DK1007691T3 - Fremgangsmåder og sammensætninger til syntese af langkædede polyumættede fedtsyrer - Google Patents

Fremgangsmåder og sammensætninger til syntese af langkædede polyumættede fedtsyrer

Info

Publication number
DK1007691T3
DK1007691T3 DK98918175T DK98918175T DK1007691T3 DK 1007691 T3 DK1007691 T3 DK 1007691T3 DK 98918175 T DK98918175 T DK 98918175T DK 98918175 T DK98918175 T DK 98918175T DK 1007691 T3 DK1007691 T3 DK 1007691T3
Authority
DK
Denmark
Prior art keywords
delta5
desaturase
fatty acids
methods
recombinant host
Prior art date
Application number
DK98918175T
Other languages
Danish (da)
English (en)
Inventor
Pradip Mukerji
Yung-Sheng Huang
Jennifer Thurmond
Amanda Eun-Yeong Leonard
Deborah Knutzon
Sunita Chaudhary
Original Assignee
Calgene Llc
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calgene Llc, Abbott Lab filed Critical Calgene Llc
Application granted granted Critical
Publication of DK1007691T3 publication Critical patent/DK1007691T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Animal Husbandry (AREA)
  • Pediatric Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
DK98918175T 1997-04-11 1998-04-10 Fremgangsmåder og sammensætninger til syntese af langkædede polyumættede fedtsyrer DK1007691T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/833,610 US5972664A (en) 1997-04-11 1997-04-11 Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
EP98918175A EP1007691B1 (en) 1997-04-11 1998-04-10 Methods and compositions for synthesis of long chain polyunsaturated fatty acids
PCT/US1998/007422 WO1998046765A1 (en) 1997-04-11 1998-04-10 Methods and compositions for synthesis of long chain polyunsaturated fatty acids

Publications (1)

Publication Number Publication Date
DK1007691T3 true DK1007691T3 (da) 2004-12-20

Family

ID=25264859

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98918175T DK1007691T3 (da) 1997-04-11 1998-04-10 Fremgangsmåder og sammensætninger til syntese af langkædede polyumættede fedtsyrer

Country Status (24)

Country Link
US (2) US5972664A (enExample)
EP (1) EP1007691B1 (enExample)
JP (1) JP4453881B2 (enExample)
KR (2) KR20010006255A (enExample)
CN (1) CN1253587A (enExample)
AT (1) ATE277188T1 (enExample)
AU (1) AU720725B2 (enExample)
BG (1) BG103796A (enExample)
BR (1) BR9809083A (enExample)
CA (1) CA2286263A1 (enExample)
DE (1) DE69826494T2 (enExample)
DK (1) DK1007691T3 (enExample)
ES (1) ES2229491T3 (enExample)
HU (1) HUP0001295A3 (enExample)
IL (1) IL132149A0 (enExample)
IN (1) IN1998KO00639A (enExample)
NO (1) NO994924L (enExample)
NZ (1) NZ337458A (enExample)
PL (1) PL336067A1 (enExample)
PT (1) PT1007691E (enExample)
SI (1) SI1007691T1 (enExample)
SK (1) SK139799A3 (enExample)
TR (1) TR199902466T2 (enExample)
WO (1) WO1998046765A1 (enExample)

