AR021789A1 - Genes de la elongasa y usos de los mismos. - Google Patents

Genes de la elongasa y usos de los mismos.

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Publication number
AR021789A1
AR021789A1 ARP990104430A ARP990104430A AR021789A1 AR 021789 A1 AR021789 A1 AR 021789A1 AR P990104430 A ARP990104430 A AR P990104430A AR P990104430 A ARP990104430 A AR P990104430A AR 021789 A1 AR021789 A1 AR 021789A1
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AR
Argentina
Prior art keywords
acid
genes
dgla
fatty acids
plant
Prior art date
Application number
ARP990104430A
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English (en)
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Abbott Lab
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Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of AR021789A1 publication Critical patent/AR021789A1/es

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Abstract

La presente invencion se relaciona con la identificacion de cuatro genes involucrados en la elongacion de ácidos grasos poliinsaturados (es decir,elongasas) y con los usos de los mismos. Dos de estos genes también están involucrados en la elongacionde ácidos grasos monoinsaturados. Proteínas purificadascodificadas por dichos genes, vector, célula huesped; planta, célula vegetal o tejido vegetal que comprende el vector; mamífero no humano cuyo genoma comprendeuna secuencia de ADN que codifica una elongasa unida a un promotor, fluido producido por el mamífero no humano. En particular, la elongasa se utiliza en laconversion de ácido gamma-linolénico (GLA) en ácido dihomogamma-linolénico (DGLA) y en la conversion de DGLA o 20:4n-3 en ácido eicosapentaenoico (EPA). ElDGLA se puede utilizar en la produccion de ácidos grasos poliinsaturados, tal como ácido araquidonico (AA), ácido docosahexaenoico (DHA), EPA, ácido adrénico,ácido omega6-docosapentaenoico o ácido omega3-docosapentaenoico, que se pueden agregar a composiciones farmacéuticas, composiciones nutricionales, alimentospara animales así como otros productos tales como cosméticos.
ARP990104430A 1998-09-02 1999-09-02 Genes de la elongasa y usos de los mismos. AR021789A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/145,828 US6403349B1 (en) 1998-09-02 1998-09-02 Elongase gene and uses thereof

Publications (1)

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AR021789A1 true AR021789A1 (es) 2002-08-07

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ARP990104430A AR021789A1 (es) 1998-09-02 1999-09-02 Genes de la elongasa y usos de los mismos.

