DK1157030T3 - Enchinocanidin/carbohydratkomplekser - Google Patents

Enchinocanidin/carbohydratkomplekser

Info

Publication number
DK1157030T3
DK1157030T3 DK00917703T DK00917703T DK1157030T3 DK 1157030 T3 DK1157030 T3 DK 1157030T3 DK 00917703 T DK00917703 T DK 00917703T DK 00917703 T DK00917703 T DK 00917703T DK 1157030 T3 DK1157030 T3 DK 1157030T3
Authority
DK
Denmark
Prior art keywords
enchinocanidin
complex
carbohydrate
carbohydrate complexes
echinocandin
Prior art date
Application number
DK00917703T
Other languages
Danish (da)
English (en)
Inventor
Larry Arnold Larew
Nathaniel Milton
James Lawrence Sabatowski
Kenneth Philip Moder
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK1157030T3 publication Critical patent/DK1157030T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K9/00Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DK00917703T 1999-03-03 2000-03-02 Enchinocanidin/carbohydratkomplekser DK1157030T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12269299P 1999-03-03 1999-03-03
PCT/US2000/005508 WO2000052037A1 (fr) 1999-03-03 2000-03-02 Complexes d'echinocandine/glucide

Publications (1)

Publication Number Publication Date
DK1157030T3 true DK1157030T3 (da) 2003-12-22

Family

ID=22404173

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00917703T DK1157030T3 (da) 1999-03-03 2000-03-02 Enchinocanidin/carbohydratkomplekser

Country Status (18)

Country Link
US (3) US7041637B2 (fr)
EP (1) EP1157030B1 (fr)
JP (1) JP4272359B2 (fr)
KR (1) KR20020003864A (fr)
CN (1) CN1345333A (fr)
AT (1) ATE248187T1 (fr)
AU (1) AU772633B2 (fr)
BR (1) BR0008712A (fr)
CA (1) CA2362016A1 (fr)
DE (1) DE60004793T2 (fr)
DK (1) DK1157030T3 (fr)
ES (1) ES2204548T3 (fr)
HK (1) HK1040088B (fr)
IL (1) IL145187A0 (fr)
PT (1) PT1157030E (fr)
RU (1) RU2001126723A (fr)
WO (1) WO2000052037A1 (fr)
ZA (1) ZA200108004B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
CA2353930A1 (fr) 1998-12-09 2000-06-15 Eli Lilly And Company Purification de composes cyclopeptidiques d'echinocandine
AU771727B2 (en) 1999-03-03 2004-04-01 Eli Lilly And Company Processes for making pharmaceutical oral ECB formulations and compositions
KR20020003864A (ko) * 1999-03-03 2002-01-15 피터 지. 스트링거 에키노칸딘/탄수화물 착물
ATE338060T1 (de) 1999-03-03 2006-09-15 Lilly Co Eli Bildung und anionenaustausch von inneren kristallinen ammoniumsalzen des echinocandins b
WO2000051564A1 (fr) 1999-03-03 2000-09-08 Eli Lilly And Company Formulations pharmaceutiques d'echinocandine contenant des tensioactifs formant des micelles
US6482847B2 (en) * 2000-10-03 2002-11-19 Hoffmann-La Roche Inc. Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
JP2005053782A (ja) * 2001-08-31 2005-03-03 Fujisawa Pharmaceut Co Ltd 環状リポペプチド化合物の新規結晶
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
RU2284832C2 (ru) * 2004-08-30 2006-10-10 Николай Александрович Киселев Антимикробная композиция для перорального введения
KR101163160B1 (ko) * 2006-03-07 2012-07-17 드리테 파텐트포트폴리오 베타일리궁스게젤샤프트 엠베하 운트 코. 카게 보존제의 가용화물 및 이들의 제조 방법
EP2012788A4 (fr) * 2006-04-18 2010-05-26 Ekr Therapeutics Inc Compositions en bolus iv pre-melangees pretes a l'emploi et procedes d'utilisation
US9394340B2 (en) 2009-03-24 2016-07-19 Cadila Healthcare Limited Purification process for lipopeptides
CN102614491B (zh) 2011-01-31 2014-04-16 上海天伟生物制药有限公司 一种含有棘白菌素类抗真菌剂米卡芬净的药用组合物及其制备方法和用途
CN102614492B (zh) * 2011-01-31 2013-12-11 上海天伟生物制药有限公司 一种含有棘白菌素类抗真菌剂米卡芬净的液体药用组合物
CN102627689B (zh) * 2012-03-30 2014-08-06 上海天伟生物制药有限公司 一种环肽类化合物的水合物及其制备方法和用途
PL3058958T3 (pl) 2015-02-23 2019-02-28 Selectchemie Ag Kompozycja anidulafunginy
CN110339341A (zh) * 2018-04-03 2019-10-18 江苏恒瑞医药股份有限公司 一种达托霉素或其盐的组合物
KR20210076040A (ko) * 2018-10-11 2021-06-23 임브리아 파마슈티칼스, 인크. Tca 회로 중간체 및 그의 사용 방법
CN109574811B (zh) * 2018-11-22 2021-12-24 中山大学 一种阿尼芬净侧链中间体对戊氧基三联苯甲酸的制备方法
CN116903706B (zh) * 2023-06-13 2024-05-17 深圳市祥根生物有限公司 一种棘白菌素类药物及其制备方法和用途