Families Citing this family (141)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6483008B1 (en) * 1990-08-15 2002-11-19 Calgene Llc Methods for producing plants with elevated oleic acid content
US6428990B1 (en) 1997-04-11 2002-08-06 Abbott Laboratories Human desaturase gene and uses thereof
US6432684B1 (en) * 1997-04-11 2002-08-13 Abbott Laboratories Human desaturase gene and uses thereof
US7745694B1 (en) 1997-04-11 2010-06-29 Monsanto Technology Llc Methods and compositions for synthesis of long chain polyunsaturated fatty acids in plants
US5968809A (en) 1997-04-11 1999-10-19 Abbot Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
PL344868A1 (en) * 1997-12-23 2001-11-19 Univ Bristol Desaturase
US20030152983A1 (en) * 1997-12-23 2003-08-14 University Of Bristol Desaturase
WO1999061602A1 (en) * 1998-05-29 1999-12-02 Ohio University Compositions and methods for the synthesis of fatty acids, their derivatives and downstream products
DK1086236T3 (da) 1998-06-12 2007-12-03 Calgene Llc Polyumættede fedtsyrer i planter
US20030163845A1 (en) 1998-09-02 2003-08-28 Pradip Mukerji Elongase genes and uses thereof
US6677145B2 (en) * 1998-09-02 2004-01-13 Abbott Laboratories Elongase genes and uses thereof
US6913916B1 (en) 1998-09-02 2005-07-05 Abbott Laboratories Elongase genes and uses thereof
WO2000020602A2 (en) * 1998-10-05 2000-04-13 Abbott Laboratories Delta 6 and delta 12 desaturases and modified fatty acid biosynthesis and products produced therefrom
WO2000020603A1 (en) * 1998-10-05 2000-04-13 Abbott Laboratories Altered fatty acid biosynthesis in insect cells using delta five desaturase
US6140081A (en) * 1998-10-16 2000-10-31 The Scripps Research Institute Zinc finger binding domains for GNN
DE10030976A1 (de) 2000-06-30 2002-01-10 Basf Ag DELTA6-Desaturasegene exprimierende Pflanzen und PUFAS enthaltende Öle aus diesen Pflanzen und ein Verfahren zur Herstellung ungesättigter Fettsäuren
WO2001004636A1 (en) * 1999-07-12 2001-01-18 Ohio University Mammalian cells expressing desaturases and elongases
US7070970B2 (en) 1999-08-23 2006-07-04 Abbott Laboratories Elongase genes and uses thereof
PL207026B1 (pl) 2000-02-09 2010-10-29 Basf Ag Wyizolowany kwas nukleinowy, konstrukt genowy zawierający ten kwas, sekwencja aminokwasowa kodowana przez wyizolowaną sekwencję tego kwasu nukleinowego, wektor zawierający kwas nukleinowy lub konstrukt genowy, roślina transgeniczna lub mikroorganizm transgeniczny zawierający kwas nukleinowy, konstrukt genowy lub wektor, przeciwciało specyficznie wiążące się z polipeptydem kodowanym przez kwas nukleinowy, cząsteczka antysensownego kwasu nukleinowego oraz sposób wytwarzania wielonienasyconych kwasów tłuszczowych (PUFA)
JP4071622B2 (ja) * 2000-09-28 2008-04-02 バイオリジナル フード アンド サイエンス コーポレーション 脂肪酸不飽和化酵素ファミリーのメンバーであるｆａｄ４、ｆａｄ５、ｆａｄ５−２およびｆａｄ６、ならびにそれらの使用方法
DE10102337A1 (de) 2001-01-19 2002-07-25 Basf Plant Science Gmbh Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren, neue Biosynthesegene sowie neue pflanzliche Expressionskonstrukte
EP1392823B1 (en) * 2001-01-25 2011-11-30 Abbott Laboratories Desaturase genes and uses thereof
US6635451B2 (en) * 2001-01-25 2003-10-21 Abbott Laboratories Desaturase genes and uses thereof
GB0107510D0 (en) 2001-03-26 2001-05-16 Univ Bristol New elongase gene and a process for the production of -9-polyunsaturated fatty acids
AU2003206714B2 (en) * 2002-01-30 2007-09-06 Basf Plant Science Gmbh Elongase gene and method for producing polyunsaturated fatty acids
GB2385852A (en) 2002-02-27 2003-09-03 Rothamsted Ex Station Delta 6-desaturases from Primulaceae
DE10219203A1 (de) 2002-04-29 2003-11-13 Basf Plant Science Gmbh Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in Pflanzen
