DK1117627T3 - Fremgangsmåde til overføringshydrogenering - Google Patents
Fremgangsmåde til overføringshydrogeneringInfo
- Publication number
- DK1117627T3 DK1117627T3 DK99949137T DK99949137T DK1117627T3 DK 1117627 T3 DK1117627 T3 DK 1117627T3 DK 99949137 T DK99949137 T DK 99949137T DK 99949137 T DK99949137 T DK 99949137T DK 1117627 T3 DK1117627 T3 DK 1117627T3
- Authority
- DK
- Denmark
- Prior art keywords
- bidentate ligands
- transfer hydrogenation
- employed
- transfer
- preferred
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- C07B43/04—Formation or introduction of functional groups containing nitrogen of amino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/10—Quaternary compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9821067.7A GB9821067D0 (en) | 1998-09-29 | 1998-09-29 | Transfer hydrogenation process |
| PCT/GB1999/003176 WO2000018708A1 (en) | 1998-09-29 | 1999-09-22 | Transfer hydrogenation process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1117627T3 true DK1117627T3 (da) | 2003-09-15 |
Family
ID=10839587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99949137T DK1117627T3 (da) | 1998-09-29 | 1999-09-22 | Fremgangsmåde til overføringshydrogenering |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6509467B1 (de) |
| EP (1) | EP1117627B1 (de) |
| JP (1) | JP2002525342A (de) |
| KR (1) | KR100674631B1 (de) |
| CN (1) | CN1231433C (de) |
| AT (1) | ATE241578T1 (de) |
| AU (1) | AU764996B2 (de) |
| CA (1) | CA2343088C (de) |
| CZ (1) | CZ299368B6 (de) |
| DE (1) | DE69908390T2 (de) |
| DK (1) | DK1117627T3 (de) |
| ES (1) | ES2201780T3 (de) |
| GB (1) | GB9821067D0 (de) |
| HK (1) | HK1042887B (de) |
| HU (1) | HU225492B1 (de) |
| IL (1) | IL142093A (de) |
| NO (1) | NO325921B1 (de) |
| PT (1) | PT1117627E (de) |
| WO (1) | WO2000018708A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6353112B1 (en) | 1998-07-17 | 2002-03-05 | The University Of Tennessee Research Corporation | Sultams: Solid phase and other synthesis of anti-HIV compounds and compositions |
| US6562850B1 (en) | 1998-07-17 | 2003-05-13 | The University Of Tennessee Research Corporation | Methods of synthesizing sultams and anti-viral compositions |
| US6458962B1 (en) | 1999-03-25 | 2002-10-01 | The University Of Tennesseee Research Corporation | Sultams: catalyst systems for asymmetric reduction of a C=N intermediate biological compositions and methods for making the sultams |
| GB0029356D0 (en) | 2000-12-01 | 2001-01-17 | Avecia Ltd | Transfer hydrogenation |
| US6743921B2 (en) | 2002-01-24 | 2004-06-01 | Dsm Catalytica Pharmaceuticals, Inc. | Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol compounds |
| CA2565130C (en) * | 2003-05-02 | 2011-03-15 | Kamaluddin Abdur-Rashid | Transfer hydrogenation processes and catalysts |
| US8133717B2 (en) | 2006-12-22 | 2012-03-13 | Richmond Chemical Corporation | Stereoinversion of amino acids in a single reactor |
| TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類 |
| ES2407033T3 (es) * | 2007-05-04 | 2013-06-11 | Mallinckrodt Llc | Procedimientos mejorados para la preparación de opiáceos 6-alfa-hidroxi-n-alquilados |
| NZ582668A (en) * | 2007-07-17 | 2012-02-24 | Mallinckrodt Llc | Preparation of n-alkylated opiates by reductive amination |
| EP3190121B1 (de) | 2007-12-27 | 2019-02-20 | Infinity Pharmaceuticals, Inc. | Verfahren zur stereoselektiven reduktion von cyclopamin 4-en-3-on derivat |
| CA2738628C (en) * | 2008-09-30 | 2017-07-04 | Mallinckrodt Inc. | Processes for the selective amination of ketomorphinans |
| US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| WO2010144641A1 (en) * | 2009-06-11 | 2010-12-16 | Mallinckrodt Inc. | Preparation of 6-alpha-amino n-substituted morphinans by catalytic hydrogen transfer |
| EP2440561B1 (de) * | 2009-06-11 | 2014-04-30 | Mallinckrodt LLC | Reduktive aminierung von 6-keto-normorphinanen durch katalytischen wasserstofftransfer |
