DE60038010D1 - Hydrogel-formendes system mit hydrophoben und hydrophilen komponenten - Google Patents

Hydrogel-formendes system mit hydrophoben und hydrophilen komponenten

Info

Publication number
DE60038010D1
DE60038010D1 DE60038010T DE60038010T DE60038010D1 DE 60038010 D1 DE60038010 D1 DE 60038010D1 DE 60038010 T DE60038010 T DE 60038010T DE 60038010 T DE60038010 T DE 60038010T DE 60038010 D1 DE60038010 D1 DE 60038010D1
Authority
DE
Germany
Prior art keywords
hydrophobic
hydrogel
forming system
hydrophilic components
unsaturated group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60038010T
Other languages
English (en)
Other versions
DE60038010T2 (de
Inventor
Chee-Youb Won
Yeli Zhang
Chih-Chang Chu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cornell Research Foundation Inc
Original Assignee
Cornell Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Research Foundation Inc filed Critical Cornell Research Foundation Inc
Publication of DE60038010D1 publication Critical patent/DE60038010D1/de
Application granted granted Critical
Publication of DE60038010T2 publication Critical patent/DE60038010T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/02—Dextran; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/64—Macromolecular compounds not provided for by groups C08G18/42 - C08G18/63
    • C08G18/6484—Polysaccharides and derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/81—Unsaturated isocyanates or isothiocyanates
    • C08G18/8108—Unsaturated isocyanates or isothiocyanates having only one isocyanate or isothiocyanate group
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/06—Unsaturated polyesters
    • C08L67/07—Unsaturated polyesters having terminal carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2210/00—Compositions for preparing hydrogels
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S525/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S525/937—Utility as body contact e.g. implant, contact lens or I.U.D.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Colloid Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Graft Or Block Polymers (AREA)
DE60038010T 1999-04-12 2000-03-20 Hydrogel-formendes system mit hydrophoben und hydrophilen komponenten Expired - Lifetime DE60038010T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12880399P 1999-04-12 1999-04-12
US128803P 1999-04-12
PCT/US2000/006416 WO2000060956A1 (en) 1999-04-12 2000-03-20 Hydrogel-forming system with hydrophobic and hydrophilic components

Publications (2)

Publication Number Publication Date
DE60038010D1 true DE60038010D1 (de) 2008-03-27
DE60038010T2 DE60038010T2 (de) 2009-03-05

Family

ID=22437052

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60038010T Expired - Lifetime DE60038010T2 (de) 1999-04-12 2000-03-20 Hydrogel-formendes system mit hydrophoben und hydrophilen komponenten

Country Status (10)

Country Link
US (4) US6388047B1 (de)
EP (1) EP1168934B1 (de)
JP (1) JP4558213B2 (de)
AT (1) ATE386075T1 (de)
AU (1) AU3877200A (de)
CA (1) CA2368617C (de)
DE (1) DE60038010T2 (de)
DK (1) DK1168934T3 (de)
ES (1) ES2298135T3 (de)
WO (1) WO2000060956A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111196863A (zh) * 2016-12-16 2020-05-26 杜邦工业生物科学美国有限责任公司 两亲多糖衍生物和包含其的组合物

