DK1132393T3 - L-Ribavirin og anvendelser heraf - Google Patents

L-Ribavirin og anvendelser heraf

Info

Publication number
DK1132393T3
DK1132393T3 DK01108303T DK01108303T DK1132393T3 DK 1132393 T3 DK1132393 T3 DK 1132393T3 DK 01108303 T DK01108303 T DK 01108303T DK 01108303 T DK01108303 T DK 01108303T DK 1132393 T3 DK1132393 T3 DK 1132393T3
Authority
DK
Denmark
Prior art keywords
compounds
useful
novel
diseases
infestations
Prior art date
Application number
DK01108303T
Other languages
Danish (da)
English (en)
Inventor
Kandasamy Ramasamy
Robert Tam
Devron Averett
Original Assignee
Ribapharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribapharm Inc filed Critical Ribapharm Inc
Application granted granted Critical
Publication of DK1132393T3 publication Critical patent/DK1132393T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Glass Compositions (AREA)
DK01108303T 1996-10-16 1997-10-15 L-Ribavirin og anvendelser heraf DK1132393T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2858596P 1996-10-16 1996-10-16

Publications (1)

Publication Number Publication Date
DK1132393T3 true DK1132393T3 (da) 2003-07-21

Family

ID=21844262

Family Applications (2)

Application Number Title Priority Date Filing Date
DK97912762T DK1027359T3 (da) 1996-10-16 1997-10-15 Monocykliske L-nukleosider, analoger og anvendelser deraf
DK01108303T DK1132393T3 (da) 1996-10-16 1997-10-15 L-Ribavirin og anvendelser heraf

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK97912762T DK1027359T3 (da) 1996-10-16 1997-10-15 Monocykliske L-nukleosider, analoger og anvendelser deraf

Country Status (26)

Country Link
US (4) US6130326A (fr)
EP (1) EP1027359B9 (fr)
JP (2) JP2002503212A (fr)
KR (1) KR100398923B1 (fr)
CN (1) CN1268140A (fr)
AT (2) ATE238328T1 (fr)
AU (1) AU738170B2 (fr)
BR (1) BR9712527A (fr)
CA (1) CA2267279A1 (fr)
CZ (1) CZ120699A3 (fr)
DE (2) DE69721339T2 (fr)
DK (2) DK1027359T3 (fr)
ES (2) ES2195970T3 (fr)
HK (2) HK1038365A1 (fr)
HU (1) HUP0001107A3 (fr)
IL (1) IL129126A0 (fr)
NO (1) NO313417B1 (fr)
NZ (1) NZ334915A (fr)
PL (1) PL187107B1 (fr)
PT (2) PT1027359E (fr)
RU (2) RU2188828C2 (fr)
SI (1) SI20076A (fr)
SK (1) SK284054B6 (fr)
UA (1) UA63915C2 (fr)
WO (1) WO1998016186A2 (fr)
YU (1) YU18799A (fr)

