BR0205508A - Genes para dessaturase e usos dos mesmos - Google Patents

Genes para dessaturase e usos dos mesmos

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Publication number
BR0205508A
BR0205508A BR0205508-2A BR0205508A BR0205508A BR 0205508 A BR0205508 A BR 0205508A BR 0205508 A BR0205508 A BR 0205508A BR 0205508 A BR0205508 A BR 0205508A
Authority
BR
Brazil
Prior art keywords
desaturase
acid
conversion
carbon
fatty acids
Prior art date
Application number
BR0205508-2A
Other languages
English (en)
Inventor
Pradip Mukerji
Yung-Sheng Huang
Tapas Das
Jennifer Thurmond
Suzette L Pereira
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/769,863 external-priority patent/US6635451B2/en
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of BR0205508A publication Critical patent/BR0205508A/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6431—Linoleic acids [18:2[n-6]]
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6432—Eicosapentaenoic acids [EPA]
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434—Docosahexenoic acids [DHA]
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6458—Glycerides by transesterification, e.g. interesterification, ester interchange, alcoholysis or acidolysis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
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  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Cell Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)

Abstract

"GENES PARA DESSATURASE E USOS DOS MESMOS". A invenção exposta relaciona-se à identificação de genes envolvidos na dessaturação de ácidos graxos poliinsaturados no carbono 5 (i.e., '<30>5-dessaturase') e no carbono 6 (i.e., '<30>6-dessaturase') e aos usos dos mesmos. Em particular, a <30>S-dessaturase pode ser utilizada, por exemplo, na conversão de ácido diomo-g-linolênico (DGLA) em ácido araquidónico (AA) e na conversão de ácido 20:4n-3 em ácido eicosapentaenóico (EPA). A delta-6 dessaturase pode ser usada, por exemplo, na conversão de linoléico (LA) em ácido g-linolênico (GLA). O AA, ou os ácidos graxos poliinsaturados produzidos a partir do mesmo, pode ser adicionado a composições farmacêuticas, composições nutricionais, alimentos para animais, bem como a outros produtos, tais como os cosméticos.
BR0205508-2A 2001-01-25 2002-01-24 Genes para dessaturase e usos dos mesmos BR0205508A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/769,863 US6635451B2 (en) 2001-01-25 2001-01-25 Desaturase genes and uses thereof
US10/054,534 US7067285B2 (en) 2001-01-25 2002-01-22 Desaturase genes and uses thereof
PCT/US2002/001924 WO2002081668A2 (en) 2001-01-25 2002-01-24 Desaturase genes and uses thereof

Publications (1)

Publication Number Publication Date
BR0205508A true BR0205508A (pt) 2005-05-03

Family

ID=26733138

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0205508-2A BR0205508A (pt) 2001-01-25 2002-01-24 Genes para dessaturase e usos dos mesmos

Country Status (7)

Country Link
EP (1) EP1392823B1 (pt)
JP (1) JP4347572B2 (pt)
AU (1) AU2002309482B2 (pt)
BR (1) BR0205508A (pt)
CA (1) CA2435685C (pt)
MX (1) MXPA03006663A (pt)
WO (1) WO2002081668A2 (pt)