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1168934T3 (da) 1999-04-12 2008-05-13 Cornell Res Foundation Inc Hydrogeldannende system med hydrofobe og hydrofile komponenter
US6716445B2 (en) * 1999-04-12 2004-04-06 Cornell Research Foundation, Inc. Hydrogel entrapping therapeutic agent and stent with coating comprising this
JP4335002B2 (ja) * 2001-08-02 2009-09-30 コーネル・リサーチ・ファンデーション・インコーポレイテッド 生分解性多価アルコールエステル
US20050064587A1 (en) * 2001-09-07 2005-03-24 Lawrence Rosenberg Pancreatic small cells and uses thereof
US7037983B2 (en) 2002-06-14 2006-05-02 Kimberly-Clark Worldwide, Inc. Methods of making functional biodegradable polymers
JP3742842B2 (ja) * 2002-06-17 2006-02-08 独立行政法人産業技術総合研究所 生分解性ポリ乳酸樹脂組成物
ES2424348T3 (es) * 2002-06-24 2013-10-01 Incept, Llc Cargas y métodos para desplazar tejidos para mejorar los resultados radiológicos
AU2002950340A0 (en) * 2002-07-23 2002-09-12 Commonwealth Scientific And Industrial Research Organisation Biodegradable polyurethane/urea compositions
KR101053792B1 (ko) * 2002-08-09 2011-08-04 내셔날 리서치 카운실 오브 캐나다 생체 합성 매트릭스 및 그의 용도
AU2003270593A1 (en) * 2002-09-13 2004-04-30 Ocular Sciences, Inc. Devices and methods for improving vision
EP1583520A4 (de) * 2003-01-16 2007-05-23 Cornell Res Foundation Inc Teilweise biologisch abbaubares temperatur- und ph-empfindliches hydrogel
WO2004085712A2 (en) 2003-03-24 2004-10-07 Penn State Research Foundation Multi-functional polymeric materials and their uses
JP2007509716A (ja) * 2003-10-29 2007-04-19 ジェンティス インコーポレイテッド 組織工学用の重合可能なエマルション
ATE524203T1 (de) * 2003-11-03 2011-09-15 Medtronic Inc Hydrogel für zellspezifisches einwachsen
US8729202B2 (en) * 2004-03-03 2014-05-20 Polynovo Biomaterials Pty Limited Biocompatible polymer compositions for dual or multi staged curing
CA2560016A1 (en) * 2004-03-17 2005-10-13 Ciphergen Biosystems, Inc. Photocrosslinked hydrogel blend surface coatings
EP2329852A1 (de) 2004-03-26 2011-06-08 SurModics, Inc. Zusammensetzung und Verfahren zur Herstellung von biokompatiblen Oberflächen
GB0407661D0 (en) * 2004-04-03 2004-05-05 Univ Hull Liquid crystalline interpenetrating polymer networks
JP4599550B2 (ja) * 2004-04-09 2010-12-15 国立大学法人 東京医科歯科大学 ナノゲル工学によるハイブリッドゲルの調製とバイオマテリアル応用
CA2564588A1 (en) * 2004-05-12 2005-12-01 Surmodics, Inc. Natural biodegradable polysaccharide coatings for medical articles
US7446131B1 (en) 2004-06-10 2008-11-04 The United States Of America As Represented By The Secretary Of Agriculture Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making
US8246993B2 (en) 2004-06-10 2012-08-21 Cytogel Pharma, Llc Advantageous hydrogel composition
US20060013886A1 (en) 2004-06-28 2006-01-19 Daqing Wu Injectable microspheres
US7235592B2 (en) * 2004-10-12 2007-06-26 Zimmer Gmbh PVA hydrogel
WO2006091706A1 (en) * 2005-02-23 2006-08-31 Zimmer Technology, Inc. Blend hydrogels and methods of making
US20060222596A1 (en) 2005-04-01 2006-10-05 Trivascular, Inc. Non-degradable, low swelling, water soluble radiopaque hydrogel polymer
WO2007033418A1 (en) 2005-09-20 2007-03-29 Polynovo Biomaterials Pty Limited Chain extenders
WO2007040557A1 (en) * 2005-09-21 2007-04-12 Surmodics, Inc. Coatings and articles including natural biodegradable polysaccharides
US20070071792A1 (en) * 2005-09-21 2007-03-29 Varner Signe E In VIVO formed matrices including natural biodegradale polysaccharides and ophthalmic uses thereof
US20070098799A1 (en) * 2005-10-28 2007-05-03 Zimmer, Inc. Mineralized Hydrogels and Methods of Making and Using Hydrogels
US8262730B2 (en) * 2005-12-07 2012-09-11 Zimmer, Inc. Methods of bonding or modifying hydrogels using irradiation
US20070141108A1 (en) * 2005-12-20 2007-06-21 Zimmer, Inc. Fiber-reinforced water-swellable articles
DE602006017160D1 (de) * 2005-12-22 2010-11-11 Zimmer Inc Perfluorcyclobutanvernetzte Hydrogele
TW200740416A (en) * 2006-02-08 2007-11-01 Coopervision Inc Corneal onlays and related methods
ES2339181T3 (es) * 2006-03-14 2010-05-17 Novozymes Biopharma Dk A/S Acido hialuronico acrilatado.
US8110242B2 (en) * 2006-03-24 2012-02-07 Zimmer, Inc. Methods of preparing hydrogel coatings
US8795709B2 (en) 2006-03-29 2014-08-05 Incept Llc Superabsorbent, freeze dried hydrogels for medical applications
US7812098B2 (en) * 2006-03-31 2010-10-12 Depuy Products, Inc. Bearing material of medical implant having reduced wear rate and method for reducing wear rate
US20070232762A1 (en) * 2006-03-31 2007-10-04 Depuy Products, Inc. Bearing material of medical implant having reduced wear rate and method for reducing wear rate