Families Citing this family (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ120699A3 (cs) 1996-10-16 1999-09-15 Icn Pharmaceuticals, Inc. Monocyklická L-nukleosidová analoga a jejich využití
CN1261370A (zh) * 1997-06-30 2000-07-26 Icn药品公司 生产噻唑呋林及其它c-核苷的方法
JP4596495B2 (ja) * 1997-07-18 2010-12-08 ソニー株式会社 制御装置、制御方法、電気機器システム、電気機器システムの制御方法、および、記録媒体
US7901400B2 (en) 1998-10-23 2011-03-08 Covidien Ag Method and system for controlling output of RF medical generator
JP2002528554A (ja) 1998-11-05 2002-09-03 サントル・ナシオナル・ドウ・ラ・ルシエルシユ・シアンテイフイク B型肝炎ウイルス活性を持ったヌクレオシド
US6407077B1 (en) 1998-11-05 2002-06-18 Emory University β-L nucleosides for the treatment of HIV infection
ES2262366T3 (es) * 1998-11-05 2006-11-16 Centre National De La Recherche Scientifique Derivados azido de beta-l-2'-desoxi-nucleosidos para el tratamiento de la infeccin por vih.
CN1334736A (zh) * 1999-01-29 2002-02-06 Icn药品公司 病毒唑对免疫反应的调节作用
US7084125B2 (en) 1999-03-18 2006-08-01 Exiqon A/S Xylo-LNA analogues
EP1178999B1 (fr) 1999-05-04 2007-03-14 Santaris Pharma A/S Analogues de l-ribo-lna
US6525191B1 (en) * 1999-05-11 2003-02-25 Kanda S. Ramasamy Conformationally constrained L-nucleosides
CA2382324A1 (fr) * 1999-08-31 2001-03-08 Amersham Plc Analogues de nucleoside
US6664399B1 (en) * 1999-09-02 2003-12-16 E. I. Du Pont De Nemours & Company Triazole linked carbohydrates
US6518253B1 (en) * 1999-11-19 2003-02-11 Robert Tam Treatment of viral infections using the L-isomer of ribavirin
KR20030032908A (ko) * 1999-12-23 2003-04-26 아이씨엔 파마슈티컬스, 인코포레이티드 L-누클레오시드, l-누클레오티드 및 이들의 유사체에대한 조성물 및 방법
US6455508B1 (en) * 2000-02-15 2002-09-24 Kanda S. Ramasamy Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides
US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
US6495677B1 (en) 2000-02-15 2002-12-17 Kanda S. Ramasamy Nucleoside compounds
CN100457118C (zh) * 2000-04-13 2009-02-04 法玛塞特有限公司 用于治疗肝炎病毒感染的3′-或2′-羟甲基取代的核苷衍生物
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
NZ547204A (en) * 2000-05-26 2008-01-31 Idenix Cayman Ltd Methods and compositions for treating flaviviruses and pestiviruses
US6815542B2 (en) * 2000-06-16 2004-11-09 Ribapharm, Inc. Nucleoside compounds and uses thereof
US7022830B2 (en) * 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
US6858590B2 (en) * 2000-08-17 2005-02-22 Tripep Ab Vaccines containing ribavirin and methods of use thereof
KR100801123B1 (ko) 2000-08-17 2008-02-05 트리펩 아베 리바비린 함유 백신 및 이것의 사용 방법
US6680059B2 (en) * 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US6720000B2 (en) * 2001-03-19 2004-04-13 Three Rivers Pharmaceutical, Llc Process for producing wet ribavirin pellets
ES2208540T3 (es) * 2001-07-30 2004-06-16 Clariant Life Science Molecules (Italia) Spa Procedimiento para la preparacion de ribavirina.
EP1435974A4 (fr) * 2001-09-28 2006-09-06 Idenix Cayman Ltd Procedes et compositions pour le traitement du virus de l'hepatite c au moyen de nucleosides modifies en 4'
BR0213861A (pt) * 2001-11-02 2004-12-21 Sandoz Ag Processo para a preparação de composições de ribavirina de carga elevada, de dissolução rápida
KR100411398B1 (ko) * 2001-12-06 2003-12-18 주식회사유한양행 베타-디-리보푸라노즈 유도체의 제조방법
US20040023901A1 (en) * 2002-02-28 2004-02-05 Cook Phillip D. Nucleoside 5'-monophosphate mimics and their prodrugs
CA2484875C (fr) 2002-05-06 2013-04-23 Sherwood Services Ag Methode et systeme de detection optique du sang et de controle d'un generateur pendant une electrochirurgie
US6982253B2 (en) 2002-06-05 2006-01-03 Supergen, Inc. Liquid formulation of decitabine and use of the same
JP2005533824A (ja) * 2002-06-28 2005-11-10 イデニクス(ケイマン)リミテツド フラビウイルス科感染の治療のための2’−c−メチル−3’−o−l−バリンエステルリボフラノシルシチジン