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US (1) US6403349B1 (es)
EP (1) EP1108039B1 (es)
JP (2) JP5421508B2 (es)
AR (1) AR021789A1 (es)
AT (1) ATE392475T1 (es)
AU (1) AU768301B2 (es)
CA (3) CA2633516C (es)
CO (1) CO5021164A1 (es)
DE (1) DE69938554T2 (es)
DK (1) DK1108039T3 (es)
ES (1) ES2306523T3 (es)
HK (1) HK1040414A1 (es)
PT (1) PT1108039E (es)
WO (1) WO2000012720A2 (es)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030163845A1 (en) 1998-09-02 2003-08-28 Pradip Mukerji Elongase genes and uses thereof
US6403349B1 (en) * 1998-09-02 2002-06-11 Abbott Laboratories Elongase gene and uses thereof
US6913916B1 (en) 1998-09-02 2005-07-05 Abbott Laboratories Elongase genes and uses thereof
US6677145B2 (en) * 1998-09-02 2004-01-13 Abbott Laboratories Elongase genes and uses thereof
EP1161542A1 (en) * 1999-03-18 2001-12-12 University Of Bristol Polysaturated fatty acid (pufa) elongase from caenorhabditis elegans
AU5394100A (en) * 1999-05-20 2000-12-12 Karolinska Innovations Ab Fatty acid elongation genes and uses thereof
DE10030976A1 (de) 2000-06-30 2002-01-10 Basf Ag DELTA6-Desaturasegene exprimierende Pflanzen und PUFAS enthaltende Öle aus diesen Pflanzen und ein Verfahren zur Herstellung ungesättigter Fettsäuren
US7070970B2 (en) 1999-08-23 2006-07-04 Abbott Laboratories Elongase genes and uses thereof
WO2001031013A1 (en) * 1999-10-28 2001-05-03 Curagen Corporation Human gold-induced glycoprotein 30-like protein and nucleic acid encoding the same
AU1472801A (en) * 1999-11-12 2001-06-06 Human Genome Sciences, Inc. 24 human secreted proteins
KR20020073580A (ko) * 2000-02-09 2002-09-27 바스프 악티엔게젤샤프트 신규 연장효소 유전자 및 다가불포화 지방산의 제조 방법
PT1322752E (pt) 2000-09-28 2010-05-06 Bioriginal Food & Science Corp Fad4, fad5, fad5-2 e fad6, novos membros da família de dessaturases de ácidos gordos e susas utilizações
US7297523B2 (en) 2000-11-29 2007-11-20 Xenon Pharmaceuticals Inc. Human elongase genes and uses thereof
AU2002231779A1 (en) * 2001-02-09 2002-08-28 Bayer Aktiengesellschaft Regulation of human long chain polyunsaturated fatty acid elongation enzyme-like protein
US20040121044A1 (en) * 2001-03-14 2004-06-24 John Tiano Nutritional product with high protein, low carbohydrate content and good physical stability
GB0107510D0 (en) * 2001-03-26 2001-05-16 Univ Bristol New elongase gene and a process for the production of -9-polyunsaturated fatty acids
US7045683B2 (en) 2001-05-04 2006-05-16 Abbott Laboratories Δ4-desaturase genes and uses thereof
AU2002351007A1 (en) * 2001-11-06 2003-05-19 Decode Genetics Ehf. Nucleic acids encoding very long chain fatty acid biosynthesis enzymes
US7211656B2 (en) * 2002-01-30 2007-05-01 Abbott Laboratories Desaturase genes, enzymes encoded thereby, and uses thereof
US8010174B2 (en) 2003-08-22 2011-08-30 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9282925B2 (en) 2002-02-12 2016-03-15 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9247901B2 (en) 2003-08-22 2016-02-02 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US8260393B2 (en) 2003-07-25 2012-09-04 Dexcom, Inc. Systems and methods for replacing signal data artifacts in a glucose sensor data stream
US6979468B1 (en) 2002-12-06 2005-12-27 Sirius Laboratories Oral composition and method for the treatment of inflammatory cutaneous disorders
US20040172682A1 (en) 2003-02-12 2004-09-02 Kinney Anthony J. Production of very long chain polyunsaturated fatty acids in oilseed plants
US8084074B2 (en) 2003-02-12 2011-12-27 E. I. Du Pont De Nemours And Company Production of very long chain polyunsaturated fatty acids in oil seed plants
US7125672B2 (en) 2003-05-07 2006-10-24 E. I. Du Pont De Nemours And Company Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts
US7238482B2 (en) 2003-05-07 2007-07-03 E. I. Du Pont De Nemours And Company Production of polyunsaturated fatty acids in oleaginous yeasts
US11952581B2 (en) 2003-08-01 2024-04-09 Basf Plant Science Gmbh Process for the production of polyunsaturated fatty acids in transgenic organisms
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
EP1654344B1 (de) 2003-08-01 2018-10-17 BASF Plant Science GmbH Verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US8761856B2 (en) 2003-08-01 2014-06-24 Dexcom, Inc. System and methods for processing analyte sensor data