US7883520B2 (en) * 2006-04-10 2011-02-08 Forsight Labs, Llc Corneal epithelial pocket formation systems, components and methods
US7872068B2 (en) * 2006-05-30 2011-01-18 Incept Llc Materials formable in situ within a medical device
AU2007281035A1 (en) * 2006-08-02 2008-02-07 Polynovo Biomaterials Pty Ltd Biocompatible polymer compositions
US20080075785A1 (en) * 2006-09-22 2008-03-27 San-Laung Chow Controlled release hydrogel formulation
US20110165236A1 (en) * 2006-09-22 2011-07-07 Biokey, Inc. Controlled release hydrogel formulation
US20080154241A1 (en) * 2006-12-07 2008-06-26 Burkstrand Michael J Latent stabilization of bioactive agents releasable from implantable medical articles
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
US7731988B2 (en) 2007-08-03 2010-06-08 Zimmer, Inc. Multi-polymer hydrogels
US20090043398A1 (en) * 2007-08-09 2009-02-12 Zimmer, Inc. Method of producing gradient articles by centrifugation molding or casting
US20110136935A1 (en) * 2007-08-30 2011-06-09 National University Of Singapore Bone and/or dental cement composition and uses thereof
US8062739B2 (en) * 2007-08-31 2011-11-22 Zimmer, Inc. Hydrogels with gradient
CN101896526B (zh) * 2007-10-03 2013-09-11 新型聚合物生物材料有限公司 高模量聚氨酯和聚氨酯/脲组合物
US7947784B2 (en) 2007-11-16 2011-05-24 Zimmer, Inc. Reactive compounding of hydrogels
US8034362B2 (en) * 2008-01-04 2011-10-11 Zimmer, Inc. Chemical composition of hydrogels for use as articulating surfaces
JP5667559B2 (ja) 2008-03-28 2015-02-12 サーモディクス，インコーポレイティド 微粒子が配置された弾性基質を有する挿入可能な医療機器、および薬物送達方法
CA2723192A1 (en) 2008-05-07 2009-11-12 Surmodics, Inc. Delivery of nucleic acid complexes from particles
US20100087920A1 (en) * 2008-10-07 2010-04-08 Forsight Labs, Llc Corneal Onlay Lenses and Related Methods for Improving Vision of Presbyopic Patients
CA2750242C (en) 2009-02-12 2018-05-22 Incept, Llc Drug delivery through hydrogel plugs
EP2427233B1 (de) 2009-05-04 2016-12-21 Incept Llc Biomaterialien für bahn- und punktionsverschluss
JP2012235797A (ja) 2009-09-18 2012-12-06 Terumo Corp ステント
CA2780294C (en) 2009-11-09 2018-01-16 Spotlight Technology Partners Llc Polysaccharide based hydrogels
CA2780274C (en) 2009-11-09 2018-06-26 Spotlight Technology Partners Llc Fragmented hydrogels
EP3960215B1 (de) 2009-12-15 2024-10-16 Incept, LLC Implantate und biologisch abbaubare bezugsmarkierungen
EP2574172A4 (de) 2010-05-21 2013-10-30 Cytogel Pharma Llc Materialien und verfahren zur behandlung von entzündungen
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
US8901092B2 (en) 2010-12-29 2014-12-02 Surmodics, Inc. Functionalized polysaccharides for active agent delivery
CA2842321C (en) 2011-07-18 2022-05-03 President And Fellows Of Harvard College Engineered microbe-targeting molecules and uses thereof
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
RU2521194C2 (ru) * 2011-11-16 2014-06-27 Общество с ограниченной ответственностью предприятие "Репер" Матрица для клеточной трансплантологии
AU2012347926B2 (en) 2011-12-05 2018-03-15 Incept, Llc Medical organogel processes and compositions
WO2014154804A1 (en) * 2013-03-27 2014-10-02 Centre Hospitalier Universitaire Vaudois (C.H.U.V) Pharmaceutical formulation for use in the treatment and/or prevention of restenosis
CA2913155A1 (en) 2013-05-21 2014-11-27 President And Fellows Of Harvard College Engineered heme-binding compositions and uses thereof
EP3083658B1 (de) 2013-12-18 2019-05-08 President and Fellows of Harvard College Detektion gram-positiver bakterien mit crp
US10519443B2 (en) 2014-09-08 2019-12-31 University Of Iowa Research Foundation Microrna inhibitor system and methods of use thereof
EP3763378A1 (de) 2015-08-06 2021-01-13 President and Fellows of Harvard College Verbesserte mikrobenbindende moleküle und verwendungen davon
US10273476B2 (en) 2016-04-30 2019-04-30 University Of Iowa Research Foundation MicroRNA-200 based approaches for modulating bone formation inhibition and bone regeneration
CN106913915B (zh) * 2017-04-21 2019-05-31 浙江大学 一种自愈合支架复合涂层及其制备方法和应用
CN107216450B (zh) * 2017-04-21 2019-06-11 浙江大学 一种自愈合抗菌涂层及其制备方法和应用
US10975121B2 (en) 2017-06-24 2021-04-13 Cytogel Pharma, Llc Analgesic mu-opioid receptor binding peptide pharmaceutical formulations and uses thereof
CN110108537B (zh) * 2018-02-01 2020-08-25 中国科学技术大学 一种用于生物组织包埋的包埋剂和包埋方法
CN108359054A (zh) * 2018-02-10 2018-08-03 西北大学 一种葡萄糖敏感型全互穿网络水凝胶及其制备方法
CN116496475B (zh) * 2023-06-26 2023-09-22 海杰亚（北京）医疗器械有限公司 用于栓塞微球的可降解交联剂、可降解栓塞微球及其制备方法和药物组合物

