DK1054673T3 - Benzoxazinforbindelser til forstærkelse af synaptisk reaktion - Google Patents
Benzoxazinforbindelser til forstærkelse af synaptisk reaktionInfo
- Publication number
- DK1054673T3 DK1054673T3 DK98964112T DK98964112T DK1054673T3 DK 1054673 T3 DK1054673 T3 DK 1054673T3 DK 98964112 T DK98964112 T DK 98964112T DK 98964112 T DK98964112 T DK 98964112T DK 1054673 T3 DK1054673 T3 DK 1054673T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- ampa receptors
- disclosed
- methods
- benzoxazine compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/998,300 US5985871A (en) | 1997-12-24 | 1997-12-24 | Benzoxazine compounds for enhancing synaptic response |
PCT/US1998/027027 WO1999033469A1 (en) | 1997-12-24 | 1998-12-16 | Benzoxazine compounds for enhancing synaptic response |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1054673T3 true DK1054673T3 (da) | 2004-07-05 |
Family
ID=25545024
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98964112T DK1054673T3 (da) | 1997-12-24 | 1998-12-16 | Benzoxazinforbindelser til forstærkelse af synaptisk reaktion |
Country Status (22)
Country | Link |
---|---|
US (1) | US5985871A (ja) |
EP (1) | EP1054673B1 (ja) |
JP (1) | JP4620244B2 (ja) |
KR (1) | KR100561049B1 (ja) |
CN (1) | CN1160360C (ja) |
AT (1) | ATE261306T1 (ja) |
AU (1) | AU746971B2 (ja) |
BR (1) | BR9814478A (ja) |
CA (1) | CA2316356C (ja) |
DE (1) | DE69822344T2 (ja) |
DK (1) | DK1054673T3 (ja) |
ES (1) | ES2217615T3 (ja) |
HU (1) | HUP0102056A3 (ja) |
IL (1) | IL136783A (ja) |
MX (1) | MXPA00006155A (ja) |
NO (1) | NO325764B1 (ja) |
NZ (1) | NZ505212A (ja) |
PL (1) | PL194905B1 (ja) |
PT (1) | PT1054673E (ja) |
RU (1) | RU2246497C2 (ja) |
TR (1) | TR200001971T2 (ja) |
WO (1) | WO1999033469A1 (ja) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6110935A (en) | 1997-02-13 | 2000-08-29 | The Regents Of The University Of California | Benzofurazan compounds for enhancing glutamatergic synaptic responses |
US6124278A (en) * | 1998-04-03 | 2000-09-26 | The Regents Of The University Of California | Acylbenzoxazines for enhancing synaptic response |
DE10004572A1 (de) | 2000-02-02 | 2001-08-09 | Boehringer Ingelheim Pharma | Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
TWI232863B (en) | 2001-06-11 | 2005-05-21 | Akzo Nobel Nv | Benzoxazepine derivatives |
KR100864267B1 (ko) | 2001-06-14 | 2008-10-20 | 엔.브이.오가논 | AMPA 수용체의 양성 조절제로서의(피리도/티에노)-[f]-옥사제핀-5-온 유도체 |
JP2006516283A (ja) | 2003-01-13 | 2006-06-29 | コーテックス ファーマシューティカルズ, インコーポレイテッド | 睡眠不足とストレスに起因する知覚衰退の処置方法 |
WO2006034196A1 (en) * | 2004-09-17 | 2006-03-30 | Lifelike Biomatic Inc. | Compositions for enhancing memory and methods therefor |
NZ578293A (en) | 2007-01-03 | 2012-01-12 | Cortex Pharma Inc | 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses |
EP2114158B1 (en) * | 2007-01-03 | 2012-08-08 | Cortex Pharmaceuticals, Inc. | 3-substituted-[1,2,3]benzotriazinone compounds for enhancing glutamatergic synaptic responses |
KR101599661B1 (ko) | 2007-05-17 | 2016-03-03 | 코텍스 파마슈티칼스, 인크. | 글루타메이트에 의한 시냅스 반응을 향상시키기 위한 이치환된 아미드 화합물 |
SG163526A1 (en) | 2007-08-10 | 2010-08-30 | Cortex Pharma Inc | Bicyclic amides for enhancing glutamatergic synaptic responses |
US8168632B2 (en) | 2007-08-10 | 2012-05-01 | Cortex Pharmaceuticals, Inc. | Bicyclic amide derivatives for the treatment of respiratory disorders |
US20110218190A1 (en) * | 2008-11-10 | 2011-09-08 | The Regents Of The University Of California | Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction |
EP2544688B1 (en) | 2010-03-02 | 2016-09-07 | President and Fellows of Harvard College | Methods and compositions for treatment of angelman syndrome |
EP2701727B1 (en) | 2011-03-04 | 2019-05-08 | The Regents of The University of California | Locally released growth factors to mediate motor recovery after stroke |
