DK1088549T3 - Modafinil med defineret partikelstörrelse - Google Patents

Modafinil med defineret partikelstörrelse

Info

Publication number
DK1088549T3
DK1088549T3 DK00125091T DK00125091T DK1088549T3 DK 1088549 T3 DK1088549 T3 DK 1088549T3 DK 00125091 T DK00125091 T DK 00125091T DK 00125091 T DK00125091 T DK 00125091T DK 1088549 T3 DK1088549 T3 DK 1088549T3
Authority
DK
Denmark
Prior art keywords
modafinil
particle size
defined particle
potency
altering
Prior art date
Application number
DK00125091T
Other languages
Danish (da)
English (en)
Inventor
Peter E Grebow
Vincent Corvari
David Stong
Original Assignee
Cephalon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23240954&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1088549(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cephalon Inc filed Critical Cephalon Inc
Application granted granted Critical
Publication of DK1088549T3 publication Critical patent/DK1088549T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
DK00125091T 1994-10-06 1995-10-04 Modafinil med defineret partikelstörrelse DK1088549T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/319,124 US5618845A (en) 1994-10-06 1994-10-06 Acetamide derivative having defined particle size

Publications (1)

Publication Number Publication Date
DK1088549T3 true DK1088549T3 (da) 2008-11-17

Family

ID=23240954

Family Applications (3)

Application Number Title Priority Date Filing Date
DK00125091T DK1088549T3 (da) 1994-10-06 1995-10-04 Modafinil med defineret partikelstörrelse
DK95937389T DK0731698T3 (da) 1994-10-06 1995-10-04 Modafinil med defineret partikelstørrelse
DK200001006T DK0966962T3 (da) 1994-10-06 1995-10-04 Modafinil med defineret partikelstørrelse

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK95937389T DK0731698T3 (da) 1994-10-06 1995-10-04 Modafinil med defineret partikelstørrelse
DK200001006T DK0966962T3 (da) 1994-10-06 1995-10-04 Modafinil med defineret partikelstørrelse

Country Status (34)

