DK1012154T3 - Salte af di(uridin-5'-tetraphosphat), fremgangsmåde til fremstilling og anvendelser deraf - Google Patents
Salte af di(uridin-5'-tetraphosphat), fremgangsmåde til fremstilling og anvendelser derafInfo
- Publication number
- DK1012154T3 DK1012154T3 DK98937115T DK98937115T DK1012154T3 DK 1012154 T3 DK1012154 T3 DK 1012154T3 DK 98937115 T DK98937115 T DK 98937115T DK 98937115 T DK98937115 T DK 98937115T DK 1012154 T3 DK1012154 T3 DK 1012154T3
- Authority
- DK
- Denmark
- Prior art keywords
- sub
- treatment
- tetraphosphate
- uridine
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5414797P | 1997-07-25 | 1997-07-25 | |
PCT/US1998/015445 WO1999005155A2 (en) | 1997-07-25 | 1998-07-24 | Salts of di(uridine 5'-tetraphosphate), method for preparation and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1012154T3 true DK1012154T3 (da) | 2004-07-26 |
Family
ID=21989063
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98937115T DK1012154T3 (da) | 1997-07-25 | 1998-07-24 | Salte af di(uridin-5'-tetraphosphat), fremgangsmåde til fremstilling og anvendelser deraf |
Country Status (17)
Country | Link |
---|---|
US (1) | US7432252B1 (de) |
EP (1) | EP1012154B1 (de) |
JP (1) | JP3723227B2 (de) |
KR (1) | KR20010013797A (de) |
CN (1) | CN1147502C (de) |
AT (1) | ATE261982T1 (de) |
AU (1) | AU747196B2 (de) |
BR (1) | BRPI9810436B1 (de) |
CA (1) | CA2295515C (de) |
DE (1) | DE69822482T2 (de) |
DK (1) | DK1012154T3 (de) |
ES (1) | ES2217569T3 (de) |
HK (1) | HK1028613A1 (de) |
NO (1) | NO328229B1 (de) |
NZ (1) | NZ501696A (de) |
PT (1) | PT1012154E (de) |
WO (1) | WO1999005155A2 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6319908B1 (en) | 1996-07-03 | 2001-11-20 | Inspire Pharmaceuticals, Inc. | Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof |
US5763447C1 (en) | 1996-07-23 | 2002-05-07 | Inspire Pharmaceuticals | Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds |
US7223744B2 (en) | 1997-02-10 | 2007-05-29 | Inspire Pharmaceuticals, Inc. | Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof |
TW593331B (en) | 1997-07-25 | 2004-06-21 | Inspire Pharmaceuticals Inc | Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof |
US6462028B2 (en) * | 1997-07-25 | 2002-10-08 | Inspire Pharmaceuticals, Inc. | Method of promoting cervical and vaginal secretions |
JP3723227B2 (ja) | 1997-07-25 | 2005-12-07 | インスパイアー ファーマシューティカルズ,インコーポレイティド | ジ(ウリジン5’)−テトラホスフェート及びその塩の大規模生産のための方法 |
US6548658B2 (en) * | 1997-07-25 | 2003-04-15 | Inspire Pharmaceuticals, Inc. | Di-(uridine 5′)-tetraphosphate and salts thereof |
US6872710B2 (en) | 1997-07-25 | 2005-03-29 | Inspire Pharmaceuticals, Inc. | Di(uridine 5′)-tetraphosphate and salts thereof |
CN100354296C (zh) * | 1998-10-02 | 2007-12-12 | 雅玛山酱油株式会社 | 二尿苷四磷酸或其盐的晶体和其制备方法、以及制备该化合物的方法 |