BRPI0311324B1 (pt) 2002-05-22 2020-01-28 Monsanto Technology Llc polinucleotídeo, vetor, polipeptídeo com atividade dessasturase, métodos para produção de planta e óleo de milho contendo ácidos graxos de ômega-3, para aumentar o valor nutricional de um produto comestível, de fabricação de alimento ou alimentação, bem como composição comestível
AU2003296638B2 (en) 2002-12-19 2009-06-11 University Of Bristol Method for the production of polyunsaturated fatty acids
US8084074B2 (en) * 2003-02-12 2011-12-27 E. I. Du Pont De Nemours And Company Production of very long chain polyunsaturated fatty acids in oil seed plants
US20040172682A1 (en) * 2003-02-12 2004-09-02 Kinney Anthony J. Production of very long chain polyunsaturated fatty acids in oilseed plants
ATE517984T1 (de) 2003-02-27 2011-08-15 Basf Plant Science Gmbh Verfahren zur herstellung mehrfach ungesättigter fettsäuren
US7855321B2 (en) 2003-03-31 2010-12-21 University Of Bristol Plant acyltransferases specific for long-chained, multiply unsaturated fatty acids
WO2004090123A2 (de) 2003-04-08 2004-10-21 Basf Plant Science Gmbh Δ-4-desaturasen aus euglena gracilis, exprimierende pflanzen und pufa enthaltende öle
US7125672B2 (en) * 2003-05-07 2006-10-24 E. I. Du Pont De Nemours And Company Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts
US7238482B2 (en) * 2003-05-07 2007-07-03 E. I. Du Pont De Nemours And Company Production of polyunsaturated fatty acids in oleaginous yeasts
EP2166067B1 (de) 2003-08-01 2015-07-01 BASF Plant Science GmbH Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen Organismen
ATE430802T1 (de) * 2003-08-21 2009-05-15 Monsanto Technology Llc Fettsäuredesaturasen aus primula
EP1682566B1 (en) 2003-11-12 2013-06-05 E.I. Du Pont De Nemours And Company Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous plants and yeast
ATE516295T1 (de) 2004-01-20 2011-07-15 Monsanto Technology Llc Chimäre promotoren zur verwendung in pflanzen
EP1720988B1 (de) 2004-02-27 2011-10-12 BASF Plant Science GmbH Verfahren zur herstellung von ungesättigten omega-3-fettsäuren in transgenen organismen
US9458436B2 (en) 2004-02-27 2016-10-04 Basf Plant Science Gmbh Method for producing polyunsaturated fatty acids in transgenic plants
CN1968688A (zh) 2004-04-16 2007-05-23 孟山都技术有限公司 脂肪酸去饱和酶在玉米中的表达
CA3023314C (en) 2004-04-22 2019-12-10 Commonwealth Scientific And Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
CN103451246B (zh) 2004-04-22 2018-02-16 联邦科学技术研究组织 用重组细胞合成长链多不饱和脂肪酸
US20050266051A1 (en) * 2004-05-27 2005-12-01 The Procter & Gamble Company Pet food compositions and methods
EP1766023B1 (en) * 2004-06-04 2010-09-01 Fluxome Sciences A/S Metabolically engineered cells for the production of polyunsaturated fatty acids
WO2006012325A1 (en) 2004-06-25 2006-02-02 E.I. Dupont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
US7588931B2 (en) 2004-11-04 2009-09-15 E. I. Du Pont De Nemours And Company High arachidonic acid producing strains of Yarrowia lipolytica
WO2006092449A2 (en) 2005-03-02 2006-09-08 Metanomics Gmbh Process for the production of fine chemicals
DE102005013779A1 (de) 2005-03-22 2006-09-28 Basf Plant Science Gmbh Verfahren zur Herstellung von mehrfach ungesättigten C20- und C22-Fettsäuren mit mindestens vier Doppelbindungen in transgenen Pflanzen
AR053477A1 (es) 2005-05-23 2007-05-09 Arcadia Biosciences Inc Cartamo con acido gamma - linolenico elevado
DE102005038036A1 (de) 2005-08-09 2007-02-15 Basf Plant Science Gmbh Verfahren zur Herstellung von Arachidonsäure und/oder Eicosapentaensäure in transgenen Nutzpflanzen
GB2431158A (en) 2005-10-13 2007-04-18 Rothamsted Res Ltd Process for the production of arachidonic and/or eicosapentaenoic acid
DE102005052551A1 (de) 2005-11-02 2007-05-16 Rothamsted Res Harpenden Verfahren zur Herstellung von y-Linolensäure und/oder Stearidonsäure in transgenen Brassicaceae und Linaceae