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US151474A (en) * 1874-06-02 Improvement in corn-shellers
US54981A (en) * 1866-05-22 Improvement in nail-machines
US161176A (en) * 1875-03-23 Improvement in heaters for cheese-vats
US3293482A (en) 1962-06-21 1966-12-20 Rca Corp Plural output traveling wave tube
JPS5134916B2 (fr) 1974-03-06 1976-09-29
DE2803581A1 (de) 1978-01-27 1979-08-02 Sandoz Ag Derivate des tetrahydro-echinocandin b
US4304716A (en) 1979-12-13 1981-12-08 Eli Lilly And Company S 31794/F-1 Nucleus
CA1183127A (fr) 1979-12-13 1985-02-26 Manuel Debono Preparation de derives de noyaux de peptides cycliques
CA1170598A (fr) 1979-12-13 1984-07-10 Bernard J. Abbott Methode de preparation de noyaux peptidiques cycliques
US4293483A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4299763A (en) 1979-12-13 1981-11-10 Eli Lilly And Company A-30912B Nucleus
US4320052A (en) 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912A nucleus
US4293489A (en) 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4293482A (en) 1979-12-13 1981-10-06 Eli Lilly And Company A-30912A Nucleus
US4348384A (en) 1980-10-17 1982-09-07 Dainippon Pharmaceutical Co., Ltd. Pharmaceutical composition for oral administration containing coagulation factor VIII or IX
US4393489A (en) * 1981-03-30 1983-07-12 Rca Corporation Audio processor for single, channel, matrixed two-channel and un-matrixed two-channel signals
US5141674A (en) 1984-03-08 1992-08-25 Phares Pharmaceutical Research N.V. Methods of preparing pro-liposome dispersions and aerosols
US4876241A (en) * 1987-05-22 1989-10-24 Armour Pharmaceutical Company Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants
US5166135A (en) 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
DK173802B1 (da) 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
AU617541B2 (en) 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US4927831A (en) 1988-10-20 1990-05-22 American Home Products Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US5202309A (en) 1989-06-30 1993-04-13 Merck & Co., Inc. Antibiotic cyclopeptide fermentation product
JPH03240727A (ja) 1990-02-15 1991-10-28 Toyo Jozo Co Ltd ニューモシスチス・カリニ肺炎治療剤
CA2037957A1 (fr) 1990-03-12 1991-09-13 Merck & Co., Inc. Composes de cyclohexapeptides n-acyles
GB2241956A (en) 1990-03-16 1991-09-18 Merck & Co Inc N-acylated cyclohexapeptide compounds
IE910892A1 (en) 1990-03-19 1991-09-25 Merck & Co Inc Lipopeptide compounds
IL97347A0 (en) 1990-03-19 1992-05-25 Merck & Co Inc Lipopeptide derivatives and antimicrobial compositions containing them
US5330973A (en) 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
US5386009A (en) 1990-03-19 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
US5049546A (en) 1990-03-19 1991-09-17 Merck & Co., Inc. Antibiotic agents
US5310726A (en) 1990-03-19 1994-05-10 Merck & Co., Inc. Lipopeptide compounds
ES2089133T3 (es) 1990-06-07 1996-10-01 Lilly Co Eli Desacilasa de lipopeptidos.
IL98506A (en) 1990-06-18 1996-09-12 Fujisawa Pharmaceutical Co Peptides, of antibiotics, processes for their preparation and pharmaceutical preparations containing them
US5198421A (en) 1991-04-26 1993-03-30 Merck & Co., Inc. Phosphorylated cyclic lipopeptide
EP0486011A3 (en) 1990-11-16 1992-07-15 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical composition against pneumocystis carinii
US5369093A (en) 1991-03-15 1994-11-29 Merck & Co., Inc. Lipopeptide derivatives
US5993805A (en) 1991-04-10 1999-11-30 Quadrant Healthcare (Uk) Limited Spray-dried microparticles and their use as therapeutic vehicles
US5233023A (en) 1991-07-30 1993-08-03 Merck & Co., Inc. Process for phosphate ester compounds of certain cyclohexapeptides
JPH05271097A (ja) 1991-10-07 1993-10-19 Asahi Chem Ind Co Ltd アクレアシン類の可溶化剤および医薬組成物
MY136593A (en) 1992-03-19 2008-10-31 Lilly Co Eli Cyclic peptide antifungal agents and process for preparation thereof
US6743777B1 (en) 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US5965525A (en) * 1992-03-19 1999-10-12 Eli Lilly And Company Cyclic peptide antifungal agents
US6384013B1 (en) 1992-03-19 2002-05-07 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
EP0589074B1 (fr) * 1992-09-22 2001-11-21 Takeo Dr. Takayanagi Complexes d'hydrates de carbone pour la destruction de cellules cancéreuses
