CA2382324A1 - Analogues de nucleoside - Google Patents

Analogues de nucleoside Download PDF

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Publication number
CA2382324A1
CA2382324A1 CA002382324A CA2382324A CA2382324A1 CA 2382324 A1 CA2382324 A1 CA 2382324A1 CA 002382324 A CA002382324 A CA 002382324A CA 2382324 A CA2382324 A CA 2382324A CA 2382324 A1 CA2382324 A1 CA 2382324A1
Authority
CA
Canada
Prior art keywords
analogue
mmol
primer
nucleoside
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002382324A
Other languages
English (en)
Inventor
Clifford Smith
William Jonathan Cummins
Robert James Domett Nairne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2382324A1 publication Critical patent/CA2382324A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne des composés représentés par la structure (I) dans laquelle X est CH ou N, Y est CO-, -CONW-, -O-, -S-, -SO-, -SO¿2?-, -NWCO-, -NW-, ou OCO-, W est identique ou différent à différents endroits de la molécule et chacun est H ou alkyle ou aryle ou Rp ou Ln-Rp, Ln est un groupe de liaison, Rp est un fragment rapporteur, et Q est un sucre ou un analogue de sucre, ou un squelette d'acide nucléique ou un analogue de squelette, à condition qu'au moins un fragment rapporteur soit présent. Ces composés constituent des nucléosides triphosphates qui sont de bons substrats enzymatiques.
CA002382324A 1999-08-31 2000-08-30 Analogues de nucleoside Abandoned CA2382324A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99306887 1999-08-31
EP99306887.3 1999-08-31
PCT/GB2000/003301 WO2001016150A2 (fr) 1999-08-31 2000-08-30 Analogues de nucleoside

Publications (1)

Publication Number Publication Date
CA2382324A1 true CA2382324A1 (fr) 2001-03-08

Family

ID=8241600

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002382324A Abandoned CA2382324A1 (fr) 1999-08-31 2000-08-30 Analogues de nucleoside

Country Status (5)

Country Link
EP (1) EP1208109A2 (fr)
JP (1) JP2003508406A (fr)
AU (1) AU7019200A (fr)
CA (1) CA2382324A1 (fr)
WO (1) WO2001016150A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2506797C (fr) 2002-11-22 2009-02-10 F.Hoffmann-La Roche Ag Analogues de nucleoside marques detectables et procedes d'utilisation de ceux-ci
US7977108B2 (en) 2005-07-25 2011-07-12 Roche Molecular Systems, Inc. Method for detecting a mutation in a repetitive nucleic acid sequence

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61171497A (ja) * 1985-01-25 1986-08-02 Takeda Chem Ind Ltd ルア−・ヌクレオチド
WO1994021658A1 (fr) * 1993-03-15 1994-09-29 Kalman Thomas I Derives antiviraux de nucleoside imidazolinone
ES2195970T3 (es) * 1996-10-16 2003-12-16 Ribapharm Inc L-ribavirina y usos de la misma.

Also Published As

Publication number Publication date
WO2001016150A2 (fr) 2001-03-08
JP2003508406A (ja) 2003-03-04
EP1208109A2 (fr) 2002-05-29
AU7019200A (en) 2001-03-26
WO2001016150A3 (fr) 2001-11-15

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Legal Events

Date Code Title Description
FZDE Discontinued