KR20080071190A (ko) 2005-11-23 2008-08-01 이 아이 듀폰 디 네모아 앤드 캄파니 델타-９ 일롱가제, 및 다중불포화 지방산 생성에 있어서의이들의 용도
US7723574B2 (en) * 2005-11-24 2010-05-25 Basf Plant Science Gmbh Process for the production of Δ5-unsaturated fatty acids in transgenic organisms
GB0603160D0 (en) 2006-02-16 2006-03-29 Rothamsted Res Ltd Nucleic acid
AR059376A1 (es) 2006-02-21 2008-03-26 Basf Plant Science Gmbh Procedimiento para la produccion de acidos grasos poliinsaturados
BRPI0708477B8 (pt) 2006-03-01 2022-12-06 Pioneer Hi Bred Int Método para identificar uma primeira planta de milho ou um primeiro germoplasma de milho compreendendo em seu genoma um gene de diaglicerol o-aciltransferase do tipo 1 (dgat), polinucleotídeo isolado, método para produzir uma planta ou parte de planta possuindo um fenótipo selecionado, método para identificar a presença de um lócus marcador
US8629195B2 (en) 2006-04-08 2014-01-14 Bayer Materialscience Ag Production of polyurethane foams
US7943823B2 (en) 2006-04-28 2011-05-17 E.I. Du Pont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
EP2803728B1 (en) 2006-05-16 2018-11-21 Monsanto Technology LLC Use of non-agrobacterium bacterial species for plant transformation
US7695950B2 (en) * 2006-05-17 2010-04-13 E. I. Du Pont De Nemours And Company Δ5 desaturase and its use in making polyunsaturated fatty acids
US7678560B2 (en) 2006-05-17 2010-03-16 E.I. Du Pont De Nemours And Company Δ 5 desaturase and its use in making polyunsaturated fatty acids
MX2009000757A (es) * 2006-07-19 2009-03-09 Monsanto Technology Llc Acido graso desaturasas de tetraselmis suecica.
EP2500420B1 (en) 2006-08-24 2016-06-22 BASF Plant Science GmbH Pythium omega 3 desaturase with specificity to all omega 6 fatty acids longer than 18 carbon chains
EP2059588A4 (en) 2006-08-29 2010-07-28 Commw Scient Ind Res Org FATTY ACID SYNTHESIS
PL2177605T3 (pl) 2006-10-06 2015-05-29 Basf Plant Science Gmbh Delta-5 desaturazy i sposób wytwarzania wielokrotnie nienasyconych kwasów tłuszczowych w organizmach transgenicznych innych niż człowiek
CA2663768A1 (en) 2006-10-23 2008-05-29 E. I. Du Pont De Nemours And Company Delta-8 desaturases and their use in making polyunsaturated fatty acids
UA102063C2 (uk) 2007-02-12 2013-06-10 Е. І. Дю Пон Де Немур Енд Компані Трансгенна соєва рослина, що продукує арахідонову кислоту
US7838729B2 (en) 2007-02-26 2010-11-23 Monsanto Technology Llc Chloroplast transit peptides for efficient targeting of DMO and uses thereof
AU2008226443B2 (en) 2007-03-09 2013-07-11 Monsanto Technology Llc Preparation and use of plant embryo explants for transformation
US8188338B2 (en) 2007-04-10 2012-05-29 E. I. Du Pont De Nemours And Company Delta-8 desaturases and their use in making polyunsaturated fatty acids
US7794701B2 (en) 2007-04-16 2010-09-14 E.I. Du Pont De Nemours And Company Δ-9 elongases and their use in making polyunsaturated fatty acids
US8957280B2 (en) * 2007-05-03 2015-02-17 E. I. Du Pont De Nemours And Company Delta-5 desaturases and their use in making polyunsaturated fatty acids
US8318914B2 (en) 2007-07-31 2012-11-27 Bioriginal Food & Science Corp. Elongases and methods for producing polyunsaturated fatty acids in transgenic organisms
AU2008337600A1 (en) 2007-12-14 2009-06-25 Basf Plant Science Gmbh Promoters from brassica napus for seed specific gene expression
PT2262896E (pt) 2008-04-07 2014-04-28 Monsanto Technology Llc Elementos reguladores de plantas e suas utilizações
JP2011519552A (ja) * 2008-04-25 2011-07-14 ビーエーエスエフ プラント サイエンス ゲーエムベーハー 植物種子油
BRPI0911892A8 (pt) 2008-04-30 2018-06-26 Rothamsted Res Ltd polinucleotídeo, vetor, célula hospedeira, polipeptídeo e organismo não humano, transgênico, e uso dos mesmos, processo de geração de um polipeptídio com atividade de desaturase ou elongase, anticorpo e processo para a produção de uma composição de óleo, lipídio ou ácido graxo
