DK1012154T3 - Salte af di(uridin-5'-tetraphosphat), fremgangsmåde til fremstilling og anvendelser deraf - Google Patents

Salte af di(uridin-5'-tetraphosphat), fremgangsmåde til fremstilling og anvendelser deraf

Info

Publication number
DK1012154T3
DK1012154T3 DK98937115T DK98937115T DK1012154T3 DK 1012154 T3 DK1012154 T3 DK 1012154T3 DK 98937115 T DK98937115 T DK 98937115T DK 98937115 T DK98937115 T DK 98937115T DK 1012154 T3 DK1012154 T3 DK 1012154T3
Authority
DK
Denmark
Prior art keywords
sub
treatment
tetraphosphate
uridine
salts
Prior art date
Application number
DK98937115T
Other languages
Danish (da)
English (en)
Inventor
Benjamin R Yerxa
William Pendergast
Original Assignee
Inspire Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inspire Pharmaceuticals Inc filed Critical Inspire Pharmaceuticals Inc
Application granted granted Critical
Publication of DK1012154T3 publication Critical patent/DK1012154T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK98937115T 1997-07-25 1998-07-24 Salte af di(uridin-5'-tetraphosphat), fremgangsmåde til fremstilling og anvendelser deraf DK1012154T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5414797P 1997-07-25 1997-07-25
PCT/US1998/015445 WO1999005155A2 (en) 1997-07-25 1998-07-24 Salts of di(uridine 5'-tetraphosphate), method for preparation and uses thereof

Publications (1)

Publication Number Publication Date
DK1012154T3 true DK1012154T3 (da) 2004-07-26

Family

ID=21989063

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98937115T DK1012154T3 (da) 1997-07-25 1998-07-24 Salte af di(uridin-5'-tetraphosphat), fremgangsmåde til fremstilling og anvendelser deraf

Country Status (17)

Country Link
US (1) US7432252B1 (ja)
EP (1) EP1012154B1 (ja)
JP (1) JP3723227B2 (ja)
KR (1) KR20010013797A (ja)
CN (1) CN1147502C (ja)
AT (1) ATE261982T1 (ja)
AU (1) AU747196B2 (ja)
BR (1) BRPI9810436B1 (ja)
CA (1) CA2295515C (ja)
DE (1) DE69822482T2 (ja)
DK (1) DK1012154T3 (ja)
ES (1) ES2217569T3 (ja)
HK (1) HK1028613A1 (ja)
NO (1) NO328229B1 (ja)
NZ (1) NZ501696A (ja)
PT (1) PT1012154E (ja)
WO (1) WO1999005155A2 (ja)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319908B1 (en) 1996-07-03 2001-11-20 Inspire Pharmaceuticals, Inc. Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof
US5763447C1 (en) 1996-07-23 2002-05-07 Inspire Pharmaceuticals Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds
US7223744B2 (en) 1997-02-10 2007-05-29 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof
US6548658B2 (en) * 1997-07-25 2003-04-15 Inspire Pharmaceuticals, Inc. Di-(uridine 5′)-tetraphosphate and salts thereof
US6872710B2 (en) 1997-07-25 2005-03-29 Inspire Pharmaceuticals, Inc. Di(uridine 5′)-tetraphosphate and salts thereof
US6462028B2 (en) * 1997-07-25 2002-10-08 Inspire Pharmaceuticals, Inc. Method of promoting cervical and vaginal secretions
BRPI9810436B1 (pt) 1997-07-25 2015-12-29 Inspire Pharmaceuticals Inc processo para a produção em larga escala de di (5'-tetrafosfato de uridina) e sais do mesmo
TW593331B (en) 1997-07-25 2004-06-21 Inspire Pharmaceuticals Inc Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof
CN100354296C (zh) * 1998-10-02 2007-12-12 雅玛山酱油株式会社 二尿苷四磷酸或其盐的晶体和其制备方法、以及制备该化合物的方法
ES2183650T3 (es) * 1998-10-02 2003-03-16 Yamasa Corp Cristal de diuridina tetrafosfato o sal correspondiente y procedimiento de fabricacion.
PL202176B1 (pl) * 1999-06-30 2009-06-30 Yamasa Corp Sposób wytwarzania P¹-(2'-deoksycytydyno-5')-P⁴-(urydyno-5')czterofosforanu
AU2001230533A1 (en) * 2000-02-04 2001-08-14 Kissei Pharmaceutical Co. Ltd. Powdered preparation for inhalation and powder inhalant containing the same packed
US7018985B1 (en) 2000-08-21 2006-03-28 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US7452870B2 (en) 2000-08-21 2008-11-18 Inspire Pharmaceuticals, Inc. Drug-eluting stents coated with P2Y12 receptor antagonist compound
CN1228053C (zh) * 2001-09-11 2005-11-23 参天制药株式会社 含有二尿苷磷酸的滴眼液
KR100870104B1 (ko) * 2005-11-28 2008-11-26 주식회사 머젠스 안구건조증 치료 및 예방용 조성물
US8193338B2 (en) 2006-07-26 2012-06-05 Yamasa Corporation Process for producing di(pyrimidine nucleoside 5'-)polyphosphate
WO2010150791A1 (ja) * 2009-06-23 2010-12-29 ヤマサ醤油株式会社 アデノシンテトラホスフェート化合物の製造法
BR112013005438B1 (pt) 2010-09-10 2021-09-21 Santen Pharmaceutical Co., Ltd Agente para o tratamento de olho ressecado caracterizado por combinar o agonista do receptor de p2y2 e ácido hialurônico ou um sal do mesmo, método para o tratamento de olho ressecado, e uso do agonista do receptor de p2y2, e ácido hialurônico ou um sal do mesmo
SG10201508591UA (en) 2010-12-28 2015-11-27 Santen Pharmaceutical Co Ltd Ophthalmic solution comprising diquafosol, method for producing the same, and method for inhibiting formation of insoluble precipitate
CN102146111A (zh) * 2011-01-26 2011-08-10 北京润德康医药技术有限公司 一类新型二核苷酸化合物及其制备方法
MY169816A (en) 2012-03-26 2019-05-16 Santen Pharmaceutical Co Ltd Ophthalmic solution comprising diquafosol
US10815263B2 (en) * 2016-10-25 2020-10-27 Yamasa Corporation Method for purifying P1,P4-di(uridine 5′-)tetraphosphate
KR102504764B1 (ko) * 2017-06-21 2023-03-02 주식회사 종근당 디뉴클레오사이드 폴리포스페이트 화합물의 제조방법
CN109305991B (zh) * 2017-07-27 2021-02-26 江苏恒瑞医药股份有限公司 一种p1,p4-二(尿苷5’-)四磷酸钠的制备方法
KR20180091689A (ko) 2017-11-06 2018-08-16 주식회사 종근당 무정형 디뉴클레오사이드 폴리포스페이트 화합물의 제조방법
KR20220163519A (ko) 2018-02-28 2022-12-09 산텐 세이야꾸 가부시키가이샤 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물
CN110540555B (zh) * 2018-05-28 2023-01-24 江苏恒瑞医药股份有限公司 一种游离核苷磷酸的方法
CN109021049B (zh) * 2018-06-14 2020-12-08 扬子江药业集团北京海燕药业有限公司 一种尿苷5′-二磷酸-苯并咪唑二钠的合成方法
CN113518646B (zh) 2019-02-27 2023-12-12 参天制药株式会社 含有地夸磷索或其盐，乙烯基系高分子及纤维素系高分子的眼科用组合物
KR20200106738A (ko) 2019-03-05 2020-09-15 주식회사 파마코스텍 P1,p4-디(우리딘 5'-)테트라포스페이트, 이의 염 또는 이의 수화물의 신규한 제조방법
CN110590887B (zh) * 2019-09-04 2020-12-15 江苏金殳医药科技有限公司 一种磷酸酯的制备方法
