WO2001016150A3 - Analogues de nucleoside - Google Patents

Analogues de nucleoside Download PDF

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Publication number
WO2001016150A3
WO2001016150A3 PCT/GB2000/003301 GB0003301W WO0116150A3 WO 2001016150 A3 WO2001016150 A3 WO 2001016150A3 GB 0003301 W GB0003301 W GB 0003301W WO 0116150 A3 WO0116150 A3 WO 0116150A3
Authority
WO
WIPO (PCT)
Prior art keywords
sugar
analogue
nucleoside analogues
reporter moiety
backbone
Prior art date
Application number
PCT/GB2000/003301
Other languages
English (en)
Other versions
WO2001016150A2 (fr
Inventor
Clifford Smith
William Jonathan Cummins
Robert James Domett Nairne
Original Assignee
Nycomed Amersham Plc
Clifford Smith
William Jonathan Cummins
Robert James Domett Nairne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Amersham Plc, Clifford Smith, William Jonathan Cummins, Robert James Domett Nairne filed Critical Nycomed Amersham Plc
Priority to CA002382324A priority Critical patent/CA2382324A1/fr
Priority to AU70192/00A priority patent/AU7019200A/en
Priority to JP2001519713A priority patent/JP2003508406A/ja
Priority to EP00958770A priority patent/EP1208109A2/fr
Publication of WO2001016150A2 publication Critical patent/WO2001016150A2/fr
Publication of WO2001016150A3 publication Critical patent/WO2001016150A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne des composés représentés par la structure (I) dans laquelle X est CH ou N, Y est CO-, -CONW-, -O-, -S-, -SO-, -SO2-, -NWCO-, -NW-, ou OCO-, W est identique ou différent à différents endroits de la molécule et chacun est H ou alkyle ou aryle ou Rp ou Ln-Rp, Ln est un groupe de liaison, Rp est un fragment rapporteur, et Q est un sucre ou un analogue de sucre, ou un squelette d'acide nucléique ou un analogue de squelette, à condition qu'au moins un fragment rapporteur soit présent. Ces composés constituent des nucléosides triphosphates qui sont de bons substrats enzymatiques.
PCT/GB2000/003301 1999-08-31 2000-08-30 Analogues de nucleoside WO2001016150A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002382324A CA2382324A1 (fr) 1999-08-31 2000-08-30 Analogues de nucleoside
AU70192/00A AU7019200A (en) 1999-08-31 2000-08-30 Nucleoside analogues
JP2001519713A JP2003508406A (ja) 1999-08-31 2000-08-30 ヌクレオシドアナログ
EP00958770A EP1208109A2 (fr) 1999-08-31 2000-08-30 Analogues de nucleoside

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99306887 1999-08-31
EP99306887.3 1999-08-31

Publications (2)

Publication Number Publication Date
WO2001016150A2 WO2001016150A2 (fr) 2001-03-08
WO2001016150A3 true WO2001016150A3 (fr) 2001-11-15

Family

ID=8241600

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/003301 WO2001016150A2 (fr) 1999-08-31 2000-08-30 Analogues de nucleoside

Country Status (5)

Country Link
EP (1) EP1208109A2 (fr)
JP (1) JP2003508406A (fr)
AU (1) AU7019200A (fr)
CA (1) CA2382324A1 (fr)
WO (1) WO2001016150A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2506797C (fr) 2002-11-22 2009-02-10 F.Hoffmann-La Roche Ag Analogues de nucleoside marques detectables et procedes d'utilisation de ceux-ci
US7977108B2 (en) 2005-07-25 2011-07-12 Roche Molecular Systems, Inc. Method for detecting a mutation in a repetitive nucleic acid sequence

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61171497A (ja) * 1985-01-25 1986-08-02 Takeda Chem Ind Ltd ルア−・ヌクレオチド
WO1994021658A1 (fr) * 1993-03-15 1994-09-29 Kalman Thomas I Derives antiviraux de nucleoside imidazolinone
WO1998016186A2 (fr) * 1996-10-16 1998-04-23 Icn Pharmaceuticals, Inc. L nucleosides monocycliques, analogues et leurs utilisations

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61171497A (ja) * 1985-01-25 1986-08-02 Takeda Chem Ind Ltd ルア−・ヌクレオチド
WO1994021658A1 (fr) * 1993-03-15 1994-09-29 Kalman Thomas I Derives antiviraux de nucleoside imidazolinone
WO1998016186A2 (fr) * 1996-10-16 1998-04-23 Icn Pharmaceuticals, Inc. L nucleosides monocycliques, analogues et leurs utilisations

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BEDU E ET AL: "Novel 2'-Deoxycytidine Analogues as pH Independent Substitutes of Protonated Cytosines in Triple Helix Forming Oligonucleotides", TETRAHEDRON LETTERS,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 40, no. 5, 29 January 1999 (1999-01-29), pages 835 - 838, XP004151459, ISSN: 0040-4039 *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; JIANG, XIANG-JUN ET AL: "Synthesis of a novel antiretroviral thymidine analog: 1-(2-deoxy-.beta.-D-ribofuranosyl)-4-acetylimidazolin-2-one (imidine)", XP002161694, retrieved from STN Database accession no. 121:83843 *
DATABASE WPI Section Ch Week 198637, Derwent World Patents Index; Class B03, AN 1986-242387, XP002131974 *
FUKUDA T. ET AL.: "An alternative to the mixed probe method in DNA hybridization: synthetic "lure" nucleotide for the ambiguous position of codons", Z. NATURFORSCH., vol. 41b, 1986, pages 1571 - 1579, XP002161692 *
HAGENMAIER, HANSPAUL ET AL: "Metabolites of microorganisms. 182. Structure elucidation of the nucleoside antibiotic nikkomycin X", LIEBIGS ANN. CHEM. (1979), (10), 1494-502, XP002131972 *
KALMAN, T. I. ET AL: "Mechanism of inhibition of HIV reverse transcriptase by 1-(2-deoxy-.beta.-D-ribofuranosyl)-4-acetylimidazolin-2-one (imidine)", NUCLEOSIDES NUCLEOTIDES (APRIL-MAY 1999), 18(4 & 5), 847-848, XP002161693 *
NUCLEOSIDES NUCLEOTIDES (1994), 13(1-3), 379-88 *
SCHMIDT R -M ET AL: "BIOSYNTHESIS OF 4-FORMYL-4-IMIDAYOLINE-2-ON THE HETEROCYCLIC BASE OF NIKKOMYCIN X", ZEITSCHRIFT FUER NATURFORSCHUNG. SECTION C. BIOSCIENCES,XX,XX, vol. 41, no. 1/02, 1986, pages 135 - 140, XP000884825, ISSN: 0341-0382 *

Also Published As

Publication number Publication date
WO2001016150A2 (fr) 2001-03-08
JP2003508406A (ja) 2003-03-04
EP1208109A2 (fr) 2002-05-29
CA2382324A1 (fr) 2001-03-08
AU7019200A (en) 2001-03-26

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