Country Link
US (2) US5618845A (de)
EP (3) EP0966962B1 (de)
JP (1) JP2915146B2 (de)
KR (1) KR100249360B1 (de)
AT (3) ATE199216T1 (de)
AU (1) AU703087B2 (de)
BG (1) BG62952B1 (de)
BR (1) BR9509257A (de)
CA (2) CA2382275C (de)
CZ (1) CZ291700B6 (de)
DE (3) DE69514497T2 (de)
DK (3) DK1088549T3 (de)
EE (1) EE9700082A (de)
ES (3) ES2156457T3 (de)
FI (1) FI121454B (de)
GB (1) GB2293103B (de)
GR (2) GR3033152T3 (de)
HK (3) HK1003561A1 (de)
HU (1) HU226411B1 (de)
IS (1) IS1987B (de)
LT (1) LT4303B (de)
LV (1) LV11852B (de)
MD (1) MD970143A (de)
MX (1) MX9602176A (de)
NO (1) NO318818B1 (de)
NZ (1) NZ295869A (de)
PL (1) PL181523B1 (de)
PT (3) PT1088549E (de)
RO (1) RO118928B1 (de)
RU (1) RU2287987C2 (de)
SI (1) SI9520106B (de)
SK (1) SK283632B6 (de)
UA (1) UA42023C2 (de)
WO (1) WO1996011001A1 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6821975B1 (en) 1999-08-03 2004-11-23 Lilly Icos Llc Beta-carboline drug products
UA71629C2 (en) * 1999-08-03 2004-12-15 Lilli Icos Llc Composition containing free drug particulate form of ?-carboline (variants), method for its manufacture (variants), and method for treating sexual dysfunction
US6346548B1 (en) 1999-08-16 2002-02-12 Cephalon, Inc. Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue
US6455588B1 (en) 1999-08-20 2002-09-24 Cephalon, Inc. Compositions including modafinil for treatment of eating disorders and for appetite stimulation
FR2804322B1 (fr) * 2000-01-31 2002-04-19 Lafon Labor Utilisation du modafinil pour la fabrication d'un medicament destine a corriger les troubles de la vigilance associes aux myopathies
US20010034373A1 (en) * 2000-02-09 2001-10-25 Matthew Miller Low dose modafinil for enhancement of cognitive function
US6492396B2 (en) 2000-05-16 2002-12-10 Cephalon, Inc. Substituted thioacetamides
CN100500651C (zh) * 2000-07-27 2009-06-17 特瓦制药工业有限公司 晶体和纯莫达非尼及其制备方法
US6919378B2 (en) * 2000-10-11 2005-07-19 Cephalon, Inc. Pharmaceutical solutions of modafinil compounds
US6489363B2 (en) * 2000-10-11 2002-12-03 Cephalon, Inc. Pharmaceutical solutions of modafinil compounds
ATE417608T1 (de) * 2000-10-11 2009-01-15 Cephalon Inc Arzneizusammensetzungen enthaltend modafinilverbindungen
US7749540B2 (en) * 2000-10-11 2010-07-06 Cephalon, Inc. Compositions comprising modafinil compounds
US7704975B2 (en) * 2000-12-19 2010-04-27 Cephalon, Inc. Modafinil compound and cyclodextrin mixtures
US7141555B2 (en) 2000-12-19 2006-11-28 Cephalon, Inc. Modafinil compound and cyclodextrin mixtures
US20080058424A1 (en) * 2002-05-23 2008-03-06 Cephalon, Inc. Novel pharmaceutical formulations of modafinil
DE60219005T2 (de) * 2001-05-25 2007-12-13 Cephalon, Inc. Modafinil umfassende feste pharmazeutische Formulierungen
US7576133B2 (en) 2002-03-11 2009-08-18 Carl Henry Lawyer Methods and compositions for nasal administration of modafinil
US7229644B2 (en) * 2002-05-23 2007-06-12 Cephalon, Inc. Pharmaceutical formulations of modafinil
WO2004004692A1 (en) * 2002-07-08 2004-01-15 Ranbaxy Laboratories Limited Processes for the preparation of oral dosage formulations of modafinil
US20040048931A1 (en) * 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
EP1526842A1 (de) * 2002-07-25 2005-05-04 Ranbaxy Laboratories, Ltd. Verfahren zur herstellung oraler modafinilarzneimittel
US6992219B2 (en) * 2002-08-09 2006-01-31 Cephalon France Modafinil polymorphic forms
US20040116532A1 (en) 2002-09-13 2004-06-17 Craig Heacock Pharmaceutical formulations of modafinil
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
IL153098A0 (en) * 2002-11-26 2003-06-24 Chemagis Ltd Pharmaceutical compositions containing modafinil
CA2420180A1 (en) * 2003-02-28 2004-08-28 Bernard Charles Sherman Tablets comprising modafinil
WO2004082630A2 (en) * 2003-03-17 2004-09-30 Neurohealing Pharmaceuticals, Inc. High potency dopaminergic treatment of neurological impairment associated with brain injury
US20040253308A1 (en) * 2003-04-29 2004-12-16 Barr Laboratories, Inc. Surface-treated modafinil particles
ATE442352T1 (de) * 2003-05-16 2009-09-15 Cephalon France Verfahren zur herstellung von modafinil
US7368591B2 (en) 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
US20050137264A1 (en) * 2003-12-22 2005-06-23 Patel Ashish A. Modafinil compositions
EP2292213A1 (de) 2004-02-06 2011-03-09 Cephalon, Inc. Armodafinil Polymorph enthaltende Zusammensetzungen
US20060024370A1 (en) * 2004-07-29 2006-02-02 Cephalon France Modafinil oral lyophilizate
GT200600008A (es) * 2005-01-18 2006-08-09 Formulacion de compresion directa y proceso