| TW201105635A (en) * | 2009-06-30 | 2011-02-16 | Actelion Pharmaceuticals Ltd | Process for the preparation of an enantiomerically pure trisubstituted 1,2,3,4-tetrahydroisoquinoline derivative |
| CN102574791A (zh) | 2009-08-05 | 2012-07-11 | 无限药品股份有限公司 | 环杷明类似物的酶促转氨基反应 |
| WO2012037217A1 (en) | 2010-09-14 | 2012-03-22 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
| MX2013013634A (es) | 2011-06-09 | 2013-12-12 | Mallinckrodt Llc | Aminacion reductiva de 6-ceto-morfinanos por transfrencia catalitica de hidrogeno. |
| ES2566620T3 (es) | 2011-09-08 | 2016-04-14 | Mallinckrodt Llc | Procesamiento de alcaloides sin el aislamiento de intermedios |
| BR112017026103B1 (pt) | 2015-06-04 | 2023-10-03 | Sol-Gel Technologies Ltd | Composições tópicas com composto inibidor de hedgehog, sistema de entrega tópica e seus usos |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT333764B (de) * | 1972-06-20 | 1976-12-10 | Fujisawa Pharmaceutical Co | Verfahren zur herstellung von neuen 1,2,3,4-tetrahydroisochinolinen und deren salzen |
| JPS553349B2 (de) * | 1972-06-20 | 1980-01-24 | ||
| JP3149989B2 (ja) * | 1992-04-28 | 2001-03-26 | 広栄化学工業株式会社 | ２−クロロ−５−置換アミノメチルピリジン類の製法 |
| GB9706321D0 (en) * | 1997-03-26 | 1997-05-14 | Zeneca Ltd | Catalytic hydrogenation |
-
1998
- 1998-09-29 GB GBGB9821067.7A patent/GB9821067D0/en not_active Ceased
-
1999
- 1999-09-22 HU HU0103510A patent/HU225492B1/hu not_active IP Right Cessation
- 1999-09-22 AT AT99949137T patent/ATE241578T1/de not_active IP Right Cessation
- 1999-09-22 CN CNB998114472A patent/CN1231433C/zh not_active Expired - Fee Related
- 1999-09-22 CA CA002343088A patent/CA2343088C/en not_active Expired - Fee Related
- 1999-09-22 KR KR1020017003924A patent/KR100674631B1/ko not_active IP Right Cessation
- 1999-09-22 IL IL14209399A patent/IL142093A/xx not_active IP Right Cessation
- 1999-09-22 CZ CZ20011110A patent/CZ299368B6/cs not_active IP Right Cessation
- 1999-09-22 AU AU62125/99A patent/AU764996B2/en not_active Ceased
- 1999-09-22 EP EP99949137A patent/EP1117627B1/de not_active Expired - Lifetime
- 1999-09-22 WO PCT/GB1999/003176 patent/WO2000018708A1/en active IP Right Grant
- 1999-09-22 PT PT99949137T patent/PT1117627E/pt unknown
- 1999-09-22 DK DK99949137T patent/DK1117627T3/da active
- 1999-09-22 US US09/787,707 patent/US6509467B1/en not_active Expired - Fee Related
- 1999-09-22 DE DE69908390T patent/DE69908390T2/de not_active Expired - Fee Related
- 1999-09-22 ES ES99949137T patent/ES2201780T3/es not_active Expired - Lifetime
- 1999-09-22 JP JP2000572172A patent/JP2002525342A/ja active Pending
-
2001
- 2001-03-28 NO NO20011573A patent/NO325921B1/no not_active IP Right Cessation
-
2002
- 2002-06-25 HK HK02102896.9A patent/HK1042887B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69908390T2 (de) | 2004-04-22 |
| CN1231433C (zh) | 2005-12-14 |
| CZ299368B6 (cs) | 2008-07-02 |
| JP2002525342A (ja) | 2002-08-13 |
| CA2343088A1 (en) | 2000-04-06 |
| DE69908390D1 (de) | 2003-07-03 |
| NO20011573D0 (no) | 2001-03-28 |
| KR20010075408A (ko) | 2001-08-09 |
| CA2343088C (en) | 2009-02-24 |
| NO325921B1 (no) | 2008-08-18 |
| ES2201780T3 (es) | 2004-03-16 |
| IL142093A (en) | 2005-11-20 |
| EP1117627B1 (de) | 2003-05-28 |
| ATE241578T1 (de) | 2003-06-15 |
| NO20011573L (no) | 2001-03-28 |
| GB9821067D0 (en) | 1998-11-18 |
| PT1117627E (pt) | 2003-10-31 |
| HUP0103510A2 (hu) | 2002-01-28 |
| HU225492B1 (en) | 2007-01-29 |
| CZ20011110A3 (cs) | 2001-08-15 |
| KR100674631B1 (ko) | 2007-01-25 |
| HUP0103510A3 (en) | 2002-04-29 |
| IL142093A0 (en) | 2002-03-10 |
| AU6212599A (en) | 2000-04-17 |
| US6509467B1 (en) | 2003-01-21 |
| CN1321140A (zh) | 2001-11-07 |
| WO2000018708A1 (en) | 2000-04-06 |
| HK1042887B (zh) | 2006-08-18 |
| HK1042887A1 (en) | 2002-08-30 |
| EP1117627A1 (de) | 2001-07-25 |
| AU764996B2 (en) | 2003-09-04 |
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