact lens or I.U.D.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Colloid Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Graft Or Block Polymers (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK00917865T 1999-04-12 2000-03-20 Hydrogeldannende system med hydrofobe og hydrofile komponenter DK1168934T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12880399P 1999-04-12 1999-04-12
PCT/US2000/006416 WO2000060956A1 (en) 1999-04-12 2000-03-20 Hydrogel-forming system with hydrophobic and hydrophilic components

Publications (1)

Publication Number Publication Date
DK1168934T3 true DK1168934T3 (da) 2008-05-13

Family

ID=22437052

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00917865T DK1168934T3 (da) 1999-04-12 2000-03-20 Hydrogeldannende system med hydrofobe og hydrofile komponenter

Country Status (10)

Country Link
US (4) US6388047B1 (de)
EP (1) EP1168934B1 (de)
JP (1) JP4558213B2 (de)
AT (1) ATE386075T1 (de)
AU (1) AU3877200A (de)
CA (1) CA2368617C (de)
DE (1) DE60038010T2 (de)
DK (1) DK1168934T3 (de)
ES (1) ES2298135T3 (de)
WO (1) WO2000060956A1 (de)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716445B2 (en) 1999-04-12 2004-04-06 Cornell Research Foundation, Inc. Hydrogel entrapping therapeutic agent and stent with coating comprising this
WO2000060956A1 (en) * 1999-04-12 2000-10-19 Cornell Research Foundation, Inc. Hydrogel-forming system with hydrophobic and hydrophilic components
US6592895B2 (en) 2001-08-02 2003-07-15 Cornell Research Foundation, Inc. Biodegradable polyhydric alcohol esters
US20050064587A1 (en) * 2001-09-07 2005-03-24 Lawrence Rosenberg Pancreatic small cells and uses thereof
US7037983B2 (en) 2002-06-14 2006-05-02 Kimberly-Clark Worldwide, Inc. Methods of making functional biodegradable polymers
JP3742842B2 (ja) * 2002-06-17 2006-02-08 独立行政法人産業技術総合研究所 生分解性ポリ乳酸樹脂組成物
US7744913B2 (en) * 2002-06-24 2010-06-29 Incept, Llc Fillers and methods for displacing tissues to improve radiological outcomes
AU2002950340A0 (en) 2002-07-23 2002-09-12 Commonwealth Scientific And Industrial Research Organisation Biodegradable polyurethane/urea compositions
WO2004014969A1 (en) * 2002-08-09 2004-02-19 Ottawa Health Research Institute Bio-synthetic matrix and uses thereof
MXPA05002669A (es) * 2002-09-13 2005-08-19 Ocular Sciences Inc Dispositivos y metodos para mejorar la vision.
EP1583520A4 (de) * 2003-01-16 2007-05-23 Cornell Res Foundation Inc Teilweise biologisch abbaubares temperatur- und ph-empfindliches hydrogel
US8545830B2 (en) * 2003-03-24 2013-10-01 University Of Tennessee Research Foundation Multi-functional polymeric materials and their uses
EP1682161A4 (de) * 2003-10-29 2011-12-07 Gentis Inc Polymerisierbare emulsionen für die gewebeherstellung
US20050119762A1 (en) * 2003-11-03 2005-06-02 Peter Zilla Hydrogel providing cell-specific ingrowth
WO2005085312A1 (en) * 2004-03-03 2005-09-15 Commonwealth Scientific And Industrial Research Organisation Biocompatible polymer compositions for dual or multistaged curing
WO2005095507A1 (en) * 2004-03-17 2005-10-13 Ciphergen Biosystems, Inc. Photocrosslinked hydrogel blend surface coatings
EP1732619A1 (de) 2004-03-26 2006-12-20 SurModics, Inc. Zusammensetzung und verfahren zur herstellung von biokompatiblen oberflächen
GB0407661D0 (en) * 2004-04-03 2004-05-05 Univ Hull Liquid crystalline interpenetrating polymer networks
JP4599550B2 (ja) * 2004-04-09 2010-12-15 国立大学法人 東京医科歯科大学 ナノゲル工学によるハイブリッドゲルの調製とバイオマテリアル応用
