DK101492A - Quinolinderivater - Google Patents

Quinolinderivater Download PDF

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Publication number
DK101492A
DK101492A DK101492A DK101492A DK101492A DK 101492 A DK101492 A DK 101492A DK 101492 A DK101492 A DK 101492A DK 101492 A DK101492 A DK 101492A DK 101492 A DK101492 A DK 101492A
Authority
DK
Denmark
Prior art keywords
quinoline
Prior art date
Application number
DK101492A
Other languages
English (en)
Other versions
DK171820B1 (da
DK101492D0 (da
Inventor
Hiraki Ueda
Hisashi Miyamoto
Hiroshi Yamashita
Hitoshi Tone
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of DK101492D0 publication Critical patent/DK101492D0/da
Publication of DK101492A publication Critical patent/DK101492A/da
Application granted granted Critical
Publication of DK171820B1 publication Critical patent/DK171820B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK101492A 1987-04-16 1992-08-13 Quinolinderivater DK171820B1 (da)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
JP9419887 1987-04-16
JP9419887 1987-04-16
JP10235187 1987-04-24
JP10235187 1987-04-24
JP10836187 1987-04-30
JP10836187 1987-04-30
JP12659887 1987-05-22
JP12659887 1987-05-22
JP14954487 1987-06-16
JP14954487 1987-06-16
JP17612687 1987-07-14
JP17612687 1987-07-14
JP28377687 1987-11-09
JP28377687 1987-11-09
JP28710887 1987-11-12
JP28710887 1987-11-12

Publications (3)

Publication Number Publication Date
DK101492D0 DK101492D0 (da) 1992-08-13
DK101492A true DK101492A (da) 1992-08-13
DK171820B1 DK171820B1 (da) 1997-06-23

Family

ID=27572879

Family Applications (2)

Application Number Title Priority Date Filing Date
DK207688A DK170640B1 (da) 1987-04-16 1988-04-15 Quinolinderivater
DK101492A DK171820B1 (da) 1987-04-16 1992-08-13 Quinolinderivater

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK207688A DK170640B1 (da) 1987-04-16 1988-04-15 Quinolinderivater

Country Status (13)

Country Link
US (5) US5591744A (da)
EP (3) EP0565132B1 (da)
JP (2) JPH0696557B2 (da)
KR (2) KR940002113B1 (da)
CN (1) CN1053666C (da)
CY (1) CY2050B1 (da)
DE (4) DE3856434T2 (da)
DK (2) DK170640B1 (da)
ES (3) ES2091180T3 (da)
HK (1) HK128797A (da)
NL (1) NL980011I2 (da)
SA (1) SA97180461A (da)
SG (3) SG101541A1 (da)

