DK113585D0 - Nye peptider - Google Patents
Nye peptiderInfo
- Publication number
- DK113585D0 DK113585D0 DK113585A DK113585A DK113585D0 DK 113585 D0 DK113585 D0 DK 113585D0 DK 113585 A DK113585 A DK 113585A DK 113585 A DK113585 A DK 113585A DK 113585 D0 DK113585 D0 DK 113585D0
- Authority
- DK
- Denmark
- Prior art keywords
- insulin
- charge
- amino acid
- neutral
- new peptides
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 230000007935 neutral effect Effects 0.000 abstract 2
- 101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (25)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK113585A DK113585D0 (da) | 1985-03-12 | 1985-03-12 | Nye peptider |
| ZA861432A ZA861432B (en) | 1985-03-12 | 1986-02-26 | Novel peptides |
| PH33459A PH24260A (en) | 1985-03-12 | 1986-02-27 | Novel peptides |
| DK107086A DK158677C (da) | 1985-03-12 | 1986-03-10 | Insulinderivater og anvendelsen deraf, injicerbar oploesning indeholdende insulinderivaterne samt fremgangsmaade til fremstilling af oploesningen. |
| YU34586A YU46001B (sh) | 1985-03-12 | 1986-03-10 | Postupak za dobijanje novih peptida |
| DD86287734A DD244345A5 (de) | 1985-03-12 | 1986-03-10 | Neue peptide |
| EP86301755A EP0194864B1 (en) | 1985-03-12 | 1986-03-11 | Novel peptides |
| AU54495/86A AU612964B2 (en) | 1985-03-12 | 1986-03-11 | Insulin derivatives having a charge which is positive compared with the charge of human insulin at neutral pH |
| NO860920A NO172441C (no) | 1985-03-12 | 1986-03-11 | Analogifremgangsmaate for fremstilling av terapeutisk aktive insulinforbindelser |
| CN198686101489A CN86101489A (zh) | 1985-03-12 | 1986-03-11 | 制备新胰岛素肽及其长效注射液的方法 |
| KR1019860001737A KR930007433B1 (ko) | 1985-03-12 | 1986-03-11 | 사람 인슈린 펩티드의 제조방법 |
| JP61051586A JPS61212598A (ja) | 1985-03-12 | 1986-03-11 | インシユリン化合物 |
| ES552879A ES8800276A1 (es) | 1985-03-12 | 1986-03-11 | Un procedimiento para preparar nuevos derivados de insulina |
| PT82173A PT82173B (pt) | 1985-03-12 | 1986-03-11 | Processo para a preparacao de novos peptidos |
| IL78103A IL78103A0 (en) | 1985-03-12 | 1986-03-11 | Peptides,their preparation and pharmaceutical compositions containing them |
| CS861666A CS259536B2 (en) | 1985-03-12 | 1986-03-11 | Method of insulin's new derivatives production |
| NZ215445A NZ215445A (en) | 1985-03-12 | 1986-03-11 | Insulin derivatives and pharmaceutical composition |
| HU861024A HU201097B (en) | 1985-03-12 | 1986-03-11 | Process for producing human insulin derivatives and long-acting pharmaceutical compositions comprising same |
| DE8686301755T DE3685668T2 (de) | 1985-03-12 | 1986-03-11 | Peptide. |
| FI861007A FI861007A7 (fi) | 1985-03-12 | 1986-03-11 | Uusia peptidejä. |
| AT86301755T ATE77391T1 (de) | 1985-03-12 | 1986-03-11 | Peptide. |
| GR860687A GR860687B (en) | 1985-03-12 | 1986-03-12 | Novel peptides |
| US07/075,387 US4946828A (en) | 1985-03-12 | 1987-07-20 | Novel insulin peptides |
| MYPI87002520A MY102102A (en) | 1985-03-12 | 1987-09-30 | Novel peptides |
| US07/424,503 US5008241A (en) | 1985-03-12 | 1989-10-20 | Novel insulin peptides |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK113585A DK113585D0 (da) | 1985-03-12 | 1985-03-12 | Nye peptider |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK113585D0 true DK113585D0 (da) | 1985-03-12 |
Family
ID=8101410
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK113585A DK113585D0 (da) | 1985-03-12 | 1985-03-12 | Nye peptider |