JPH06172205A (ja) 1992-12-11 1994-06-21 Asahi Chem Ind Co Ltd アクレアシン類含有脂肪乳剤
US6268338B1 (en) 1993-04-30 2001-07-31 Merck & Co., Inc. Cyclohexapeptidyl amine compounds
JPH09500103A (ja) 1993-05-04 1997-01-07 メルク エンド カンパニー インコーポレーテッド シクロヘキサペプチジルアミノアルキルエーテル
IS1796B (is) 1993-06-24 2001-12-31 Ab Astra Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
US5541160A (en) 1994-04-04 1996-07-30 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
GB9501841D0 (en) 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
US5646111A (en) 1995-04-07 1997-07-08 Eli Lilly And Company Cyclic peptide antifungal Agents
US5618787A (en) 1995-05-26 1997-04-08 Eli Lilly And Company Cyclic peptide antifungal agents
US5786325A (en) 1995-05-26 1998-07-28 Eli Lilly And Company Cyclic peptide antifungal agents and methods of making and using
US5629290A (en) 1995-05-26 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
US5652213A (en) 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
GB9515182D0 (en) 1995-07-24 1995-09-20 Co Ordinated Drug Dev Improvements in and relating to powders for use in dry powder inhalers
US5629289A (en) 1995-07-25 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
FR2740686B1 (fr) 1995-11-03 1998-01-16 Sanofi Sa Formulation pharmaceutique lyophilisee stable
US5693611A (en) 1996-02-01 1997-12-02 Eli Lilly And Company Cyclic peptide antifungal agents
JP2001503015A (ja) 1996-02-01 2001-03-06 イーライ・リリー・アンド・カンパニー 環状ペプチド抗真菌剤
US5985309A (en) 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US5696084A (en) 1996-08-16 1997-12-09 Abbott Laboratories Amino-lipopetide antifungal agents
JP2001507701A (ja) 1996-12-31 2001-06-12 インヘイル・セラピューティック・システムズ・インコーポレーテッド 親水性賦形剤を有する疎水性薬剤の溶液を噴霧乾燥するための方法及びその方法によって作製された組成物
AU8687798A (en) 1997-08-04 1999-02-22 Eli Lilly And Company Cyclic peptide antifungal agents
US5972996A (en) 1997-08-22 1999-10-26 Merck & Co., Inc. 4-cyano-4-deformylsordarin derivatives
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6433040B1 (en) 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
EP0931834A3 (fr) 1997-12-23 2002-06-26 Eli Lilly And Company Domaine de liaison d'echinocandinl de la 1,3-beta-glucane synthase
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
US6284282B1 (en) 1998-04-29 2001-09-04 Genentech, Inc. Method of spray freeze drying proteins for pharmaceutical administration
US6423345B2 (en) 1998-04-30 2002-07-23 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
US6451349B1 (en) 1998-08-19 2002-09-17 Quadrant Healthcare (Uk) Limited Spray-drying process for the preparation of microparticles
ES2233070T3 (es) 1998-08-20 2005-06-01 ELI LILLY & COMPANY Sintesis de analogos peptidicos ciclicos modificados en el anillo.
EP1107982B1 (fr) 1998-08-28 2004-05-19 Eli Lilly & Company Complexes reversibles du bore de peptides cycliques contenant des groupes 1,2-(cis)-diol
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
CA2353930A1 (fr) 1998-12-09 2000-06-15 Eli Lilly And Company Purification de composes cyclopeptidiques d'echinocandine
WO2000035945A1 (fr) 1998-12-16 2000-06-22 Eli Lilly And Company Agents antifongiques de peptide cyclique possedant un substituant sucre
CA2354056A1 (fr) 1998-12-16 2000-06-22 James Andrew Jamison Agents antifongiques de peptide cyclique
US20030104048A1 (en) 1999-02-26 2003-06-05 Lipocine, Inc. Pharmaceutical dosage forms for highly hydrophilic materials
WO2000051564A1 (fr) 1999-03-03 2000-09-08 Eli Lilly And Company Formulations pharmaceutiques d'echinocandine contenant des tensioactifs formant des micelles
KR20020003864A (ko) 1999-03-03 2002-01-15 피터 지. 스트링거 에키노칸딘/탄수화물 착물
AU771727B2 (en) 1999-03-03 2004-04-01 Eli Lilly And Company Processes for making pharmaceutical oral ECB formulations and compositions
ATE338060T1 (de) 1999-03-03 2006-09-15 Lilly Co Eli Bildung und anionenaustausch von inneren kristallinen ammoniumsalzen des echinocandins b
US6258821B1 (en) 1999-04-26 2001-07-10 Medimmune Oncology, Inc. Compositions comprising trimetrexate and methods of their synthesis and use
WO2003018051A1 (fr) 2001-08-27 2003-03-06 Vic Jira Composition antifongique
US6991800B2 (en) 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products