US8275437B2 (en) 2003-08-01 2012-09-25 Dexcom, Inc. Transcutaneous analyte sensor
US8845536B2 (en) 2003-08-01 2014-09-30 Dexcom, Inc. Transcutaneous analyte sensor
US7774145B2 (en) 2003-08-01 2010-08-10 Dexcom, Inc. Transcutaneous analyte sensor
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US20140121989A1 (en) 2003-08-22 2014-05-01 Dexcom, Inc. Systems and methods for processing analyte sensor data
EP1682566B1 (en) 2003-11-12 2013-06-05 E.I. Du Pont De Nemours And Company Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous plants and yeast
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
WO2005051170A2 (en) 2003-11-19 2005-06-09 Dexcom, Inc. Integrated receiver for continuous analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8774886B2 (en) 2006-10-04 2014-07-08 Dexcom, Inc. Analyte sensor
US8364231B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
EP3263032B1 (en) 2003-12-09 2024-01-24 Dexcom, Inc. Signal processing for continuous analyte sensor
CA2549097C (en) * 2003-12-17 2013-03-26 Suntory Limited Method of producing arachidonic acid-containing plants
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
ES2375363T3 (es) 2004-02-27 2012-02-29 Basf Plant Science Gmbh Método para la preparación de ácidos grasos omega-3 insaturados en organismos transgénicos.
ES2421440T3 (es) 2004-02-27 2013-09-02 Basf Plant Science Gmbh Método para preparar ácidos grasos poliinsaturados en plantas transgénicas
JP2005255653A (ja) * 2004-03-15 2005-09-22 Taisho Pharmaceut Co Ltd 鉄化合物配合内服液剤
US20050220901A1 (en) * 2004-03-22 2005-10-06 Huttenbauer Samuel Jr Methods of pharmaceutical separation from plants
JP4481702B2 (ja) * 2004-03-31 2010-06-16 サントリーホールディングス株式会社 脂質生産菌の育種方法およびその利用
EP2357243B1 (en) 2004-04-22 2018-12-12 Commonwealth Scientific and Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
ES2529572T3 (es) 2004-04-22 2015-02-23 Commonwealth Scientific And Industrial Research Organisation Síntesis de ácidos grasos poliinsaturados de cadena larga por células recombinantes
US7364883B2 (en) * 2004-05-07 2008-04-29 Yeastern Biotech Co., Ltd. Process for producing poly-unsaturated fatty acids by oleaginous yeasts
CA2568689A1 (en) * 2004-06-04 2005-12-15 Fluxome Sciences A/S Metabolically engineered cells for the production of polyunsaturated fatty acids
AU2005267202B2 (en) 2004-06-25 2011-10-27 Corteva Agriscience Llc Delta-8 desaturase and its use in making polyunsaturated fatty acids
US8565848B2 (en) 2004-07-13 2013-10-22 Dexcom, Inc. Transcutaneous analyte sensor
US7310544B2 (en) 2004-07-13 2007-12-18 Dexcom, Inc. Methods and systems for inserting a transcutaneous analyte sensor
US8452368B2 (en) 2004-07-13 2013-05-28 Dexcom, Inc. Transcutaneous analyte sensor
US7588931B2 (en) 2004-11-04 2009-09-15 E. I. Du Pont De Nemours And Company High arachidonic acid producing strains of Yarrowia lipolytica
US20060246115A1 (en) * 2005-03-04 2006-11-02 Ricardo Rueda Nutritional products for ameliorating symptoms of rheumatoid arthritis
US8133178B2 (en) 2006-02-22 2012-03-13 Dexcom, Inc. Analyte sensor
DE102005013779A1 (de) 2005-03-22 2006-09-28 Basf Plant Science Gmbh Verfahren zur Herstellung von mehrfach ungesättigten C20- und C22-Fettsäuren mit mindestens vier Doppelbindungen in transgenen Pflanzen
BRPI0611480B1 (pt) * 2005-05-23 2016-06-07 Arcadia Biosciences Inc cártamo com ácido gama-linolênico elevado
DE102005038036A1 (de) 2005-08-09 2007-02-15 Basf Plant Science Gmbh Verfahren zur Herstellung von Arachidonsäure und/oder Eicosapentaensäure in transgenen Nutzpflanzen
GB2431158A (en) * 2005-10-13 2007-04-18 Rothamsted Res Ltd Process for the production of arachidonic and/or eicosapentaenoic acid
US7470532B2 (en) * 2005-10-19 2008-12-30 E.I. Du Pont De Nemours And Company Mortierella alpina C16/18 fatty acid elongase
KR20080071190A (ko) 2005-11-23 2008-08-01 이 아이 듀폰 디 네모아 앤드 캄파니 델타-９ 일롱가제, 및 다중불포화 지방산 생성에 있어서의이들의 용도
BRPI0619598A2 (pt) * 2005-12-09 2011-10-11 Drugtech Corp composição de emulsão intravenosa de ácido graxo essencial e métodos de administração da mesma
GB0603160D0 (en) 2006-02-16 2006-03-29 Rothamsted Res Ltd Nucleic acid