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ATE510908T1 (de) 2000-09-28 2011-06-15 Bioriginal Food & Science Corp Fad5-2, mitglied der desaturase-familie und verwendungen davon
US6635451B2 (en) 2001-01-25 2003-10-21 Abbott Laboratories Desaturase genes and uses thereof
US7045683B2 (en) * 2001-05-04 2006-05-16 Abbott Laboratories Δ4-desaturase genes and uses thereof
US20040172682A1 (en) * 2003-02-12 2004-09-02 Kinney Anthony J. Production of very long chain polyunsaturated fatty acids in oilseed plants
US7238482B2 (en) 2003-05-07 2007-07-03 E. I. Du Pont De Nemours And Company Production of polyunsaturated fatty acids in oleaginous yeasts
US11952581B2 (en) 2003-08-01 2024-04-09 Basf Plant Science Gmbh Process for the production of polyunsaturated fatty acids in transgenic organisms
CA3037924A1 (en) 2003-08-01 2005-02-10 Basf Plant Science Gmbh Method for the production of polyunsaturated fatty acids in transgenic organisms
AU2004290051A1 (en) 2003-11-12 2005-05-26 E.I. Dupont De Nemours And Company Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oilseed plants and oleaginous yeast
EP1716229A2 (en) * 2004-02-17 2006-11-02 The University Of York Desaturase enzymes
JP4567047B2 (ja) 2004-02-27 2010-10-20 ビーエーエスエフ プラント サイエンス ゲーエムベーハー トランスジェニック植物における多価不飽和脂肪酸の製造方法
ES2375363T3 (es) 2004-02-27 2012-02-29 Basf Plant Science Gmbh Método para la preparación de ácidos grasos omega-3 insaturados en organismos transgénicos.
CA3056110C (en) 2004-04-22 2020-07-14 Surinder Pal Singh Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
CN103451246B (zh) 2004-04-22 2018-02-16 联邦科学技术研究组织 用重组细胞合成长链多不饱和脂肪酸
DE602005023308D1 (de) 2004-06-04 2010-10-14 Fluxome Sciences As Stoffwechseltechnisch hergestellte zellen zur produktion mehrfach ungesättigter fettsäuren
AU2006249983B2 (en) 2005-05-23 2011-03-17 Arcadia Biosciences, Inc. Safflower with elevated gamma-linolenic acid
CA2630173C (en) 2005-11-18 2018-01-09 Commonwealth Scientific And Industrial Research Organisation Feedstuffs for aquaculture comprising stearidonic acid
AR059376A1 (es) 2006-02-21 2008-03-26 Basf Plant Science Gmbh Procedimiento para la produccion de acidos grasos poliinsaturados
US7678560B2 (en) * 2006-05-17 2010-03-16 E.I. Du Pont De Nemours And Company Δ 5 desaturase and its use in making polyunsaturated fatty acids
US7695950B2 (en) 2006-05-17 2010-04-13 E. I. Du Pont De Nemours And Company Δ5 desaturase and its use in making polyunsaturated fatty acids
WO2008011468A2 (en) 2006-07-19 2008-01-24 Monsanto Technology Llc Fatty acid desaturases from tetraselmis suecica
BRPI0716075A2 (pt) 2006-08-29 2013-08-06 Commw Scient Ind Res Org sÍntese de Ácidos graxos
RS20090413A (en) 2007-04-03 2010-06-30 E. I. Du Pont De Nemours And Company Multizymes and their use in making polyunsaturated fatty acids
US7943365B2 (en) 2007-05-03 2011-05-17 E.I. Du Pont De Nemours And Company Δ-5 desaturases and their use in making polyunsaturated fatty acids
WO2009133145A1 (en) * 2008-04-30 2009-11-05 Basf Plant Science Gmbh Desaturase and method for the production of polyunsaturated fatty acids in transgenic organisms
WO2010014835A1 (en) * 2008-08-01 2010-02-04 E. I. Du Pont De Nemours And Company Δ6 desaturases and their use in making polyunsaturated fatty acids
BR122021003836B1 (pt) 2008-11-18 2022-02-01 Commonwealth Scientific And Industrial Research Organisation Polinucleotídeo isolado e/ou exógeno que não ocorre de forma natural, vetor e método para produzir óleo contendo ácidos graxos insaturados
US20120100550A1 (en) * 2009-03-04 2012-04-26 University Of Miyazaki Method for determining fatty acid synthesis pathway of microorganism, and pcr primer set for use in the method
US8916154B2 (en) 2009-04-27 2014-12-23 Abbott Laboratories Antibodies against delta-5 desaturase and uses thereof
US20120247066A1 (en) 2011-04-01 2012-10-04 Ice House America, Llc Ice bagging apparatus and methods
HUE033766T2 (en) 2012-06-15 2018-01-29 Commw Scient Ind Res Org Preparation of long chain polyunsaturated fatty acids in plant cells
CA3241340A1 (en) 2013-12-18 2015-06-25 Grains Research And Development Corporation Lipid comprising long chain polyunsaturated fatty acids
SG11201610596PA (en) 2014-06-27 2017-01-27 Commw Scient Ind Res Org Lipid comprising docosapentaenoic acid

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US5130242A (en) * 1988-09-07 1992-07-14 Phycotech, Inc. Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids
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PH31293A (en) * 1991-10-10 1998-07-06 Rhone Poulenc Agrochimie Production of y-linolenic acid by a delta6-desaturage.
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WO1999061602A1 (en) * 1998-05-29 1999-12-02 Ohio University Compositions and methods for the synthesis of fatty acids, their derivatives and downstream products
WO2000020603A1 (en) * 1998-10-05 2000-04-13 Abbott Laboratories Altered fatty acid biosynthesis in insect cells using delta five desaturase
EP1035207A1 (en) * 1999-03-09 2000-09-13 MultiGene Biotech GmbH cDNA molecules of the members of gene family encoding human fatty acid desaturases and their use in diagnosis and therapy
US7183458B1 (en) * 1999-06-07 2007-02-27 Basf Plant Science Gmbh Δ6 acetylenase and Δ6-desaturase from ceratodon purpureus
ATE510908T1 (de) * 2000-09-28 2011-06-15 Bioriginal Food & Science Corp Fad5-2, mitglied der desaturase-familie und verwendungen davon

Also Published As

Publication number Publication date
JP4347572B2 (ja) 2009-10-21
CA2435685C (en) 2011-06-07
EP1392823B1 (en) 2011-11-30
EP1392823A2 (en) 2004-03-03
WO2002081668A9 (en) 2004-04-08
WO2002081668A8 (en) 2003-04-10
WO2002081668A3 (en) 2003-12-18
AU2002309482A2 (en) 2002-10-21
WO2002081668A2 (en) 2002-10-17
AU2002309482B2 (en) 2007-08-30
JP2005503770A (ja) 2005-02-10
MXPA03006663A (es) 2004-05-31
CA2435685A1 (en) 2002-10-17
AU2002309482A9 (en) 2002-10-21

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C12N 9/00

Ipc: C12N 9/00 (2006.01), A61K 31/201 (2006.01)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
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