NO20001926D0 - iso-CBI- og iso-CI-analoger av CC-1065 og duokarmyciner - Google Patents
iso-CBI- og iso-CI-analoger av CC-1065 og duokarmycinerInfo
- Publication number
- NO20001926D0 NO20001926D0 NO20001926A NO20001926A NO20001926D0 NO 20001926 D0 NO20001926 D0 NO 20001926D0 NO 20001926 A NO20001926 A NO 20001926A NO 20001926 A NO20001926 A NO 20001926A NO 20001926 D0 NO20001926 D0 NO 20001926D0
- Authority
- NO
- Norway
- Prior art keywords
- iso
- duocarmycins
- cbi
- analogues
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6189297P | 1997-10-14 | 1997-10-14 | |
PCT/US1998/021749 WO1999019298A1 (en) | 1997-10-14 | 1998-10-14 | iso-CBI AND iso-CI ANALOGS OF CC-1065 AND THE DUOCARMYCINS |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20001926D0 true NO20001926D0 (no) | 2000-04-13 |
NO20001926L NO20001926L (no) | 2000-06-14 |
Family
ID=22038819
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20001926A NO20001926L (no) | 1997-10-14 | 2000-04-13 | Iso-CBI- og iso-CI-analoger av CC-1065 og duocarmycinene |
Country Status (9)
Country | Link |
---|---|
US (2) | US6262271B1 (no) |
EP (1) | EP1042285A4 (no) |
JP (1) | JP2001519412A (no) |
AU (1) | AU756721B2 (no) |
CA (1) | CA2306420A1 (no) |
IL (1) | IL135616A0 (no) |
NO (1) | NO20001926L (no) |
NZ (1) | NZ503966A (no) |
WO (1) | WO1999019298A1 (no) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001525382A (ja) * | 1997-12-08 | 2001-12-11 | ザ スクリップス リサーチ インスティテュート | Cc−1065/デュオカルマイシン類似体の合成 |
EP1320522B8 (en) * | 2000-09-19 | 2006-02-01 | Moses Lee | Compositions and methods of the use thereof achiral analogues of cc-1065 and the duocarmycins |
EP1330459B1 (en) | 2000-10-02 | 2006-08-02 | Emory University | Triptolide analogs for the treatment of autoimmune and inflammatory disorders |
US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
WO2002092771A2 (en) | 2001-05-11 | 2002-11-21 | Ludwig Institute For Cancer Research | Specific binding proteins and uses thereof |
KR20030033007A (ko) * | 2001-05-31 | 2003-04-26 | 코울터 파머수티컬, 인코포레이티드 | 세포독소, 약물전구체, 링커 및 이에 유용한 안정화제 |
CN100519555C (zh) | 2004-03-13 | 2009-07-29 | Tmrc株式会社 | 将dna的特定碱基序列烷基化的新吲哚衍生物和使用其的烷基化剂以及药剂 |
CA2564076C (en) * | 2004-05-19 | 2014-02-18 | Medarex, Inc. | Chemical linkers and conjugates thereof |
US7691962B2 (en) * | 2004-05-19 | 2010-04-06 | Medarex, Inc. | Chemical linkers and conjugates thereof |
CN101124249B (zh) * | 2005-02-18 | 2011-06-29 | 米德列斯公司 | 抗前列腺特异性膜抗原(psma)的人单克隆抗体 |
US7714016B2 (en) * | 2005-04-08 | 2010-05-11 | Medarex, Inc. | Cytotoxic compounds and conjugates with cleavable substrates |
BRPI0617546A2 (pt) * | 2005-09-26 | 2011-07-26 | Medarex Inc | conjugado de fÁrmaco-anticorpo, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula de tumor, mÉtodo para retardar ou interromper o crescimento de um tumor em um sujeito mamÍfero e composto |
CA2627046C (en) | 2005-10-26 | 2015-09-15 | Medarex, Inc. | Methods and compounds for preparing cc-1065 analogs |
CA2627190A1 (en) | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Duocarmycin derivatives as novel cytotoxic compounds and conjugates |
TWI412367B (zh) * | 2006-12-28 | 2013-10-21 | Medarex Llc | 化學鏈接劑與可裂解基質以及其之綴合物 |
MX2009007987A (es) * | 2007-01-25 | 2010-03-01 | Dana Farber Cancer Inst Inc | Uso de anticuerpos anti-egfr en el tratamiento de enfermedad mediada por egfr mutante. |
TW200900059A (en) | 2007-02-21 | 2009-01-01 | Medarex Inc | Chemical linkers with single amino acids and conjugates thereof |
US9023356B2 (en) * | 2007-03-15 | 2015-05-05 | Ludwig Institute For Cancer Research Ltd | Treatment method using EGFR antibodies and SRC inhibitors and related formulations |
US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
JP5532486B2 (ja) | 2007-08-14 | 2014-06-25 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | Egf受容体を標的とするモノクローナル抗体175ならびにその誘導体および用途 |
US8351666B2 (en) | 2007-11-15 | 2013-01-08 | General Electric Company | Portable imaging system having a seamless form factor |
MX2011004625A (es) | 2008-11-03 | 2011-07-20 | Syntarga Bv | Analogos cc-1065 novedosos y sus conjugados. |
US20110076232A1 (en) * | 2009-09-29 | 2011-03-31 | Ludwig Institute For Cancer Research | Specific binding proteins and uses thereof |
