EA199800215A1 - Бициклические производные 4-аралкиламинопиримидина как ингибиторы тирозинкиназы - Google Patents

Бициклические производные 4-аралкиламинопиримидина как ингибиторы тирозинкиназы

Info

Publication number
EA199800215A1
EA199800215A1 EA199800215A EA199800215A EA199800215A1 EA 199800215 A1 EA199800215 A1 EA 199800215A1 EA 199800215 A EA199800215 A EA 199800215A EA 199800215 A EA199800215 A EA 199800215A EA 199800215 A1 EA199800215 A1 EA 199800215A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
alkoxycarbonyl
alkoxy
halogen
different
Prior art date
Application number
EA199800215A
Other languages
English (en)
Inventor
Мария Габриэлла Браска
Дарио Баллинари
Антонио Лонго
Франко Буццетти
Original Assignee
Фармация Энд Апджон С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармация Энд Апджон С.П.А. filed Critical Фармация Энд Апджон С.П.А.
Publication of EA199800215A1 publication Critical patent/EA199800215A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Новые и известные бициклические производные 4-аралкиламинопиримидина, имеющие формулу (I)где A представляет бензольное или имидазольное кольцо; B представляет бензольное, тетралиновое, индановое или 2-оксиндольное кольцо; R представляет (C-C)перфторалкил, фенил, фенил-(C-C)алкил, гидрокси-(C-C)алкил, (C-C)алкокси-(C-C)алкил, (C-C)ацилокси-(C-C)алкил, галогенбензоилокси-(C-C)алкил, карбокси, карбамоил, (C-C)алкоксикарбонил, циано, (C-C)алкилкарбонил, карбокси-(C-C)алкил, карбамоил-(C-C)алкил, (C-C)алкоксикарбонил-(C-C)алкил, галоген-(C-C)алкил, амино-(C-C)алкил, моно- или ди(C-C)алкиламино-(C-C)алкил, сульфо-(C-C)алкил или сульфамидо-(C-C)алкил; каждый из Rи R(которые могут быть одинаковыми или разными) представляет водород, C-Cалкил, C-Cалкокси, галоген или -NRR, где каждый из Rи R(которые могут быть одинаковыми или разными) представляет H или C-Cалкил; каждый из Rи R(которые могут быть одинаковыми или разными) представляет водород, C-Cалкил, галоген, гидрокси, C-Cалкокси, C-Cалкоксикарбонил, нитро, циано или CF; или их фармацевтически приемлемые соли являются ингибиторами тирозинкиназы.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800215A 1996-06-21 1997-06-03 Бициклические производные 4-аралкиламинопиримидина как ингибиторы тирозинкиназы EA199800215A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9613021.6A GB9613021D0 (en) 1996-06-21 1996-06-21 Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors
PCT/EP1997/002965 WO1997049689A1 (en) 1996-06-21 1997-06-03 Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors

Publications (1)

Publication Number Publication Date
EA199800215A1 true EA199800215A1 (ru) 1998-08-27

Family

ID=10795666

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800215A EA199800215A1 (ru) 1996-06-21 1997-06-03 Бициклические производные 4-аралкиламинопиримидина как ингибиторы тирозинкиназы

Country Status (20)

Country Link
US (1) US6057326A (ru)
EP (1) EP0853616B1 (ru)
JP (1) JPH11511761A (ru)
KR (1) KR19990043993A (ru)
CN (1) CN1198158A (ru)
AR (1) AR008614A1 (ru)
AT (1) ATE205836T1 (ru)
AU (1) AU3094197A (ru)
BR (1) BR9702328A (ru)
CA (1) CA2228492C (ru)
DE (1) DE69706823T2 (ru)
EA (1) EA199800215A1 (ru)
ES (1) ES2165061T3 (ru)
GB (1) GB9613021D0 (ru)
HU (1) HUP9902026A3 (ru)
IL (1) IL123124A0 (ru)
NO (1) NO980718L (ru)
PL (1) PL325122A1 (ru)
WO (1) WO1997049689A1 (ru)
ZA (1) ZA975380B (ru)