US8168858B2 (en) 2008-06-20 2012-05-01 E. I. Du Pont De Nemours And Company Delta-9 fatty acid elongase genes and their use in making polyunsaturated fatty acids
PT2294179E (pt) 2008-06-27 2014-07-08 Sapphire Energy Inc Indução de floculação em organismos fotossintéticos
AU2009265795B2 (en) 2008-07-01 2014-12-11 Basf Plant Science Gmbh Promoters from Brassica napus for seed specific gene expression
JP5757870B2 (ja) 2008-08-26 2015-08-05 ビーエーエスエフ プラント サイエンス ゲーエムベーハー デサチュラーゼをコードする核酸および改変植物油
EP2324119B1 (en) * 2008-09-19 2016-03-30 E. I. du Pont de Nemours and Company Mutant delta5 desaturases and their use in making polyunsaturated fatty acids
US8809559B2 (en) 2008-11-18 2014-08-19 Commonwelath Scientific And Industrial Research Organisation Enzymes and methods for producing omega-3 fatty acids
EP2669380B1 (en) 2008-12-12 2017-09-27 BASF Plant Science GmbH Desaturases and process for the production of polyunsaturated fatty acids in transgenic organisms
US8060617B2 (en) * 2008-12-19 2011-11-15 Cisco Technology, Inc. Reserving network resources during scheduling of meeting event
US20120277117A1 (en) 2009-02-27 2012-11-01 Adel Zayed Hydroponic apparatus and methods of use
US9212371B2 (en) 2009-05-13 2015-12-15 Basf Plant Science Company Gmbh Acyltransferases and uses thereof in fatty acid production
WO2011050271A1 (en) 2009-10-23 2011-04-28 Monsanto Technology Llc Methods and compositions for expression of transgenes in plants
BR112012019582B1 (pt) 2010-01-14 2021-09-21 Monsanto Technology Llc Molécula de dna compreendendo elementos reguladores de plantas
AU2011269059B2 (en) 2010-06-25 2016-01-28 Basf Plant Science Company Gmbh Acyltransferases and uses therof in fatty acid production
CN103249834B (zh) 2010-08-26 2016-10-26 纳幕尔杜邦公司 生产高水平二十碳五烯酸的重组微生物宿主细胞
EP2609202A1 (en) 2010-08-26 2013-07-03 E.I. Du Pont De Nemours And Company Mutant hpgg motif and hdash motif delta-5 desaturases and their use in making polyunsaturated fatty acids
KR20140016865A (ko) 2010-08-30 2014-02-10 다우 아그로사이언시즈 엘엘씨 사탕수수 간균형 바이러스(scbv) 인핸서 및 식물 기능유전체학에서의 그의 용도
EP4059342A1 (en) 2010-12-17 2022-09-21 Monsanto Technology LLC Methods for improving competency of plant cells
PH12013501978A1 (en) 2011-03-25 2013-11-25 Monsanto Technology Llc Plant regulatory elements and uses thereof
CA2997731C (en) 2011-05-13 2020-05-26 Monsanto Technology Llc Plant regulatory elements and uses thereof
IN2014DN06986A (enExample) 2012-02-29 2015-04-10 Dow Agrosciences Llc
CA3148246A1 (en) 2012-04-12 2013-10-17 Rothamsted Research Ltd Production of omega-3 long chain polyunsaturated fatty acids
US9663793B2 (en) 2012-04-20 2017-05-30 Monsanto Technology, Llc Plant regulatory elements and uses thereof
BR122019026149A8 (pt) 2012-06-15 2022-06-28 Commw Scient Ind Res Org Célula hospedeira, processo de produzir um lipídio de planta extraído, método de produzir semente, farinha de semente, método para produzir um produto alimentício, uso e processo para produzir ésteres de etila
GB201217524D0 (en) 2012-10-01 2012-11-14 Rothamsted Res Ltd Recombinant organisms
AU2013362921B2 (en) 2012-12-19 2018-03-01 Monsanto Technology Llc Plant regulatory elements and uses thereof
JP6580027B2 (ja) 2013-03-14 2019-09-25 モンサント テクノロジー エルエルシー 植物調節エレメントおよびその使用
CR20200120A (es) 2013-03-14 2020-06-05 Monsanto Technology Llc Elementos regulatorios de planta y sus usos (divisional 2015-0554)
HUE055277T2 (hu) * 2013-12-04 2021-11-29 Nippon Suisan Kaisha Ltd Dihomo-gamma-linolénsavat tartalmazó mikrobális olaj és dihomo-gamma-linolénsavat tartalmazó mikrobális biomassza
PE20170253A1 (es) 2013-12-18 2017-04-14 Nuseed Pty Ltd Lipido que comprende acidos grasos poliinsaturados de cadena larga
AU2015281791A1 (en) 2014-06-27 2017-01-12 Commonwealth Scientific And Industrial Research Organisation Lipid comprising docosapentaenoic acid