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4002173A (en) 1974-07-23 1977-01-11 International Paper Company Diester crosslinked polyglucan hydrogels and reticulated sponges thereof
US4032488A (en) * 1975-10-03 1977-06-28 Meito Sangyo Kabushiki Kaisha Dextran ester-olefin compound copolymer and process for preparing same
SU729197A1 (ru) * 1977-07-05 1980-04-25 Ордена Ленина Институт Элементоорганических Соединений Ан Ссср Сшитые сополимеры хитозана
US4277582A (en) * 1978-03-03 1981-07-07 Ciba-Geigy Corporation Water-insoluble hydrophilic copolymers
GB8418772D0 (en) 1984-07-24 1984-08-30 Geistlich Soehne Ag Chemical substances
US4857602A (en) * 1986-09-05 1989-08-15 American Cyanamid Company Bioabsorbable surgical suture coating
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5626863A (en) 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5529914A (en) * 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5210111A (en) * 1991-08-22 1993-05-11 Ciba-Geigy Corporation Crosslinked hydrogels derived from hydrophilic polymer backbones
JPH07503943A (ja) 1991-10-29 1995-04-27 クローバー　コンソリデイテッド，リミテッド 封入及び薬剤放出に有用な架橋性の多糖類、ポリカチオン及び脂質
JP3455217B2 (ja) * 1992-02-13 2003-10-14 バイオ−メトリック システムズ インコーポレイテッド 架橋マトリックス中の化学種の固定
PT627911E (pt) 1992-02-28 2001-04-30 Univ Texas Hidrogeis biodegradaveis fotopolimerizaveis como materiais de contacto de tecidos e veiculos de libertacao controlada
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
IT1260154B (it) 1992-07-03 1996-03-28 Lanfranco Callegaro Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)
US5514379A (en) 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
ES2102186T3 (es) 1992-11-30 1997-07-16 Ciba Geigy Ag Esteres de hidratos de carbono polimerizables, polimeros de los mismos y su empleo.
KR0141431B1 (ko) 1994-05-17 1998-07-01 김상웅 생분해성 하이드로겔 고분자
TW291481B (en) * 1994-10-27 1996-11-21 Novartis Erfind Verwalt Gmbh Poly-unsaturated carbohydrate derivatives, polymers thereof and their use
US5607686A (en) 1994-11-22 1997-03-04 United States Surgical Corporation Polymeric composition
US5540929A (en) 1995-03-08 1996-07-30 Board Of Trustees Operating Michigan State University Polysaccharides grafted with aliphatic polyesters derived from cyclic esters
US5900245A (en) * 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
JPH11510837A (ja) * 1995-07-28 1999-09-21 フォーカル，インコーポレイテッド 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル
JP3572144B2 (ja) * 1996-05-31 2004-09-29 名糖産業株式会社 デキストランエステル共重合体
US5854382A (en) * 1997-08-18 1998-12-29 Meadox Medicals, Inc. Bioresorbable compositions for implantable prostheses
AU9216998A (en) * 1997-09-03 1999-03-22 Regents Of The University Of California, The Novel biomimetic hydrogel materials
DE69925757T2 (de) * 1998-08-31 2006-03-23 Cornell Research Foundation, Inc. Dextran-maleinsäuremonoester und hydrogele daraus
DK1168934T3 (da) 1999-04-12 2008-05-13 Cornell Res Foundation Inc Hydrogeldannende system med hydrofobe og hydrofile komponenter
US6716445B2 (en) 1999-04-12 2004-04-06 Cornell Research Foundation, Inc. Hydrogel entrapping therapeutic agent and stent with coating comprising this
WO2001015627A1 (en) * 1999-09-02 2001-03-08 Alcon Universal Ltd. Hydrophobically-bound, hydrophilic coating compositions for surgical implants
US6503538B1 (en) 2000-08-30 2003-01-07 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes
JP4335002B2 (ja) 2001-08-02 2009-09-30 コーネル・リサーチ・ファンデーション・インコーポレイテッド 生分解性多価アルコールエステル

