CY1106085T1 - Το ανθρωπινο γονιδιο της δελτα-5δεσατουρασης και οι χρησεις του - Google Patents
Το ανθρωπινο γονιδιο της δελτα-5δεσατουρασης και οι χρησεις τουInfo
- Publication number
- CY1106085T1 CY1106085T1 CY20061100507T CY061100507T CY1106085T1 CY 1106085 T1 CY1106085 T1 CY 1106085T1 CY 20061100507 T CY20061100507 T CY 20061100507T CY 061100507 T CY061100507 T CY 061100507T CY 1106085 T1 CY1106085 T1 CY 1106085T1
- Authority
- CY
- Cyprus
- Prior art keywords
- human
- gene
- desaturase
- conversion
- acid
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 101000848239 Homo sapiens Acyl-CoA (8-3)-desaturase Proteins 0.000 abstract 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 abstract 2
- HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229940114079 arachidonic acid Drugs 0.000 abstract 1
- 235000021342 arachidonic acid Nutrition 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- -1 diamino-γ-linolenic acid Chemical compound 0.000 abstract 1
- 235000005911 diet Nutrition 0.000 abstract 1
- 230000000378 dietary effect Effects 0.000 abstract 1
- HOBAELRKJCKHQD-QNEBEIHSSA-N dihomo-γ-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L9/00—Puddings; Cream substitutes; Preparation or treatment thereof
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
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- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
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- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
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- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6432—Eicosapentaenoic acids [EPA]
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- General Chemical & Material Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Pediatric Medicine (AREA)
- Animal Husbandry (AREA)
- Dermatology (AREA)
- Cell Biology (AREA)
- Emergency Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
Abstract
Το αντικείμενο της εφεύρεσης σχετίζεται με τη ταυτοποίηση ενός γονιδίου που εμπλέκεται στον αποκορεσμό των πολυακόρεστων λιπαρών οξέων στον άνθρακα 5 (δηλ. "ανθρώπινη Δ5-δεσατουράση") και τις χρήσεις του. Συγκεκριμένα, η ανθρώπινη Δ5-δεσατουράση μπορεί να χρησιμοποιηθεί για παράδειγμα στη μετατροπή του διομο-γ-λινολενικού οξέος (DGLA) σε αραχιδονικό οξύ (ΑΛ) και στη μετατροπή του 20:4n-3 σε εικοσιπενταενοϊκό οξύ (EPA). Το ΑΑ ή τα πολυακόρεστα λιπαρά οξέα που παράγονται με αυτό τον τρόπο, μπορούν να προστεθούν σε φαρμακευτικές συνθέσεις, (δια)τροφικές συνθέσεις, ζωοτροφές, καθώς και σε άλλα προϊόντα όπως τα καλλυντικά.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/227,613 US6432684B1 (en) | 1997-04-11 | 1999-01-08 | Human desaturase gene and uses thereof |
PCT/US1999/031163 WO2000040705A2 (en) | 1999-01-08 | 1999-12-29 | Human desaturase gene and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1106085T1 true CY1106085T1 (el) | 2011-06-08 |
Family
ID=22853775
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061100507T CY1106085T1 (el) | 1999-01-08 | 2006-04-11 | Το ανθρωπινο γονιδιο της δελτα-5δεσατουρασης και οι χρησεις του |
Country Status (14)
Country | Link |
---|---|
US (2) | US6432684B1 (el) |
EP (1) | EP1141252B1 (el) |
AR (1) | AR022224A1 (el) |
AT (1) | ATE318895T1 (el) |
AU (1) | AU780422B2 (el) |
CA (1) | CA2358543A1 (el) |
CO (1) | CO5280136A1 (el) |
CY (1) | CY1106085T1 (el) |
DE (1) | DE69930165T2 (el) |
DK (1) | DK1141252T3 (el) |
ES (1) | ES2259482T3 (el) |
HK (1) | HK1043150B (el) |
PT (1) | PT1141252E (el) |
WO (1) | WO2000040705A2 (el) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6432684B1 (en) * | 1997-04-11 | 2002-08-13 | Abbott Laboratories | Human desaturase gene and uses thereof |
CA2329159A1 (en) * | 1998-05-29 | 1999-12-02 | Bruce Kelder | Compositions and methods for the synthesis of fatty acids, their derivatives and downstream products |
US7211418B2 (en) * | 1999-01-14 | 2007-05-01 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
US7247461B2 (en) * | 1999-01-14 | 2007-07-24 | Martek Biosciences Corporation | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof |
US20070244192A1 (en) * | 1999-01-14 | 2007-10-18 | Martek Biosciences Corporation | Plant seed oils containing polyunsaturated fatty acids |
PT1322752E (pt) | 2000-09-28 | 2010-05-06 | Bioriginal Food & Science Corp | Fad4, fad5, fad5-2 e fad6, novos membros da família de dessaturases de ácidos gordos e susas utilizações |
CA2427024A1 (en) * | 2000-10-26 | 2002-05-02 | Xenon Genetics Inc. | Methods for screening compounds that modulate lipid metabolism |
US7244874B2 (en) * | 2002-09-17 | 2007-07-17 | The Regents Of The University Of California | Stearoyl CoA desaturase transgenic non-human animals |
US20040172682A1 (en) | 2003-02-12 | 2004-09-02 | Kinney Anthony J. | Production of very long chain polyunsaturated fatty acids in oilseed plants |