US20180228195A1 (en) * 2014-09-30 2018-08-16 Nestec S.A. Nutritional composition for use in promoting gut and/or liver maturation and/or repair
US11519011B2 (en) 2015-03-26 2022-12-06 The Texas A&M University System Conversion of lignin into bioplastics and lipid fuels
DK3341483T3 (da) 2015-08-28 2020-03-16 Pioneer Hi Bred Int Ochrobactrum-medieret transformation af planter
EP3356537B1 (en) 2015-10-02 2022-08-17 Monsanto Technology LLC Recombinant maize b chromosome sequence and uses thereof
BR112018001122B1 (pt) 2016-03-11 2021-06-01 Monsanto Technology Llc Molécula de dna recombinante compreendendo elementos reguladores de planta e método de expressão de uma molécula de dna passível de transcrição
EP3462844B1 (en) 2016-05-24 2024-11-27 Monsanto Technology LLC Plant regulatory elements and uses thereof
US11732268B2 (en) 2016-06-28 2023-08-22 Monsanto Technology Llc Methods and compositions for use in genome modification in plants
WO2018005589A1 (en) 2016-06-28 2018-01-04 Cellectis Altering expression of gene products in plants through targeted insertion of nucleic acid sequences
CR20240086A (es) 2017-01-19 2024-09-30 Monsanto Technology Llc ELEMENTOS REGULATORIOS DE PLANTAS Y SUS USOS (Divisional 2019-0377)
US20200332311A1 (en) 2018-01-12 2020-10-22 The Texas A&M University System Increasing plant bioproduct yield
MX2021002743A (es) 2019-01-10 2021-05-12 Monsanto Technology Llc Elementos reguladores de planta y usos de los mismos.
MX2021014528A (es) 2019-05-29 2022-01-06 Monsanto Technology Llc Metodos y composiciones para generar alelos dominantes usando edicion del genoma.
US20240263206A1 (en) 2021-03-26 2024-08-08 Flagship Pioneering Innovations Vii, Llc Compositions and methods for producing circular polyribonucleotides
EP4314281A1 (en) 2021-03-26 2024-02-07 Flagship Pioneering Innovations VII, LLC Production of circular polyribonucleotides in a eukaryotic system
TW202305130A (zh) 2021-03-26 2023-02-01 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 原核系統中環狀多核糖核苷酸之產生
UY39997A (es) 2021-11-01 2023-05-15 Flagship Pioneering Innovations Vii Llc Polinucleótidos para modificar organismos
AU2023209447A1 (en) 2022-01-20 2024-07-18 Flagship Pioneering Innovations Vii, Llc Polynucleotides for modifying organisms
AU2023337091A1 (en) 2022-09-09 2025-03-06 Eidgenössische Technische Hochschule Zürich Plant regulatory elements and uses thereof
WO2024091091A1 (ko) * 2022-10-28 2024-05-02 올케어플러스 주식회사 동물용 영양식 조성물 및 이의 제조 방법
AR132591A1 (es) 2023-05-03 2025-07-16 Flagship Pioneering Innovations Vii Llc Arn satélite de secoviridae artificiales
EP4705478A1 (en) 2023-05-03 2026-03-11 Flagship Pioneering Innovations VII, LLC Artificial martellivirales satellite rnas
CN121712898A (zh) 2023-05-03 2026-03-20 旗舰创业创新第七有限责任公司 用于植物的内源核糖核酸病毒卫星rna扩增系统
EP4705474A2 (en) 2023-05-03 2026-03-11 Flagship Pioneering Innovations VII, LLC Artificial tymovirales satellite rnas
WO2024229385A1 (en) 2023-05-03 2024-11-07 Flagship Pioneering Innovations Vii, Llc Artificial ghabrivirales satellite rnas
WO2024229347A1 (en) 2023-05-03 2024-11-07 Flagship Pioneering Innovations Vii, Llc Artificial tombusviridae satellite rnas
CN121816422A (zh) 2023-05-03 2026-04-07 旗舰创业创新第七有限责任公司 人工混合病毒属卫星rna
CN121712897A (zh) 2023-05-03 2026-03-20 旗舰创业创新第七有限责任公司 用于植物的分体病毒卫星rna扩增系统
WO2024229356A2 (en) 2023-05-03 2024-11-07 Flagship Pioneering Innovations Vii, Llc Artificial solemoviridae satellite rnas
US20250075226A1 (en) 2023-08-29 2025-03-06 University Of Freiburg Proteins for regulation of symbiotic infection and associated regulatory elements
WO2026006779A1 (en) 2024-06-27 2026-01-02 The Regents Of The University Of California Transgenic plants expressing fern rapid non-photochemical quenching (npq) proteins