EP1909573A4 (de) * 2005-07-21 2010-09-22 Neurohealing Pharmaceuticals I Kurzfristig wirksame modafinilzusammensetzungen mit rascher anfangswirkung, und verfahren zu ihrer verwendung
US9034381B2 (en) * 2005-11-10 2015-05-19 Alphapharm Pty Ltd Process to control particle size
BRPI0714173A2 (pt) * 2006-07-12 2012-12-25 Elan Pharma Int Ltd composiÇço nanoparticulada estÁvel,mÉtodos para preparar a composiÇço, para prevenir e/ou tratar estados de doenÇas, sintomas, sÍndromes e condiÇÕes do sistema nervoso central, para melhorar ou manter a biodisponibilidade de modafinil, e para tratar distérbio com base neurolàgica, composiÇço farmacÊutica, e forma de dosagem
WO2008021341A2 (en) 2006-08-14 2008-02-21 Neurohealing Pharmaceuticals, Inc. Modafinil-based treatment for premature ejaculation
US20080181966A1 (en) * 2006-10-18 2008-07-31 Cephalon, Inc. Modafinil pharmaceutical compositions
WO2008074097A1 (en) 2006-12-21 2008-06-26 Alphapharm Pty Ltd Pharmaceutical compound and composition
US8173169B2 (en) * 2007-07-11 2012-05-08 Hikma Pharmaceuticals Formulation and process for the preparation of modafinil
US20090325999A1 (en) * 2008-06-27 2009-12-31 Jie Du Personalized pharmaceutical kits, packaging and compositions for the treatment of allergic conditions
CN102105427A (zh) * 2008-07-25 2011-06-22 阿尔法制药有限公司 粒度直径范围(D90)为大于3μm至约10μm的阿托伐醌
US20100036164A1 (en) * 2008-08-06 2010-02-11 Srinivas Areveli Preparation of armodafinil form i
EP2238973A1 (de) 2009-04-07 2010-10-13 Cephalon France Lyophilisierte Präparate von Proteasominhibitoren
FR2987266B1 (fr) * 2012-02-28 2014-12-19 Debregeas Et Associes Pharma Procede d'obtention d'une composition pharmaceutique a base de modafinil, composition pharmaceutique ainsi obtenue et son application
FR2987267B1 (fr) * 2012-02-28 2015-01-16 Debregeas Et Associes Pharma Application du modafinil dans le traitement de substitution des cacainomanes
FR2987265B1 (fr) * 2012-02-28 2014-02-28 Debregeas Et Associes Pharma Composition pharmaceutique sous forme de sirop a base de modafinil, son procede de fabrication et son application
US10058542B1 (en) 2014-09-12 2018-08-28 Thioredoxin Systems Ab Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4002718A (en) * 1974-10-16 1977-01-11 Arnar-Stone Laboratories, Inc. Gelatin-encapsulated digoxin solutions and method of preparing the same
FR2408345A1 (fr) * 1976-11-30 1979-06-08 Besins Jean Louis Nouvelle composition a action anti-conceptionnelle
US4122157A (en) * 1977-03-04 1978-10-24 Richardson-Merrell Inc. Nitrofurantoin sustained release tablet
GB1584462A (en) * 1977-03-31 1981-02-11 Lafon Labor N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them
IT1130924B (it) * 1980-03-06 1986-06-18 Secifarma Spa Procedimento per la preparazione di spironolattone micronizzato
US4600614A (en) * 1983-09-12 1986-07-15 The Dow Chemical Company High-frequency heatable plastics
US4713246A (en) * 1984-03-19 1987-12-15 Bristol-Myers Company Etoposide oral dosage form
IT1187751B (it) * 1985-10-15 1987-12-23 Eurand Spa Procedimento per la preparazione di formulazioni solidi di nifedipina ad elevata biodisponibilita' e ad effetto prolungato e formulazioni cosi' ottenute
FR2593809B1 (fr) * 1986-01-31 1988-07-22 Lafon Labor Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique
DE3720493A1 (de) * 1987-06-20 1989-01-26 Nattermann A & Cie Arzneizubereitungen mit mikronisierten ebselen-kristallen
FR2627696B1 (fr) * 1988-02-26 1991-09-13 Fournier Innovation Synergie Nouvelle forme galenique du fenofibrate
JP2642486B2 (ja) * 1989-08-04 1997-08-20 田辺製薬株式会社 難溶性薬物の超微粒子化法
FR2663225B1 (fr) * 1990-06-14 1994-11-04 Lafon Labor Nouvelle utilisation du modafinil.
FR2684875B1 (fr) * 1991-12-13 1995-05-24 Lafon Labor Utilisation du modafinil pour la fabrication d'un medicament ayant un effet anti-ischemique.
FR2697162B1 (fr) * 1992-10-23 1995-01-13 Lafon Labor Utilisation du modafinil pour la fabrication d'un médicament pour le traitement de l'incontinence urinaire et des troubles sphinctériens urétro vésicaux.
FR2702968B1 (fr) * 1993-03-23 1995-06-23 Lafon Labor Procédé de préparation de particules renfermant un ingrédient actif par extrusion et lyophilisation .
CA2159904C (en) 1993-04-05 2000-10-10 Malcolm Bicknell Mcinnes Percussion drilling improvements
FR2706767B1 (de) * 1993-06-22 1995-09-08 Lafon Labor
FR2708201B1 (fr) * 1993-06-30 1995-10-20 Lafon Labor Utilisation de dérivés d'acétamide pour la fabrication de médicaments.
US5493146A (en) 1994-07-14 1996-02-20 Vlsi Technology, Inc. Anti-fuse structure for reducing contamination of the anti-fuse material