AR059376A1 (es) 2006-02-21 2008-03-26 Basf Plant Science Gmbh Procedimiento para la produccion de acidos grasos poliinsaturados
US7943823B2 (en) 2006-04-28 2011-05-17 E.I. Du Pont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
US7678560B2 (en) * 2006-05-17 2010-03-16 E.I. Du Pont De Nemours And Company Δ 5 desaturase and its use in making polyunsaturated fatty acids
US7695950B2 (en) * 2006-05-17 2010-04-13 E. I. Du Pont De Nemours And Company Δ5 desaturase and its use in making polyunsaturated fatty acids
WO2008025068A1 (en) 2006-08-29 2008-03-06 Commonwealth Scientific And Industrial Research Organisation Synthesis of fatty acids
US7666369B2 (en) * 2006-09-29 2010-02-23 Tyco Healthcare Group Lp System and method for recycling sterilant gas
EP2177605B1 (de) 2006-10-06 2014-12-10 BASF Plant Science GmbH Delta-5 Desaturasen und Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen nicht-humanen Organismen
PL2390339T3 (pl) 2006-10-23 2013-12-31 Du Pont Delta-8 desaturazy i ich zastosowanie w wytwarzaniu polinienasyconych kwasów tłuszczowych
WO2008085841A1 (en) * 2007-01-03 2008-07-17 Monsanto Technology, Llc Food compositions incorporating stearidonic acid.
CA2675207A1 (en) 2007-02-12 2008-07-21 E. I. Du Pont De Nemours And Company Production of arachidonic acid in oilseed plants
EP2129777B1 (en) * 2007-04-03 2015-10-28 E. I. du Pont de Nemours and Company Multizymes and their use in making polyunsaturated fatty acids
US8188338B2 (en) 2007-04-10 2012-05-29 E. I. Du Pont De Nemours And Company Delta-8 desaturases and their use in making polyunsaturated fatty acids
US7794701B2 (en) 2007-04-16 2010-09-14 E.I. Du Pont De Nemours And Company Δ-9 elongases and their use in making polyunsaturated fatty acids
US8957280B2 (en) 2007-05-03 2015-02-17 E. I. Du Pont De Nemours And Company Delta-5 desaturases and their use in making polyunsaturated fatty acids
WO2008154312A1 (en) 2007-06-08 2008-12-18 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
AU2008281760B2 (en) 2007-07-31 2014-07-17 Basf Plant Science Gmbh Elongases and methods for producing polyunsaturated fatty acids in transgenic organisms
EP4098177A1 (en) 2007-10-09 2022-12-07 DexCom, Inc. Integrated insulin delivery system with continuous glucose sensor
US8229535B2 (en) 2008-02-21 2012-07-24 Dexcom, Inc. Systems and methods for blood glucose monitoring and alert delivery
EP2108702A1 (en) * 2008-04-07 2009-10-14 Organo Balance GmbH Synthesis of polyunsaturated fatty acids in yeast
EP2331695B1 (en) 2008-08-26 2014-07-23 BASF Plant Science GmbH Nucleic acids encoding desaturases and modified plant oil
CN114045301A (zh) 2008-11-18 2022-02-15 联邦科学技术研究组织 产生ω-3脂肪酸的酶和方法
WO2010067352A1 (en) * 2008-12-09 2010-06-17 Ben Gurion University Of The Negev Research And Development Authority Polyunsaturated fatty acid elongase
WO2010111660A1 (en) 2009-03-27 2010-09-30 Dexcom, Inc. Methods and systems for promoting glucose management
EP2609202A1 (en) 2010-08-26 2013-07-03 E.I. Du Pont De Nemours And Company Mutant hpgg motif and hdash motif delta-5 desaturases and their use in making polyunsaturated fatty acids
EP2697650B1 (en) 2011-04-15 2020-09-30 Dexcom, Inc. Advanced analyte sensor calibration and error detection
CN108936583A (zh) 2012-03-01 2018-12-07 雀巢产品技术援助有限公司 具有已调节的异味强度的营养产品及其制备和使用方法
ES2769448T3 (es) 2012-04-12 2020-06-25 Rothamsted Res Limited Producción de ácidos grasos poliinsaturados omega-3 de cadena larga
KR20150037771A (ko) 2012-06-15 2015-04-08 커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션 식물 세포에서 장쇄 다중불포화 지방산의 생성
GB201217524D0 (en) 2012-10-01 2012-11-14 Rothamsted Res Ltd Recombinant organisms
MX2016008270A (es) 2013-12-18 2017-05-26 Commw Scient Ind Res Org Lipido que comprende acidos grasos poliinsaturados de cadena larga.
AU2015281791A1 (en) 2014-06-27 2017-01-12 Commonwealth Scientific And Industrial Research Organisation Lipid comprising docosapentaenoic acid
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
JP2021500162A (ja) 2017-10-24 2021-01-07 デックスコム・インコーポレーテッド 事前接続された分析物センサ
CN110373436B (zh) * 2018-12-11 2022-09-23 山东理工大学 一种产双高-γ-亚麻酸卷枝毛霉细胞工厂的构建方法及发酵技术
CN114452309B (zh) * 2022-01-17 2022-12-02 广东海洋大学 杨叶肖槿内生真菌发酵提取物及其制备方法与用途