PL2698372T3 (pl) * | 2011-04-06 | 2016-07-29 | Taiho Pharmaceutical Co Ltd | Nowy związek imidazooksazynowy lub jego sól |
CA2915405A1 (en) | 2013-06-13 | 2014-12-18 | Veroscience Llc | Compositions and methods for treating metabolic disorders |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE215079T1 (de) * | 1992-07-24 | 2002-04-15 | Univ California | Arzneimittel, die den durch ampa rezeptoren vermittelten synaptischen respons erhöhen |
JPH0943929A (ja) * | 1995-05-19 | 1997-02-14 | Matsushita Electric Ind Co Ltd | 電子写真複写装置 |
US5650409A (en) * | 1995-06-02 | 1997-07-22 | Cortex Pharmaceuticals, Inc. | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
US5736543A (en) * | 1996-04-03 | 1998-04-07 | The Regents Of The University Of California | Benzoxazines for enhancing synaptic response |
-
1997
- 1997-12-24 US US08/998,300 patent/US5985871A/en not_active Expired - Fee Related
-
1998
- 1998-12-16 JP JP2000526226A patent/JP4620244B2/ja not_active Expired - Fee Related
- 1998-12-16 ES ES98964112T patent/ES2217615T3/es not_active Expired - Lifetime
- 1998-12-16 KR KR1020007007128A patent/KR100561049B1/ko not_active IP Right Cessation
- 1998-12-16 WO PCT/US1998/027027 patent/WO1999033469A1/en not_active Application Discontinuation
- 1998-12-16 EP EP98964112A patent/EP1054673B1/en not_active Expired - Lifetime
- 1998-12-16 PT PT98964112T patent/PT1054673E/pt unknown
- 1998-12-16 AT AT98964112T patent/ATE261306T1/de active
- 1998-12-16 DE DE69822344T patent/DE69822344T2/de not_active Expired - Lifetime
- 1998-12-16 AU AU19305/99A patent/AU746971B2/en not_active Ceased
- 1998-12-16 IL IL13678398A patent/IL136783A/xx not_active IP Right Cessation
- 1998-12-16 BR BR9814478-2A patent/BR9814478A/pt not_active Application Discontinuation
- 1998-12-16 RU RU2000119735/04A patent/RU2246497C2/ru not_active IP Right Cessation
- 1998-12-16 MX MXPA00006155A patent/MXPA00006155A/es not_active IP Right Cessation
- 1998-12-16 CN CNB988125390A patent/CN1160360C/zh not_active Expired - Fee Related
- 1998-12-16 DK DK98964112T patent/DK1054673T3/da active
- 1998-12-16 PL PL341427A patent/PL194905B1/pl not_active IP Right Cessation
- 1998-12-16 TR TR2000/01971T patent/TR200001971T2/xx unknown
- 1998-12-16 HU HU0102056A patent/HUP0102056A3/hu unknown
- 1998-12-16 CA CA002316356A patent/CA2316356C/en not_active Expired - Fee Related
-
2000
- 2000-06-16 NZ NZ505212A patent/NZ505212A/xx unknown
- 2000-06-19 NO NO20003166A patent/NO325764B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HUP0102056A2 (hu) | 2001-11-28 |
KR100561049B1 (ko) | 2006-03-16 |
PL341427A1 (en) | 2001-04-09 |
RU2246497C2 (ru) | 2005-02-20 |
TR200001971T2 (tr) | 2001-01-22 |
DE69822344T2 (de) | 2005-02-17 |
NZ505212A (en) | 2003-02-28 |
IL136783A0 (en) | 2001-06-14 |
EP1054673B1 (en) | 2004-03-10 |
NO20003166D0 (no) | 2000-06-19 |
PT1054673E (pt) | 2004-08-31 |
CA2316356A1 (en) | 1999-07-08 |
AU746971B2 (en) | 2002-05-09 |
MXPA00006155A (es) | 2002-04-24 |
BR9814478A (pt) | 2000-10-10 |
NO325764B1 (no) | 2008-07-14 |
HUP0102056A3 (en) | 2003-03-28 |
DE69822344D1 (de) | 2004-04-15 |
NO20003166L (no) | 2000-08-07 |
CN1283114A (zh) | 2001-02-07 |
EP1054673A1 (en) | 2000-11-29 |
CN1160360C (zh) | 2004-08-04 |
JP4620244B2 (ja) | 2011-01-26 |
US5985871A (en) | 1999-11-16 |
WO1999033469A1 (en) | 1999-07-08 |
IL136783A (en) | 2005-11-20 |
AU1930599A (en) | 1999-07-19 |
CA2316356C (en) | 2009-11-03 |
JP2001527045A (ja) | 2001-12-25 |
ATE261306T1 (de) | 2004-03-15 |
PL194905B1 (pl) | 2007-07-31 |
KR20010033615A (ko) | 2001-04-25 |
EP1054673A4 (en) | 2001-07-18 |
ES2217615T3 (es) | 2004-11-01 |
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