NZ537662A (en) * 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
MXPA05001298A (es) * 2002-08-01 2005-11-04 Pharmasset Inc Compuestos con el sistema biciclo[4.2.1] nonano para el tratamiento de infecciones por flaviviridae.
EP1537134B1 (fr) * 2002-08-12 2006-04-05 F.Hoffmann-La Roche Ag Procede de production d'un ribofuranose
US7538094B2 (en) * 2002-09-19 2009-05-26 Three Rivers Pharmacueticals, Llc Composition containing ribavirin and use thereof
US20040077607A1 (en) * 2002-10-21 2004-04-22 Uckun Fatih M. Aryl phosphate derivatives of d4T with potent anti-viral activity against hemorrhagic fever viruses
JP2006515277A (ja) 2002-10-29 2006-05-25 コーリー ファーマシューティカル グループ, リミテッド C型肝炎ウィルス感染の処置および予防に関する方法および製品
WO2004046331A2 (fr) * 2002-11-15 2004-06-03 Idenix (Cayman) Limited Nucleoside a ramification en 2’ et mutation de flaviviridae
US7044948B2 (en) 2002-12-10 2006-05-16 Sherwood Services Ag Circuit for controlling arc energy from an electrosurgical generator
WO2004052899A2 (fr) * 2002-12-12 2004-06-24 Idenix (Cayman) Limited Procede de production de nucleosides ramifies en position 2'
AU2003300434A1 (en) * 2002-12-23 2004-07-22 Idenix (Cayman) Limited Process for the production of 3'-nucleoside prodrugs
US6943249B2 (en) 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
US7038038B2 (en) * 2003-03-17 2006-05-02 Pharmion Corporation Synthesis of 5-azacytidine
US6887855B2 (en) 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
CN1980678A (zh) * 2003-03-28 2007-06-13 法莫赛特股份有限公司 治疗黄病毒感染的化合物
CA2524289C (fr) 2003-05-01 2016-01-19 Sherwood Services Ag Procede et systeme de programmation et de commande d'un generateur electrochirurgical
WO2005003147A2 (fr) 2003-05-30 2005-01-13 Pharmasset, Inc. Analogues de nucleosides fluores modifies
US20050009848A1 (en) * 2003-07-10 2005-01-13 Icn Pharmaceuticals Switzerland Ltd. Use of antivirals against inflammatory bowel diseases
US6930093B2 (en) * 2003-07-10 2005-08-16 Valeant Research & Development Use of ribofuranose derivatives against inflammatory bowel diseases
ATE478886T1 (de) 2003-07-25 2010-09-15 Idenix Pharmaceuticals Inc Purin nucleoside für die behandlung von durch flavividrae verursachten krankheiten, einschliesslich hepatitis c
WO2005018330A1 (fr) * 2003-08-18 2005-03-03 Pharmasset, Inc. Regime de dosage pour therapie contre flaviviridae
US8104956B2 (en) 2003-10-23 2012-01-31 Covidien Ag Thermocouple measurement circuit
WO2005048809A1 (fr) 2003-10-23 2005-06-02 Sherwood Services Ag Systeme de surveillance de la temperature redondant utilise dans des systemes electrochirurgicaux pour augmenter la securite
US7396336B2 (en) 2003-10-30 2008-07-08 Sherwood Services Ag Switched resonant ultrasonic power amplifier system
US7131860B2 (en) 2003-11-20 2006-11-07 Sherwood Services Ag Connector systems for electrosurgical generator
US7766905B2 (en) 2004-02-12 2010-08-03 Covidien Ag Method and system for continuity testing of medical electrodes
US20050182252A1 (en) 2004-02-13 2005-08-18 Reddy K. R. Novel 2'-C-methyl nucleoside derivatives
US7780662B2 (en) 2004-03-02 2010-08-24 Covidien Ag Vessel sealing system using capacitive RF dielectric heating
WO2006000922A2 (fr) * 2004-06-23 2006-01-05 Idenix (Cayman) Limited Derives de 5-aza-7-deazapurine pour le traitement des flaviviridae
CN101023094B (zh) * 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
EP1809301B1 (fr) 2004-09-14 2019-11-06 Gilead Pharmasset LLC Intermédiaires de d-ribonolactone à substitution 2-fluoro-2-alkyl
US7687473B2 (en) * 2005-01-07 2010-03-30 Health Research, Inc. 5-amino-4-imidazolecarboxamide riboside and its nucleobase as potentiators of antifolate transport and metabolism