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111196863A (zh) * 2016-12-16 2020-05-26 杜邦工业生物科学美国有限责任公司 两亲多糖衍生物和包含其的组合物

Also Published As

Publication number Publication date
US20030125509A1 (en) 2003-07-03
CA2368617C (en) 2010-03-16
ES2298135T3 (es) 2008-05-16
US20020161169A1 (en) 2002-10-31
CA2368617A1 (en) 2000-10-19
EP1168934A1 (de) 2002-01-09
US6583219B2 (en) 2003-06-24
WO2000060956A1 (en) 2000-10-19
ATE386075T1 (de) 2008-03-15
JP4558213B2 (ja) 2010-10-06
US6388047B1 (en) 2002-05-14
EP1168934A4 (de) 2004-12-08
AU3877200A (en) 2000-11-14
JP2002541308A (ja) 2002-12-03
DE60038010T2 (de) 2009-03-05
US20040122165A1 (en) 2004-06-24
US6709668B2 (en) 2004-03-23
EP1168934B1 (de) 2008-02-13
DK1168934T3 (da) 2008-05-13
US6916857B2 (en) 2005-07-12

Similar Documents

Publication Publication Date Title
DE60038010D1 (de) Hydrogel-formendes system mit hydrophoben und hydrophilen komponenten
Pettinelli et al. Entrapment of chitosan, pectin or κ-carrageenan within methacrylate based hydrogels: effect on swelling and mechanical properties
FI103381B1 (fi) Hyaluronihapon veteen liukenemattomia geelejä ja menetelmä sen valmistamiseksi
ATE238068T1 (de) Hydrolysierbare hydrogele zur gesteuerten freisetzung
AU640927B2 (en) Water soluble high molecular polymerized drug preparation
BR9206222A (pt) Catalisador de ácido de lewis imobilizado de preparação de um catalisador imobilizado moldado, processo para polimerizar monômero cationicamente polimerizável, composição e polímero cationicamente polimerizado.
AU590565B2 (en) Controlled release delivery system for macromolecules
ES547195A0 (es) Un procedimiento para la preparacion de un polisilaxano macromero con grupos polimerizables no saturados.
DE59208029D1 (de) Lösliche Katalysatorsysteme zur Herstellung von Polyalk-1-enen mit hohen Molmassen
CA2117584A1 (en) Gels for Encapsulation of Biological Materials
AU8755791A (en) Biocompatible microcapsules
SE8503486D0 (sv) Tverbundna geler av hyaluronsyra, metod for framstellning av sadana geler och produkter som innehaller sadana geler
MD20020072A (en) Combination of antibiotic(s) - polymer and utilization there of
AU8679198A (en) Modified polylactide compositions, water-responsive, biodegradable films and fibers comprising polylactide and poly(vinyl alcohol) and methods for making the same
CA2264330A1 (en) Silicone hydrogel polymers
TW200502011A (en) Superabsorbent polymer with high permeability
DE68916707D1 (de) Verfahren zur Herstellung eines hydrophilen Polymers.
ES2054795T3 (es) Un producto de polimerizacion.
MX193604B (es) Hidrogeles hidrofilicos altamente hinchables
ES2092183T3 (es) Procedimiento para la preparacion de poli(tereftalato de butileno) a partir de residuos de poli(tereftalato de etileno).
DE59913412D1 (de) Verfahren zur herstellung einer wässrigen polymerdispersion, enthaltend einen emulgator mit phosphatgruppen
AU2205995A (en) Process for producing polymers with multi-modal molecular weight distributions
ATE239042T1 (de) Wasserlösliches arabinogalactan, das mit lipophilen gruppen derivatisiert ist
BR0014638A (pt) Composição polimérica superabsorvente, artigo absorvente, e processo para preparar um artigo absorvente
ES481386A1 (es) Procedimiento de preparacion de polimeros hidrosolubles.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition