DK1032424T3 - Kombination af en aldosereduktaseinhibitor og en glycogenphosphorylaseinhibitor - Google Patents
Kombination af en aldosereduktaseinhibitor og en glycogenphosphorylaseinhibitorInfo
- Publication number
- DK1032424T3 DK1032424T3 DK98949193T DK98949193T DK1032424T3 DK 1032424 T3 DK1032424 T3 DK 1032424T3 DK 98949193 T DK98949193 T DK 98949193T DK 98949193 T DK98949193 T DK 98949193T DK 1032424 T3 DK1032424 T3 DK 1032424T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitor
- combination
- aldose reductase
- glycogen phosphorylase
- reductase inhibitor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Superheterodyne Receivers (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Noise Elimination (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6636597P | 1997-11-21 | 1997-11-21 | |
| PCT/IB1998/001752 WO1999026659A1 (fr) | 1997-11-21 | 1998-11-02 | Combinaison d'un inhibiteur de reductase d'aldose et d'un inhibiteur de phosphorylase de glycogene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1032424T3 true DK1032424T3 (da) | 2001-11-19 |
Family
ID=22069038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98949193T DK1032424T3 (da) | 1997-11-21 | 1998-11-02 | Kombination af en aldosereduktaseinhibitor og en glycogenphosphorylaseinhibitor |
Country Status (38)
| Country | Link |
|---|---|
| EP (1) | EP1032424B9 (fr) |
| JP (1) | JP2002504478A (fr) |
| KR (2) | KR20010032304A (fr) |
| CN (1) | CN1279617A (fr) |
| AP (1) | AP911A (fr) |
| AR (1) | AR016423A1 (fr) |
| AT (1) | ATE205403T1 (fr) |
| AU (1) | AU733304B2 (fr) |
| BG (1) | BG104435A (fr) |
| BR (1) | BR9814698A (fr) |
| CA (1) | CA2310069A1 (fr) |
| DE (1) | DE69801680T2 (fr) |
| DK (1) | DK1032424T3 (fr) |
| DZ (1) | DZ2656A1 (fr) |
| EA (1) | EA002365B1 (fr) |
| ES (1) | ES2161548T3 (fr) |
| GR (1) | GR3037071T3 (fr) |
| GT (1) | GT199800166A (fr) |
| HR (1) | HRP20000327A2 (fr) |
| HU (1) | HUP0100272A3 (fr) |
| ID (1) | ID24524A (fr) |
| IL (1) | IL135713A0 (fr) |
| IS (1) | IS5453A (fr) |
| MA (1) | MA26568A1 (fr) |
| NO (1) | NO20002164L (fr) |
| OA (1) | OA11379A (fr) |
| PA (1) | PA8462301A1 (fr) |
| PE (1) | PE135399A1 (fr) |
| PL (1) | PL340643A1 (fr) |
| PT (1) | PT1032424E (fr) |
| SK (1) | SK7222000A3 (fr) |
| TN (1) | TNSN98211A1 (fr) |
| TR (1) | TR200001451T2 (fr) |
| UA (1) | UA57811C2 (fr) |
| UY (1) | UY25258A1 (fr) |
| WO (1) | WO1999026659A1 (fr) |
| YU (1) | YU30700A (fr) |
| ZA (1) | ZA9810636B (fr) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2535700A (en) * | 1999-02-12 | 2000-08-29 | Novo Nordisk A/S | Use of pyrrolidine derivatives for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of obesity or appetite regulation |
| DK1741445T3 (da) | 2000-01-21 | 2013-11-04 | Novartis Ag | Kombinationer omfattende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler |
| CO5271699A1 (es) * | 2000-01-24 | 2003-04-30 | Pfizer Prod Inc | Procedimiento para el tratamiento de cardiomiopatia utilizando inhibidores de la glucogeno fosforilasa |
| US6570013B2 (en) | 2000-02-16 | 2003-05-27 | Pfizer Inc | Salts of zopolrestat |
| US6395767B2 (en) | 2000-03-10 | 2002-05-28 | Bristol-Myers Squibb Company | Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method |
| IL144507A0 (en) * | 2000-07-31 | 2002-05-23 | Pfizer Prod Inc | Use of glycogen phosphorylase inhibitors to inhibit tumor growth |
| WO2002098429A1 (fr) * | 2001-06-07 | 2002-12-12 | Pfizer Products Inc. | Formes salines du zopolrestat, a savoir ethanolamine, diethanolamine ou triethanolamine |
| GB0205162D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0205165D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0205175D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0205166D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0205170D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| GB0205176D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| US7057046B2 (en) | 2002-05-20 | 2006-06-06 | Bristol-Myers Squibb Company | Lactam glycogen phosphorylase inhibitors and method of use |