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US4920120A (en) * 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
US5585491A (en) * 1988-01-25 1996-12-17 Otsuka Pharmaceutical Co., Ltd. Antibacterial agents
FI901201A0 (fi) * 1989-03-13 1990-03-09 Bristol Myers Squibb Co Antibakteriella 5-substituerade 1,4-dihydro-4-oxonaftyridin-3-karboxylatderivat och deras framstaellning.
DE3910663A1 (de) * 1989-04-03 1990-10-04 Bayer Ag 5-alkylchinoloncarbonsaeuren
EP0525057B1 (en) 1990-04-18 2000-06-14 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolonyl lactams
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WO1992021659A1 (en) * 1991-05-28 1992-12-10 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivative
FR2692577B1 (fr) * 1992-05-26 1996-02-02 Bouchara Sa Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant.
ES2140531T3 (es) * 1993-03-10 2000-03-01 Otsuka Pharma Co Ltd Inhibidor de la interleucina-1.
DE4329600A1 (de) * 1993-09-02 1995-03-09 Bayer Ag Pyrido [1,2,3-d,e] [1,3,4] benzoxadiazinderivate
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DE4408212A1 (de) * 1994-03-11 1995-09-14 Bayer Ag 5-Vinyl- und 5-Ethinyl-chinolon- und -naphthyridon-carbonsäuren
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CN1183778A (zh) * 1995-01-24 1998-06-03 北陆制药株式会社 喹啉羧酸衍生物
ATE247089T1 (de) * 1996-11-28 2003-08-15 Wakunaga Pharma Co Ltd Pyridoncarbonsäurederivate oder ihre salze und diese als aktive bestandteile enthaltende medikamente
DE19652239A1 (de) 1996-12-16 1998-06-18 Bayer Ag Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
US6333431B1 (en) * 1998-09-14 2001-12-25 Otsuka Pharmaceutical Co., Ltd. Processes for the preparation of fluorinated benzoic acids
US6509327B1 (en) 1998-09-30 2003-01-21 Alcon Manufacturing, Ltd. Compositions and methods for treating otic, ophthalmic and nasal infections
US6716830B2 (en) 1998-09-30 2004-04-06 Alcon, Inc. Ophthalmic antibiotic compositions containing moxifloxacin
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US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
DE19850788A1 (de) * 1998-11-04 2000-05-11 Clariant Gmbh Verfahren zur Herstellung von Trifluorbenzoesäuren
EP2275141A1 (en) 1999-03-17 2011-01-19 Daiichi Pharmaceutical Co., Ltd. Tastemasked pharmaceutical compositions
DE19962470A1 (de) * 1999-12-22 2001-07-12 Schulz Hans Herrmann Verwendung von Chemotherapeutika
US6608078B2 (en) 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
AU2002239395A1 (en) * 2000-11-01 2002-06-03 The Procter And Gamble Company Hiv treatment with benzimidazoles
US6964966B2 (en) 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US7022712B2 (en) * 2002-03-26 2006-04-04 Arizona Board Of Regents On Behalf Of The University Of Arizona Solubilization of weak bases
WO2003099815A1 (en) 2002-05-28 2003-12-04 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
EP1564210B9 (en) * 2002-11-20 2010-03-31 Japan Tobacco Inc. 4-oxoquinoline compounds and utilization thereof as hiv integrase inhibitors
US7164023B2 (en) 2003-09-04 2007-01-16 Wockhardt Limited Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate
CA2536429C (en) 2003-09-10 2012-02-14 Kyorin Pharmaceutical Co., Ltd. 7-(4-substituted-3-cyclopropylaminomethyl-1-pyrrolidinyl) quinolonecarboxylic acid derivative
WO2005026145A2 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
KR101023635B1 (ko) 2006-03-06 2011-03-22 니뽄 다바코 산교 가부시키가이샤 4-옥소퀴놀린 화합물 제조 방법
US8420821B2 (en) 2006-03-06 2013-04-16 Japan Tobacco Inc. Process for production of 4-oxoquinoline compound
EP2066672B1 (en) 2006-09-29 2015-06-24 Cipla Limited An improved process for the preparation of temozolomide and analogs
EP2149571A4 (en) * 2007-05-24 2010-09-01 Kyorin Seiyaku Kk MUTILINE DERIVATIVE WITH A RINGED, HETEROCYCLIC AND AROMATIC CARBOXYLIC ACID STRUCTURE IN A SUBSTITUTE AT POSITION 14
EP2222662A4 (en) * 2007-11-15 2011-08-03 Univ Maryland INHIBITORS OF KYNURENINE AMINO TRANSFERASE
US20090270379A1 (en) * 2008-04-23 2009-10-29 Macielag Mark J Quinolone derivatives useful as antibacterial agents
CN106913569B (zh) * 2016-01-04 2022-04-22 广东工业大学 苯酞类化合物在制备抗耐药菌药物中的应用
CN112266326A (zh) * 2020-11-10 2021-01-26 杭州臻挚生物科技有限公司 二氯甲苯硝化物中间体的制备方法

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Also Published As

Publication number Publication date
US5723648A (en) 1998-03-03
DE3856434T2 (de) 2001-06-13
HK128797A (en) 1997-09-19
JPH01230558A (ja) 1989-09-14
KR960006145B1 (ko) 1996-05-09
DE3856515D1 (de) 2002-03-21
JPH0696557B2 (ja) 1994-11-30
DK207688D0 (da) 1988-04-15
KR940002113B1 (ko) 1994-03-17
DK171820B1 (da) 1997-06-23
CN1030237A (zh) 1989-01-11
DK101492D0 (da) 1992-08-13
DE3855388T2 (de) 1997-02-13
EP0823413A3 (en) 1998-12-09
EP0823413B1 (en) 2002-02-13
US5811576A (en) 1998-09-22
EP0287951B1 (en) 1996-07-03
ES2152936T3 (es) 2001-02-16
US5591744A (en) 1997-01-07
DK170640B1 (da) 1995-11-20
EP0823413A2 (en) 1998-02-11
EP0287951A3 (en) 1990-06-13
NL980011I1 (nl) 1998-05-06
SG49836A1 (en) 1998-06-15
CY2050B1 (en) 1998-04-30
EP0565132B1 (en) 2000-10-25
SG101541A1 (en) 2004-01-30
SG97777A1 (en) 2003-08-20
DE19775083I2 (de) 2001-06-13
DE3856515T2 (de) 2002-08-14
NL980011I2 (nl) 1998-10-01
EP0565132A3 (en) 1994-05-18
SA97180461A (ar) 2005-12-03
DK207688A (da) 1988-10-17
DE3855388D1 (de) 1996-08-08
ES2172734T3 (es) 2002-10-01
KR880012506A (ko) 1988-11-28
US5563138A (en) 1996-10-08
JPH07138232A (ja) 1995-05-30
ES2091180T3 (es) 1996-11-01
EP0287951A2 (en) 1988-10-26
CN1053666C (zh) 2000-06-21
US5495020A (en) 1996-02-27
EP0565132A2 (en) 1993-10-13
DE3856434D1 (de) 2000-11-30
JP2654537B2 (ja) 1997-09-17

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