PL2560645T3 (pl) | 2010-04-21 | 2017-01-31 | Syntarga B.V. | Koniugaty analogów CC-1065 i łączników dwufunkcyjnych |
JP6133431B2 (ja) | 2012-11-24 | 2017-05-24 | ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. | 親水性連結体及び薬物分子と細胞結合分子との共役反応における親水性連結体の使用 |
SG11201504887TA (en) | 2012-12-21 | 2015-07-30 | Bioalliance Cv | Hydrophilic self-immolative linkers and conjugates thereof |
MY177390A (en) | 2014-01-10 | 2020-09-14 | Byondis Bv | Method for purifying cys-linked antibody-drug conjugates |
US10464955B2 (en) | 2014-02-28 | 2019-11-05 | Hangzhou Dac Biotech Co., Ltd. | Charged linkers and their uses for conjugation |
CN106661124A (zh) | 2014-06-20 | 2017-05-10 | 荷商台医(有限合伙)公司 | 抗叶酸受体α(FRA)抗体‑药物缀合物及其使用方法 |
AU2015242213A1 (en) | 2015-07-12 | 2018-03-08 | Hangzhou Dac Biotech Co., Ltd | Bridge linkers for conjugation of cell-binding molecules |
US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
EP3400239B1 (en) | 2016-01-08 | 2021-06-02 | AltruBio Inc. | Tetravalent anti-psgl-1 antibodies and uses thereof |
KR20220147720A (ko) | 2016-11-14 | 2022-11-03 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2076465C (en) * | 1992-03-25 | 2002-11-26 | Ravi V. J. Chari | Cell binding agent conjugates of analogues and derivatives of cc-1065 |
-
1998
- 1998-10-14 CA CA002306420A patent/CA2306420A1/en not_active Abandoned
- 1998-10-14 AU AU11887/99A patent/AU756721B2/en not_active Ceased
- 1998-10-14 JP JP2000515871A patent/JP2001519412A/ja active Pending
- 1998-10-14 US US09/529,345 patent/US6262271B1/en not_active Expired - Fee Related
- 1998-10-14 IL IL13561698A patent/IL135616A0/xx unknown
- 1998-10-14 EP EP98954974A patent/EP1042285A4/en not_active Withdrawn
- 1998-10-14 NZ NZ503966A patent/NZ503966A/xx unknown
- 1998-10-14 WO PCT/US1998/021749 patent/WO1999019298A1/en not_active Application Discontinuation
-
2000
- 2000-04-13 NO NO20001926A patent/NO20001926L/no not_active Application Discontinuation
-
2001
- 2001-07-17 US US09/908,272 patent/US6486326B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2001519412A (ja) | 2001-10-23 |
IL135616A0 (en) | 2001-05-20 |
AU1188799A (en) | 1999-05-03 |
NO20001926L (no) | 2000-06-14 |
NZ503966A (en) | 2002-10-25 |
US20020049335A1 (en) | 2002-04-25 |
US6262271B1 (en) | 2001-07-17 |
US6486326B2 (en) | 2002-11-26 |
AU756721B2 (en) | 2003-01-23 |
EP1042285A4 (en) | 2002-11-20 |
CA2306420A1 (en) | 1999-04-22 |
EP1042285A1 (en) | 2000-10-11 |
WO1999019298A1 (en) | 1999-04-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20001926D0 (no) | iso-CBI- og iso-CI-analoger av CC-1065 og duokarmyciner | |
MA26668A1 (fr) | ACTIVATEURS DE hPPARy ET hPPARa | |
AU3217897A (en) | Analogs of cc-1065 and the duocarmycins | |
IS5341A (is) | Samsett meðferð sem inniheldur atórvastatin og þrýstingslækkandi miðil | |
DK0915880T3 (da) | Azolotriaziner og pyrimidiner | |
NO975759D0 (no) | Inokuleringsmiddel og fremgangsmåte for fremstilling av inokuleringsmiddel | |
PL339053A1 (en) | Novel derivatives of 2-oxy-pyrimidyn-4-one and pyrimidin-4-thione as fungicides | |
NO984094L (no) | Utladningsreaktor og anvendelse av samme | |
NO995324L (no) | Baerer for gjenstander og emne for denne | |
FI980246A (fi) | Menetelmä keittimen käyttämiseksi ja keitin | |
NO980718D0 (no) | Bicykliske 4-aralkylaminopyrimidinderivater og tyrosinkinaseinhibitorer | |
ID17406A (id) | Benda-benda penyerap berpori | |
NO972103L (no) | Eleutherobin og analoger av denne | |
DE69802692D1 (de) | Derivate der chinoloncarbonsäure | |
DE29608389U1 (de) | Personenbeförderungsmittel | |
NO990832D0 (no) | Syntese av bisendolylmalimider | |
NO20002508D0 (no) | Ballastering av halvt nedsenkbar plattform | |
NO990806L (no) | Biologisk nedbrytning av eksplosiver | |
BR9704770A (pt) | Derivados de 1-carba-(detia)-cefalosporina | |
DK1042286T3 (da) | Gamme-glutamyl- og beta-aspartyl-holdige immunmodulerende forbindelser og tilhørense fremgangsmåder | |
PL338862A1 (en) | Derivatives of 2-oxypyroimidin-4-one and 2-oxypyroimidin-4-thione | |
NO20000038L (no) | Benzodiazepinderivater og tilsvarende anvendelse og sammensetning | |
NO995269D0 (no) | Anvendelse av immunmodulerende midler | |
ID17459A (id) | Unsur-unsur pengobatan | |
UA2072S (uk) | Набір блюд |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |