HUP0002839A2 - Pirrolo[3,4-d]pirimidinon-származékok, alkalmazásuk, az ezeket tartalmazó gyógyszerkészítmények, eljárás előállításukra - Google Patents

Pirrolo[3,4-d]pirimidinon-származékok, alkalmazásuk, az ezeket tartalmazó gyógyszerkészítmények, eljárás előállításukra

Info

Publication number
HUP0002839A2
HUP0002839A2 HU0002839A HUP0002839A HUP0002839A2 HU P0002839 A2 HUP0002839 A2 HU P0002839A2 HU 0002839 A HU0002839 A HU 0002839A HU P0002839 A HUP0002839 A HU P0002839A HU P0002839 A2 HUP0002839 A2 HU P0002839A2
Authority
HU
Hungary
Prior art keywords
group
pyrrolo
pyrimidinone derivatives
preparation
pharmaceutical compositions
Prior art date
Application number
HU0002839A
Other languages
English (en)
Inventor
David Cheshire
Martin Cooper
David Donald
Mark Furber
Richard Harrison
Matthew Perry
Nicholas Tomkinson
Original Assignee
Astrazeneca Ab.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab. filed Critical Astrazeneca Ab.
Publication of HUP0002839A2 publication Critical patent/HUP0002839A2/hu
Publication of HUP0002839A3 publication Critical patent/HUP0002839A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány tárgyát az általános képletű, új pirrolo[3,4-d]pirimidinon-származékok - ahol a szubsztituensek főbb jelentéseibizonyos megkötésekkel: W metiléncsoport vagy vegyértékvonal; Q W-től függően bizonyos körből választható, adott esetbenszubsztituált arilcsoport; R10 -X-(A)p-Y általános képletű csoport, amelyben X kénatom,szulfinil-, szulfonil-, etinilén-, etilén-, vinilén- vagypropeniléncsoport, A alkiléncsoport, p 0 vagy 1, és Y ciano-,hidroxi-, alkoxi-, karboxi-, alkoxi-karbonil-, adott esetbenszubsztituált karbamoil-, amino-, aril- vagy heteroarilcsoport; és R1 és R2 hidrogénatom vagy alkilcsoport -, és előállításukra szolgálóeljárás, immunszuppresszánsként való alkalmazásuk, valaminthatóanyagként ezeket tartalmazó gyógyszerkészítmények és előállításukképezik. Ó
HU0002839A 1996-12-21 1997-12-18 Pyrrolo[3,4-d]pyrimidinone derivatives, their use, pharmaceutical compositions containing them, process for their preparation HUP0002839A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9626643.2A GB9626643D0 (en) 1996-12-21 1996-12-21 Compounds

Publications (2)

Publication Number Publication Date
HUP0002839A2 true HUP0002839A2 (hu) 2001-02-28
HUP0002839A3 HUP0002839A3 (en) 2001-04-28

Family

ID=10804862

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002839A HUP0002839A3 (en) 1996-12-21 1997-12-18 Pyrrolo[3,4-d]pyrimidinone derivatives, their use, pharmaceutical compositions containing them, process for their preparation

Country Status (23)

Country Link
US (8) US6046204A (hu)
EP (1) EP0946562B1 (hu)
JP (1) JP2001507687A (hu)
KR (1) KR20000069605A (hu)
CN (1) CN1246119A (hu)
AT (1) ATE215088T1 (hu)
AU (1) AU717429B2 (hu)
BR (1) BR9714063A (hu)
CA (1) CA2275312A1 (hu)
CZ (1) CZ289925B6 (hu)
DE (1) DE69711430T2 (hu)
EE (1) EE9900315A (hu)
GB (1) GB9626643D0 (hu)
HU (1) HUP0002839A3 (hu)
ID (1) ID21682A (hu)
IL (1) IL130538A0 (hu)
IS (1) IS5082A (hu)
NO (1) NO993027L (hu)
NZ (1) NZ336124A (hu)
PL (1) PL334228A1 (hu)
SK (1) SK76699A3 (hu)
TR (1) TR199901433T2 (hu)
WO (1) WO1998028301A1 (hu)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9801399D0 (sv) 1998-04-21 1998-04-21 Astra Pharma Prod Method and apparatus for filling containers
US6534519B1 (en) 1999-01-15 2003-03-18 Altana Pharma Ag Phenanthridine-N-oxides with PDE-IV inhibiting activity
PT1147087E (pt) 1999-01-15 2005-09-30 Altana Pharma Ag Feantridina-n-oxidos com actividade de inibicao de pde-iv
CA2360386A1 (en) 1999-01-15 2000-07-20 Beate Gutterer Polysubstituted 6-phenylphenanthridines with pde-iv inhibiting activity
US6361486B1 (en) * 2000-02-29 2002-03-26 Agilent Technologies, Inc. Coaxial-drive centrifuge providing tilt control relative to centrifugal force
AU8125501A (en) * 2000-08-14 2002-02-25 Ortho Mcneil Pharm Inc Substituted pyrazoles
US20070105841A1 (en) * 2000-08-14 2007-05-10 Breitenbucher J G Method for treating allergies using substituted pyrazoles
TW200407315A (en) * 2002-04-23 2004-05-16 Sankyo Co Pyrimidine derivatives
JP2006528515A (ja) * 2003-07-24 2006-12-21 テコメット・インコーポレーテッド 海綿状の構造体
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
MY140748A (en) 2004-12-06 2010-01-15 Astrazeneca Ab Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
US8198288B2 (en) 2006-05-04 2012-06-12 Pulmagen Therapeutics (Inflammation) Limited Tetrahydropyrrolopyrimidinediones and their use in therapy
WO2007129060A1 (en) 2006-05-04 2007-11-15 Argenta Discovery Limited Tetrahydropyrrolopyrimidinediones and their use as human neutrophil elastase inhibitors
CA2651519A1 (en) 2006-06-06 2007-12-13 Intra-Cellular Therapies, Inc. Organic compounds
EP2240028B1 (en) 2007-12-06 2016-07-20 Intra-Cellular Therapies, Inc. Pyrazolopyrimidine-4,6-dione derivatives and their use as pharmaceutical
WO2009100403A1 (en) * 2008-02-07 2009-08-13 Neurogen Corporation Substituted aryl pyrimidinones
KR20110098730A (ko) * 2008-12-06 2011-09-01 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
MA32940B1 (fr) 2008-12-06 2012-01-02 Intra Cellular Therapies Inc Composes organiques
JP5813511B2 (ja) 2008-12-06 2015-11-17 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 有機化合物
WO2011019737A1 (en) * 2009-08-10 2011-02-17 The Regents Of The University Of California Pyrimido-pyrrolo-quinoxalinedione inhibitors of cystic fibrosis transmembrane conductance regulator protein and uses therefor
US9434730B2 (en) 2010-05-31 2016-09-06 Intra-Cellular Therapies, Inc. PDE1 inhibitor compounds
US9371327B2 (en) 2010-05-31 2016-06-21 Intra-Cellular Therapies, Inc. PDE1 inhibitor compounds
US9062073B2 (en) 2011-05-27 2015-06-23 The Regents Of The University Of California Pyrimido-pyrrolo-oxazine-dione compound inhibitors of the cystic fibrosis transmembrane conductance regulator protein and uses therefor
US9546175B2 (en) 2014-08-07 2017-01-17 Intra-Cellular Therapies, Inc. Organic compounds
CN108129486B (zh) * 2018-01-25 2020-06-05 华东理工大学 嘧啶酮衍生物及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2436792A (en) * 1991-08-16 1993-03-16 Merck & Co., Inc. Quinazoline derivatives as inhibitors of hiv reverse transcriptase
GB9424842D0 (en) * 1994-12-09 1995-02-08 British Tech Group Pharmaceutical compositions

Also Published As

Publication number Publication date
HUP0002839A3 (en) 2001-04-28
CZ220499A3 (cs) 2000-02-16
US20030162798A1 (en) 2003-08-28
CN1246119A (zh) 2000-03-01
US6306863B1 (en) 2001-10-23
CA2275312A1 (en) 1998-07-02
CZ289925B6 (cs) 2002-04-17
US6166206A (en) 2000-12-26
US6211368B1 (en) 2001-04-03
EE9900315A (et) 2000-02-15
NZ336124A (en) 2001-03-30
PL334228A1 (en) 2000-02-14
EP0946562B1 (en) 2002-03-27
ID21682A (id) 1999-07-08
US20020025966A1 (en) 2002-02-28
AU717429B2 (en) 2000-03-23
EP0946562A1 (en) 1999-10-06
NO993027D0 (no) 1999-06-18
IS5082A (is) 1999-06-14
DE69711430T2 (de) 2002-10-31
KR20000069605A (ko) 2000-11-25
BR9714063A (pt) 2002-01-02
IL130538A0 (en) 2000-06-01
US6229013B1 (en) 2001-05-08
GB9626643D0 (en) 1997-02-12
JP2001507687A (ja) 2001-06-12
SK76699A3 (en) 2000-05-16
US6136974A (en) 2000-10-24
NO993027L (no) 1999-08-20
WO1998028301A1 (en) 1998-07-02
AU5580998A (en) 1998-07-17
ATE215088T1 (de) 2002-04-15
DE69711430D1 (de) 2002-05-02
TR199901433T2 (xx) 1999-09-21
US6046204A (en) 2000-04-04

Similar Documents

Publication Publication Date Title
HUP0002839A2 (hu) Pirrolo[3,4-d]pirimidinon-származékok, alkalmazásuk, az ezeket tartalmazó gyógyszerkészítmények, eljárás előállításukra
HUP0002104A2 (hu) Pirazolo[3,4-d]pirimidindion-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények
TR200003256T2 (tr) P-38 mapkinaz engelleyicileri olan pirazol türevleri
ATE296826T1 (de) Pyrazolo(1,5)pyridinderivate
HUP0300641A2 (hu) Triazaspiro[5.5]undekán-származékok és hatóanyagként ezeket tartalmazó gyógyszerkészítmények
EA200400432A1 (ru) Производные мочевины
TR200200778T2 (tr) Pirazol türevleri.
HUP0105231A2 (hu) Heteroaril-szubsztituált kinolin-2-on-származék rákellenes szerek és a vegyületeket tartalmazó gyógyszerkészítmények
WO2003016282A3 (en) Substituted 1h-dihydropyrazoles, their preparation and use
ATE267200T1 (de) Bicyclische kinase inhibitoren
HUP0402026A2 (hu) 5,6-Diaril-pirazin-2-amid-származékok mint CB1 antagonisták, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
MXPA02003199A (es) Derivados de sulfonamida farmaceuticamente activos.
TR200302268T4 (tr) NOS inhibitörleri olarak yararlı N-heterosiklik türevler.
HUP0202186A2 (hu) Benzimidazolonszármazékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és ezeknek mint foszfodiészteráz enzimet gátló anyagoknak az alkalmazása gyógyszerkészítmények előállítására
ATE300541T1 (de) Pyrazolopyridinderivate
MY101721A (en) 6-vinyl-furo-(3,4-c)-pyridine derivatives
DE60014404D1 (de) Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha
YU75394A (sh) Anelirani dihidropiridini i njihova primena za pripremanje farmaceutskih preparata
HUP0303204A2 (hu) 1-Metilkarbapenem-származékok és ezeket tartalmazó gyógyszerkészítmények
CA2399377A1 (en) New positive allosteric ampa receptor modulators (paarm), processes for preparing them and their use as pharmaceutical compositions
SE9802574D0 (sv) Novel compounds
CY1106317T1 (el) Παραγωγα 1-ν-φαινυλαμινο-1η-ιμιδαζολης, ως αναστολεις αρωματασης
DE69330601D1 (de) Serotoninergische ergolin derivate
EP1144393A3 (en) Heterocyclic derivatives and their use as integrin inhibitor
TR199901416T2 (xx) Heterosiklik karbonikasit t�revleri.