KR20210077946A (ko) 2019-12-18 2021-06-28 주식회사 종근당 우리딘 5’-디인산(udp), 이의 염 또는 이의 수화물의 제조방법
KR20210110055A (ko) * 2020-02-28 2021-09-07 주식회사 종근당바이오 P1, p4-디(우리딘 5'-)테트라포스페이트 나트륨염 4 수화물 결정형 a의 제조방법
CN111662350B (zh) * 2020-07-07 2022-06-07 南京宸翔医药研究有限责任公司 一种绿色化智能化高纯度地夸磷索四钠的制备方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3639562A (en) 1970-04-29 1972-02-01 Smith Kline French Lab Vaginal suppositories and impregnated tampons
US3639561A (en) 1970-04-29 1972-02-01 Smith Kline French Lab Vaginal suppositories and impregnated tampons
US5292498A (en) 1991-06-19 1994-03-08 The University Of North Carolina At Chapel Hill Method of treating lung disease with uridine triphosphates
JPH05346549A (ja) 1992-04-17 1993-12-27 Canon Inc 走査光学装置
WO1995010538A1 (en) 1993-10-15 1995-04-20 The University Of North Carolina At Chapel Hill Dna encoding the human p2u receptor and null cells expressing p2u receptors
US5656256A (en) 1994-12-14 1997-08-12 The University Of North Carolina At Chapel Hill Methods of treating lung disease by an aerosol containing benzamil or phenamil
US5635160A (en) 1995-06-07 1997-06-03 The University Of North Carolina At Chapel Hill Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions
US5628984A (en) 1995-07-31 1997-05-13 University Of North Carolina At Chapel Hill Method of detecting lung disease
JP3519199B2 (ja) 1996-02-06 2004-04-12 株式会社ソニー・コンピュータエンタテインメント 画像生成装置
US6423694B1 (en) * 1996-02-21 2002-07-23 Inspire Pharmaceuticals, Inc. Method of treating otitis media with uridine triphosphates and related compounds
US5837861A (en) 1997-02-10 1998-11-17 Inspire Pharmaceuticals, Inc. Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency
DE69736468T2 (de) * 1996-03-27 2007-03-29 Inspire Pharmaceuticals, Inc. Verfahren zur behandlung der ziliardyskinesie mit uridintriphosphaten und verwandten verbindungen
US5900407A (en) * 1997-02-06 1999-05-04 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with uridine triphosphates and related compounds
US5789391A (en) 1996-07-03 1998-08-04 Inspire Pharmaceuticals, Inc. Method of treating sinusitis with uridine triphosphates and related compounds
US5968913A (en) 1996-07-03 1999-10-19 Inspire Pharmaceuticals, Inc. Pharmaceutical compositions of uridine triphosphate
US5962432A (en) 1996-07-03 1999-10-05 Inspire Pharmaceuticals, Inc. Sterilized, isotonic and pH-adjusted pharmaceutical formulation of uridine triphosphate
US5763447C1 (en) * 1996-07-23 2002-05-07 Inspire Pharmaceuticals Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds
AU4978897A (en) 1996-10-08 1998-05-05 Inspire Pharmaceuticals, Inc. Method of early lung cancer detection via sputum induction and analysis of sputum to detect cancer associated substances
US6159952A (en) 1996-11-07 2000-12-12 Inspire Pharmaceuticals, Inc. Method of treating bronchitis with uridine triphosphate and related compounds
DK0981534T3 (da) * 1997-02-06 2006-09-04 Inspire Pharmaceuticals Inc Dinukleotider og deres anvendelser
US6462028B2 (en) 1997-07-25 2002-10-08 Inspire Pharmaceuticals, Inc. Method of promoting cervical and vaginal secretions
BRPI9810436B1 (pt) 1997-07-25 2015-12-29 Inspire Pharmaceuticals Inc processo para a produção em larga escala de di (5'-tetrafosfato de uridina) e sais do mesmo
EP1011688B1 (en) 1997-08-29 2005-02-02 The University of North Carolina at Chapel Hill Use of uridine 5'-diphosphate and analogs thereof for the treatment of lung diseases
JP4633927B2 (ja) 1998-05-22 2011-02-16 インスパイアー ファーマシューティカルズ，インコーポレイティド 治療用ジヌクレオチドおよび誘導体
US6294188B1 (en) 1998-07-09 2001-09-25 Aviana Biopharm Inc. Methods involving changing the constitutive and stimulated secretions of the local reproductive system of women
GB9827477D0 (en) 1998-12-15 1999-02-10 Kalon Limited Paint
EP1140967A1 (en) 1998-12-23 2001-10-10 University Of North Carolina At Chapel Hill Targeted gene transfer using g protein coupled receptors
MXPA01008547A (es) 1999-02-26 2003-06-06 Inspire Pharmaceuticals Inc Metodo para promover la hidratacion de mucosas con ciertos difosfatos de uridina, adenina y citidina, y analogos de estos.