US6458946B1 (en) * | 1998-10-02 | 2002-10-01 | Yamasa Corporation | Crystals of diuridine tetraphosphate or salt thereof, process for producing the crystals, and process for producing the compounds |
CZ303172B6 (cs) * | 1999-06-30 | 2012-05-09 | Inspire Pharmaceuticals, Inc. | Krystalická forma P1-(2'-deoxycytidin-5'-)P4-(uridin-5'-)tetrafosfátu |
WO2001056581A1 (fr) * | 2000-02-04 | 2001-08-09 | Kissei Pharmaceutical Co., Ltd. | Preparation en poudre pour inhalation et inhalateur de poudre contenant cette preparation |
US7018985B1 (en) | 2000-08-21 | 2006-03-28 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
US7452870B2 (en) | 2000-08-21 | 2008-11-18 | Inspire Pharmaceuticals, Inc. | Drug-eluting stents coated with P2Y12 receptor antagonist compound |
CN1228053C (zh) * | 2001-09-11 | 2005-11-23 | 参天制药株式会社 | 含有二尿苷磷酸的滴眼液 |
KR100870104B1 (ko) * | 2005-11-28 | 2008-11-26 | 주식회사 머젠스 | 안구건조증 치료 및 예방용 조성물 |
CN101495497B (zh) | 2006-07-26 | 2012-03-14 | Yamasa酱油株式会社 | 二(嘧啶核苷5’-)多磷酸的制备方法 |
WO2010150791A1 (ja) * | 2009-06-23 | 2010-12-29 | ヤマサ醤油株式会社 | アデノシンテトラホスフェート化合物の製造法 |
CN106729718A (zh) | 2010-09-10 | 2017-05-31 | 参天制药株式会社 | 以组合p2y2受体激动剂和透明质酸或其盐为特征的干眼症治疗剂 |
EP2659894A4 (de) | 2010-12-28 | 2014-12-10 | Santen Pharmaceutical Co Ltd | Ophthalmische lösung mit diquafosol, herstellungsverfahren dafür und verfahren zur verhinderung der bildung von unlöslichem niederschlag |
CN102146111A (zh) * | 2011-01-26 | 2011-08-10 | 北京润德康医药技术有限公司 | 一类新型二核苷酸化合物及其制备方法 |
UA113981C2 (xx) | 2012-03-26 | 2017-04-10 | Офтальмологічний розчин, що містить диквафасол | |
EP3546472B1 (de) * | 2016-10-25 | 2021-06-16 | Yamasa Corporation | Verfahren zur reinigung von p1,p4-di(uridin 5'-)tetraphosphat |
KR102504764B1 (ko) * | 2017-06-21 | 2023-03-02 | 주식회사 종근당 | 디뉴클레오사이드 폴리포스페이트 화합물의 제조방법 |
CN109305991B (zh) * | 2017-07-27 | 2021-02-26 | 江苏恒瑞医药股份有限公司 | 一种p1,p4-二(尿苷5’-)四磷酸钠的制备方法 |
KR20180091689A (ko) * | 2017-11-06 | 2018-08-16 | 주식회사 종근당 | 무정형 디뉴클레오사이드 폴리포스페이트 화합물의 제조방법 |
MX2020008925A (es) | 2018-02-28 | 2020-10-01 | Santen Pharmaceutical Co Ltd | Composicion oftalmica que comprende dicuafosol y polimero cationico. |
CN110540555B (zh) * | 2018-05-28 | 2023-01-24 | 江苏恒瑞医药股份有限公司 | 一种游离核苷磷酸的方法 |
CN109021049B (zh) * | 2018-06-14 | 2020-12-08 | 扬子江药业集团北京海燕药业有限公司 | 一种尿苷5′-二磷酸-苯并咪唑二钠的合成方法 |
JPWO2020175525A1 (ja) | 2019-02-27 | 2021-12-23 | 参天製薬株式会社 | ジクアホソルまたはその塩、ビニル系高分子およびセルロース系高分子を含有する眼科用組成物 |
KR20200106738A (ko) | 2019-03-05 | 2020-09-15 | 주식회사 파마코스텍 | P1,p4-디(우리딘 5'-)테트라포스페이트, 이의 염 또는 이의 수화물의 신규한 제조방법 |
CN110590887B (zh) * | 2019-09-04 | 2020-12-15 | 江苏金殳医药科技有限公司 | 一种磷酸酯的制备方法 |
KR20210077946A (ko) | 2019-12-18 | 2021-06-28 | 주식회사 종근당 | 우리딘 5’-디인산(udp), 이의 염 또는 이의 수화물의 제조방법 |
KR20210110055A (ko) * | 2020-02-28 | 2021-09-07 | 주식회사 종근당바이오 | P1, p4-디(우리딘 5'-)테트라포스페이트 나트륨염 4 수화물 결정형 a의 제조방법 |