US8084074B2 (en) | 2003-02-12 | 2011-12-27 | E. I. Du Pont De Nemours And Company | Production of very long chain polyunsaturated fatty acids in oil seed plants |
GB0311081D0 (en) * | 2003-05-14 | 2003-06-18 | Btg Internat Limted | Treatment of neurodegenerative conditions |
US7259255B2 (en) * | 2003-06-25 | 2007-08-21 | E. I. Du Pont De Nemours And Company | Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast |
DE112004001520B4 (de) * | 2003-08-18 | 2008-04-10 | Btg International Ltd. | Verwendung eines Lipidglyzerids festgelegter Struktur zur Herstellung eines Medikamentes zur Behandlung der multiplen Sklerose |
US20050220901A1 (en) * | 2004-03-22 | 2005-10-06 | Huttenbauer Samuel Jr | Methods of pharmaceutical separation from plants |
US7807849B2 (en) | 2004-04-22 | 2010-10-05 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
BR122019013214B1 (pt) | 2004-04-22 | 2022-04-12 | Commonwealth Scientific And Industrial Research Organisation | Polinucleotídeo isolado, vetor, célula recombinante, método para produzir uma célula recombinante, método para produzir um ou mais ácido graxo(s) poliinsaturado de cadeia longa, método para produzir uma semente transgênica, método para produzir óleo, método para produzir uma semente oleaginosa, extrato da semente transgênica, composição compreendendo o referido extrato, ração e uso da referida célula recombinante ou extrato |
PT1766023E (pt) * | 2004-06-04 | 2010-12-09 | Fluxome Sciences As | Células metabolicamente manipuladas para a produção de ácidos gordos poliinsaturados |
WO2006012326A1 (en) | 2004-06-25 | 2006-02-02 | E.I. Dupont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
US7273746B2 (en) * | 2004-11-04 | 2007-09-25 | E.I. Dupont De Nemours And Company | Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
US7588931B2 (en) * | 2004-11-04 | 2009-09-15 | E. I. Du Pont De Nemours And Company | High arachidonic acid producing strains of Yarrowia lipolytica |
EP1656839A1 (en) | 2004-11-11 | 2006-05-17 | N.V. Nutricia | Nutrition containing lipid blend |
GB0425932D0 (en) * | 2004-11-25 | 2004-12-29 | Btg Int Ltd | Structured phospholipids |
GB0504333D0 (en) * | 2005-03-02 | 2005-04-06 | Btg Int Ltd | Treatment of cytokine dysregulation |
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CA2083259C (en) | 1990-05-25 | 2007-05-15 | William D. Hitz | Nucleotide sequence of soybean stearoyl-acp desaturase gene |
PH31293A (en) | 1991-10-10 | 1998-07-06 | Rhone Poulenc Agrochimie | Production of y-linolenic acid by a delta6-desaturage. |
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US5654402A (en) | 1994-10-26 | 1997-08-05 | Michigan State University | Methods and compositions relating to plant Δ6 palmitoyl-acyl carrier protein desaturase |
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US6432684B1 (en) * | 1997-04-11 | 2002-08-13 | Abbott Laboratories | Human desaturase gene and uses thereof |
US5972664A (en) | 1997-04-11 | 1999-10-26 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
IL132148A0 (en) * | 1997-04-11 | 2001-03-19 | Calgene Llc | Methods and compositions for synthesis of long chain polyunsaturated fatty acids in plants |
WO2000020603A1 (en) | 1998-10-05 | 2000-04-13 | Abbott Laboratories | Altered fatty acid biosynthesis in insect cells using delta five desaturase |
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1999
- 1999-01-08 US US09/227,613 patent/US6432684B1/en not_active Expired - Lifetime
- 1999-12-29 PT PT99966710T patent/PT1141252E/pt unknown
- 1999-12-29 EP EP99966710A patent/EP1141252B1/en not_active Expired - Lifetime
- 1999-12-29 WO PCT/US1999/031163 patent/WO2000040705A2/en active IP Right Grant
- 1999-12-29 DE DE69930165T patent/DE69930165T2/de not_active Expired - Lifetime
- 1999-12-29 AU AU22204/00A patent/AU780422B2/en not_active Ceased
- 1999-12-29 ES ES99966710T patent/ES2259482T3/es not_active Expired - Lifetime
- 1999-12-29 AT AT99966710T patent/ATE318895T1/de active
- 1999-12-29 CA CA002358543A patent/CA2358543A1/en not_active Abandoned
- 1999-12-29 DK DK99966710T patent/DK1141252T3/da active
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2002
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- 2002-07-09 US US10/191,513 patent/US6858416B2/en not_active Expired - Fee Related
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AU2220400A (en) | 2000-07-24 |
DE69930165D1 (de) | 2006-04-27 |
US20030104596A1 (en) | 2003-06-05 |
EP1141252B1 (en) | 2006-03-01 |
PT1141252E (pt) | 2006-07-31 |
DE69930165T2 (de) | 2006-12-07 |
ES2259482T3 (es) | 2006-10-01 |
ATE318895T1 (de) | 2006-03-15 |
US6432684B1 (en) | 2002-08-13 |
US6858416B2 (en) | 2005-02-22 |
AR022224A1 (es) | 2002-09-04 |
EP1141252A2 (en) | 2001-10-10 |
AU780422B2 (en) | 2005-03-17 |
DK1141252T3 (da) | 2006-06-19 |
HK1043150B (zh) | 2006-10-13 |
WO2000040705A3 (en) | 2000-11-09 |
CO5280136A1 (es) | 2003-05-30 |
HK1043150A1 (en) | 2002-09-06 |
WO2000040705A2 (en) | 2000-07-13 |
CA2358543A1 (en) | 2000-07-13 |
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