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3649295A (en) * 1970-06-01 1972-03-14 American Home Prod Humanized fat compositions and infant formulas thereof
US4058594A (en) * 1974-04-25 1977-11-15 John Williams Immuno-suppressive agents
ATE24266T1 (de) * 1982-04-16 1987-01-15 Nestle Sa Lipidhaltige zusammensetzung fuer die orale, enterale oder parenterale ernaehrung.
US4670285A (en) * 1982-08-06 1987-06-02 The University Of Toronto Innovations Foundation Infant formula
GB8317248D0 (en) * 1983-06-24 1983-07-27 Wyeth John & Brother Ltd Fat compositions
US4526902A (en) * 1983-10-24 1985-07-02 Century Laboratories, Inc. Combined fatty acid composition for treatment or prophylaxis of thrombo-embolic conditions
US4920098A (en) * 1986-09-17 1990-04-24 Baxter International Inc. Nutritional support or therapy for individuals at risk or under treatment for atherosclerotic vascular, cardiovascular, and/or thrombotic diseases
US4843095A (en) * 1987-08-07 1989-06-27 Century Laboratories, Inc. Free fatty acids for treatment or propyhlaxis of rheumatoid arthritis arthritis
US5057419A (en) * 1988-09-22 1991-10-15 Rutgers University Genetically engineered plasmid and organisms for the production of specialized oils
US5407957A (en) * 1990-02-13 1995-04-18 Martek Corporation Production of docosahexaenoic acid by dinoflagellates
US5512482A (en) * 1990-04-26 1996-04-30 Calgene, Inc. Plant thioesterases
AU659087B2 (en) * 1990-05-25 1995-05-11 E.I. Du Pont De Nemours And Company Nucleotide sequence of soybean stearoyl-ACP desaturase gene
ES2157898T3 (es) * 1991-01-24 2001-09-01 Martek Corp Aceites microbianos y usos de los mismos.
US5658767A (en) 1991-01-24 1997-08-19 Martek Corporation Arachidonic acid and methods for the production and use thereof
JPH0591886A (ja) * 1991-09-30 1993-04-16 Suntory Ltd ８，１１−エイコサジエン酸及びこれを含有する脂質の製造方法
US5614393A (en) * 1991-10-10 1997-03-25 Rhone-Poulenc Agrochimie Production of γ-linolenic acid by a Δ6-desaturase
PH31293A (en) * 1991-10-10 1998-07-06 Rhone Poulenc Agrochimie Production of y-linolenic acid by a delta6-desaturage.
JPH0614667A (ja) * 1992-03-13 1994-01-25 Lubrizol Corp:The デサチュラーゼを使用しての植物油の改変
DE69333025T2 (de) 1992-11-17 2004-04-29 E.I. Du Pont De Nemours And Co., Wilmington Für mikrosom delta 12 fettsäuredesaturase kodierende gene und verwandte enzyme von pflanzen
US7205457B1 (en) * 1993-02-05 2007-04-17 Monsanto Technology Llc Altered linolenic and linoleic acid content in plants
US5545553A (en) * 1994-09-26 1996-08-13 The Rockefeller University Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them
US5654402A (en) * 1994-10-26 1997-08-05 Michigan State University Methods and compositions relating to plant Δ6 palmitoyl-acyl carrier protein desaturase

Also Published As

Publication number Publication date
IN1998KO00639A (enExample) 2005-03-18
HUP0001295A1 (en) 2000-07-28
PL336067A1 (en) 2000-06-05
KR20010006258A (ko) 2001-01-26
TR199902466T2 (xx) 2000-07-21
ES2229491T3 (es) 2005-04-16
HUP0001295A3 (en) 2003-10-28
KR20010006255A (ko) 2001-01-26
CA2286263A1 (en) 1998-10-22
DE69826494D1 (de) 2004-10-28
IL132149A0 (en) 2001-03-19
AU7114898A (en) 1998-11-11
JP2001523092A (ja) 2001-11-20
NZ337458A (en) 2000-07-28
BG103796A (bg) 2000-05-31
US6589767B1 (en) 2003-07-08
JP4453881B2 (ja) 2010-04-21
EP1007691A1 (en) 2000-06-14
NO994924D0 (no) 1999-10-08
NO994924L (no) 1999-11-30
ATE277188T1 (de) 2004-10-15
AU720725B2 (en) 2000-06-08
EP1007691B1 (en) 2004-09-22
US5972664A (en) 1999-10-26
MX9909327A (es) 2000-04-30
PT1007691E (pt) 2005-02-28
CN1253587A (zh) 2000-05-17
SK139799A3 (en) 2000-05-16
DE69826494T2 (de) 2006-03-09
BR9809083A (pt) 2000-08-01
SI1007691T1 (en) 2005-02-28
WO1998046765A1 (en) 1998-10-22

Similar Documents

Publication Publication Date Title
NO994924L (no) Fremgangsmåter og blandinger for syntese av langkjedede flerumettede fettsyrer
DK0975766T3 (da) Fremgangsmåder og sammensætninger til syntese af langkædede polyumættede fedtsyrer
EP1401259A4 (en) -4 DESATURASE GENES AND THEIR USE
ATE495263T1 (de) Transgene pflanzen, die fettsäurebiosynthese enzyme exprimieren
CY1106085T1 (el) Το ανθρωπινο γονιδιο της δελτα-5δεσατουρασης και οι χρησεις του
BRPI0410681A (pt) moléculas de ácido nucléico isoladas, polipeptìdio, gene quimérico, célula hospedeira transformada, métodos para a produção de ácido linoléico e de ácidos graxos w-3, método para modular a biosìntese de ácidos graxos w-3 ou w-6, óleo microbial, e métodos para a obtenção de uma molécula de ácido nucléico
DK1911837T3 (da) FAD5-2 fedtsyredesaturasefamiliemedlem og anvendelser deraf
DE60322515D1 (de) Desaturasegene, von diesen codierte enzyme und verwendungen dafür
PT996732E (pt) Metodos e composicoes para sintese de acidos gordos polinsaturados de cadeia longa em plantas
BR0205508A (pt) Genes para dessaturase e usos dos mesmos
AR021789A1 (es) Genes de la elongasa y usos de los mismos.
WO2000020602A3 (en) Delta 6 and delta 12 desaturases and modified fatty acid biosynthesis and products produced therefrom
NO20015967L (no) 6-acetylenase og 6-desaturase fra ceratodon purpureus
ES2376225T5 (es) Genes de elongasa y usos de los mismos