Also Published As

Publication number Publication date
NO971541L (no) 1997-06-04
ATE188607T1 (de) 2000-01-15
DE69514497T2 (de) 2000-08-10
GB2293103A (en) 1996-03-20
FI121454B (fi) 2010-11-30
ATE400260T1 (de) 2008-07-15
PL181523B1 (en) 2001-08-31
FI971417A (fi) 1997-04-04
CA2201967C (en) 2002-12-10
US5618845A (en) 1997-04-08
BG101389A (en) 1997-12-30
EP0966962A1 (de) 1999-12-29
PT1088549E (pt) 2008-09-23
KR100249360B1 (ko) 2000-04-01
GR3035451T3 (en) 2001-05-31
HK1034676A1 (en) 2001-11-02
DE69520161D1 (de) 2001-03-29
HK1003561A1 (en) 1998-10-30
GB2293103B (en) 1997-05-07
SI9520106B (sl) 2003-12-31
AU3951495A (en) 1996-05-02
MX9602176A (es) 1997-05-31
HU226411B1 (en) 2008-11-28
SI9520106A (sl) 1998-02-28
RU2287987C2 (ru) 2006-11-27
USRE37516E1 (en) 2002-01-15
DE69535786D1 (de) 2008-08-21
CA2382275A1 (en) 1996-04-18
EP0731698A1 (de) 1996-09-18
DK0966962T3 (da) 2001-03-19
DK0731698T3 (da) 2000-05-08
BR9509257A (pt) 1998-07-07
SK44597A3 (en) 1997-09-10
EP0731698B1 (de) 2000-01-12
CZ291700B6 (cs) 2003-05-14
EP1088549A1 (de) 2001-04-04
EE9700082A (et) 1997-10-15
PT966962E (pt) 2001-06-29
MD970143A (ro) 1998-12-31
ATE199216T1 (de) 2001-03-15
JP2915146B2 (ja) 1999-07-05
HK1024625A1 (en) 2000-10-20
SK283632B6 (sk) 2003-11-04
DE69520161T2 (de) 2001-08-02
DE69514497D1 (de) 2000-02-17
LT4303B (lt) 1998-03-25
FI971417A0 (fi) 1997-04-04
ES2142499T3 (es) 2000-04-16
JPH09511754A (ja) 1997-11-25
WO1996011001A1 (en) 1996-04-18
PL319480A1 (en) 1997-08-04
GR3033152T3 (en) 2000-08-31
PT731698E (pt) 2000-05-31
NO971541D0 (no) 1997-04-04
UA42023C2 (uk) 2001-10-15
RO118928B1 (ro) 2004-01-30
CA2201967A1 (en) 1996-04-18
CZ103297A3 (en) 1997-09-17
ES2308960T3 (es) 2008-12-16
IS1987B (is) 2005-02-15
CA2382275C (en) 2003-12-16
NO318818B1 (no) 2005-05-09
AU703087B2 (en) 1999-03-18
LV11852A (lv) 1997-10-20
EP1088549B1 (de) 2008-07-09
ES2156457T3 (es) 2001-06-16
GB9524328D0 (en) 1996-01-31
HUT77778A (hu) 1998-08-28
LV11852B (en) 1998-03-20
EP0966962B1 (de) 2001-02-21
LT97060A (en) 1997-10-27
IS4451A (is) 1997-03-24
BG62952B1 (bg) 2000-12-29
NZ295869A (en) 1998-02-26

Similar Documents

Publication Publication Date Title
DK1088549T3 (da) Modafinil med defineret partikelstörrelse
DK0547952T3 (da) Anvendelse af modafinil til fremstilling af et antiisskæmisk lægemiddel
BR9407720A (pt) Composto composiçao farmacêutica e processo para a prevençao ou tratamento de pertubaçoes imunorreguladoras ou doenças que compreendem a administraçao do composto
PT95656A (pt) Dispositivo de dupla extremidade para aplicacao e medicao de drogas
EP0515995A3 (en) N-(5-thioxo-l-prolyl)-l-cysteine, derivatives thereof, processes for the preparation thereof and pharmaceutical compositions containing them
BR9205411A (pt) Aparelho e processo para administrar partículas farmaceuticas respiráveis
DE59410107D1 (de) Chinoxaline und arzneimittel daraus
BR9205493A (pt) Composicao farmaceutica e processo para fabricacao de composicao farmaceutica
ZA945892B (en) Microparticles processes for their preparation and their use for the preparation of medicaments
ZA906792B (en) Pharmaceutical compositions and a device for administering the same
NO920032D0 (no) Farmasoeytiske blandinger med kontinuerlig frigjoering
IL96117A0 (en) Methionine n alpha-acetyl-transferase and methods for the use thereof