| CA2392486A1 (fr) | 2002-07-05 | 2002-12-08 | Duchesnay Inc. | Forme posologique pharmaceutique portant une inscription pour les femmes enceintes |
| US7098235B2 (en) | 2002-11-14 | 2006-08-29 | Bristol-Myers Squibb Co. | Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds |
| US7767828B2 (en) | 2003-11-12 | 2010-08-03 | Phenomix Corporation | Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| US7576121B2 (en) | 2003-11-12 | 2009-08-18 | Phenomix Corporation | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| US7317109B2 (en) | 2003-11-12 | 2008-01-08 | Phenomix Corporation | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| KR100918322B1 (ko) | 2003-11-12 | 2009-09-22 | 페노믹스 코포레이션 | 헤테로시클릭 보론산 화합물 |
| EP1778220A1 (fr) | 2004-07-12 | 2007-05-02 | Phenomix Corporation | Composes cyano contraints |
| WO2006055462A1 (fr) | 2004-11-15 | 2006-05-26 | Bristol-Myers Squibb Company | Derives 2-amino-4- tetraline fonctionnalisee et inhibiteurs de la glycogene phosphorylase associes |
| WO2006053274A2 (fr) | 2004-11-15 | 2006-05-18 | Bristol-Myers Squibb Company | Derives de tetraline 2-amino-1-fonctionnalises et inhibiteurs correspondants de glycogene phosphorylase |
| US7223786B2 (en) | 2004-11-15 | 2007-05-29 | Bristol-Myers Squibb Company | 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors |
| WO2006055463A2 (fr) | 2004-11-15 | 2006-05-26 | Bristol-Myers Squibb Company | Derives de 2-amino-3-tetraline fonctionnalisee et inhibiteurs de la glycogene phosphorylase associes |
| EP1879881A2 (fr) | 2005-04-14 | 2008-01-23 | Bristol-Myers Squibb Company | Inhibiteurs de la 11-beta hydroxysteroide deshydrogenase de type i |
| US7825139B2 (en) | 2005-05-25 | 2010-11-02 | Forest Laboratories Holdings Limited (BM) | Compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| KR101352588B1 (ko) | 2005-09-14 | 2014-01-17 | 다케다 야쿠힌 고교 가부시키가이샤 | 당뇨병 치료용 디펩티딜 펩티다아제 억제제 |
| US8318941B2 (en) | 2006-07-06 | 2012-11-27 | Bristol-Myers Squibb Company | Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
| US7727978B2 (en) | 2006-08-24 | 2010-06-01 | Bristol-Myers Squibb Company | Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors |
| CN101687873A (zh) | 2007-04-17 | 2010-03-31 | 百时美施贵宝公司 | 具有稠合杂环的11β-羟基类固醇Ⅰ型脱氢酶抑制剂 |
| PE20090213A1 (es) | 2007-05-04 | 2009-02-28 | Bristol Myers Squibb Co | Agonistas del receptor acoplado a la proteina g gpr119 [6,5]-biciclicos |
| ES2388967T3 (es) | 2007-05-04 | 2012-10-22 | Bristol-Myers Squibb Company | Agonistas [6,6]- y [6,7]-bicíclicos del receptor GPR119 acoplado a la proteína G |
| CA2693439A1 (fr) | 2007-07-17 | 2009-01-22 | Bristol-Myers Squibb Company | Agonistes du recepteur gpr119 couple a la proteine g pyridone |
| TW201006821A (en) | 2008-07-16 | 2010-02-16 | Bristol Myers Squibb Co | Pyridone and pyridazone analogues as GPR119 modulators |
| WO2011041293A1 (fr) | 2009-09-30 | 2011-04-07 | Takeda Pharmaceutical Company Limited | Dérivés pyrazolo [1, 5a] pyrimidines comme inhibiteurs de kinase 1 régulatrice de signal d'apoptose |
| PL2531501T3 (pl) | 2010-02-03 | 2014-05-30 | Takeda Pharmaceuticals Co | Inhibitory kinazy 1 regulującej sygnał apoptotyczny |
| WO2011127106A1 (fr) | 2010-04-08 | 2011-10-13 | Bristol-Myers Squibb Company | Composés analogues de la pyrimidinylpipéridinyloxypyridinone comme modulateurs du gpr119 |
| WO2011130459A1 (fr) | 2010-04-14 | 2011-10-20 | Bristol-Myers Squibb Company | Nouveaux activateurs de la glucokinase et méthodes d'utilisation desdits activateurs |
| JP2013525489A (ja) | 2010-05-06 | 2013-06-20 | ブリストル−マイヤーズ スクイブ カンパニー | Ｇｐｒ１１９修飾因子としての二環式ヘテロアリール類似体 |
| EP2566862B1 (fr) | 2010-05-06 | 2015-09-16 | Bristol-Myers Squibb Company | Analogues de benzofuranyle en tant que modulateurs de gpr119 |
| RS54447B1 (en) | 2011-01-20 | 2016-06-30 | Bionevia Pharmaceuticals Inc. | MODIFIED LABELING COMPOSITIONS OF EPALRESTAT OR ITS DERIVATIVES AND PROCEDURES FOR THEIR USE |
