CA2354056A1 - Agents antifongiques de peptide cyclique - Google Patents

Agents antifongiques de peptide cyclique Download PDF

Info

Publication number
CA2354056A1
CA2354056A1 CA002354056A CA2354056A CA2354056A1 CA 2354056 A1 CA2354056 A1 CA 2354056A1 CA 002354056 A CA002354056 A CA 002354056A CA 2354056 A CA2354056 A CA 2354056A CA 2354056 A1 CA2354056 A1 CA 2354056A1
Authority
CA
Canada
Prior art keywords
hydroxy
group
alkyl
formula
moiety
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002354056A
Other languages
English (en)
Inventor
James Andrew Jamison
John Michael Rodriguez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2354056A1 publication Critical patent/CA2354056A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne un composé représenté par la formule (I), R?4¿ et/ou R?8¿ représentant une fraction de sucre. Ces composés sont utiles comme agent antifongique ou antiparasite ou comme intermédiaire de cet agent. L'invention concerne des techniques de traitement et des formulations pharmaceutiques renfermant ces composés.
CA002354056A 1998-12-16 1999-12-15 Agents antifongiques de peptide cyclique Abandoned CA2354056A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11243498P 1998-12-16 1998-12-16
US60/112,434 1998-12-16
PCT/US1999/029914 WO2000035944A1 (fr) 1998-12-16 1999-12-15 Agents antifongiques de peptide cyclique

Publications (1)

Publication Number Publication Date
CA2354056A1 true CA2354056A1 (fr) 2000-06-22

Family

ID=22343886

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002354056A Abandoned CA2354056A1 (fr) 1998-12-16 1999-12-15 Agents antifongiques de peptide cyclique

Country Status (5)

Country Link
EP (1) EP1140991A1 (fr)
JP (1) JP2002535248A (fr)
AU (1) AU767357B2 (fr)
CA (1) CA2354056A1 (fr)
WO (1) WO2000035944A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002528388A (ja) 1998-08-20 2002-09-03 イーライ リリー アンド カンパニー 環改変された環状ペプチドアナログ
PT1137663E (pt) 1998-12-09 2006-12-29 Lilly Co Eli Purificação de compostos ciclopéptidos equinocandina
EP1582204B1 (fr) 1999-03-03 2013-09-25 Eli Lilly & Company Formulations pharmaceutiques d'échinocandine contenant des tensioactifs formant des micelles
DE60030415T2 (de) 1999-03-03 2007-08-30 Eli Lilly And Co., Indianapolis Bildung und anionenaustausch von inneren kristallinen ammoniumsalzen des echinocandins b
JP2002538097A (ja) 1999-03-03 2002-11-12 イーライ リリー アンド カンパニー 薬学的経口ｅｃｂ処方物および組成物の作製方法
ATE248187T1 (de) 1999-03-03 2003-09-15 Lilly Co Eli Echinocandin-kohlenhydrate-komplexe
US9956240B2 (en) * 2014-11-21 2018-05-01 University Of South Carolina Therapeutic monosaccharide-based inhibitors of hexokinase and glucokinase for parasitic diseases, along with methods of their formation and use
US10682359B2 (en) 2017-03-31 2020-06-16 University Of South Carolina Inhibitors of glucose kinases, along with methods of their formation and use
US11059842B2 (en) 2019-04-29 2021-07-13 University Of South Carolina Monosaccharide amine and 3-nitro-2-phenyl-2H-chromene based inhibitors of glucose kinases
US11555047B2 (en) 2019-10-31 2023-01-17 University Of South Carolina One-step synthesis of phosphate-based inhibitors and applications thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5652213A (en) * 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
US6323176B1 (en) * 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents

Also Published As

Publication number Publication date
AU767357B2 (en) 2003-11-06
JP2002535248A (ja) 2002-10-22
AU2189200A (en) 2000-07-03
EP1140991A1 (fr) 2001-10-10
WO2000035944A1 (fr) 2000-06-22

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Legal Events

Date Code Title Description
FZDE Dead