| DK107086A DK158677C (da) | 1985-03-12 | 1986-03-10 | Insulinderivater og anvendelsen deraf, injicerbar oploesning indeholdende insulinderivaterne samt fremgangsmaade til fremstilling af oploesningen. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK107086A DK158677C (da) | 1985-03-12 | 1986-03-10 | Insulinderivater og anvendelsen deraf, injicerbar oploesning indeholdende insulinderivaterne samt fremgangsmaade til fremstilling af oploesningen. |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0194864B1 (cs) |
| JP (1) | JPS61212598A (cs) |
| KR (1) | KR930007433B1 (cs) |
| CN (1) | CN86101489A (cs) |
| AT (1) | ATE77391T1 (cs) |
| AU (1) | AU612964B2 (cs) |
| CS (1) | CS259536B2 (cs) |
| DD (1) | DD244345A5 (cs) |
| DE (1) | DE3685668T2 (cs) |
| DK (2) | DK113585D0 (cs) |
| ES (1) | ES8800276A1 (cs) |
| FI (1) | FI861007A7 (cs) |
| GR (1) | GR860687B (cs) |
| HU (1) | HU201097B (cs) |
| IL (1) | IL78103A0 (cs) |
| MY (1) | MY102102A (cs) |
| NO (1) | NO172441C (cs) |
| NZ (1) | NZ215445A (cs) |
| PH (1) | PH24260A (cs) |
| PT (1) | PT82173B (cs) |
| YU (1) | YU46001B (cs) |
| ZA (1) | ZA861432B (cs) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK347086D0 (da) * | 1986-07-21 | 1986-07-21 | Novo Industri As | Novel peptides |
| US5008241A (en) * | 1985-03-12 | 1991-04-16 | Novo Nordisk A/S | Novel insulin peptides |
| DK119785D0 (da) * | 1985-03-15 | 1985-03-15 | Nordisk Gentofte | Insulinpraeparat |
| DK437786D0 (da) * | 1986-09-12 | 1986-09-12 | Nordisk Gentofte | Insulinprecursorer |
| US5149777A (en) * | 1988-07-20 | 1992-09-22 | Novo Nordisk A/S | Human insulin analogs and preparations containing them |
| DE3827533A1 (de) * | 1988-08-13 | 1990-02-15 | Hoechst Ag | Pharmazeutische zubereitung zur behandlung des diabetes mellitus |
| DE3837825A1 (de) * | 1988-11-08 | 1990-05-10 | Hoechst Ag | Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| DK134189D0 (da) * | 1989-03-20 | 1989-03-20 | Nordisk Gentofte | Insulinforbindelser |
| US5130298A (en) * | 1989-05-16 | 1992-07-14 | Ethicon, Inc. | Stabilized compositions containing epidermal growth factor |
| DE3936876A1 (de) * | 1989-11-06 | 1991-05-23 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| US6933272B1 (en) | 1998-09-22 | 2005-08-23 | Erik Helmerhorst | Use of non-peptidyl compounds for the treatment of insulin related ailments |
| AUPP609198A0 (en) * | 1998-09-22 | 1998-10-15 | Curtin University Of Technology | Use of non-peptidyl compounds for the treatment of insulin related ailments |
| DE10114178A1 (de) | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
| DE10227232A1 (de) | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
| EP2368579A1 (en) | 2004-01-21 | 2011-09-28 | Novo Nordisk Health Care AG | Transglutaminase mediated conjugation of peptides |
| JP4808785B2 (ja) | 2005-12-28 | 2011-11-02 | ノボ・ノルデイスク・エー／エス | インスリン組成物および組成物の製造方法 |
| DE102006031962A1 (de) * | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Amidiertes Insulin Glargin |
| DE102006031955A1 (de) * | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende |
| JP5694779B2 (ja) * | 2008-01-09 | 2015-04-01 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 極度に遅延した時間作用プロファイルを有する新規なインスリン誘導体 |
| JP5695909B2 (ja) | 2008-01-09 | 2015-04-08 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 極度に遅延した時間作用プロファイルを有する新規なインスリン誘導体 |
| DE102008003566A1 (de) * | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| RS56632B1 (sr) | 2008-10-17 | 2018-03-30 | Sanofi Aventis Deutschland | Kombinacija insulina i glp-1-agonista |
