NO980718D0 - Bicykliske 4-aralkylaminopyrimidinderivater og tyrosinkinaseinhibitorer - Google Patents
Bicykliske 4-aralkylaminopyrimidinderivater og tyrosinkinaseinhibitorerInfo
- Publication number
- NO980718D0 NO980718D0 NO980718A NO980718A NO980718D0 NO 980718 D0 NO980718 D0 NO 980718D0 NO 980718 A NO980718 A NO 980718A NO 980718 A NO980718 A NO 980718A NO 980718 D0 NO980718 D0 NO 980718D0
- Authority
- NO
- Norway
- Prior art keywords
- bicyclic
- tyrosine kinase
- kinase inhibitors
- aralkylaminopyrimidine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9613021.6A GB9613021D0 (en) | 1996-06-21 | 1996-06-21 | Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors |
PCT/EP1997/002965 WO1997049689A1 (en) | 1996-06-21 | 1997-06-03 | Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
NO980718D0 true NO980718D0 (no) | 1998-02-20 |
NO980718L NO980718L (no) | 1998-04-08 |
Family
ID=10795666
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO980718A NO980718L (no) | 1996-06-21 | 1998-02-20 | Bicykliske 4-aralkylaminopyrimidinderivater og tyrosinkinaseinhibitorer |
Country Status (20)
Country | Link |
---|---|
US (1) | US6057326A (no) |
EP (1) | EP0853616B1 (no) |
JP (1) | JPH11511761A (no) |
KR (1) | KR19990043993A (no) |
CN (1) | CN1198158A (no) |
AR (1) | AR008614A1 (no) |
AT (1) | ATE205836T1 (no) |
AU (1) | AU3094197A (no) |
BR (1) | BR9702328A (no) |
CA (1) | CA2228492C (no) |
DE (1) | DE69706823T2 (no) |
EA (1) | EA199800215A1 (no) |
ES (1) | ES2165061T3 (no) |
GB (1) | GB9613021D0 (no) |
HU (1) | HUP9902026A3 (no) |
IL (1) | IL123124A0 (no) |
NO (1) | NO980718L (no) |
PL (1) | PL325122A1 (no) |
WO (1) | WO1997049689A1 (no) |
ZA (1) | ZA975380B (no) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6347480B1 (en) * | 1997-07-07 | 2002-02-19 | Southpac Trust International, Inc. | Method for wrapping a floral grouping with a sheet of material constructed of paper and having printed and embossed patterns thereon |
IL125686A (en) | 1996-02-13 | 2002-11-10 | Zeneca Ltd | Quinazoline derivatives, processes for their preparation, pharmaceutical preparations containing them and their use in the manufacture of a drug with an anti-angiogenic effect and / or an effect of reducing vascular permeability |
DE69709319T2 (de) | 1996-03-05 | 2002-08-14 | Astrazeneca Ab | 4-anilinochinazolin derivate |
GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
US6608060B1 (en) | 1996-12-18 | 2003-08-19 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
US5945418A (en) * | 1996-12-18 | 1999-08-31 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
US6147080A (en) * | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
DE19653646A1 (de) * | 1996-12-20 | 1998-06-25 | Hoechst Ag | Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung |
EP1230225A2 (en) * | 1999-11-01 | 2002-08-14 | Eli Lilly And Company | Pharmaceutically active 4-substituted pyrimidine derivatives |
US7173038B1 (en) | 1999-11-05 | 2007-02-06 | Astrazeneca Ab | Quinazoline derivatives as VEGF inhibitors |
WO2003009852A1 (en) * | 2001-07-24 | 2003-02-06 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