Also Published As

Publication number Publication date
CA2362016A1 (fr) 2000-09-08
BR0008712A (pt) 2001-12-26
AU3863500A (en) 2000-09-21
EP1157030A1 (fr) 2001-11-28
US20020160942A1 (en) 2002-10-31
IL145187A0 (en) 2002-06-30
ES2204548T3 (es) 2004-05-01
JP4272359B2 (ja) 2009-06-03
US20060111277A1 (en) 2006-05-25
ATE248187T1 (de) 2003-09-15
AU772633B2 (en) 2004-05-06
KR20020003864A (ko) 2002-01-15
HK1040088B (zh) 2004-04-16
RU2001126723A (ru) 2003-09-27
HK1040088A1 (en) 2002-05-24
PT1157030E (pt) 2004-01-30
EP1157030B1 (fr) 2003-08-27
DE60004793T2 (de) 2004-07-01
ZA200108004B (en) 2003-06-25
US20090258820A1 (en) 2009-10-15
US8022033B2 (en) 2011-09-20
DE60004793D1 (de) 2003-10-02
WO2000052037A8 (fr) 2001-03-22
US7550428B2 (en) 2009-06-23
JP2002539090A (ja) 2002-11-19
CN1345333A (zh) 2002-04-17
WO2000052037A1 (fr) 2000-09-08
US7041637B2 (en) 2006-05-09

Similar Documents

Publication Publication Date Title
ATE248187T1 (de) Echinocandin-kohlenhydrate-komplexe
DE69907977D1 (de) Pyrrolobenzodiazepine
UY26082A1 (es) Derivados de 1,4-diazabiciclo [3.2.2] nonan-4-carboxilato y -carboxamidas, su preparacion y su aplicacion en terapeutica
AR030245A1 (es) Composiciones de gel que contienen metronidazol
SE9503143D0 (sv) New preparation
ECSP066314A (es) Derivados piridilo y su uso como agentes terapéuticos
DE69713151D1 (de) Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung
UY25055A1 (es) Formulaciones farmacéuticas que contienen voriconazol
NZ533179A (en) Hydroxycucurbituril derivatives, their preparation methods and uses
DK1565471T3 (da) Quionolinylpyrazoler
SE9900961D0 (sv) Novel compounds
TR199802060T2 (xx) Aminoisokinolinler ve aminopiridin t�revlerinin iltihap �nleyiciler olarak kullan�m�.
EA200300406A1 (ru) Фармацевтическая композиция дронедарона для парентерального введения
NO20013414D0 (no) Ny anvendelse av melagatran
EE05241B1 (et) Distamtsiini a-halogenoakrlolderivaadi kasutamine
EE200100066A (et) Naatriumkloriidi kasutamine kamptotetsiini derivaatide manustamisest tingitud gastrointestinaalsetekõrvaltoimete vähendamiseks
TR200103125T2 (tr) Otizmin iyileştirilmesinde kullanıma yönelik antikonvülsan türevleri.
SE0001916D0 (sv) Novel formulation
DK1181300T3 (da) 6-O-carbamatketolidderivater
ATE525605T1 (de) Verbindungsstück
SE9902742D0 (sv) New pharmaceutical formultion
DE60039122D1 (de) 6-o-alkyl-2-nor-2-substituierte ketolidderivate
ES2124844T3 (es) Palau'amina: un compuesto farmacologicamente activo aislado a partir de una esponja.
NO20015207L (no) Anvendelse av antiprogestagener i kombinert terapi
MX9605312A (es) Dipsipeptidos ciclicos antifungales.