CN111662350B (zh) * | 2020-07-07 | 2022-06-07 | 南京宸翔医药研究有限责任公司 | 一种绿色化智能化高纯度地夸磷索四钠的制备方法 |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3639561A (en) | 1970-04-29 | 1972-02-01 | Smith Kline French Lab | Vaginal suppositories and impregnated tampons |
US3639562A (en) | 1970-04-29 | 1972-02-01 | Smith Kline French Lab | Vaginal suppositories and impregnated tampons |
US5292498A (en) | 1991-06-19 | 1994-03-08 | The University Of North Carolina At Chapel Hill | Method of treating lung disease with uridine triphosphates |
JPH05346549A (ja) | 1992-04-17 | 1993-12-27 | Canon Inc | 走査光学装置 |
WO1995010538A1 (en) | 1993-10-15 | 1995-04-20 | The University Of North Carolina At Chapel Hill | Dna encoding the human p2u receptor and null cells expressing p2u receptors |
US5656256A (en) | 1994-12-14 | 1997-08-12 | The University Of North Carolina At Chapel Hill | Methods of treating lung disease by an aerosol containing benzamil or phenamil |
US5635160A (en) | 1995-06-07 | 1997-06-03 | The University Of North Carolina At Chapel Hill | Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions |
US5628984A (en) | 1995-07-31 | 1997-05-13 | University Of North Carolina At Chapel Hill | Method of detecting lung disease |
JP3519199B2 (ja) | 1996-02-06 | 2004-04-12 | 株式会社ソニー・コンピュータエンタテインメント | 画像生成装置 |
US6423694B1 (en) * | 1996-02-21 | 2002-07-23 | Inspire Pharmaceuticals, Inc. | Method of treating otitis media with uridine triphosphates and related compounds |
CN1229114C (zh) * | 1996-03-27 | 2005-11-30 | 印斯拜尔药品股份有限公司 | 用三磷酸尿苷和相关化合物治疗纤毛运动障碍的方法 |
US5900407A (en) | 1997-02-06 | 1999-05-04 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with uridine triphosphates and related compounds |
US5837861A (en) | 1997-02-10 | 1998-11-17 | Inspire Pharmaceuticals, Inc. | Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency |
US5962432A (en) | 1996-07-03 | 1999-10-05 | Inspire Pharmaceuticals, Inc. | Sterilized, isotonic and pH-adjusted pharmaceutical formulation of uridine triphosphate |
US5968913A (en) | 1996-07-03 | 1999-10-19 | Inspire Pharmaceuticals, Inc. | Pharmaceutical compositions of uridine triphosphate |
US5789391A (en) | 1996-07-03 | 1998-08-04 | Inspire Pharmaceuticals, Inc. | Method of treating sinusitis with uridine triphosphates and related compounds |
US5763447C1 (en) * | 1996-07-23 | 2002-05-07 | Inspire Pharmaceuticals | Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds |
WO1998015835A1 (en) | 1996-10-08 | 1998-04-16 | Inspire Pharmaceuticals, Inc. | Method of early lung cancer detection via sputum induction and analysis of sputum to detect cancer associated substances |
US6159952A (en) | 1996-11-07 | 2000-12-12 | Inspire Pharmaceuticals, Inc. | Method of treating bronchitis with uridine triphosphate and related compounds |
DK0981534T3 (da) * | 1997-02-06 | 2006-09-04 | Inspire Pharmaceuticals Inc | Dinukleotider og deres anvendelser |