KR100468352B1 (ko) * | 2002-09-24 | 2005-01-27 | 한국과학기술연구원 | 신규 피라졸로피리미딘계 유도체, 그의 제조방법 및 이를 유효성분으로 하는 약학적 조성물 |
BRPI0413563A (pt) * | 2003-08-15 | 2006-10-17 | Irm Llc | compostos e composições como inibidores de atividade do receptor de quìnase de tirosina |
MXPA06009475A (es) * | 2004-02-19 | 2007-05-15 | Rexahn Corp | Derivados de quinazolina y usos terapeuticos de los mismos. |
US7151176B2 (en) * | 2004-10-21 | 2006-12-19 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds |
ES2319462T3 (es) * | 2005-03-28 | 2009-05-07 | Bristol-Myers Squibb Company | Inhibidores competitivos de atp cinasas. |
TWI385174B (zh) * | 2008-11-10 | 2013-02-11 | Nat Health Research Institutes | 作為酪胺酸激酶抑制劑之稠合雙環及多環嘧啶化合物 |
UA110113C2 (xx) * | 2010-07-29 | 2015-11-25 | Біциклічні азагетероциклічні карбоксаміди | |
EP2655374B1 (en) * | 2010-12-20 | 2019-10-23 | Incyte Holdings Corporation | N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL89028A0 (en) * | 1988-01-29 | 1989-08-15 | Lilly Co Eli | Quinoline,quinazoline and cinnoline derivatives |
ZA902280B (en) * | 1989-03-29 | 1990-12-28 | Merrell Dow Pharma | Selective adenosine receptor agents |
JP2762430B2 (ja) * | 1991-01-18 | 1998-06-04 | 宇部興産株式会社 | アラルキルアミノピリミジン類の製法 |
US5710158A (en) * | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
JPH06172321A (ja) * | 1992-10-08 | 1994-06-21 | Agro Kanesho Co Ltd | 置換アミノピリミジン誘導体、その製造法及びそれを有効成分とする有害生物駆除剤 |
GB9313638D0 (en) * | 1993-07-01 | 1993-08-18 | Erba Carlo Spa | Arylidene and heteroarylidene oxindole derivatives and process for their preparation |
GB9326136D0 (en) * | 1993-12-22 | 1994-02-23 | Erba Carlo Spa | Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents |
IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
GB9406137D0 (en) * | 1994-03-28 | 1994-05-18 | Erba Carlo Spa | N-substituted beta-aryl- and betaheteroaryl-alpha-cyanoacrylamide derivatives and process for their preparation |
GB9412719D0 (en) * | 1994-06-24 | 1994-08-17 | Erba Carlo Spa | Substituted azaindolylidene compounds and process for their preparation |
GB9423997D0 (en) * | 1994-11-28 | 1995-01-11 | Erba Carlo Spa | Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation |
-
1996
- 1996-06-21 GB GBGB9613021.6A patent/GB9613021D0/en active Pending
-
1997
- 1997-06-03 WO PCT/EP1997/002965 patent/WO1997049689A1/en not_active Application Discontinuation
- 1997-06-03 KR KR1019980701225A patent/KR19990043993A/ko not_active Application Discontinuation
- 1997-06-03 ES ES97925987T patent/ES2165061T3/es not_active Expired - Lifetime
- 1997-06-03 HU HU9902026A patent/HUP9902026A3/hu unknown
- 1997-06-03 DE DE69706823T patent/DE69706823T2/de not_active Expired - Fee Related
- 1997-06-03 US US09/000,238 patent/US6057326A/en not_active Expired - Fee Related
- 1997-06-03 EA EA199800215A patent/EA199800215A1/ru unknown
- 1997-06-03 PL PL97325122A patent/PL325122A1/xx unknown
- 1997-06-03 JP JP10502193A patent/JPH11511761A/ja not_active Ceased
- 1997-06-03 IL IL12312497A patent/IL123124A0/xx unknown
- 1997-06-03 CN CN97190942A patent/CN1198158A/zh active Pending
- 1997-06-03 BR BR9702328A patent/BR9702328A/pt not_active Application Discontinuation
- 1997-06-03 CA CA002228492A patent/CA2228492C/en not_active Expired - Fee Related