JP5026956B2 (ja) * 2004-05-12 2012-09-19 サーモディクス,インコーポレイティド 医療用具のための天然生分解性多糖コーティング
US8246993B2 (en) 2004-06-10 2012-08-21 Cytogel Pharma, Llc Advantageous hydrogel composition
US7446131B1 (en) 2004-06-10 2008-11-04 The United States Of America As Represented By The Secretary Of Agriculture Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making
US20060013886A1 (en) 2004-06-28 2006-01-19 Daqing Wu Injectable microspheres
US7235592B2 (en) * 2004-10-12 2007-06-26 Zimmer Gmbh PVA hydrogel
WO2006091706A1 (en) * 2005-02-23 2006-08-31 Zimmer Technology, Inc. Blend hydrogels and methods of making
US20060222596A1 (en) 2005-04-01 2006-10-05 Trivascular, Inc. Non-degradable, low swelling, water soluble radiopaque hydrogel polymer
EP1945690B1 (de) * 2005-09-20 2016-07-27 Polynovo Biomaterials Pty Limited Kettenverlängerungsmittel
ATE454908T1 (de) * 2005-09-21 2010-01-15 Surmodics Inc In situ okklusionszusammensetzungen mit natürlichen biologisch abbaubaren polysacchariden
WO2007040557A1 (en) * 2005-09-21 2007-04-12 Surmodics, Inc. Coatings and articles including natural biodegradable polysaccharides
US20070098799A1 (en) * 2005-10-28 2007-05-03 Zimmer, Inc. Mineralized Hydrogels and Methods of Making and Using Hydrogels
AU2006321809A1 (en) * 2005-12-07 2007-06-14 Zimmer, Inc. Methods of bonding or modifying hydrogels using irradiation
US20070141108A1 (en) * 2005-12-20 2007-06-21 Zimmer, Inc. Fiber-reinforced water-swellable articles
US8017107B2 (en) * 2005-12-22 2011-09-13 Zimmer, Inc. Perfluorocyclobutane crosslinked hydrogels
US20070182920A1 (en) * 2006-02-08 2007-08-09 Coopervision, Inc. Corneal Onlays and Related Methods
JP5123285B2 (ja) * 2006-03-14 2013-01-23 ノボザイムス バイオファーマ デーコー アクティーゼルスカブ アクリル化ヒアルロン酸
US8110242B2 (en) * 2006-03-24 2012-02-07 Zimmer, Inc. Methods of preparing hydrogel coatings
US8795709B2 (en) 2006-03-29 2014-08-05 Incept Llc Superabsorbent, freeze dried hydrogels for medical applications
US20070232762A1 (en) * 2006-03-31 2007-10-04 Depuy Products, Inc. Bearing material of medical implant having reduced wear rate and method for reducing wear rate
US7812098B2 (en) * 2006-03-31 2010-10-12 Depuy Products, Inc. Bearing material of medical implant having reduced wear rate and method for reducing wear rate
US7883520B2 (en) * 2006-04-10 2011-02-08 Forsight Labs, Llc Corneal epithelial pocket formation systems, components and methods
US7872068B2 (en) * 2006-05-30 2011-01-18 Incept Llc Materials formable in situ within a medical device
EP2049591A4 (de) * 2006-08-02 2009-08-19 Polynovo Biomaterials Pty Ltd Biokompatible polymerzusammensetzungen
US20110165236A1 (en) * 2006-09-22 2011-07-07 Biokey, Inc. Controlled release hydrogel formulation
US20080075785A1 (en) * 2006-09-22 2008-03-27 San-Laung Chow Controlled release hydrogel formulation
US20080154241A1 (en) * 2006-12-07 2008-06-26 Burkstrand Michael J Latent stabilization of bioactive agents releasable from implantable medical articles
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
US7731988B2 (en) 2007-08-03 2010-06-08 Zimmer, Inc. Multi-polymer hydrogels
US20090043398A1 (en) * 2007-08-09 2009-02-12 Zimmer, Inc. Method of producing gradient articles by centrifugation molding or casting
WO2009029049A1 (en) * 2007-08-30 2009-03-05 National University Of Singapore A bone and/or dental cement composition and uses thereof
US8062739B2 (en) * 2007-08-31 2011-11-22 Zimmer, Inc. Hydrogels with gradient
EP2195361B1 (de) * 2007-10-03 2014-11-26 Polynovo Biomaterials Limited Hochmodulige polyurethan- und polyurethan/harnstoff-zusammensetzungen
US7947784B2 (en) 2007-11-16 2011-05-24 Zimmer, Inc. Reactive compounding of hydrogels
US8034362B2 (en) * 2008-01-04 2011-10-11 Zimmer, Inc. Chemical composition of hydrogels for use as articulating surfaces
CA2719222C (en) 2008-03-28 2018-07-24 Surmodics, Inc. Insertable medical devices having microparticulate-associated elastic substrates and methods for drug delivery
WO2009137689A2 (en) 2008-05-07 2009-11-12 Surmodics, Inc. Delivery of nucleic acid complexes from particles
US20100087920A1 (en) * 2008-10-07 2010-04-08 Forsight Labs, Llc Corneal Onlay Lenses and Related Methods for Improving Vision of Presbyopic Patients
CN102395401B (zh) 2009-02-12 2015-08-19 因赛普特有限责任公司 经由水凝胶塞的药物递送
CA2977830C (en) 2009-05-04 2019-09-17 Incept, Llc Biomaterials for track and puncture closure
JP2012235797A (ja) 2009-09-18 2012-12-06 Terumo Corp ステント
EP2498764B1 (de) 2009-11-09 2017-09-06 Spotlight Technology Partners LLC Fragmentierte hydrogele
JP5864429B2 (ja) 2009-11-09 2016-02-17 スポットライト テクノロジー パートナーズ エルエルシーSpotlight Technology Partners Llc 架橋ヒドロゲル組成物、ヒドロゲル組成物の形成方法、及びキット
AU2010340067B2 (en) 2009-12-15 2015-03-19 Incept, Llc Implants and biodegradable fiducial markers
EP2574172A4 (de) 2010-05-21 2013-10-30 Cytogel Pharma Llc Materialien und verfahren zur behandlung von entzündungen
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
US8901092B2 (en) 2010-12-29 2014-12-02 Surmodics, Inc. Functionalized polysaccharides for active agent delivery
SG10201608671SA (en) 2011-07-18 2016-12-29 Harvard College Engineered Microbe-Targeting Molecules and Uses Thereof
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
RU2521194C2 (ru) * 2011-11-16 2014-06-27 Общество с ограниченной ответственностью предприятие "Репер" Матрица для клеточной трансплантологии
EP3613413A1 (de) 2011-12-05 2020-02-26 Incept, LLC Medizinische organogelprozesse und -zusammensetzungen
EP2978408B1 (de) * 2013-03-27 2019-01-16 Centre Hospitaller Universitaire Vaudois (CHUV) Pharmazeutische formulierung zur verwendung bei der behandlung und/oder prävention von restenose
AU2014268603B2 (en) 2013-05-21 2018-03-22 President And Fellows Of Harvard College Engineered heme-binding compositions and uses thereof
EP3546474B1 (de) 2013-12-18 2021-07-07 President and Fellows of Harvard College Crp-erfassung/-detektion von grampositiven bakterien
US10519443B2 (en) 2014-09-08 2019-12-31 University Of Iowa Research Foundation Microrna inhibitor system and methods of use thereof
US10435457B2 (en) 2015-08-06 2019-10-08 President And Fellows Of Harvard College Microbe-binding molecules and uses thereof
US10273476B2 (en) 2016-04-30 2019-04-30 University Of Iowa Research Foundation MicroRNA-200 based approaches for modulating bone formation inhibition and bone regeneration
MX2019006868A (es) * 2016-12-16 2019-09-23 Du Pont Derivados de polisacáridos anfifílicos y composiciones que los comprenden.
CN106913915B (zh) * 2017-04-21 2019-05-31 浙江大学 一种自愈合支架复合涂层及其制备方法和应用
CN107216450B (zh) * 2017-04-21 2019-06-11 浙江大学 一种自愈合抗菌涂层及其制备方法和应用
US10975121B2 (en) 2017-06-24 2021-04-13 Cytogel Pharma, Llc Analgesic mu-opioid receptor binding peptide pharmaceutical formulations and uses thereof
CN110108537B (zh) * 2018-02-01 2020-08-25 中国科学技术大学 一种用于生物组织包埋的包埋剂和包埋方法
CN108359054A (zh) * 2018-02-10 2018-08-03 西北大学 一种葡萄糖敏感型全互穿网络水凝胶及其制备方法
CN116496475B (zh) * 2023-06-26 2023-09-22 海杰亚(北京)医疗器械有限公司 用于栓塞微球的可降解交联剂、可降解栓塞微球及其制备方法和药物组合物