US6462028B2 (en) | 1997-07-25 | 2002-10-08 | Inspire Pharmaceuticals, Inc. | Method of promoting cervical and vaginal secretions |
JP3723227B2 (ja) | 1997-07-25 | 2005-12-07 | インスパイアー ファーマシューティカルズ,インコーポレイティド | ジ(ウリジン5’)−テトラホスフェート及びその塩の大規模生産のための方法 |
ZA987847B (en) | 1997-08-29 | 1999-06-28 | Univ North Carolina | Method of treating lung diseases with uridine 5'-diphosphate and analogs thereof |
EP1087777B1 (de) | 1998-05-22 | 2003-02-19 | Inspire Pharmaceuticals, Inc. | Therapeutische dinucleotide und deren derivate |
US6294188B1 (en) | 1998-07-09 | 2001-09-25 | Aviana Biopharm Inc. | Methods involving changing the constitutive and stimulated secretions of the local reproductive system of women |
GB9827477D0 (en) | 1998-12-15 | 1999-02-10 | Kalon Limited | Paint |
WO2000039145A1 (en) | 1998-12-23 | 2000-07-06 | The University Of North Carolina At Chapel Hill | Targeted gene transfer using g protein coupled receptors |
CA2359891A1 (en) | 1999-02-26 | 2000-08-31 | Inspire Pharmaceuticals, Inc. | Method of promoting mucosal hydration with certain uridine, adenine and cytidine diphosphates and analogs thereof |
-
1998
- 1998-07-24 JP JP51015699A patent/JP3723227B2/ja not_active Expired - Lifetime
- 1998-07-24 KR KR1019997011815A patent/KR20010013797A/ko active Search and Examination
- 1998-07-24 BR BRPI9810436A patent/BRPI9810436B1/pt not_active IP Right Cessation
- 1998-07-24 DE DE69822482T patent/DE69822482T2/de not_active Expired - Lifetime
- 1998-07-24 WO PCT/US1998/015445 patent/WO1999005155A2/en active IP Right Grant
- 1998-07-24 AT AT98937115T patent/ATE261982T1/de active
- 1998-07-24 CA CA002295515A patent/CA2295515C/en not_active Expired - Lifetime
- 1998-07-24 AU AU85903/98A patent/AU747196B2/en not_active Expired
- 1998-07-24 PT PT98937115T patent/PT1012154E/pt unknown
- 1998-07-24 DK DK98937115T patent/DK1012154T3/da active
- 1998-07-24 CN CNB988061996A patent/CN1147502C/zh not_active Expired - Lifetime
- 1998-07-24 EP EP98937115A patent/EP1012154B1/de not_active Expired - Lifetime
- 1998-07-24 NZ NZ501696A patent/NZ501696A/en not_active IP Right Cessation
- 1998-07-24 ES ES98937115T patent/ES2217569T3/es not_active Expired - Lifetime
-
1999
- 1999-12-14 NO NO19996189A patent/NO328229B1/no not_active IP Right Cessation
-
2000
- 2000-03-20 US US09/531,851 patent/US7432252B1/en not_active Expired - Fee Related
- 2000-12-14 HK HK00108028A patent/HK1028613A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69822482T2 (de) | 2005-03-03 |
AU747196B2 (en) | 2002-05-09 |
NZ501696A (en) | 2001-08-31 |
JP2001510484A (ja) | 2001-07-31 |
CA2295515A1 (en) | 1999-02-04 |
AU8590398A (en) | 1999-02-16 |
ES2217569T3 (es) | 2004-11-01 |
WO1999005155A2 (en) | 1999-02-04 |
HK1028613A1 (en) | 2001-02-23 |
ATE261982T1 (de) | 2004-04-15 |
JP3723227B2 (ja) | 2005-12-07 |
DE69822482D1 (de) | 2004-04-22 |
KR20010013797A (ko) | 2001-02-26 |