Also Published As

Publication number Publication date
CA2295515C (en) 2006-03-14
JP2001510484A (ja) 2001-07-31
HK1028613A1 (en) 2001-02-23
CN1147502C (zh) 2004-04-28
CN1265114A (zh) 2000-08-30
AU8590398A (en) 1999-02-16
NO328229B1 (no) 2010-01-11
CA2295515A1 (en) 1999-02-04
ES2217569T3 (es) 2004-11-01
NZ501696A (en) 2001-08-31
EP1012154B1 (en) 2004-03-17
NO996189L (no) 2000-03-27
BRPI9810436B1 (pt) 2015-12-29
AU747196B2 (en) 2002-05-09
PT1012154E (pt) 2004-08-31
DE69822482T2 (de) 2005-03-03
EP1012154A2 (en) 2000-06-28
US7432252B1 (en) 2008-10-07
DE69822482D1 (de) 2004-04-22
ATE261982T1 (de) 2004-04-15
KR20010013797A (ko) 2001-02-26
NO996189D0 (no) 1999-12-14
JP3723227B2 (ja) 2005-12-07
WO1999005155A2 (en) 1999-02-04
BR9810436A (pt) 2000-12-12
WO1999005155A3 (en) 1999-06-24

Similar Documents

Publication Publication Date Title
DK1012154T3 (da) Salte af di(uridin-5'-tetraphosphat), fremgangsmåde til fremstilling og anvendelser deraf
NO20012555L (no) Fremgangsmåte for å fremme cervikale og vaginale sekresjoner
DE60144479D1 (ja)
BR9809562A (pt) Método de tratar doença de secura ocular com agonistas receptores purinérgicos
DK1414837T3 (da) Adenosin A3-receptoragonister
EA200100298A1 (ru) ФАРМАЦЕВТИЧЕСКИЕ ПРЕПАРАТЫ С РЕГУЛИРУЕМЫМ ВЫСВОБОЖДЕНИЕМ, СОДЕРЖАЩИЕ ИНГИБИТОР cGMP-ФОСФОДИЭСТЕРАЗЫ-5
LU92425I2 (fr) Dichlorure de radium Ra 2232 et ses dérivés pharmaceutiquement acceptables (XOFIGO®)
TR200003513T2 (tr) Pirolo[2,3d]Pirimidin kompozisyonları ve kullanımları
NZ522326A (en) Adenosine A2A receptor antagonists
TR200002218T2 (tr) 2-(Pürin-9-il)-Tetrahidrofüran -3,4-Diol türevleri
UA66945C2 (uk) ПОХІДНІ ПУРИНУ З ВЛАСТИВОСТЯМИ АГОНІСТА ЛЮДСЬКОГО А2<sub>А</sub> РЕЦЕПТОРА, СПОСІБ ЇХ ОДЕРЖАННЯ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА СПОСІБ ЛІКУВАННЯ
BR9811876A (pt) Uso de compostos contendo citidina e contendo citosina como tratamento para exposiçào a estimulante
BR0011521B1 (pt) Compostos nucleósidos de purina de 4 -c-etinila
DK468288D0 (da) Antivirale forbindelser
BR0112659A (pt) Processo para o tratamento de secura vaginal ou disfunção sexual em mulheres durante ou depois da menopausa e utilização do composto (diaminoidroxi)toremifeno ou de um sal, éster ou metabolito farmaceuticamente aceitável do mesmo
US6696425B2 (en) Method of treating dry eye disease with purinergic receptor agonists
DK0906329T3 (da) 2'-Substituerede nukleosider og oligonukleotidderivater
ITMI922673A1 (it) Procedimento di coniugazione di nucleosidi antivirali con albumina umana lattosaminata
BR9811422A (pt) Processo para a inibição de hiperplasia celular de músculo liso vascular em um paciente humano ou em outro paciente animal de sangue quente necessitando de tal tratamento, uso de pelo menos um oligossacarìdeo sulfatado, e, composição farmacêutica ou veterinária para a inibição de hiperplasia celular de músculo liso vascular
IT1251160B (it) Impiego di composti adenosinici nel trattamento dell'ischemia
AP2004003082A0 (en) Pharmaceutical combinations of adenosine A-2A and beta-2- adrenergic receptor agonists
ATE260118T1 (de) Zusammensetzungen von adenosin a1 agonisten mit 5ht1 agonisten
ES2173027A2 (es) Uso de nucleotidos en el tratamiento del glaucoma y la hipertension ocular.
DK0629209T3 (da) Sukkerderivater af makrolider
ATE186732T1 (de) (e)-2'-deoxy-2'-(fluormethylen)cytidin-monohydr t