- 1997-06-03 AU AU30941/97A patent/AU3094197A/en not_active Abandoned
- 1997-06-03 EP EP97925987A patent/EP0853616B1/en not_active Expired - Lifetime
- 1997-06-03 AT AT97925987T patent/ATE205836T1/de not_active IP Right Cessation
- 1997-06-18 ZA ZA9705380A patent/ZA975380B/xx unknown
- 1997-06-20 AR ARP970102715A patent/AR008614A1/es unknown
-
1998
- 1998-02-20 NO NO980718A patent/NO980718L/no unknown
Also Published As
Publication number | Publication date |
---|---|
KR19990043993A (ko) | 1999-06-25 |
EA199800215A1 (ru) | 1998-08-27 |
CA2228492C (en) | 2007-05-08 |
DE69706823T2 (de) | 2002-04-11 |
EP0853616A1 (en) | 1998-07-22 |
HUP9902026A2 (hu) | 2000-04-28 |
ES2165061T3 (es) | 2002-03-01 |
MX9801408A (es) | 1998-05-31 |
WO1997049689A1 (en) | 1997-12-31 |
CN1198158A (zh) | 1998-11-04 |
DE69706823D1 (en) | 2001-10-25 |
AU3094197A (en) | 1998-01-14 |
US6057326A (en) | 2000-05-02 |
GB9613021D0 (en) | 1996-08-28 |
BR9702328A (pt) | 1999-07-20 |
AR008614A1 (es) | 2000-02-09 |
ATE205836T1 (de) | 2001-10-15 |
IL123124A0 (en) | 1998-09-24 |
HUP9902026A3 (en) | 2000-07-28 |
NO980718L (no) | 1998-04-08 |
PL325122A1 (en) | 1998-07-06 |
CA2228492A1 (en) | 1997-12-31 |
JPH11511761A (ja) | 1999-10-12 |
ZA975380B (en) | 1998-01-05 |
EP0853616B1 (en) | 2001-09-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1000039T3 (da) | Substituerede quinazolinderivater og anvendelse deraf som tyrosinkinaseinhibitorer | |
NO980718D0 (no) | Bicykliske 4-aralkylaminopyrimidinderivater og tyrosinkinaseinhibitorer | |
DK0915880T3 (da) | Azolotriaziner og pyrimidiner | |
NO992336D0 (no) | Raf-kinase-inhibitorer | |
NO20002121D0 (no) | Benzotiazol-protein-tyrosin-kinaseinhibitorer | |
AU2396897A (en) | 5-aminopyrazoles useful as selective inhibitors of the protein tyrosine kinase p56ick | |
NO974453D0 (no) | Proteinkinase C-hemmere | |
DE69600784D1 (de) | Proteinkinase-C-Inhibitor | |
DE69716615D1 (de) | Heterozyklische metalloproteaseinhibitoren | |
DE69435267D1 (de) | Proteinkinase C Inhibitoren | |
DK0811006T3 (da) | Benzopyranholdige forbindelser og fremgangsmåde til deres anvendelse | |
NO20001323D0 (no) | Dipeptid-apoptose inhibitorer og deres anvendelse | |
DK1015444T3 (da) | Pyrimidinderivater og fremgangsmåder til fremstilling deraf | |
DK0906301T3 (da) | Benzofurylderivater og anvendelsen deraf | |
PT927183E (pt) | Inibidores espirociclicos de metaloproteases | |
PT956294E (pt) | Inibidores da trombina | |
AU3885900A (en) | Inhibitors of the egf-receptor tyrosine kinase and their use | |
PT934280E (pt) | Derivados 2-cianoiminoimidazolo inibidores da pde iv | |
NO986174L (no) | Triazinderivater og anvendelse derav | |
DK0906268T3 (da) | Alkoxyaminosubstituerede fluorenoner og deres anvendelse som proteinkinase C-inhibitorer | |
NO984921D0 (no) | Tienopyridinderivater og deres anvendelse | |
GB0102712D0 (en) | Cytokine Producion and Tyrosine Kinase Inhibitors | |
SI0906268T1 (en) | Alkyloxyamino substituted fluorenones and their use as protein kinase c inhibitors | |
GB9600997D0 (en) | N-indolinyl-pyridopyrimidines as tyrosine kinase inhibitors | |
GB9425409D0 (en) | Inhibitors of protein tyrosine kinases |