BR9810436A (pt) | 2000-12-12 |
CN1147502C (zh) | 2004-04-28 |
WO1999005155A3 (en) | 1999-06-24 |
PT1012154E (pt) | 2004-08-31 |
NO996189D0 (no) | 1999-12-14 |
NO996189L (no) | 2000-03-27 |
NO328229B1 (no) | 2010-01-11 |
EP1012154B1 (de) | 2004-03-17 |
CN1265114A (zh) | 2000-08-30 |
US7432252B1 (en) | 2008-10-07 |
BRPI9810436B1 (pt) | 2015-12-29 |
CA2295515C (en) | 2006-03-14 |
EP1012154A2 (de) | 2000-06-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1012154T3 (da) | Salte af di(uridin-5'-tetraphosphat), fremgangsmåde til fremstilling og anvendelser deraf | |
NO20012555L (no) | Fremgangsmåte for å fremme cervikale og vaginale sekresjoner | |
DE60144479D1 (de) | ||
BR0011856A (pt) | Agonistas de receptor a2a de n-pirazol | |
DK1003474T3 (da) | Fremgangsmåde til behandling af tör öjensygdom med purinergiske receptoragonister | |
DK1414837T3 (da) | Adenosin A3-receptoragonister | |
YU76100A (sh) | Pirolo(2,3-d) pirimidin preparati i njihova primena | |
EA200100298A1 (ru) | ФАРМАЦЕВТИЧЕСКИЕ ПРЕПАРАТЫ С РЕГУЛИРУЕМЫМ ВЫСВОБОЖДЕНИЕМ, СОДЕРЖАЩИЕ ИНГИБИТОР cGMP-ФОСФОДИЭСТЕРАЗЫ-5 | |
BR0011854A (pt) | Agonistas de receptores de a2a de c-pirazola | |
TR200103607T2 (tr) | Pürin Türevleri | |
NZ522326A (en) | Adenosine A2A receptor antagonists | |
TR200002218T2 (tr) | 2-(Pürin-9-il)-Tetrahidrofüran -3,4-Diol türevleri | |
BR9811876A (pt) | Uso de compostos contendo citidina e contendo citosina como tratamento para exposiçào a estimulante | |
BR0011521B8 (pt) | compostos nucleósidos de purina de 4 -c-etinila | |
DK0906329T3 (da) | 2'-Substituerede nukleosider og oligonukleotidderivater | |
ITMI922673A1 (it) | Procedimento di coniugazione di nucleosidi antivirali con albumina umana lattosaminata | |
BR9811422A (pt) | Processo para a inibição de hiperplasia celular de músculo liso vascular em um paciente humano ou em outro paciente animal de sangue quente necessitando de tal tratamento, uso de pelo menos um oligossacarìdeo sulfatado, e, composição farmacêutica ou veterinária para a inibição de hiperplasia celular de músculo liso vascular | |
IT1251160B (it) | Impiego di composti adenosinici nel trattamento dell'ischemia | |
AP2004003082A0 (en) | Pharmaceutical combinations of adenosine A-2A and beta-2- adrenergic receptor agonists | |
DE60008589D1 (de) | Zusammensetzungen von adenosin a1 agonisten mit 5ht1 agonisten | |
ES2173027A2 (es) | Uso de nucleotidos en el tratamiento del glaucoma y la hipertension ocular. | |
ATE186732T1 (de) | (e)-2'-deoxy-2'-(fluormethylen)cytidin-monohydr t | |
Ćetković et al. | An efficient de novo synthesis of 3'-deoxythymidine from D-xylose | |
ES551865A0 (es) | Procedimiento para la preparacion de derivados de 5'-o-(glicosilureidosulfonil) uridina. | |
IT1281503B1 (it) | Combinazioni di pirrolobenzotiazepine con analoghi di nucleosidi per la terapia dell'aids. |