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4002173A (en) 1974-07-23 1977-01-11 International Paper Company Diester crosslinked polyglucan hydrogels and reticulated sponges thereof
US4032488A (en) * 1975-10-03 1977-06-28 Meito Sangyo Kabushiki Kaisha Dextran ester-olefin compound copolymer and process for preparing same
SU729197A1 (ru) * 1977-07-05 1980-04-25 Ордена Ленина Институт Элементоорганических Соединений Ан Ссср Сшитые сополимеры хитозана
US4277582A (en) * 1978-03-03 1981-07-07 Ciba-Geigy Corporation Water-insoluble hydrophilic copolymers
GB8418772D0 (en) 1984-07-24 1984-08-30 Geistlich Soehne Ag Chemical substances
US4857602A (en) * 1986-09-05 1989-08-15 American Cyanamid Company Bioabsorbable surgical suture coating
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5626863A (en) 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5529914A (en) * 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5210111A (en) * 1991-08-22 1993-05-11 Ciba-Geigy Corporation Crosslinked hydrogels derived from hydrophilic polymer backbones
EP0610441A4 (de) 1991-10-29 1996-01-10 Clover Cons Ltd Vernetzbare polysacchariden, polykationen und lipiden verwendbar zum einkapseln und abgabe von arzneimitteln.
DE69328523T2 (de) * 1992-02-13 2000-09-21 Surmodics Inc Immobilisierung eines chemischen spezies in einer vernetzten matrix
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
EP0627911B1 (de) 1992-02-28 2000-10-25 Board Of Regents The University Of Texas System Photopolymerinierbare, biologisch abbaubare hydrogele als gewebekontaktmaterialien und trägerstoffe für kontrollierte freisetzung
IT1260154B (it) 1992-07-03 1996-03-28 Lanfranco Callegaro Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)
US5514379A (en) 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
ATE151778T1 (de) 1992-11-30 1997-05-15 Ciba Geigy Ag Polymerisierbare kohlenhydratester, polymere daraus und deren verwendung
KR0141431B1 (ko) 1994-05-17 1998-07-01 김상웅 생분해성 하이드로겔 고분자
TW291481B (en) * 1994-10-27 1996-11-21 Novartis Erfind Verwalt Gmbh Poly-unsaturated carbohydrate derivatives, polymers thereof and their use
US5607686A (en) 1994-11-22 1997-03-04 United States Surgical Corporation Polymeric composition
US5540929A (en) 1995-03-08 1996-07-30 Board Of Trustees Operating Michigan State University Polysaccharides grafted with aliphatic polyesters derived from cyclic esters
US5900245A (en) * 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
CA2228118A1 (en) * 1995-07-28 1997-02-13 Focal, Inc. Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatments agents
JP3572144B2 (ja) * 1996-05-31 2004-09-29 名糖産業株式会社 デキストランエステル共重合体
US5854382A (en) * 1997-08-18 1998-12-29 Meadox Medicals, Inc. Bioresorbable compositions for implantable prostheses
JP4330268B2 (ja) * 1997-09-03 2009-09-16 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 新規な生体模倣ヒドロゲル材料
AU5571399A (en) * 1998-08-31 2000-03-21 Cornell Research Foundation Inc. Dextran-maleic acid monoesters and hydrogels based thereon
WO2000060956A1 (en) 1999-04-12 2000-10-19 Cornell Research Foundation, Inc. Hydrogel-forming system with hydrophobic and hydrophilic components
US6716445B2 (en) 1999-04-12 2004-04-06 Cornell Research Foundation, Inc. Hydrogel entrapping therapeutic agent and stent with coating comprising this
WO2001015627A1 (en) * 1999-09-02 2001-03-08 Alcon Universal Ltd. Hydrophobically-bound, hydrophilic coating compositions for surgical implants
US6503538B1 (en) 2000-08-30 2003-01-07 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes
US6592895B2 (en) 2001-08-02 2003-07-15 Cornell Research Foundation, Inc. Biodegradable polyhydric alcohol esters