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
US7250416B2 (en) 2005-03-11 2007-07-31 Supergen, Inc. Azacytosine analogs and derivatives
WO2006105440A2 (fr) * 2005-03-30 2006-10-05 Sirtris Pharmaceuticals, Inc. Nicotinamide riboside et analogues
US20070014833A1 (en) * 2005-03-30 2007-01-18 Sirtris Pharmaceuticals, Inc. Treatment of eye disorders with sirtuin modulators
US20060292099A1 (en) * 2005-05-25 2006-12-28 Michael Milburn Treatment of eye disorders with sirtuin modulators
US7968697B2 (en) * 2005-05-25 2011-06-28 Chrontech Pharma Ab Hepatitis C virus non-structural NS3/4A fusion gene
US7700567B2 (en) 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
US8734438B2 (en) 2005-10-21 2014-05-27 Covidien Ag Circuit and method for reducing stored energy in an electrosurgical generator
US7947039B2 (en) 2005-12-12 2011-05-24 Covidien Ag Laparoscopic apparatus for performing electrosurgical procedures
US7781576B2 (en) * 2005-12-23 2010-08-24 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
US7651493B2 (en) 2006-03-03 2010-01-26 Covidien Ag System and method for controlling electrosurgical snares
ZA200806266B (en) * 2006-03-09 2010-05-26 Om Pharma Immunomodulatory compounds and treatment of diseases related to an overproduction of inflammatory cytokines
FR2907786B1 (fr) * 2006-10-27 2009-09-18 Univ Grenoble 1 Thionucleosides et applications pharmaceutiques
EA016830B1 (ru) * 2006-09-11 2012-07-30 Саузерн Рисерч Инститьют Азольные нуклеозиды и их применение в качестве ингибиторов вариальных рнк- и днк-полимераз
JP5550234B2 (ja) * 2006-12-08 2014-07-16 株式会社エーピーアイ コーポレーション フラノース誘導体の製造方法
WO2008086341A1 (fr) * 2007-01-09 2008-07-17 Pericor Therapeutics, Inc. Procédés, compositions et formulations pour prévenir ou réduire les effets indésirables chez un patient
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US8071561B2 (en) * 2007-08-16 2011-12-06 Chrontech Pharma Ab Immunogen platform
US20090214593A1 (en) * 2007-08-16 2009-08-27 Tripep Ab Immunogen platform
US9233107B2 (en) 2007-09-14 2016-01-12 Biogen Ma Inc. Compositions and methods for the treatment of progressive multifocal leukoencephalopathy (PML)
US8227431B2 (en) 2008-03-17 2012-07-24 Hetero Drugs Limited Nucleoside derivatives
PT3782612T (pt) 2008-05-15 2024-01-18 Celgene Corp Formulações orais de análogos da citidina e métodos de utilização dos mesmos
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
US8716263B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Synthesis of purine nucleosides
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
EP3222628A1 (fr) 2008-12-23 2017-09-27 Gilead Pharmasset LLC Phosphoramidates nucléosidiques
WO2010108140A1 (fr) * 2009-03-20 2010-09-23 Alios Biopharma, Inc. Nucleoside substitue et analogues nucleotidiques
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
PL3290428T3 (pl) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
PT3290428T (pt) 2010-03-31 2021-12-27 Gilead Pharmasset Llc Comprimido compreendendo 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1-(2h)-il)¿4¿fluoro¿3¿hidroxi¿4¿metiltetrahidrofuran¿2¿il)metoxi) (fenoxi)fosforil)amino)propanoato de (s)- isopropil cristalino
WO2012040124A1 (fr) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Azido nucléosides et analogues nucléotidiques
CN105061534A (zh) 2010-09-22 2015-11-18 艾丽奥斯生物制药有限公司 取代的核苷酸类似物
AU2011336632B2 (en) 2010-11-30 2015-09-03 Gilead Pharmasset Llc Compounds
GB201021867D0 (en) * 2010-12-23 2011-02-02 Mologen Ag Non-coding immunomodulatory DNA construct
CN102153548B (zh) * 2011-02-24 2012-11-28 河北大学 一种含有噻唑(嗪)烷酮环的类核苷衍生物及其制备方法和其在药物制剂中的应用