| US9174965B2 (en) | 2012-05-16 | 2015-11-03 | Bristol-Myers Squibb Company | Pyrimidinylpiperidinyloxypyridone analogues as GPR119 modulators |
| US9580422B2 (en) | 2013-10-22 | 2017-02-28 | Bristol-Myers Squibb Company | Isotopically labeled triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
| US10604541B2 (en) | 2016-07-22 | 2020-03-31 | Bristol-Myers Squibb Company | Glucokinase activators and methods of using same |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4825448A (en) * | 1986-08-07 | 1989-04-25 | International Mobile Machines Corporation | Subscriber unit for wireless digital telephone system |
| EP0343273B1 (fr) * | 1988-05-27 | 1994-04-27 | Deutsche ITT Industries GmbH | Circuit de correction pour une paire de signaux numériques en quadrature |
| US5391551A (en) * | 1993-05-10 | 1995-02-21 | Pfizer Inc. | Method of lowering blood lipid levels |
| JP3314938B2 (ja) * | 1995-06-06 | 2002-08-19 | ファイザー・インコーポレーテッド | グリコーゲンホスホリラーゼ抑制剤としての置換されたｎ−（インドール−２−カルボニル）−グリシンアミド類および誘導体 |
| AP9600817A0 (en) * | 1995-06-06 | 1996-07-31 | Pfizer | Novel cryatal form of anhydrous 7-( [1A,5A,6A]-6-amino3-3-azabicyclo [3.1.0.] hex-3-yl) -6-fluro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt. |
-
1998
- 1998-02-11 UA UA2000052869A patent/UA57811C2/uk unknown
- 1998-10-27 GT GT199800166A patent/GT199800166A/es unknown
- 1998-10-28 PA PA19988462301A patent/PA8462301A1/es unknown
- 1998-11-02 AT AT98949193T patent/ATE205403T1/de not_active IP Right Cessation
- 1998-11-02 EA EA200000433A patent/EA002365B1/ru not_active IP Right Cessation
- 1998-11-02 AU AU95558/98A patent/AU733304B2/en not_active Ceased
- 1998-11-02 TR TR2000/01451T patent/TR200001451T2/xx unknown
- 1998-11-02 CN CN98811329A patent/CN1279617A/zh active Pending
- 1998-11-02 KR KR1020007005514A patent/KR20010032304A/ko not_active Application Discontinuation
- 1998-11-02 EP EP98949193A patent/EP1032424B9/fr not_active Expired - Lifetime
- 1998-11-02 PT PT81300054T patent/PT1032424E/pt unknown
- 1998-11-02 BR BR9814698-0A patent/BR9814698A/pt not_active IP Right Cessation
- 1998-11-02 JP JP2000521860A patent/JP2002504478A/ja active Pending
- 1998-11-02 CA CA002310069A patent/CA2310069A1/fr not_active Abandoned
- 1998-11-02 ID IDW20000958A patent/ID24524A/id unknown
- 1998-11-02 WO PCT/IB1998/001752 patent/WO1999026659A1/fr not_active Application Discontinuation
- 1998-11-02 SK SK722-2000A patent/SK7222000A3/sk unknown
- 1998-11-02 HU HU0100272A patent/HUP0100272A3/hu unknown
- 1998-11-02 DK DK98949193T patent/DK1032424T3/da active
- 1998-11-02 ES ES98949193T patent/ES2161548T3/es not_active Expired - Lifetime
- 1998-11-02 YU YU30700A patent/YU30700A/sh unknown
- 1998-11-02 IL IL13571398A patent/IL135713A0/xx unknown
- 1998-11-02 PL PL98340643A patent/PL340643A1/xx unknown
- 1998-11-02 DE DE69801680T patent/DE69801680T2/de not_active Expired - Fee Related
- 1998-11-16 PE PE1998001113A patent/PE135399A1/es not_active Application Discontinuation
- 1998-11-18 DZ DZ980266A patent/DZ2656A1/fr active
- 1998-11-18 TN TNTNSN98211A patent/TNSN98211A1/fr unknown
- 1998-11-19 AP APAP/P/1998/001401A patent/AP911A/en active
- 1998-11-19 AR ARP980105883A patent/AR016423A1/es not_active Application Discontinuation
- 1998-11-19 UY UY25258A patent/UY25258A1/es not_active Application Discontinuation
- 1998-11-19 MA MA25356A patent/MA26568A1/fr unknown
- 1998-11-20 ZA ZA9810636A patent/ZA9810636B/xx unknown
-
1999
- 1999-05-07 KR KR1020007013394A patent/KR100661214B1/ko not_active IP Right Cessation
-
2000
- 2000-04-14 IS IS5453A patent/IS5453A/is unknown
- 2000-04-27 NO NO20002164A patent/NO20002164L/no not_active Application Discontinuation
- 2000-05-12 OA OA1200000137A patent/OA11379A/en unknown
- 2000-05-15 BG BG104435A patent/BG104435A/bg unknown
- 2000-05-19 HR HR20000327A patent/HRP20000327A2/hr not_active Application Discontinuation
-
2001
- 2001-10-30 GR GR20010401943T patent/GR3037071T3/el not_active IP Right Cessation
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