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US6347480B1 (en) * 1997-07-07 2002-02-19 Southpac Trust International, Inc. Method for wrapping a floral grouping with a sheet of material constructed of paper and having printed and embossed patterns thereon
SK285141B6 (sk) 1996-02-13 2006-07-07 Astrazeneca Uk Limited Použitie chinazolínového derivátu, chinazolínový derivát, spôsob jeho prípravy a farmaceutická kompozícia, ktorá ho obsahuje
EP0885198B1 (en) 1996-03-05 2001-12-19 AstraZeneca AB 4-anilinoquinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
US6608060B1 (en) 1996-12-18 2003-08-19 Vertex Pharmaceuticals Incorporated Inhibitors of p38
US6147080A (en) * 1996-12-18 2000-11-14 Vertex Pharmaceuticals Incorporated Inhibitors of p38
US5945418A (en) * 1996-12-18 1999-08-31 Vertex Pharmaceuticals Incorporated Inhibitors of p38
DE19653646A1 (de) * 1996-12-20 1998-06-25 Hoechst Ag Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung
AU1071301A (en) * 1999-11-01 2001-05-14 Eli Lilly And Company Pharmaceutical compounds
ES2306306T3 (es) 1999-11-05 2008-11-01 Astrazeneca Ab Nuevos derivados de quinazolina.
WO2003009852A1 (en) * 2001-07-24 2003-02-06 Merck & Co., Inc. Tyrosine kinase inhibitors
KR100468352B1 (ko) * 2002-09-24 2005-01-27 한국과학기술연구원 신규 피라졸로피리미딘계 유도체, 그의 제조방법 및 이를 유효성분으로 하는 약학적 조성물
US20050124637A1 (en) * 2003-08-15 2005-06-09 Irm Llc Compounds and compositions as inhibitors of receptor tyrosine kinase activity
CA2557433C (en) * 2004-02-19 2013-05-14 Rexahn Corporation Quinazoline derivatives and therapeutic use thereof
US7151176B2 (en) * 2004-10-21 2006-12-19 Bristol-Myers Squibb Company Pyrrolotriazine compounds
WO2006104971A1 (en) * 2005-03-28 2006-10-05 Bristol-Myers Squibb Company Atp competitive kinase inhibitors
KR101703941B1 (ko) * 2008-11-10 2017-02-07 내셔날 헬스 리서치 인스티튜트 티로신 키나아제 억제제로서의 접합 이환 및 삼환 피리미딘 화합물
UA110113C2 (xx) * 2010-07-29 2015-11-25 Біциклічні азагетероциклічні карбоксаміди
JP5961187B2 (ja) * 2010-12-20 2016-08-02 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｐｉ３ｋ阻害剤としてのｎ−（１−（置換フェニル）エチル）−９ｈ−プリン−６−アミン

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IL89028A0 (en) * 1988-01-29 1989-08-15 Lilly Co Eli Quinoline,quinazoline and cinnoline derivatives
ZA902280B (en) * 1989-03-29 1990-12-28 Merrell Dow Pharma Selective adenosine receptor agents
JP2762430B2 (ja) * 1991-01-18 1998-06-04 宇部興産株式会社 アラルキルアミノピリミジン類の製法
US5710158A (en) * 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
JPH06172321A (ja) * 1992-10-08 1994-06-21 Agro Kanesho Co Ltd 置換アミノピリミジン誘導体、その製造法及びそれを有効成分とする有害生物駆除剤
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Also Published As

Publication number Publication date
DE69706823T2 (de) 2002-04-11
IL123124A0 (en) 1998-09-24
EP0853616B1 (en) 2001-09-19
AU3094197A (en) 1998-01-14
HUP9902026A2 (hu) 2000-04-28
KR19990043993A (ko) 1999-06-25
CN1198158A (zh) 1998-11-04
ES2165061T3 (es) 2002-03-01
DE69706823D1 (en) 2001-10-25
MX9801408A (es) 1998-05-31
AR008614A1 (es) 2000-02-09
EP0853616A1 (en) 1998-07-22
NO980718D0 (no) 1998-02-20
PL325122A1 (en) 1998-07-06
US6057326A (en) 2000-05-02
GB9613021D0 (en) 1996-08-28
CA2228492A1 (en) 1997-12-31
ZA975380B (en) 1998-01-05
WO1997049689A1 (en) 1997-12-31
HUP9902026A3 (en) 2000-07-28
ATE205836T1 (de) 2001-10-15
NO980718L (no) 1998-04-08
CA2228492C (en) 2007-05-08
BR9702328A (pt) 1999-07-20
JPH11511761A (ja) 1999-10-12

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