MX2013010945A (es) * 2011-03-31 2014-03-12 Celgene Internat Sarl Sintesis de 5 - azacitidina.
MY163296A (en) 2011-08-30 2017-09-15 Astex Pharmaceuticals Inc Drug formulations
ME03009B (fr) 2011-09-16 2018-10-20 Gilead Pharmasset Llc Procédés permettant de traiter le virus de l'hépatite c (hcv)
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
LT2794627T (lt) 2011-12-22 2019-01-10 Alios Biopharma, Inc. Pakeistieji nukleozidai, nukleotidai ir jų analogai
AU2012358804B2 (en) 2011-12-22 2018-04-19 Alios Biopharma, Inc. Substituted phosphorothioate nucleotide analogs
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US8916538B2 (en) 2012-03-21 2014-12-23 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
NZ630805A (en) 2012-03-22 2016-01-29 Alios Biopharma Inc Pharmaceutical combinations comprising a thionucleotide analog
HUE029038T2 (en) 2012-05-25 2017-01-30 Janssen Sciences Ireland Uc Uracil spirooxetan nucleosides
KR102168621B1 (ko) 2012-12-21 2020-10-22 얀센 바이오파마, 인코퍼레이트. 치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체
JP2015508418A (ja) 2013-01-31 2015-03-19 ギリアド ファーマセット エルエルシー 2種の抗ウイルス化合物のコンビナトリアル製剤
WO2014169278A1 (fr) 2013-04-12 2014-10-16 Achillion Pharmaceuticals, Inc. Dérivé de nucléoside d'activité élevée pour le traitement du vhc
EP4005560A1 (fr) 2013-08-27 2022-06-01 Gilead Pharmasset LLC Formulation de combinaison de deux composés antiviraux
AU2014331863C1 (en) 2013-10-11 2019-05-16 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
CN106102771B (zh) 2014-01-07 2021-06-29 巴比塔·阿格拉沃尔 免疫调节组合物及其使用方法
WO2015123352A1 (fr) 2014-02-13 2015-08-20 Ligand Pharmaceuticals, Inc. Composés de promédicaments et leurs utilisations
JP6559713B2 (ja) 2014-06-06 2019-08-14 グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッドGlaxosmithkline Intellectual Property (No.2) Limited ニコチンアミドリボシド類似体ならびにその医薬組成物および使用
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
EP3277316A1 (fr) 2015-04-02 2018-02-07 Ablynx N.V. Polypeptides cxcr4-cd-4 bispécifiques à activité anti-vih puissante
MX2018000016A (es) 2015-07-02 2019-01-31 Otsuka Pharma Co Ltd Composiciones farmaceuticas liofilizadas.
LU92821B1 (en) 2015-09-09 2017-03-20 Mologen Ag Combination comprising immunostimulatory oligonucleotides
GB2542425A (en) 2015-09-21 2017-03-22 Mologen Ag Means for the treatment of HIV
WO2017218580A1 (fr) 2016-06-14 2017-12-21 Rejuvenation Therapeutics Corporation Procédés synthétiques pour la préparation de nicotinamide riboside et de composés apparentés
US10202412B2 (en) 2016-07-08 2019-02-12 Atea Pharmaceuticals, Inc. β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections
RU2624018C2 (ru) * 2016-09-26 2017-06-30 Федеральное государственное бюджетное учреждение науки Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН (ИБХ РАН) Амид 5-(тетрагидрофуран-2-ил)-1,2,4-триазол-3-карбоновой кислоты, обладающий противовирусной активностью, и способ его получения
EP3661522A2 (fr) 2017-08-03 2020-06-10 Otsuka Pharmaceutical Co., Ltd. Composé médicamenteux et ses procédés de purification
CN111788196A (zh) 2018-01-09 2020-10-16 配体药物公司 缩醛化合物及其治疗用途
JP2022518943A (ja) * 2019-02-01 2022-03-17 ヤンセン バイオファーマ インク. 抗ウイルスヌクレオシド及びその誘導体
CR20220316A (es) 2019-12-06 2022-10-07 Vertex Pharma Tetrahidrofuranos sustituidos como moduladores de canales de sodio
WO2022256622A1 (fr) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hétéro)aryl) tétrahydrofuran carboxamides utilisés en tant que modulateurs de canaux sodiques
WO2023288047A2 (fr) * 2021-07-15 2023-01-19 Alnylam Pharmaceuticals, Inc. Multiplexage ciblant des ligands par chimie clic au niveau du site anomérique de sucres