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0285405A1 (en) 1987-03-31 1988-10-05 Schering Biotech Corporation Glycosylation inhibition factors
GB8714772D0 (en) 1987-06-24 1987-07-29 Efamol Ltd Essential fatty acid compositions
FR2648347B1 (fr) * 1989-06-15 1994-04-29 Sederma Sa Preparations cosmetiques possedant des proprietes adoucissantes
DK0537178T4 (da) 1990-05-25 2007-07-16 Du Pont Nukleotidsekvens af sojabönne-stearoyl-ACP-desaturase-gen
PH31293A (en) 1991-10-10 1998-07-06 Rhone Poulenc Agrochimie Production of y-linolenic acid by a delta6-desaturage.
EP0616644B1 (en) 1991-12-04 2003-07-02 E.I. Du Pont De Nemours And Company Fatty acid desaturase genes from plants
DK0668919T3 (da) 1992-11-17 2003-09-15 Du Pont Gener for mikorsomale delta-12-fedtsyredesaturaser og beslægtede enzymer fra planter
US5484724A (en) 1994-05-26 1996-01-16 Merck & Co., Inc. DNA encoding GLSI
US5545553A (en) 1994-09-26 1996-08-13 The Rockefeller University Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them
US5654402A (en) 1994-10-26 1997-08-05 Michigan State University Methods and compositions relating to plant Δ6 palmitoyl-acyl carrier protein desaturase
JP3792309B2 (ja) 1996-08-30 2006-07-05 サントリー株式会社 不飽和脂肪酸含有油脂の製造方法
US6403349B1 (en) * 1998-09-02 2002-06-11 Abbott Laboratories Elongase gene and uses thereof
EP1161542A1 (en) * 1999-03-18 2001-12-12 University Of Bristol Polysaturated fatty acid (pufa) elongase from caenorhabditis elegans
JP2002540792A (ja) * 1999-04-07 2002-12-03 インサイト・ファーマスーティカルズ・インコーポレイテッド 小胞関連タンパク質
US7070970B2 (en) * 1999-08-23 2006-07-04 Abbott Laboratories Elongase genes and uses thereof

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