Also Published As

Publication number Publication date
US20020161169A1 (en) 2002-10-31
US20030125509A1 (en) 2003-07-03
US6583219B2 (en) 2003-06-24
DE60038010D1 (de) 2008-03-27
WO2000060956A1 (en) 2000-10-19
JP4558213B2 (ja) 2010-10-06
AU3877200A (en) 2000-11-14
US6709668B2 (en) 2004-03-23
JP2002541308A (ja) 2002-12-03
EP1168934A1 (de) 2002-01-09
CA2368617C (en) 2010-03-16
US20040122165A1 (en) 2004-06-24
EP1168934B1 (de) 2008-02-13
CA2368617A1 (en) 2000-10-19
US6388047B1 (en) 2002-05-14
ES2298135T3 (es) 2008-05-16
US6916857B2 (en) 2005-07-12
EP1168934A4 (de) 2004-12-08
ATE386075T1 (de) 2008-03-15
DE60038010T2 (de) 2009-03-05

Similar Documents

Publication Publication Date Title
DK1168934T3 (da) Hydrogeldannende system med hydrofobe og hydrofile komponenter
DE69721265D1 (de) Hydrolysierbare hydrogele zur gesteuerten freisetzung
FI103381B1 (fi) Hyaluronihapon veteen liukenemattomia geelejä ja menetelmä sen valmistamiseksi
US7049351B2 (en) Moldings and preparation and uses thereof
AU5469990A (en) Water soluble high molecular polymerized drug preparation
AU590565B2 (en) Controlled release delivery system for macromolecules
DE3751647D1 (de) Biologisch abbaubare Mikrokugeln als Träger für Makromoleküle
MX193604B (es) Hidrogeles hidrofilicos altamente hinchables
WO2002087001A3 (en) Polymer electrolyte membrane
BR9206222A (pt) Catalisador de ácido de lewis imobilizado de preparação de um catalisador imobilizado moldado, processo para polimerizar monômero cationicamente polimerizável, composição e polímero cationicamente polimerizado.
CA2336138A1 (en) Polymers for delivering nitric oxide in vivo
TW200502011A (en) Superabsorbent polymer with high permeability
BR0010083A (pt) Processo de preparação de poliolefinas, poliolefinas comportando grupos ácidos parcialmente neutralizados, utilização de poliolefinas, e, processo de extrusão em espuma
DE59504351D1 (de) Implantierbare formkörper zur verabreichung von wirkstoffen an pflanzen
ATE410473T1 (de) Polymerstrukturen mit einem hydrophil/lipophil- system
ZA957471B (en) Contrast agents
MXPA02009064A (es) Pelicula superabsorbente a base de polisacarido..
WO2005065712A3 (en) Complexes having adjuvant activity
EP1106189A3 (de) Lichthärtender Gewebeklebstoff
BR0014638A (pt) Composição polimérica superabsorvente, artigo absorvente, e processo para preparar um artigo absorvente
AU8085691A (en) Activation of polysaccharide hydrolase
EP0331052A3 (de) Verfahren zur Imidierung von Acrylpolymeren
ES481386A1 (es) Procedimiento de preparacion de polimeros hidrosolubles.
ES481385A1 (es) Procedimiento de preparacion de polimeros organicos.
EP1077200A3 (de) Aus wasserlöslichen radikalpolymerisierbaren Monomeren erhaltenes Polymer, dessen Verfahren zur Herstellung und dies enthaltendes Flockungsmittel