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3948885A (en) * 1973-03-19 1976-04-06 Icn Pharmaceuticals, Inc. 5-Hydroxyl-1,2,3-triazole-4-carboxamide nucleoside
US4138547A (en) * 1977-12-22 1979-02-06 Icn Pharmaceuticals, Inc. Process for preparing 1,2,4-triazole nucleosides
EP0054432B1 (fr) * 1980-12-15 1990-01-31 Viratek, Inc. Utilisation de 2-Bêta-D-ribofuranosylthiazole-4-carboxamides pour l'obtension d'un medicament destiné pour la traitement de tumeurs malignes
JPS60193997A (ja) * 1984-03-14 1985-10-02 Sumitomo Chem Co Ltd 新規シアノイミダゾ−ルリボヌクレオシド誘導体およびその製造法
EP0331080A3 (fr) * 1988-02-29 1990-11-22 Yamasa Shoyu Kabushiki Kaisha Dérivés d'imidazole, procédé pour leur préparation et leur utilisation
US5082829A (en) * 1989-01-24 1992-01-21 Gensia Pharmaceuticals AICA riboside prodrugs
US4992426A (en) * 1989-02-27 1991-02-12 Nucleic Acid Research Institute Antiparasitic 5'-sulfamoyl nucleosides
IT1246983B (it) * 1990-11-13 1994-12-12 Consiglio Nazionale Ricerche L-2'-desossiuridine e composizioni farmaceutiche che le contengono.
US5248776A (en) * 1990-12-05 1993-09-28 University Of Georgia Research Foundation, Inc. Process for enantiomerically pure β-L-1,3-oxathiolane nucleosides
US5438131A (en) * 1992-09-16 1995-08-01 Bergstrom; Donald E. 3-nitropyrrole nucleoside
WO1994021658A1 (fr) * 1993-03-15 1994-09-29 Kalman Thomas I Derives antiviraux de nucleoside imidazolinone
US5627160A (en) * 1993-05-25 1997-05-06 Yale University L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents
TW374087B (en) * 1993-05-25 1999-11-11 Univ Yale L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents
US5567689A (en) * 1993-08-13 1996-10-22 The Uab Research Foundation Methods for increasing uridine levels with L-nucleosides
US5599796A (en) * 1993-12-02 1997-02-04 Emory University Treatment of urogenital cancer with boron neutron capture therapy
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
DE19518216A1 (de) * 1994-10-07 1996-04-11 Max Delbrueck Centrum Neue ß-L-Nucleoside und ihre Verwendung
US5559101A (en) * 1994-10-24 1996-09-24 Genencor International, Inc. L-ribofuranosyl nucleosides
US5672594A (en) * 1994-10-24 1997-09-30 Genencor International, Inc. L-erythrosyl nucleosides
IT1281498B1 (it) * 1995-06-07 1998-02-18 Sardinian Antiviral Research C Pirazolo - derivati ad attivita' antitumorale, processo per la loro preparazione e composizioni farmaceutiche che li contengono , e
CZ120699A3 (cs) * 1996-10-16 1999-09-15 Icn Pharmaceuticals, Inc. Monocyklická L-nukleosidová analoga a jejich využití