| US20120241356A1 (en) * | 2009-07-06 | 2012-09-27 | Sanofi-Aventis Deutschland Gmbh | Heat- and vibration-stable insulin preparations |
| EP2498801B1 (de) | 2009-11-13 | 2018-01-24 | Sanofi-Aventis Deutschland GmbH | HARMAZEUTISCHE ZUSAMMENSETZUNG UMFASSEND desPro36Exendin-4(1-39)-Lys6-NH2 UND METHIONIN |
| ES2534191T3 (es) | 2009-11-13 | 2015-04-20 | Sanofi-Aventis Deutschland Gmbh | Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina |
| AU2011252127B2 (en) * | 2010-05-10 | 2014-02-20 | Novo Nordisk A/S | Process for the preparation of insulin-zinc complexes |
| RU2546520C2 (ru) | 2010-08-30 | 2015-04-10 | Санофи-Авентис Дойчланд Гмбх | Применение ave0010 для производства лекарственного средства для лечения сахарного диабета 2 типа |
| CN102174495A (zh) * | 2011-01-20 | 2011-09-07 | 马忠仁 | 一种提取糜胰蛋白酶的方法 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| CA2846413C (en) | 2011-08-29 | 2021-11-02 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for use in glycemic control in diabetes type 2 patients |
| AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
| CR20170314A (es) | 2014-12-12 | 2017-10-20 | Sanofi Aventis Deutschland | Formulación de relación fija de insulina glargina/lixisenatida |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| JP7518149B2 (ja) | 2019-07-12 | 2024-07-17 | ノヴォ ノルディスク アー／エス | 高濃度インスリン製剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK319780A (da) * | 1980-07-24 | 1982-01-25 | Forenede Bryggerier As | Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner |
| DE3326472A1 (de) * | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus |
| DE3333640A1 (de) * | 1983-09-17 | 1985-04-25 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung |
| DK119785D0 (da) * | 1985-03-15 | 1985-03-15 | Nordisk Gentofte | Insulinpraeparat |
-
1985
- 1985-03-12 DK DK113585A patent/DK113585D0/da unknown
-
1986
- 1986-02-26 ZA ZA861432A patent/ZA861432B/xx unknown
- 1986-02-27 PH PH33459A patent/PH24260A/en unknown
- 1986-03-10 DD DD86287734A patent/DD244345A5/de not_active IP Right Cessation
- 1986-03-10 DK DK107086A patent/DK158677C/da active
- 1986-03-10 YU YU34586A patent/YU46001B/sh unknown
- 1986-03-11 EP EP86301755A patent/EP0194864B1/en not_active Expired - Lifetime
- 1986-03-11 KR KR1019860001737A patent/KR930007433B1/ko not_active Expired - Lifetime
- 1986-03-11 CS CS861666A patent/CS259536B2/cs unknown
- 1986-03-11 DE DE8686301755T patent/DE3685668T2/de not_active Expired - Fee Related
- 1986-03-11 ES ES552879A patent/ES8800276A1/es not_active Expired
- 1986-03-11 NZ NZ215445A patent/NZ215445A/xx unknown
- 1986-03-11 CN CN198686101489A patent/CN86101489A/zh active Pending
- 1986-03-11 NO NO860920A patent/NO172441C/no unknown
- 1986-03-11 FI FI861007A patent/FI861007A7/fi not_active Application Discontinuation
- 1986-03-11 HU HU861024A patent/HU201097B/hu not_active IP Right Cessation
- 1986-03-11 JP JP61051586A patent/JPS61212598A/ja active Pending
- 1986-03-11 AT AT86301755T patent/ATE77391T1/de not_active IP Right Cessation
- 1986-03-11 AU AU54495/86A patent/AU612964B2/en not_active Ceased
- 1986-03-11 PT PT82173A patent/PT82173B/pt not_active IP Right Cessation
- 1986-03-11 IL IL78103A patent/IL78103A0/xx not_active IP Right Cessation
- 1986-03-12 GR GR860687A patent/GR860687B/el unknown
-
1987
- 1987-09-30 MY MYPI87002520A patent/MY102102A/en unknown
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