MX9801408A - Derivados de 4-aralquilaminopirimidina biciclicos, como inhibidores de la tirosina cinasa. - Google Patents

Derivados de 4-aralquilaminopirimidina biciclicos, como inhibidores de la tirosina cinasa.

Info

Publication number
MX9801408A
MX9801408A MX9801408A MX9801408A MX9801408A MX 9801408 A MX9801408 A MX 9801408A MX 9801408 A MX9801408 A MX 9801408A MX 9801408 A MX9801408 A MX 9801408A MX 9801408 A MX9801408 A MX 9801408A
Authority
MX
Mexico
Prior art keywords
alkyl
kinase inhibitors
alkoxy
phenyl
bicyclic
Prior art date
Application number
MX9801408A
Other languages
English (en)
Other versions
MXPA98001408A (es
Inventor
Maria Gabriela Brasca
Dario Ballinari
Antonio Longo
Franco Buzzetti
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of MX9801408A publication Critical patent/MX9801408A/es
Publication of MXPA98001408A publication Critical patent/MXPA98001408A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Derivados novedosos y conocidos de 4-aralquilamino-pirimidina bicíclicos de la formula (I), donde A es una cadena cerrada de benceno o imidazol; B es una cadena cerrada de benceno, tetralina, indano o 2-oxindol; R es perfluoroalquilo(C1-C4) fenilo, fenil-alquilo (C1-C4), hidroxi-alquilo (C1-C4), alcoxi (C1-C4)-alquilo (C1-C4), aciloxi (C2-C4)-alquilo (C1-C4), halobenzoiloxi-alquilo (C1-C4), carboxi, carbamoilo, alcoxicarbonilo (C1-C4), ciano, alquilcarbonilo (C1-C4), carboxi-alquilo (C1-C4), carbamoil-alquilo (C1-C4), alcoxicarbonil(C1-C4)-alquilo(C1-C4), halo-alquilo(C1-C4), amino-alquilo(C1-C4), mono- o di-alquilamino(C1-C4)-alquilo(C1-C4), sulfo-alquilo(C1-C4) o sulfamido-alquilo(C1-C4); cada una de R1 y R2 las cuales pueden ser iguales o diferentes es hidrogeno, alquilo C1-C4, alcoxi C1-C4, halogeno o -NR5R6, en las que cada una de R5 y R6, que pueden ser iguales o diferentes, H o alquilo C1-C4; y cada una de R3 y R4, que pueden ser iguales o diferentes es, hidrogeno, alquilo C1-C4, halogeno, hidroxi, alcoxi C1-C4, alcoxicarbonilo C1-C4, nitro, ciano o CF3; como también las sales farmacéuticamente aceptables de los mismos, constituyen los inhibidores de la tirosina cinasa.
MXPA/A/1998/001408A 1996-06-21 1998-02-20 Derivados de 4-aralquilaminopirimidina biciclicos, como inhibidores de la tirosina cinasa MXPA98001408A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9613021.6 1996-06-21
GBGB9613021.6A GB9613021D0 (en) 1996-06-21 1996-06-21 Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors
PCT/EP1997/002965 WO1997049689A1 (en) 1996-06-21 1997-06-03 Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors

Publications (2)

Publication Number Publication Date
MX9801408A true MX9801408A (es) 1998-05-31
MXPA98001408A MXPA98001408A (es) 1998-10-23

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Also Published As

Publication number Publication date
DE69706823T2 (de) 2002-04-11
EA199800215A1 (ru) 1998-08-27
IL123124A0 (en) 1998-09-24
EP0853616B1 (en) 2001-09-19
AU3094197A (en) 1998-01-14
HUP9902026A2 (hu) 2000-04-28
KR19990043993A (ko) 1999-06-25
CN1198158A (zh) 1998-11-04
ES2165061T3 (es) 2002-03-01
DE69706823D1 (en) 2001-10-25
AR008614A1 (es) 2000-02-09
EP0853616A1 (en) 1998-07-22
NO980718D0 (no) 1998-02-20
PL325122A1 (en) 1998-07-06
US6057326A (en) 2000-05-02
GB9613021D0 (en) 1996-08-28
CA2228492A1 (en) 1997-12-31
ZA975380B (en) 1998-01-05
WO1997049689A1 (en) 1997-12-31
HUP9902026A3 (en) 2000-07-28
ATE205836T1 (de) 2001-10-15
NO980718L (no) 1998-04-08
CA2228492C (en) 2007-05-08
BR9702328A (pt) 1999-07-20
JPH11511761A (ja) 1999-10-12

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