Also Published As

Publication number Publication date
HK1028977A1 (en) 2001-03-16
EP1027359A4 (fr) 2001-07-25
PT1027359E (pt) 2003-09-30
PL187107B1 (pl) 2004-05-31
KR100398923B1 (ko) 2003-09-19
AU738170B2 (en) 2001-09-13
JP2003176296A (ja) 2003-06-24
WO1998016186A3 (fr) 1998-06-11
US6552183B1 (en) 2003-04-22
SK284054B6 (sk) 2004-08-03
EP1027359B1 (fr) 2003-04-23
DK1027359T3 (da) 2003-08-11
EP1027359A2 (fr) 2000-08-16
HUP0001107A2 (hu) 2001-06-28
CZ120699A3 (cs) 1999-09-15
PT1132393E (pt) 2003-08-29
ES2195125T3 (es) 2003-12-01
KR20000049224A (ko) 2000-07-25
ATE238328T1 (de) 2003-05-15
US6642206B2 (en) 2003-11-04
NO991785D0 (no) 1999-04-15
DE69721339T2 (de) 2004-01-22
HK1038365A1 (en) 2002-03-15
ATE236921T1 (de) 2003-04-15
CA2267279A1 (fr) 1998-04-23
SK47199A3 (en) 2000-12-11
NO991785L (no) 1999-06-15
DE69720811T2 (de) 2004-03-11
EP1027359B9 (fr) 2003-09-17
AU4986797A (en) 1998-05-11
SI20076A (sl) 2000-04-30
US20030018186A1 (en) 2003-01-23
BR9712527A (pt) 2000-03-08
DE69720811D1 (de) 2003-05-15
NO313417B1 (no) 2002-09-30
NZ334915A (en) 2000-11-24
ES2195970T3 (es) 2003-12-16
HUP0001107A3 (en) 2003-01-28
RU2001132536A (ru) 2003-08-20
CN1268140A (zh) 2000-09-27
RU2188828C2 (ru) 2002-09-10
UA63915C2 (uk) 2004-02-16
DE69721339D1 (de) 2003-05-28
PL333419A1 (en) 1999-12-06
US6573248B2 (en) 2003-06-03
YU18799A (sh) 2002-06-19
US20020095033A1 (en) 2002-07-18
JP2002503212A (ja) 2002-01-29
WO1998016186A2 (fr) 1998-04-23
IL129126A0 (en) 2000-02-17
US6130326A (en) 2000-10-10

Similar Documents

Publication Publication Date Title
DK1132393T3 (da) L-Ribavirin og anvendelser heraf
ATE303993T1 (de) 4-hydroxychinolin-3-carboxamide und hydrazide als antivirale wirkstoffe
DE68909219D1 (de) Behandlung von obesitas.
DE69413765D1 (de) An die Einführung von chirurgischen Instrumenten anpassbare Dichtung
ATE280160T1 (de) Substituierte aryl-oder heteroarylamide mit retinoid-ähnlicher biologischer aktivität
HN1998000143A (es) Tetrahidronaftalenos substituidos y compuestos analogos.
DE3779250D1 (de) Acrylcopolymere, diese enthaltende hautschutzmittel und ihre anwendung.
ITTO910156A1 (it) Composto per esaltare le prestazione umane
ATE197395T1 (de) Äusserlisches hautbehandlungsmittel
DE69208681D1 (de) Verwendungen von 1,1,1,3,3,3-hexafluoropropan
EE03170B1 (et) Perifeerse vere mononukleaarsete rakkude tsütotoksilise aktiivsuse stimuleerimine IL-10 abil
ATE247649T1 (de) Disubstituierte biphenyloxazoline
PT86104A (de) Pyrazoline ihre herstellung und ihre verwendung als mittel mit insektizider und akarizider wirkung
ES2158441T3 (es) Arilheterociclos con actividad herbicida.
DE69718911D1 (de) Interleukin - 8 als antivirale- und antitumorwirkstoffe
BR6801156U (pt) Mesa de praia,lago,lagoa,rio
DE69804843D1 (de) Heterozyklische verbidungen mit mmp und tnf inhibitorisher wirkung
LV5670A3 (lv) 3,3-Diaizvietotu indolin-2-onu un to salu legusanas panemiens
ATE76286T1 (de) Acrylcopolymere, diese enthaltende hautschutzmittel und ihre anwendung.
SU1531433A1 (ru) 4-(n-Фторфенил)-5-фенил-2-(α-гидрокси-α -карбометокситрифторэтил)-тиофен, проявляющий антимикробную и противовоспалительную активность
SU1351053A1 (ru) Бензил (4-фторфенил)селенид, обладающий антимикробной и анальгетической активностью
ATE102478T1 (de) Kosmetische und hautbehandlungszusammensetzungen.
IT218809Z2 (it) . pannello ortopedico anatomico per riposare, dormire e curare
ATE91231T1 (de) Behandlung der akne.
NO881342L (no) Kosmetisk hudbehandling.